Amino acid dipepetide frequency for Ulvibacter sp. MAR_2010_11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.007AlaAla: 5.007 ± 0.091
0.591AlaCys: 0.591 ± 0.03
3.341AlaAsp: 3.341 ± 0.079
4.62AlaGlu: 4.62 ± 0.086
3.539AlaPhe: 3.539 ± 0.07
4.76AlaGly: 4.76 ± 0.081
1.202AlaHis: 1.202 ± 0.047
5.795AlaIle: 5.795 ± 0.099
4.596AlaLys: 4.596 ± 0.092
6.602AlaLeu: 6.602 ± 0.108
1.731AlaMet: 1.731 ± 0.046
3.581AlaAsn: 3.581 ± 0.069
2.161AlaPro: 2.161 ± 0.063
2.681AlaGln: 2.681 ± 0.055
2.185AlaArg: 2.185 ± 0.052
4.749AlaSer: 4.749 ± 0.078
4.405AlaThr: 4.405 ± 0.099
4.701AlaVal: 4.701 ± 0.086
0.618AlaTrp: 0.618 ± 0.023
2.496AlaTyr: 2.496 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
0.497CysAla: 0.497 ± 0.023
0.106CysCys: 0.106 ± 0.012
0.497CysAsp: 0.497 ± 0.038
0.484CysGlu: 0.484 ± 0.024
0.383CysPhe: 0.383 ± 0.023
0.661CysGly: 0.661 ± 0.037
0.159CysHis: 0.159 ± 0.015
0.587CysIle: 0.587 ± 0.027
0.415CysLys: 0.415 ± 0.024
0.638CysLeu: 0.638 ± 0.027
0.166CysMet: 0.166 ± 0.016
0.438CysAsn: 0.438 ± 0.024
0.365CysPro: 0.365 ± 0.024
0.228CysGln: 0.228 ± 0.033
0.212CysArg: 0.212 ± 0.017
0.513CysSer: 0.513 ± 0.028
0.479CysThr: 0.479 ± 0.03
0.475CysVal: 0.475 ± 0.028
0.067CysTrp: 0.067 ± 0.009
0.288CysTyr: 0.288 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
4.244AspAla: 4.244 ± 0.077
0.458AspCys: 0.458 ± 0.025
2.947AspAsp: 2.947 ± 0.097
3.436AspGlu: 3.436 ± 0.071
3.498AspPhe: 3.498 ± 0.065
4.11AspGly: 4.11 ± 0.116
0.833AspHis: 0.833 ± 0.029
4.302AspIle: 4.302 ± 0.065
3.435AspLys: 3.435 ± 0.076
4.829AspLeu: 4.829 ± 0.085
1.14AspMet: 1.14 ± 0.039
3.03AspAsn: 3.03 ± 0.085
2.079AspPro: 2.079 ± 0.082
1.269AspGln: 1.269 ± 0.049
1.892AspArg: 1.892 ± 0.046
3.259AspSer: 3.259 ± 0.061
3.191AspThr: 3.191 ± 0.079
3.887AspVal: 3.887 ± 0.078
0.699AspTrp: 0.699 ± 0.033
2.674AspTyr: 2.674 ± 0.061
0.0AspXaa: 0.0 ± 0.0
Glu
5.479GluAla: 5.479 ± 0.104
0.346GluCys: 0.346 ± 0.019
3.684GluAsp: 3.684 ± 0.068
4.935GluGlu: 4.935 ± 0.114
2.903GluPhe: 2.903 ± 0.054
4.074GluGly: 4.074 ± 0.078
1.09GluHis: 1.09 ± 0.041
5.62GluIle: 5.62 ± 0.083
5.787GluLys: 5.787 ± 0.121
5.88GluLeu: 5.88 ± 0.095
1.685GluMet: 1.685 ± 0.047
4.293GluAsn: 4.293 ± 0.085
1.499GluPro: 1.499 ± 0.04
2.053GluGln: 2.053 ± 0.054
2.612GluArg: 2.612 ± 0.061
3.212GluSer: 3.212 ± 0.066
4.152GluThr: 4.152 ± 0.072
4.527GluVal: 4.527 ± 0.076
0.559GluTrp: 0.559 ± 0.025
2.351GluTyr: 2.351 ± 0.051
0.0GluXaa: 0.0 ± 0.0
Phe
3.158PheAla: 3.158 ± 0.063
0.431PheCys: 0.431 ± 0.021
3.29PheAsp: 3.29 ± 0.072
3.43PheGlu: 3.43 ± 0.067
2.678PhePhe: 2.678 ± 0.07
3.664PheGly: 3.664 ± 0.069
0.839PheHis: 0.839 ± 0.028
3.711PheIle: 3.711 ± 0.084
3.376PheLys: 3.376 ± 0.075
4.763PheLeu: 4.763 ± 0.094
0.999PheMet: 0.999 ± 0.034
2.92PheAsn: 2.92 ± 0.061
1.901PhePro: 1.901 ± 0.045
1.59PheGln: 1.59 ± 0.037
1.719PheArg: 1.719 ± 0.047
4.08PheSer: 4.08 ± 0.068
3.334PheThr: 3.334 ± 0.067
3.22PheVal: 3.22 ± 0.078
0.546PheTrp: 0.546 ± 0.029
2.104PheTyr: 2.104 ± 0.055
0.0PheXaa: 0.0 ± 0.0
Gly
4.692GlyAla: 4.692 ± 0.094
0.628GlyCys: 0.628 ± 0.034
3.782GlyAsp: 3.782 ± 0.105
3.821GlyGlu: 3.821 ± 0.069
3.699GlyPhe: 3.699 ± 0.072
5.148GlyGly: 5.148 ± 0.128
1.128GlyHis: 1.128 ± 0.036
5.682GlyIle: 5.682 ± 0.085
4.674GlyLys: 4.674 ± 0.089
5.779GlyLeu: 5.779 ± 0.092
1.762GlyMet: 1.762 ± 0.051
3.973GlyAsn: 3.973 ± 0.095
1.579GlyPro: 1.579 ± 0.065
1.822GlyGln: 1.822 ± 0.057
2.15GlyArg: 2.15 ± 0.054
4.403GlySer: 4.403 ± 0.105
4.473GlyThr: 4.473 ± 0.111
4.589GlyVal: 4.589 ± 0.087
0.753GlyTrp: 0.753 ± 0.036
2.863GlyTyr: 2.863 ± 0.072
0.0GlyXaa: 0.0 ± 0.0
His
0.983HisAla: 0.983 ± 0.035
0.194HisCys: 0.194 ± 0.017
0.811HisAsp: 0.811 ± 0.029
0.925HisGlu: 0.925 ± 0.029
1.158HisPhe: 1.158 ± 0.035
1.088HisGly: 1.088 ± 0.037
0.48HisHis: 0.48 ± 0.024
1.391HisIle: 1.391 ± 0.039
1.125HisLys: 1.125 ± 0.039
1.799HisLeu: 1.799 ± 0.053
0.365HisMet: 0.365 ± 0.021
0.96HisAsn: 0.96 ± 0.034
0.915HisPro: 0.915 ± 0.03
0.584HisGln: 0.584 ± 0.03
0.721HisArg: 0.721 ± 0.031
1.036HisSer: 1.036 ± 0.036
1.035HisThr: 1.035 ± 0.029
0.907HisVal: 0.907 ± 0.035
0.206HisTrp: 0.206 ± 0.016
0.828HisTyr: 0.828 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
6.132IleAla: 6.132 ± 0.098
0.644IleCys: 0.644 ± 0.029
4.707IleAsp: 4.707 ± 0.069
5.168IleGlu: 5.168 ± 0.079
3.54IlePhe: 3.54 ± 0.069
4.944IleGly: 4.944 ± 0.096
1.282IleHis: 1.282 ± 0.037
5.455IleIle: 5.455 ± 0.099
4.932IleLys: 4.932 ± 0.093
6.931IleLeu: 6.931 ± 0.105
1.288IleMet: 1.288 ± 0.045
4.073IleAsn: 4.073 ± 0.063
3.371IlePro: 3.371 ± 0.058
2.53IleGln: 2.53 ± 0.049
2.542IleArg: 2.542 ± 0.059
5.763IleSer: 5.763 ± 0.095
5.003IleThr: 5.003 ± 0.09
5.027IleVal: 5.027 ± 0.067
0.635IleTrp: 0.635 ± 0.027
2.578IleTyr: 2.578 ± 0.058
0.0IleXaa: 0.0 ± 0.0
Lys
4.802LysAla: 4.802 ± 0.098
0.317LysCys: 0.317 ± 0.02
4.076LysAsp: 4.076 ± 0.085
5.844LysGlu: 5.844 ± 0.112
2.621LysPhe: 2.621 ± 0.058
4.213LysGly: 4.213 ± 0.078
1.249LysHis: 1.249 ± 0.036
5.537LysIle: 5.537 ± 0.09
6.29LysLys: 6.29 ± 0.123
6.1LysLeu: 6.1 ± 0.107
1.914LysMet: 1.914 ± 0.055
4.5LysAsn: 4.5 ± 0.08
2.2LysPro: 2.2 ± 0.055
2.496LysGln: 2.496 ± 0.063
2.832LysArg: 2.832 ± 0.06
4.096LysSer: 4.096 ± 0.086
4.287LysThr: 4.287 ± 0.079
4.298LysVal: 4.298 ± 0.075
0.662LysTrp: 0.662 ± 0.027
2.636LysTyr: 2.636 ± 0.068
0.0LysXaa: 0.0 ± 0.0
Leu
6.074LeuAla: 6.074 ± 0.092
0.716LeuCys: 0.716 ± 0.034
4.916LeuAsp: 4.916 ± 0.084
6.039LeuGlu: 6.039 ± 0.113
5.039LeuPhe: 5.039 ± 0.1
5.936LeuGly: 5.936 ± 0.099
1.699LeuHis: 1.699 ± 0.046
6.626LeuIle: 6.626 ± 0.106
6.893LeuLys: 6.893 ± 0.107
9.388LeuLeu: 9.388 ± 0.14
1.933LeuMet: 1.933 ± 0.049
4.919LeuAsn: 4.919 ± 0.082
3.542LeuPro: 3.542 ± 0.075
3.854LeuGln: 3.854 ± 0.061
3.407LeuArg: 3.407 ± 0.071
6.56LeuSer: 6.56 ± 0.107
5.049LeuThr: 5.049 ± 0.077
5.725LeuVal: 5.725 ± 0.085
0.825LeuTrp: 0.825 ± 0.033
3.314LeuTyr: 3.314 ± 0.069
0.0LeuXaa: 0.0 ± 0.0
Met
1.698MetAla: 1.698 ± 0.044
0.12MetCys: 0.12 ± 0.011
1.231MetAsp: 1.231 ± 0.037
1.589MetGlu: 1.589 ± 0.045
0.76MetPhe: 0.76 ± 0.032
1.513MetGly: 1.513 ± 0.046
0.426MetHis: 0.426 ± 0.022
1.418MetIle: 1.418 ± 0.043
2.13MetLys: 2.13 ± 0.05
2.07MetLeu: 2.07 ± 0.06
0.526MetMet: 0.526 ± 0.023
1.224MetAsn: 1.224 ± 0.039
0.813MetPro: 0.813 ± 0.03
0.922MetGln: 0.922 ± 0.031
0.862MetArg: 0.862 ± 0.028
1.336MetSer: 1.336 ± 0.042
1.164MetThr: 1.164 ± 0.036
1.443MetVal: 1.443 ± 0.045
0.15MetTrp: 0.15 ± 0.012
0.795MetTyr: 0.795 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
3.907AsnAla: 3.907 ± 0.065
0.465AsnCys: 0.465 ± 0.03
3.2AsnAsp: 3.2 ± 0.084
3.482AsnGlu: 3.482 ± 0.075
2.989AsnPhe: 2.989 ± 0.057
4.081AsnGly: 4.081 ± 0.104
0.898AsnHis: 0.898 ± 0.029
4.118AsnIle: 4.118 ± 0.067
3.493AsnLys: 3.493 ± 0.069
5.09AsnLeu: 5.09 ± 0.083
1.195AsnMet: 1.195 ± 0.038
3.526AsnAsn: 3.526 ± 0.083
2.934AsnPro: 2.934 ± 0.066
1.719AsnGln: 1.719 ± 0.051
2.16AsnArg: 2.16 ± 0.046
3.699AsnSer: 3.699 ± 0.072
3.662AsnThr: 3.662 ± 0.082
3.56AsnVal: 3.56 ± 0.078
0.729AsnTrp: 0.729 ± 0.024
2.568AsnTyr: 2.568 ± 0.052
0.0AsnXaa: 0.0 ± 0.0
Pro
2.224ProAla: 2.224 ± 0.06
0.225ProCys: 0.225 ± 0.016
2.199ProAsp: 2.199 ± 0.057
2.816ProGlu: 2.816 ± 0.054
1.906ProPhe: 1.906 ± 0.047
2.325ProGly: 2.325 ± 0.069
0.637ProHis: 0.637 ± 0.024
2.601ProIle: 2.601 ± 0.059
2.556ProLys: 2.556 ± 0.065
3.133ProLeu: 3.133 ± 0.061
0.75ProMet: 0.75 ± 0.029
2.244ProAsn: 2.244 ± 0.053
1.079ProPro: 1.079 ± 0.053
1.255ProGln: 1.255 ± 0.038
0.946ProArg: 0.946 ± 0.03
2.268ProSer: 2.268 ± 0.061
2.104ProThr: 2.104 ± 0.061
2.624ProVal: 2.624 ± 0.061
0.334ProTrp: 0.334 ± 0.021
1.35ProTyr: 1.35 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
2.077GlnAla: 2.077 ± 0.054
0.19GlnCys: 0.19 ± 0.015
1.64GlnAsp: 1.64 ± 0.049
2.123GlnGlu: 2.123 ± 0.053
1.714GlnPhe: 1.714 ± 0.043
1.816GlnGly: 1.816 ± 0.057
0.66GlnHis: 0.66 ± 0.029
2.48GlnIle: 2.48 ± 0.058
2.77GlnLys: 2.77 ± 0.061
3.661GlnLeu: 3.661 ± 0.064
0.828GlnMet: 0.828 ± 0.029
2.027GlnAsn: 2.027 ± 0.049
1.167GlnPro: 1.167 ± 0.042
1.568GlnGln: 1.568 ± 0.049
1.352GlnArg: 1.352 ± 0.043
1.852GlnSer: 1.852 ± 0.043
1.877GlnThr: 1.877 ± 0.043
1.897GlnVal: 1.897 ± 0.047
0.385GlnTrp: 0.385 ± 0.021
1.275GlnTyr: 1.275 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
2.16ArgAla: 2.16 ± 0.053
0.191ArgCys: 0.191 ± 0.017
1.94ArgAsp: 1.94 ± 0.05
2.314ArgGlu: 2.314 ± 0.054
1.926ArgPhe: 1.926 ± 0.05
2.083ArgGly: 2.083 ± 0.054
0.606ArgHis: 0.606 ± 0.025
2.894ArgIle: 2.894 ± 0.066
2.889ArgLys: 2.889 ± 0.063
3.305ArgLeu: 3.305 ± 0.063
0.971ArgMet: 0.971 ± 0.039
2.117ArgAsn: 2.117 ± 0.055
1.125ArgPro: 1.125 ± 0.039
1.127ArgGln: 1.127 ± 0.037
1.369ArgArg: 1.369 ± 0.042
1.949ArgSer: 1.949 ± 0.043
1.911ArgThr: 1.911 ± 0.046
2.213ArgVal: 2.213 ± 0.05
0.382ArgTrp: 0.382 ± 0.021
1.576ArgTyr: 1.576 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
4.088SerAla: 4.088 ± 0.057
0.631SerCys: 0.631 ± 0.031
3.382SerAsp: 3.382 ± 0.069
4.977SerGlu: 4.977 ± 0.085
3.626SerPhe: 3.626 ± 0.067
5.089SerGly: 5.089 ± 0.123
1.059SerHis: 1.059 ± 0.032
4.911SerIle: 4.911 ± 0.079
4.405SerLys: 4.405 ± 0.077
5.934SerLeu: 5.934 ± 0.099
1.382SerMet: 1.382 ± 0.042
3.621SerAsn: 3.621 ± 0.066
2.2SerPro: 2.2 ± 0.054
2.129SerGln: 2.129 ± 0.049
2.106SerArg: 2.106 ± 0.051
3.91SerSer: 3.91 ± 0.076
3.477SerThr: 3.477 ± 0.064
4.247SerVal: 4.247 ± 0.076
0.711SerTrp: 0.711 ± 0.032
2.567SerTyr: 2.567 ± 0.063
0.0SerXaa: 0.0 ± 0.0
Thr
4.269ThrAla: 4.269 ± 0.076
0.404ThrCys: 0.404 ± 0.032
3.209ThrAsp: 3.209 ± 0.09
3.765ThrGlu: 3.765 ± 0.06
3.239ThrPhe: 3.239 ± 0.064
4.556ThrGly: 4.556 ± 0.123
1.162ThrHis: 1.162 ± 0.038
4.95ThrIle: 4.95 ± 0.075
3.624ThrLys: 3.624 ± 0.075
5.717ThrLeu: 5.717 ± 0.081
1.088ThrMet: 1.088 ± 0.035
3.332ThrAsn: 3.332 ± 0.092
2.688ThrPro: 2.688 ± 0.07
2.011ThrGln: 2.011 ± 0.054
1.765ThrArg: 1.765 ± 0.046
3.911ThrSer: 3.911 ± 0.065
4.202ThrThr: 4.202 ± 0.131
4.399ThrVal: 4.399 ± 0.127
0.613ThrTrp: 0.613 ± 0.027
2.432ThrTyr: 2.432 ± 0.076
0.0ThrXaa: 0.0 ± 0.0
Val
4.781ValAla: 4.781 ± 0.078
0.582ValCys: 0.582 ± 0.03
3.546ValAsp: 3.546 ± 0.063
4.031ValGlu: 4.031 ± 0.076
3.55ValPhe: 3.55 ± 0.07
4.154ValGly: 4.154 ± 0.08
1.102ValHis: 1.102 ± 0.038
5.012ValIle: 5.012 ± 0.086
4.091ValLys: 4.091 ± 0.077
6.273ValLeu: 6.273 ± 0.102
1.422ValMet: 1.422 ± 0.041
3.596ValAsn: 3.596 ± 0.077
2.227ValPro: 2.227 ± 0.052
1.843ValGln: 1.843 ± 0.049
2.176ValArg: 2.176 ± 0.05
4.613ValSer: 4.613 ± 0.079
4.396ValThr: 4.396 ± 0.141
4.675ValVal: 4.675 ± 0.091
0.717ValTrp: 0.717 ± 0.044
2.53ValTyr: 2.53 ± 0.07
0.0ValXaa: 0.0 ± 0.0
Trp
0.604TrpAla: 0.604 ± 0.025
0.091TrpCys: 0.091 ± 0.009
0.615TrpAsp: 0.615 ± 0.029
0.691TrpGlu: 0.691 ± 0.029
0.533TrpPhe: 0.533 ± 0.027
0.596TrpGly: 0.596 ± 0.026
0.241TrpHis: 0.241 ± 0.015
0.752TrpIle: 0.752 ± 0.034
0.761TrpLys: 0.761 ± 0.031
0.963TrpLeu: 0.963 ± 0.035
0.305TrpMet: 0.305 ± 0.021
0.633TrpAsn: 0.633 ± 0.028
0.23TrpPro: 0.23 ± 0.016
0.406TrpGln: 0.406 ± 0.021
0.406TrpArg: 0.406 ± 0.02
0.59TrpSer: 0.59 ± 0.029
0.563TrpThr: 0.563 ± 0.032
0.653TrpVal: 0.653 ± 0.029
0.142TrpTrp: 0.142 ± 0.014
0.418TrpTyr: 0.418 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.482TyrAla: 2.482 ± 0.051
0.328TyrCys: 0.328 ± 0.019
2.199TyrAsp: 2.199 ± 0.058
2.255TyrGlu: 2.255 ± 0.054
2.45TyrPhe: 2.45 ± 0.048
2.592TyrGly: 2.592 ± 0.065
0.761TyrHis: 0.761 ± 0.03
2.705TyrIle: 2.705 ± 0.059
2.725TyrLys: 2.725 ± 0.069
3.597TyrLeu: 3.597 ± 0.074
0.741TyrMet: 0.741 ± 0.03
2.468TyrAsn: 2.468 ± 0.057
1.498TyrPro: 1.498 ± 0.042
1.271TyrGln: 1.271 ± 0.038
1.636TyrArg: 1.636 ± 0.046
2.653TyrSer: 2.653 ± 0.057
2.571TyrThr: 2.571 ± 0.086
2.25TyrVal: 2.25 ± 0.057
0.46TyrTrp: 0.46 ± 0.023
1.808TyrTyr: 1.808 ± 0.05
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2733 proteins (915841 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski