Amino acid dipepetide frequency for Vitiosangium sp. GDMCC 1.1324

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.369AlaAla: 13.369 ± 0.089	1.277AlaCys: 1.277 ± 0.023	4.848AlaAsp: 4.848 ± 0.034	7.487AlaGlu: 7.487 ± 0.067	3.746AlaPhe: 3.746 ± 0.032	9.085AlaGly: 9.085 ± 0.059	2.429AlaHis: 2.429 ± 0.028	3.417AlaIle: 3.417 ± 0.028	2.979AlaLys: 2.979 ± 0.036	14.071AlaLeu: 14.071 ± 0.093	2.301AlaMet: 2.301 ± 0.023	2.294AlaAsn: 2.294 ± 0.029	6.876AlaPro: 6.876 ± 0.064	4.155AlaGln: 4.155 ± 0.041	10.264AlaArg: 10.264 ± 0.079	7.076AlaSer: 7.076 ± 0.049	5.731AlaThr: 5.731 ± 0.051	8.178AlaVal: 8.178 ± 0.051	1.743AlaTrp: 1.743 ± 0.024	2.31AlaTyr: 2.31 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	1.125CysAla: 1.125 ± 0.019	0.113CysCys: 0.113 ± 0.007	0.515CysAsp: 0.515 ± 0.016	0.572CysGlu: 0.572 ± 0.013	0.338CysPhe: 0.338 ± 0.01	1.025CysGly: 1.025 ± 0.02	0.272CysHis: 0.272 ± 0.01	0.325CysIle: 0.325 ± 0.008	0.251CysLys: 0.251 ± 0.009	0.888CysLeu: 0.888 ± 0.013	0.171CysMet: 0.171 ± 0.006	0.264CysAsn: 0.264 ± 0.009	0.589CysPro: 0.589 ± 0.016	0.339CysGln: 0.339 ± 0.011	0.678CysArg: 0.678 ± 0.012	0.62CysSer: 0.62 ± 0.015	0.61CysThr: 0.61 ± 0.015	0.737CysVal: 0.737 ± 0.014	0.126CysTrp: 0.126 ± 0.006	0.208CysTyr: 0.208 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	6.019AspAla: 6.019 ± 0.047	0.497AspCys: 0.497 ± 0.014	2.36AspAsp: 2.36 ± 0.03	3.446AspGlu: 3.446 ± 0.027	2.045AspPhe: 2.045 ± 0.02	4.86AspGly: 4.86 ± 0.058	0.842AspHis: 0.842 ± 0.016	1.875AspIle: 1.875 ± 0.024	1.428AspLys: 1.428 ± 0.025	4.84AspLeu: 4.84 ± 0.039	0.857AspMet: 0.857 ± 0.013	1.051AspAsn: 1.051 ± 0.019	3.08AspPro: 3.08 ± 0.038	1.248AspGln: 1.248 ± 0.018	3.017AspArg: 3.017 ± 0.036	2.647AspSer: 2.647 ± 0.029	2.577AspThr: 2.577 ± 0.031	4.22AspVal: 4.22 ± 0.034	0.817AspTrp: 0.817 ± 0.016	1.174AspTyr: 1.174 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	8.332GluAla: 8.332 ± 0.075	0.467GluCys: 0.467 ± 0.012	3.145GluAsp: 3.145 ± 0.029	4.674GluGlu: 4.674 ± 0.061	1.606GluPhe: 1.606 ± 0.024	5.445GluGly: 5.445 ± 0.039	1.545GluHis: 1.545 ± 0.019	1.741GluIle: 1.741 ± 0.025	2.268GluLys: 2.268 ± 0.027	8.078GluLeu: 8.078 ± 0.059	1.24GluMet: 1.24 ± 0.018	1.223GluAsn: 1.223 ± 0.017	3.924GluPro: 3.924 ± 0.04	2.955GluGln: 2.955 ± 0.033	6.563GluArg: 6.563 ± 0.061	3.392GluSer: 3.392 ± 0.033	2.897GluThr: 2.897 ± 0.027	5.361GluVal: 5.361 ± 0.041	0.835GluTrp: 0.835 ± 0.016	1.198GluTyr: 1.198 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.371PheAla: 3.371 ± 0.031	0.309PheCys: 0.309 ± 0.01	2.087PheAsp: 2.087 ± 0.023	2.278PheGlu: 2.278 ± 0.022	1.419PhePhe: 1.419 ± 0.022	2.867PheGly: 2.867 ± 0.031	0.818PheHis: 0.818 ± 0.013	1.272PheIle: 1.272 ± 0.018	0.902PheLys: 0.902 ± 0.016	3.51PheLeu: 3.51 ± 0.033	0.582PheMet: 0.582 ± 0.015	0.909PheAsn: 0.909 ± 0.016	1.686PhePro: 1.686 ± 0.02	1.235PheGln: 1.235 ± 0.016	2.34PheArg: 2.34 ± 0.025	2.278PheSer: 2.278 ± 0.026	2.118PheThr: 2.118 ± 0.022	2.494PheVal: 2.494 ± 0.029	0.474PheTrp: 0.474 ± 0.011	0.805PheTyr: 0.805 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	8.874GlyAla: 8.874 ± 0.053	1.022GlyCys: 1.022 ± 0.018	3.997GlyAsp: 3.997 ± 0.044	5.317GlyGlu: 5.317 ± 0.041	3.065GlyPhe: 3.065 ± 0.029	7.574GlyGly: 7.574 ± 0.067	1.859GlyHis: 1.859 ± 0.021	2.968GlyIle: 2.968 ± 0.034	3.037GlyLys: 3.037 ± 0.032	9.039GlyLeu: 9.039 ± 0.055	1.942GlyMet: 1.942 ± 0.025	2.189GlyAsn: 2.189 ± 0.029	4.261GlyPro: 4.261 ± 0.034	3.171GlyGln: 3.171 ± 0.029	6.638GlyArg: 6.638 ± 0.043	5.404GlySer: 5.404 ± 0.047	5.556GlyThr: 5.556 ± 0.058	6.563GlyVal: 6.563 ± 0.049	1.444GlyTrp: 1.444 ± 0.02	2.103GlyTyr: 2.103 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	2.339HisAla: 2.339 ± 0.027	0.229HisCys: 0.229 ± 0.008	0.962HisAsp: 0.962 ± 0.016	1.388HisGlu: 1.388 ± 0.021	0.868HisPhe: 0.868 ± 0.015	1.95HisGly: 1.95 ± 0.022	0.636HisHis: 0.636 ± 0.014	0.683HisIle: 0.683 ± 0.012	0.459HisLys: 0.459 ± 0.01	2.442HisLeu: 2.442 ± 0.025	0.378HisMet: 0.378 ± 0.009	0.409HisAsn: 0.409 ± 0.01	1.699HisPro: 1.699 ± 0.022	0.707HisGln: 0.707 ± 0.015	1.678HisArg: 1.678 ± 0.021	1.083HisSer: 1.083 ± 0.017	1.005HisThr: 1.005 ± 0.018	1.702HisVal: 1.702 ± 0.021	0.337HisTrp: 0.337 ± 0.011	0.588HisTyr: 0.588 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	3.571IleAla: 3.571 ± 0.032	0.302IleCys: 0.302 ± 0.009	1.823IleAsp: 1.823 ± 0.023	2.087IleGlu: 2.087 ± 0.024	0.986IlePhe: 0.986 ± 0.018	2.597IleGly: 2.597 ± 0.028	0.813IleHis: 0.813 ± 0.015	1.244IleIle: 1.244 ± 0.022	0.796IleLys: 0.796 ± 0.017	2.824IleLeu: 2.824 ± 0.029	0.34IleMet: 0.34 ± 0.009	0.916IleAsn: 0.916 ± 0.016	2.017IlePro: 2.017 ± 0.021	1.153IleGln: 1.153 ± 0.019	2.293IleArg: 2.293 ± 0.024	2.017IleSer: 2.017 ± 0.025	1.859IleThr: 1.859 ± 0.027	2.239IleVal: 2.239 ± 0.022	0.358IleTrp: 0.358 ± 0.01	0.72IleTyr: 0.72 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	3.501LysAla: 3.501 ± 0.038	0.207LysCys: 0.207 ± 0.009	1.759LysAsp: 1.759 ± 0.028	1.889LysGlu: 1.889 ± 0.026	0.677LysPhe: 0.677 ± 0.013	2.512LysGly: 2.512 ± 0.03	0.588LysHis: 0.588 ± 0.013	0.779LysIle: 0.779 ± 0.015	1.36LysLys: 1.36 ± 0.026	3.306LysLeu: 3.306 ± 0.031	0.623LysMet: 0.623 ± 0.013	0.791LysAsn: 0.791 ± 0.016	1.975LysPro: 1.975 ± 0.027	1.12LysGln: 1.12 ± 0.017	2.144LysArg: 2.144 ± 0.022	1.508LysSer: 1.508 ± 0.018	1.569LysThr: 1.569 ± 0.023	2.609LysVal: 2.609 ± 0.032	0.354LysTrp: 0.354 ± 0.01	0.617LysTyr: 0.617 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	13.622LeuAla: 13.622 ± 0.094	1.047LeuCys: 1.047 ± 0.017	5.571LeuAsp: 5.571 ± 0.039	8.02LeuGlu: 8.02 ± 0.056	3.56LeuPhe: 3.56 ± 0.034	9.44LeuGly: 9.44 ± 0.06	2.365LeuHis: 2.365 ± 0.028	3.009LeuIle: 3.009 ± 0.029	3.498LeuLys: 3.498 ± 0.024	12.2LeuLeu: 12.2 ± 0.09	2.001LeuMet: 2.001 ± 0.023	2.207LeuAsn: 2.207 ± 0.027	6.65LeuPro: 6.65 ± 0.052	3.532LeuGln: 3.532 ± 0.031	8.987LeuArg: 8.987 ± 0.062	7.17LeuSer: 7.17 ± 0.049	5.925LeuThr: 5.925 ± 0.04	8.725LeuVal: 8.725 ± 0.056	1.434LeuTrp: 1.434 ± 0.022	2.382LeuTyr: 2.382 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.318MetAla: 2.318 ± 0.026	0.139MetCys: 0.139 ± 0.006	0.978MetAsp: 0.978 ± 0.016	1.162MetGlu: 1.162 ± 0.018	0.466MetPhe: 0.466 ± 0.011	1.68MetGly: 1.68 ± 0.021	0.381MetHis: 0.381 ± 0.01	0.449MetIle: 0.449 ± 0.01	0.83MetLys: 0.83 ± 0.013	2.092MetLeu: 2.092 ± 0.022	0.446MetMet: 0.446 ± 0.011	0.564MetAsn: 0.564 ± 0.011	1.212MetPro: 1.212 ± 0.022	0.618MetGln: 0.618 ± 0.011	1.666MetArg: 1.666 ± 0.021	1.432MetSer: 1.432 ± 0.019	1.124MetThr: 1.124 ± 0.015	1.39MetVal: 1.39 ± 0.018	0.197MetTrp: 0.197 ± 0.006	0.298MetTyr: 0.298 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.524AsnAla: 2.524 ± 0.027	0.243AsnCys: 0.243 ± 0.01	1.056AsnAsp: 1.056 ± 0.021	1.176AsnGlu: 1.176 ± 0.022	0.725AsnPhe: 0.725 ± 0.016	2.198AsnGly: 2.198 ± 0.034	0.475AsnHis: 0.475 ± 0.01	0.867AsnIle: 0.867 ± 0.016	0.594AsnLys: 0.594 ± 0.013	2.365AsnLeu: 2.365 ± 0.026	0.368AsnMet: 0.368 ± 0.01	0.651AsnAsn: 0.651 ± 0.015	1.759AsnPro: 1.759 ± 0.023	0.734AsnGln: 0.734 ± 0.013	1.471AsnArg: 1.471 ± 0.022	1.094AsnSer: 1.094 ± 0.021	1.338AsnThr: 1.338 ± 0.022	1.809AsnVal: 1.809 ± 0.022	0.335AsnTrp: 0.335 ± 0.009	0.576AsnTyr: 0.576 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	6.92ProAla: 6.92 ± 0.053	0.415ProCys: 0.415 ± 0.009	3.335ProAsp: 3.335 ± 0.035	5.275ProGlu: 5.275 ± 0.047	1.964ProPhe: 1.964 ± 0.02	5.88ProGly: 5.88 ± 0.048	1.188ProHis: 1.188 ± 0.016	1.658ProIle: 1.658 ± 0.023	1.618ProLys: 1.618 ± 0.023	6.029ProLeu: 6.029 ± 0.045	1.254ProMet: 1.254 ± 0.019	1.237ProAsn: 1.237 ± 0.022	4.577ProPro: 4.577 ± 0.056	1.842ProGln: 1.842 ± 0.023	4.171ProArg: 4.171 ± 0.038	4.064ProSer: 4.064 ± 0.039	3.14ProThr: 3.14 ± 0.032	4.795ProVal: 4.795 ± 0.041	0.866ProTrp: 0.866 ± 0.017	1.182ProTyr: 1.182 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	4.244GlnAla: 4.244 ± 0.039	0.306GlnCys: 0.306 ± 0.012	1.491GlnAsp: 1.491 ± 0.021	2.279GlnGlu: 2.279 ± 0.026	0.925GlnPhe: 0.925 ± 0.017	3.076GlnGly: 3.076 ± 0.026	0.737GlnHis: 0.737 ± 0.013	0.874GlnIle: 0.874 ± 0.016	1.141GlnLys: 1.141 ± 0.018	3.795GlnLeu: 3.795 ± 0.04	0.676GlnMet: 0.676 ± 0.014	0.662GlnAsn: 0.662 ± 0.012	2.197GlnPro: 2.197 ± 0.031	1.551GlnGln: 1.551 ± 0.025	2.996GlnArg: 2.996 ± 0.035	1.747GlnSer: 1.747 ± 0.022	1.572GlnThr: 1.572 ± 0.02	3.23GlnVal: 3.23 ± 0.031	0.524GlnTrp: 0.524 ± 0.013	0.708GlnTyr: 0.708 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	8.846ArgAla: 8.846 ± 0.064	0.753ArgCys: 0.753 ± 0.015	3.566ArgAsp: 3.566 ± 0.035	5.874ArgGlu: 5.874 ± 0.054	3.193ArgPhe: 3.193 ± 0.028	5.703ArgGly: 5.703 ± 0.035	1.774ArgHis: 1.774 ± 0.023	2.961ArgIle: 2.961 ± 0.027	2.384ArgLys: 2.384 ± 0.029	9.328ArgLeu: 9.328 ± 0.07	2.006ArgMet: 2.006 ± 0.023	1.646ArgAsn: 1.646 ± 0.018	4.358ArgPro: 4.358 ± 0.042	2.801ArgGln: 2.801 ± 0.033	6.322ArgArg: 6.322 ± 0.053	4.066ArgSer: 4.066 ± 0.033	4.095ArgThr: 4.095 ± 0.032	6.355ArgVal: 6.355 ± 0.05	1.336ArgTrp: 1.336 ± 0.022	2.077ArgTyr: 2.077 ± 0.026	0.0ArgXaa: 0.0 ± 0.0
Ser	6.684SerAla: 6.684 ± 0.049	0.657SerCys: 0.657 ± 0.014	2.702SerAsp: 2.702 ± 0.028	3.428SerGlu: 3.428 ± 0.028	2.276SerPhe: 2.276 ± 0.026	5.984SerGly: 5.984 ± 0.054	1.229SerHis: 1.229 ± 0.017	2.001SerIle: 2.001 ± 0.026	1.512SerLys: 1.512 ± 0.023	6.615SerLeu: 6.615 ± 0.046	1.147SerMet: 1.147 ± 0.018	1.393SerAsn: 1.393 ± 0.023	3.895SerPro: 3.895 ± 0.033	1.911SerGln: 1.911 ± 0.024	4.503SerArg: 4.503 ± 0.034	4.092SerSer: 4.092 ± 0.042	3.517SerThr: 3.517 ± 0.043	4.402SerVal: 4.402 ± 0.034	0.936SerTrp: 0.936 ± 0.017	1.305SerTyr: 1.305 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	5.662ThrAla: 5.662 ± 0.051	0.596ThrCys: 0.596 ± 0.015	2.464ThrAsp: 2.464 ± 0.029	2.935ThrGlu: 2.935 ± 0.028	2.024ThrPhe: 2.024 ± 0.024	5.026ThrGly: 5.026 ± 0.051	1.165ThrHis: 1.165 ± 0.016	1.468ThrIle: 1.468 ± 0.022	1.244ThrLys: 1.244 ± 0.02	6.565ThrLeu: 6.565 ± 0.05	0.792ThrMet: 0.792 ± 0.015	1.217ThrAsn: 1.217 ± 0.027	4.096ThrPro: 4.096 ± 0.038	1.827ThrGln: 1.827 ± 0.025	4.032ThrArg: 4.032 ± 0.034	3.314ThrSer: 3.314 ± 0.036	2.963ThrThr: 2.963 ± 0.04	4.469ThrVal: 4.469 ± 0.044	0.932ThrTrp: 0.932 ± 0.018	1.36ThrTyr: 1.36 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	8.652ValAla: 8.652 ± 0.05	0.786ValCys: 0.786 ± 0.017	4.292ValAsp: 4.292 ± 0.032	5.404ValGlu: 5.404 ± 0.037	2.454ValPhe: 2.454 ± 0.025	6.126ValGly: 6.126 ± 0.051	1.651ValHis: 1.651 ± 0.022	2.358ValIle: 2.358 ± 0.028	2.463ValLys: 2.463 ± 0.03	9.212ValLeu: 9.212 ± 0.061	1.532ValMet: 1.532 ± 0.022	1.693ValAsn: 1.693 ± 0.021	4.717ValPro: 4.717 ± 0.037	2.502ValGln: 2.502 ± 0.023	6.486ValArg: 6.486 ± 0.046	4.859ValSer: 4.859 ± 0.035	4.445ValThr: 4.445 ± 0.045	6.634ValVal: 6.634 ± 0.053	0.94ValTrp: 0.94 ± 0.017	1.618ValTyr: 1.618 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.349TrpAla: 1.349 ± 0.019	0.162TrpCys: 0.162 ± 0.007	0.672TrpAsp: 0.672 ± 0.014	0.797TrpGlu: 0.797 ± 0.015	0.512TrpPhe: 0.512 ± 0.012	1.084TrpGly: 1.084 ± 0.02	0.32TrpHis: 0.32 ± 0.009	0.382TrpIle: 0.382 ± 0.009	0.573TrpLys: 0.573 ± 0.015	1.763TrpLeu: 1.763 ± 0.021	0.398TrpMet: 0.398 ± 0.009	0.469TrpAsn: 0.469 ± 0.012	0.725TrpPro: 0.725 ± 0.013	0.503TrpGln: 0.503 ± 0.011	1.327TrpArg: 1.327 ± 0.017	1.0TrpSer: 1.0 ± 0.017	0.861TrpThr: 0.861 ± 0.015	1.149TrpVal: 1.149 ± 0.019	0.263TrpTrp: 0.263 ± 0.008	0.313TrpTyr: 0.313 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.314TyrAla: 2.314 ± 0.026	0.24TyrCys: 0.24 ± 0.007	1.273TyrAsp: 1.273 ± 0.022	1.4TyrGlu: 1.4 ± 0.021	0.904TyrPhe: 0.904 ± 0.014	1.911TyrGly: 1.911 ± 0.025	0.455TyrHis: 0.455 ± 0.01	0.622TyrIle: 0.622 ± 0.011	0.553TyrLys: 0.553 ± 0.013	2.385TyrLeu: 2.385 ± 0.027	0.388TyrMet: 0.388 ± 0.01	0.57TyrAsn: 0.57 ± 0.014	1.119TyrPro: 1.119 ± 0.017	0.829TyrGln: 0.829 ± 0.017	1.869TyrArg: 1.869 ± 0.025	1.326TyrSer: 1.326 ± 0.021	1.25TyrThr: 1.25 ± 0.024	1.762TyrVal: 1.762 ± 0.022	0.371TyrTrp: 0.371 ± 0.011	0.592TyrTyr: 0.592 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11115 proteins (4118807 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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