Amino acid dipepetide frequency for Muriicola sp. MMS17-SY002

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.955AlaAla: 4.955 ± 0.115	0.587AlaCys: 0.587 ± 0.032	3.741AlaAsp: 3.741 ± 0.104	4.624AlaGlu: 4.624 ± 0.08	3.351AlaPhe: 3.351 ± 0.066	4.857AlaGly: 4.857 ± 0.121	1.236AlaHis: 1.236 ± 0.039	5.336AlaIle: 5.336 ± 0.096	4.202AlaLys: 4.202 ± 0.083	7.045AlaLeu: 7.045 ± 0.118	1.81AlaMet: 1.81 ± 0.052	3.095AlaAsn: 3.095 ± 0.064	2.092AlaPro: 2.092 ± 0.063	2.42AlaGln: 2.42 ± 0.056	2.628AlaArg: 2.628 ± 0.054	4.478AlaSer: 4.478 ± 0.081	3.433AlaThr: 3.433 ± 0.078	4.59AlaVal: 4.59 ± 0.091	0.71AlaTrp: 0.71 ± 0.033	2.678AlaTyr: 2.678 ± 0.064	0.0AlaXaa: 0.0 ± 0.0
Cys	0.455CysAla: 0.455 ± 0.024	0.096CysCys: 0.096 ± 0.011	0.44CysAsp: 0.44 ± 0.039	0.439CysGlu: 0.439 ± 0.024	0.377CysPhe: 0.377 ± 0.021	0.592CysGly: 0.592 ± 0.031	0.195CysHis: 0.195 ± 0.018	0.51CysIle: 0.51 ± 0.024	0.421CysLys: 0.421 ± 0.024	0.654CysLeu: 0.654 ± 0.028	0.155CysMet: 0.155 ± 0.014	0.341CysAsn: 0.341 ± 0.021	0.351CysPro: 0.351 ± 0.026	0.202CysGln: 0.202 ± 0.014	0.264CysArg: 0.264 ± 0.016	0.537CysSer: 0.537 ± 0.026	0.441CysThr: 0.441 ± 0.032	0.429CysVal: 0.429 ± 0.021	0.07CysTrp: 0.07 ± 0.01	0.29CysTyr: 0.29 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	3.696AspAla: 3.696 ± 0.076	0.38AspCys: 0.38 ± 0.032	2.898AspAsp: 2.898 ± 0.085	3.741AspGlu: 3.741 ± 0.073	3.461AspPhe: 3.461 ± 0.082	4.118AspGly: 4.118 ± 0.142	1.123AspHis: 1.123 ± 0.038	4.161AspIle: 4.161 ± 0.076	3.745AspLys: 3.745 ± 0.086	5.813AspLeu: 5.813 ± 0.09	1.256AspMet: 1.256 ± 0.038	2.699AspAsn: 2.699 ± 0.082	2.476AspPro: 2.476 ± 0.098	1.925AspGln: 1.925 ± 0.075	2.321AspArg: 2.321 ± 0.05	3.462AspSer: 3.462 ± 0.085	2.823AspThr: 2.823 ± 0.07	3.427AspVal: 3.427 ± 0.069	0.728AspTrp: 0.728 ± 0.027	2.599AspTyr: 2.599 ± 0.062	0.0AspXaa: 0.0 ± 0.0
Glu	5.003GluAla: 5.003 ± 0.088	0.328GluCys: 0.328 ± 0.021	4.049GluAsp: 4.049 ± 0.082	6.243GluGlu: 6.243 ± 0.12	2.99GluPhe: 2.99 ± 0.059	4.547GluGly: 4.547 ± 0.078	1.204GluHis: 1.204 ± 0.036	5.505GluIle: 5.505 ± 0.089	5.642GluLys: 5.642 ± 0.106	6.661GluLeu: 6.661 ± 0.098	1.768GluMet: 1.768 ± 0.043	4.042GluAsn: 4.042 ± 0.072	1.726GluPro: 1.726 ± 0.047	2.466GluGln: 2.466 ± 0.056	2.935GluArg: 2.935 ± 0.068	3.353GluSer: 3.353 ± 0.061	3.458GluThr: 3.458 ± 0.066	5.077GluVal: 5.077 ± 0.101	0.706GluTrp: 0.706 ± 0.031	2.428GluTyr: 2.428 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	3.08PheAla: 3.08 ± 0.064	0.415PheCys: 0.415 ± 0.024	3.107PheAsp: 3.107 ± 0.065	3.239PheGlu: 3.239 ± 0.056	2.658PhePhe: 2.658 ± 0.073	3.656PheGly: 3.656 ± 0.075	0.829PheHis: 0.829 ± 0.032	3.545PheIle: 3.545 ± 0.072	3.276PheLys: 3.276 ± 0.064	4.993PheLeu: 4.993 ± 0.106	1.095PheMet: 1.095 ± 0.04	2.746PheAsn: 2.746 ± 0.065	1.882PhePro: 1.882 ± 0.052	1.568PheGln: 1.568 ± 0.055	2.097PheArg: 2.097 ± 0.052	3.696PheSer: 3.696 ± 0.074	2.997PheThr: 2.997 ± 0.065	2.974PheVal: 2.974 ± 0.064	0.617PheTrp: 0.617 ± 0.033	2.071PheTyr: 2.071 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	4.623GlyAla: 4.623 ± 0.111	0.638GlyCys: 0.638 ± 0.04	3.802GlyAsp: 3.802 ± 0.092	4.19GlyGlu: 4.19 ± 0.077	3.675GlyPhe: 3.675 ± 0.075	4.8GlyGly: 4.8 ± 0.109	1.232GlyHis: 1.232 ± 0.049	6.051GlyIle: 6.051 ± 0.088	4.894GlyLys: 4.894 ± 0.084	6.408GlyLeu: 6.408 ± 0.092	1.863GlyMet: 1.863 ± 0.051	3.507GlyAsn: 3.507 ± 0.084	1.88GlyPro: 1.88 ± 0.142	2.091GlyGln: 2.091 ± 0.058	2.594GlyArg: 2.594 ± 0.064	4.392GlySer: 4.392 ± 0.092	4.153GlyThr: 4.153 ± 0.122	4.505GlyVal: 4.505 ± 0.067	0.828GlyTrp: 0.828 ± 0.036	2.822GlyTyr: 2.822 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	1.058HisAla: 1.058 ± 0.032	0.193HisCys: 0.193 ± 0.016	0.758HisAsp: 0.758 ± 0.029	1.005HisGlu: 1.005 ± 0.034	1.117HisPhe: 1.117 ± 0.034	1.135HisGly: 1.135 ± 0.034	0.476HisHis: 0.476 ± 0.029	1.314HisIle: 1.314 ± 0.04	1.104HisLys: 1.104 ± 0.036	1.974HisLeu: 1.974 ± 0.056	0.395HisMet: 0.395 ± 0.02	0.781HisAsn: 0.781 ± 0.03	1.014HisPro: 1.014 ± 0.038	0.798HisGln: 0.798 ± 0.03	0.784HisArg: 0.784 ± 0.035	1.088HisSer: 1.088 ± 0.038	0.907HisThr: 0.907 ± 0.033	0.93HisVal: 0.93 ± 0.037	0.264HisTrp: 0.264 ± 0.017	0.8HisTyr: 0.8 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.362IleAla: 5.362 ± 0.08	0.545IleCys: 0.545 ± 0.027	4.389IleAsp: 4.389 ± 0.074	4.952IleGlu: 4.952 ± 0.089	3.431IlePhe: 3.431 ± 0.067	5.081IleGly: 5.081 ± 0.104	1.288IleHis: 1.288 ± 0.04	4.872IleIle: 4.872 ± 0.095	4.622IleLys: 4.622 ± 0.092	7.25IleLeu: 7.25 ± 0.126	1.385IleMet: 1.385 ± 0.051	3.841IleAsn: 3.841 ± 0.073	3.452IlePro: 3.452 ± 0.066	2.34IleGln: 2.34 ± 0.045	3.21IleArg: 3.21 ± 0.064	5.549IleSer: 5.549 ± 0.098	4.42IleThr: 4.42 ± 0.09	4.232IleVal: 4.232 ± 0.076	0.732IleTrp: 0.732 ± 0.034	2.561IleTyr: 2.561 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	5.139LysAla: 5.139 ± 0.091	0.269LysCys: 0.269 ± 0.019	4.097LysAsp: 4.097 ± 0.07	6.158LysGlu: 6.158 ± 0.113	2.348LysPhe: 2.348 ± 0.05	4.623LysGly: 4.623 ± 0.078	1.163LysHis: 1.163 ± 0.042	4.94LysIle: 4.94 ± 0.087	6.109LysLys: 6.109 ± 0.12	5.597LysLeu: 5.597 ± 0.085	1.824LysMet: 1.824 ± 0.058	3.908LysAsn: 3.908 ± 0.07	2.313LysPro: 2.313 ± 0.054	2.13LysGln: 2.13 ± 0.054	2.95LysArg: 2.95 ± 0.067	4.12LysSer: 4.12 ± 0.078	3.813LysThr: 3.813 ± 0.068	4.424LysVal: 4.424 ± 0.089	0.73LysTrp: 0.73 ± 0.034	2.568LysTyr: 2.568 ± 0.062	0.0LysXaa: 0.0 ± 0.0
Leu	6.714LeuAla: 6.714 ± 0.105	0.775LeuCys: 0.775 ± 0.029	5.433LeuAsp: 5.433 ± 0.094	6.586LeuGlu: 6.586 ± 0.1	4.865LeuPhe: 4.865 ± 0.111	6.576LeuGly: 6.576 ± 0.113	1.645LeuHis: 1.645 ± 0.047	6.912LeuIle: 6.912 ± 0.104	7.192LeuLys: 7.192 ± 0.116	9.775LeuLeu: 9.775 ± 0.164	2.343LeuMet: 2.343 ± 0.059	5.2LeuAsn: 5.2 ± 0.099	4.011LeuPro: 4.011 ± 0.08	3.525LeuGln: 3.525 ± 0.073	4.088LeuArg: 4.088 ± 0.076	6.955LeuSer: 6.955 ± 0.102	4.862LeuThr: 4.862 ± 0.093	5.97LeuVal: 5.97 ± 0.113	1.009LeuTrp: 1.009 ± 0.043	3.312LeuTyr: 3.312 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	1.944MetAla: 1.944 ± 0.058	0.136MetCys: 0.136 ± 0.013	1.325MetAsp: 1.325 ± 0.045	1.801MetGlu: 1.801 ± 0.055	0.828MetPhe: 0.828 ± 0.033	1.744MetGly: 1.744 ± 0.051	0.395MetHis: 0.395 ± 0.021	1.675MetIle: 1.675 ± 0.049	2.12MetLys: 2.12 ± 0.053	1.997MetLeu: 1.997 ± 0.052	0.636MetMet: 0.636 ± 0.032	1.24MetAsn: 1.24 ± 0.038	0.928MetPro: 0.928 ± 0.034	0.754MetGln: 0.754 ± 0.029	1.042MetArg: 1.042 ± 0.037	1.464MetSer: 1.464 ± 0.043	1.146MetThr: 1.146 ± 0.044	1.584MetVal: 1.584 ± 0.045	0.176MetTrp: 0.176 ± 0.015	0.722MetTyr: 0.722 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.39AsnAla: 3.39 ± 0.057	0.415AsnCys: 0.415 ± 0.025	2.724AsnAsp: 2.724 ± 0.077	3.215AsnGlu: 3.215 ± 0.067	2.713AsnPhe: 2.713 ± 0.066	3.504AsnGly: 3.504 ± 0.09	0.831AsnHis: 0.831 ± 0.034	3.739AsnIle: 3.739 ± 0.078	3.381AsnLys: 3.381 ± 0.063	4.849AsnLeu: 4.849 ± 0.083	1.194AsnMet: 1.194 ± 0.037	2.701AsnAsn: 2.701 ± 0.075	2.696AsnPro: 2.696 ± 0.066	1.834AsnGln: 1.834 ± 0.051	2.247AsnArg: 2.247 ± 0.055	3.384AsnSer: 3.384 ± 0.072	3.195AsnThr: 3.195 ± 0.085	2.895AsnVal: 2.895 ± 0.068	0.685AsnTrp: 0.685 ± 0.03	2.245AsnTyr: 2.245 ± 0.061	0.0AsnXaa: 0.0 ± 0.0
Pro	2.295ProAla: 2.295 ± 0.058	0.234ProCys: 0.234 ± 0.021	2.565ProAsp: 2.565 ± 0.073	3.429ProGlu: 3.429 ± 0.076	2.113ProPhe: 2.113 ± 0.051	2.601ProGly: 2.601 ± 0.064	0.657ProHis: 0.657 ± 0.028	2.37ProIle: 2.37 ± 0.051	2.334ProLys: 2.334 ± 0.061	3.401ProLeu: 3.401 ± 0.062	0.928ProMet: 0.928 ± 0.035	1.993ProAsn: 1.993 ± 0.052	1.064ProPro: 1.064 ± 0.044	1.291ProGln: 1.291 ± 0.12	1.222ProArg: 1.222 ± 0.038	2.339ProSer: 2.339 ± 0.052	1.888ProThr: 1.888 ± 0.052	2.744ProVal: 2.744 ± 0.055	0.415ProTrp: 0.415 ± 0.021	1.551ProTyr: 1.551 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	2.212GlnAla: 2.212 ± 0.052	0.202GlnCys: 0.202 ± 0.015	1.799GlnAsp: 1.799 ± 0.05	2.499GlnGlu: 2.499 ± 0.067	1.617GlnPhe: 1.617 ± 0.045	2.211GlnGly: 2.211 ± 0.165	0.622GlnHis: 0.622 ± 0.027	2.585GlnIle: 2.585 ± 0.062	2.582GlnLys: 2.582 ± 0.061	3.717GlnLeu: 3.717 ± 0.062	0.881GlnMet: 0.881 ± 0.028	1.861GlnAsn: 1.861 ± 0.05	1.14GlnPro: 1.14 ± 0.041	1.446GlnGln: 1.446 ± 0.045	1.503GlnArg: 1.503 ± 0.043	1.776GlnSer: 1.776 ± 0.041	1.64GlnThr: 1.64 ± 0.046	1.894GlnVal: 1.894 ± 0.046	0.459GlnTrp: 0.459 ± 0.025	1.262GlnTyr: 1.262 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.545ArgAla: 2.545 ± 0.055	0.216ArgCys: 0.216 ± 0.016	2.266ArgAsp: 2.266 ± 0.057	3.023ArgGlu: 3.023 ± 0.074	2.141ArgPhe: 2.141 ± 0.056	2.384ArgGly: 2.384 ± 0.056	0.712ArgHis: 0.712 ± 0.032	3.401ArgIle: 3.401 ± 0.062	3.36ArgLys: 3.36 ± 0.078	3.844ArgLeu: 3.844 ± 0.068	1.037ArgMet: 1.037 ± 0.039	2.377ArgAsn: 2.377 ± 0.052	1.378ArgPro: 1.378 ± 0.038	1.375ArgGln: 1.375 ± 0.05	1.777ArgArg: 1.777 ± 0.054	2.486ArgSer: 2.486 ± 0.072	2.058ArgThr: 2.058 ± 0.048	2.508ArgVal: 2.508 ± 0.054	0.496ArgTrp: 0.496 ± 0.027	1.786ArgTyr: 1.786 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	3.927SerAla: 3.927 ± 0.071	0.634SerCys: 0.634 ± 0.031	3.605SerAsp: 3.605 ± 0.068	4.391SerGlu: 4.391 ± 0.079	3.716SerPhe: 3.716 ± 0.075	5.01SerGly: 5.01 ± 0.124	1.094SerHis: 1.094 ± 0.038	4.493SerIle: 4.493 ± 0.084	4.087SerLys: 4.087 ± 0.062	6.736SerLeu: 6.736 ± 0.104	1.415SerMet: 1.415 ± 0.041	3.109SerAsn: 3.109 ± 0.064	2.323SerPro: 2.323 ± 0.061	2.108SerGln: 2.108 ± 0.046	2.738SerArg: 2.738 ± 0.064	4.296SerSer: 4.296 ± 0.105	3.391SerThr: 3.391 ± 0.072	3.962SerVal: 3.962 ± 0.084	0.82SerTrp: 0.82 ± 0.033	2.67SerTyr: 2.67 ± 0.062	0.0SerXaa: 0.0 ± 0.0
Thr	3.913ThrAla: 3.913 ± 0.086	0.297ThrCys: 0.297 ± 0.023	3.255ThrAsp: 3.255 ± 0.12	3.32ThrGlu: 3.32 ± 0.067	2.799ThrPhe: 2.799 ± 0.065	4.075ThrGly: 4.075 ± 0.092	0.981ThrHis: 0.981 ± 0.038	4.029ThrIle: 4.029 ± 0.082	2.873ThrLys: 2.873 ± 0.065	5.502ThrLeu: 5.502 ± 0.091	1.011ThrMet: 1.011 ± 0.04	2.509ThrAsn: 2.509 ± 0.078	2.405ThrPro: 2.405 ± 0.059	1.682ThrGln: 1.682 ± 0.05	2.019ThrArg: 2.019 ± 0.051	3.575ThrSer: 3.575 ± 0.08	2.963ThrThr: 2.963 ± 0.072	3.72ThrVal: 3.72 ± 0.092	0.533ThrTrp: 0.533 ± 0.025	2.305ThrTyr: 2.305 ± 0.071	0.0ThrXaa: 0.0 ± 0.0
Val	4.351ValAla: 4.351 ± 0.075	0.512ValCys: 0.512 ± 0.026	3.613ValAsp: 3.613 ± 0.091	4.046ValGlu: 4.046 ± 0.079	3.428ValPhe: 3.428 ± 0.076	3.952ValGly: 3.952 ± 0.077	1.134ValHis: 1.134 ± 0.042	4.879ValIle: 4.879 ± 0.091	3.99ValLys: 3.99 ± 0.078	6.523ValLeu: 6.523 ± 0.106	1.516ValMet: 1.516 ± 0.046	3.17ValAsn: 3.17 ± 0.075	2.399ValPro: 2.399 ± 0.059	1.962ValGln: 1.962 ± 0.056	2.358ValArg: 2.358 ± 0.061	4.432ValSer: 4.432 ± 0.079	3.392ValThr: 3.392 ± 0.087	4.487ValVal: 4.487 ± 0.086	0.649ValTrp: 0.649 ± 0.028	2.403ValTyr: 2.403 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.652TrpAla: 0.652 ± 0.03	0.083TrpCys: 0.083 ± 0.011	0.689TrpAsp: 0.689 ± 0.033	0.808TrpGlu: 0.808 ± 0.033	0.565TrpPhe: 0.565 ± 0.03	0.767TrpGly: 0.767 ± 0.035	0.241TrpHis: 0.241 ± 0.016	0.826TrpIle: 0.826 ± 0.038	0.766TrpLys: 0.766 ± 0.03	1.075TrpLeu: 1.075 ± 0.043	0.351TrpMet: 0.351 ± 0.023	0.697TrpAsn: 0.697 ± 0.031	0.316TrpPro: 0.316 ± 0.02	0.427TrpGln: 0.427 ± 0.02	0.482TrpArg: 0.482 ± 0.025	0.622TrpSer: 0.622 ± 0.026	0.576TrpThr: 0.576 ± 0.027	0.713TrpVal: 0.713 ± 0.031	0.181TrpTrp: 0.181 ± 0.016	0.471TrpTyr: 0.471 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.554TyrAla: 2.554 ± 0.054	0.303TyrCys: 0.303 ± 0.02	2.297TyrAsp: 2.297 ± 0.058	2.423TyrGlu: 2.423 ± 0.057	2.349TyrPhe: 2.349 ± 0.055	2.716TyrGly: 2.716 ± 0.056	0.838TyrHis: 0.838 ± 0.034	2.373TyrIle: 2.373 ± 0.049	2.525TyrLys: 2.525 ± 0.051	3.936TyrLeu: 3.936 ± 0.074	0.791TyrMet: 0.791 ± 0.032	2.02TyrAsn: 2.02 ± 0.056	1.589TyrPro: 1.589 ± 0.041	1.559TyrGln: 1.559 ± 0.043	1.91TyrArg: 1.91 ± 0.045	2.522TyrSer: 2.522 ± 0.056	2.211TyrThr: 2.211 ± 0.066	2.133TyrVal: 2.133 ± 0.053	0.497TyrTrp: 0.497 ± 0.025	1.671TyrTyr: 1.671 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2593 proteins (868456 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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