Amino acid dipepetide frequency for Streptococcus cuniculi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.712AlaAla: 6.712 ± 0.149
0.597AlaCys: 0.597 ± 0.031
4.845AlaAsp: 4.845 ± 0.122
5.466AlaGlu: 5.466 ± 0.107
3.631AlaPhe: 3.631 ± 0.098
6.217AlaGly: 6.217 ± 0.117
1.534AlaHis: 1.534 ± 0.057
6.06AlaIle: 6.06 ± 0.108
4.958AlaLys: 4.958 ± 0.1
8.185AlaLeu: 8.185 ± 0.135
2.054AlaMet: 2.054 ± 0.06
2.98AlaAsn: 2.98 ± 0.079
2.453AlaPro: 2.453 ± 0.079
3.34AlaGln: 3.34 ± 0.083
3.224AlaArg: 3.224 ± 0.069
4.87AlaSer: 4.87 ± 0.103
4.7AlaThr: 4.7 ± 0.101
5.876AlaVal: 5.876 ± 0.124
0.688AlaTrp: 0.688 ± 0.031
2.957AlaTyr: 2.957 ± 0.066
0.0AlaXaa: 0.0 ± 0.0
Cys
0.362CysAla: 0.362 ± 0.027
0.068CysCys: 0.068 ± 0.011
0.308CysAsp: 0.308 ± 0.024
0.28CysGlu: 0.28 ± 0.02
0.281CysPhe: 0.281 ± 0.023
0.546CysGly: 0.546 ± 0.036
0.2CysHis: 0.2 ± 0.018
0.409CysIle: 0.409 ± 0.026
0.232CysLys: 0.232 ± 0.022
0.72CysLeu: 0.72 ± 0.039
0.117CysMet: 0.117 ± 0.012
0.194CysAsn: 0.194 ± 0.018
0.257CysPro: 0.257 ± 0.02
0.367CysGln: 0.367 ± 0.025
0.255CysArg: 0.255 ± 0.02
0.384CysSer: 0.384 ± 0.026
0.235CysThr: 0.235 ± 0.02
0.334CysVal: 0.334 ± 0.028
0.058CysTrp: 0.058 ± 0.009
0.232CysTyr: 0.232 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
3.816AspAla: 3.816 ± 0.091
0.379AspCys: 0.379 ± 0.027
2.692AspAsp: 2.692 ± 0.08
4.405AspGlu: 4.405 ± 0.112
3.048AspPhe: 3.048 ± 0.078
4.116AspGly: 4.116 ± 0.23
0.966AspHis: 0.966 ± 0.033
4.207AspIle: 4.207 ± 0.088
3.839AspLys: 3.839 ± 0.117
5.494AspLeu: 5.494 ± 0.102
1.537AspMet: 1.537 ± 0.051
2.088AspAsn: 2.088 ± 0.068
1.594AspPro: 1.594 ± 0.072
1.989AspGln: 1.989 ± 0.067
2.115AspArg: 2.115 ± 0.057
3.07AspSer: 3.07 ± 0.104
3.143AspThr: 3.143 ± 0.087
3.997AspVal: 3.997 ± 0.095
0.746AspTrp: 0.746 ± 0.039
2.757AspTyr: 2.757 ± 0.066
0.0AspXaa: 0.0 ± 0.0
Glu
6.141GluAla: 6.141 ± 0.118
0.344GluCys: 0.344 ± 0.026
3.843GluAsp: 3.843 ± 0.101
6.456GluGlu: 6.456 ± 0.135
2.572GluPhe: 2.572 ± 0.073
3.829GluGly: 3.829 ± 0.082
1.473GluHis: 1.473 ± 0.049
5.138GluIle: 5.138 ± 0.11
5.656GluLys: 5.656 ± 0.105
6.952GluLeu: 6.952 ± 0.122
2.138GluMet: 2.138 ± 0.062
3.444GluAsn: 3.444 ± 0.083
1.868GluPro: 1.868 ± 0.117
3.421GluGln: 3.421 ± 0.078
3.598GluArg: 3.598 ± 0.081
3.014GluSer: 3.014 ± 0.099
4.028GluThr: 4.028 ± 0.103
5.105GluVal: 5.105 ± 0.099
0.64GluTrp: 0.64 ± 0.035
2.229GluTyr: 2.229 ± 0.067
0.0GluXaa: 0.0 ± 0.0
Phe
3.502PheAla: 3.502 ± 0.077
0.258PheCys: 0.258 ± 0.02
2.813PheAsp: 2.813 ± 0.077
3.134PheGlu: 3.134 ± 0.081
2.1PhePhe: 2.1 ± 0.065
3.3PheGly: 3.3 ± 0.079
0.91PheHis: 0.91 ± 0.041
2.984PheIle: 2.984 ± 0.09
2.229PheLys: 2.229 ± 0.056
4.601PheLeu: 4.601 ± 0.127
0.998PheMet: 0.998 ± 0.045
1.541PheAsn: 1.541 ± 0.049
1.604PhePro: 1.604 ± 0.057
1.663PheGln: 1.663 ± 0.054
1.635PheArg: 1.635 ± 0.058
2.987PheSer: 2.987 ± 0.083
2.479PheThr: 2.479 ± 0.068
3.3PheVal: 3.3 ± 0.089
0.437PheTrp: 0.437 ± 0.032
1.784PheTyr: 1.784 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
4.927GlyAla: 4.927 ± 0.105
0.429GlyCys: 0.429 ± 0.027
3.402GlyAsp: 3.402 ± 0.108
3.993GlyGlu: 3.993 ± 0.083
3.336GlyPhe: 3.336 ± 0.074
4.46GlyGly: 4.46 ± 0.113
1.337GlyHis: 1.337 ± 0.044
5.347GlyIle: 5.347 ± 0.096
4.51GlyLys: 4.51 ± 0.096
7.028GlyLeu: 7.028 ± 0.127
1.949GlyMet: 1.949 ± 0.063
2.59GlyAsn: 2.59 ± 0.064
1.438GlyPro: 1.438 ± 0.058
3.207GlyGln: 3.207 ± 0.085
2.947GlyArg: 2.947 ± 0.085
3.71GlySer: 3.71 ± 0.094
3.958GlyThr: 3.958 ± 0.118
5.19GlyVal: 5.19 ± 0.113
0.675GlyTrp: 0.675 ± 0.036
2.836GlyTyr: 2.836 ± 0.072
0.0GlyXaa: 0.0 ± 0.0
His
1.35HisAla: 1.35 ± 0.052
0.134HisCys: 0.134 ± 0.016
1.038HisAsp: 1.038 ± 0.04
1.24HisGlu: 1.24 ± 0.051
1.147HisPhe: 1.147 ± 0.046
1.41HisGly: 1.41 ± 0.047
0.626HisHis: 0.626 ± 0.034
1.36HisIle: 1.36 ± 0.05
0.885HisLys: 0.885 ± 0.036
2.347HisLeu: 2.347 ± 0.07
0.425HisMet: 0.425 ± 0.026
0.647HisAsn: 0.647 ± 0.032
0.923HisPro: 0.923 ± 0.04
1.105HisGln: 1.105 ± 0.048
0.933HisArg: 0.933 ± 0.043
1.104HisSer: 1.104 ± 0.042
1.008HisThr: 1.008 ± 0.047
1.249HisVal: 1.249 ± 0.05
0.17HisTrp: 0.17 ± 0.017
1.036HisTyr: 1.036 ± 0.047
0.0HisXaa: 0.0 ± 0.0
Ile
6.426IleAla: 6.426 ± 0.112
0.594IleCys: 0.594 ± 0.034
4.129IleAsp: 4.129 ± 0.08
5.026IleGlu: 5.026 ± 0.095
3.105IlePhe: 3.105 ± 0.093
5.037IleGly: 5.037 ± 0.11
1.352IleHis: 1.352 ± 0.051
4.433IleIle: 4.433 ± 0.107
3.753IleLys: 3.753 ± 0.085
7.169IleLeu: 7.169 ± 0.143
1.574IleMet: 1.574 ± 0.05
2.649IleAsn: 2.649 ± 0.065
2.927IlePro: 2.927 ± 0.072
2.8IleGln: 2.8 ± 0.071
3.028IleArg: 3.028 ± 0.077
4.422IleSer: 4.422 ± 0.099
3.632IleThr: 3.632 ± 0.085
5.041IleVal: 5.041 ± 0.1
0.652IleTrp: 0.652 ± 0.031
2.477IleTyr: 2.477 ± 0.08
0.0IleXaa: 0.0 ± 0.0
Lys
4.98LysAla: 4.98 ± 0.125
0.217LysCys: 0.217 ± 0.018
3.74LysAsp: 3.74 ± 0.096
5.837LysGlu: 5.837 ± 0.11
1.668LysPhe: 1.668 ± 0.058
3.902LysGly: 3.902 ± 0.086
1.109LysHis: 1.109 ± 0.044
4.202LysIle: 4.202 ± 0.091
4.703LysLys: 4.703 ± 0.093
4.895LysLeu: 4.895 ± 0.102
1.887LysMet: 1.887 ± 0.057
2.731LysAsn: 2.731 ± 0.068
1.999LysPro: 1.999 ± 0.081
2.683LysGln: 2.683 ± 0.069
3.033LysArg: 3.033 ± 0.071
3.154LysSer: 3.154 ± 0.072
3.664LysThr: 3.664 ± 0.09
4.397LysVal: 4.397 ± 0.11
0.647LysTrp: 0.647 ± 0.032
2.016LysTyr: 2.016 ± 0.062
0.0LysXaa: 0.0 ± 0.0
Leu
9.684LeuAla: 9.684 ± 0.158
0.569LeuCys: 0.569 ± 0.037
5.663LeuAsp: 5.663 ± 0.103
7.086LeuGlu: 7.086 ± 0.133
4.427LeuPhe: 4.427 ± 0.122
6.663LeuGly: 6.663 ± 0.121
1.903LeuHis: 1.903 ± 0.062
6.264LeuIle: 6.264 ± 0.144
5.59LeuLys: 5.59 ± 0.106
10.459LeuLeu: 10.459 ± 0.196
2.544LeuMet: 2.544 ± 0.07
3.72LeuAsn: 3.72 ± 0.083
4.275LeuPro: 4.275 ± 0.08
3.786LeuGln: 3.786 ± 0.089
3.839LeuArg: 3.839 ± 0.102
6.845LeuSer: 6.845 ± 0.104
6.26LeuThr: 6.26 ± 0.125
7.455LeuVal: 7.455 ± 0.127
0.766LeuTrp: 0.766 ± 0.042
3.397LeuTyr: 3.397 ± 0.092
0.0LeuXaa: 0.0 ± 0.0
Met
2.178MetAla: 2.178 ± 0.064
0.131MetCys: 0.131 ± 0.015
1.331MetAsp: 1.331 ± 0.047
1.746MetGlu: 1.746 ± 0.053
0.839MetPhe: 0.839 ± 0.039
1.705MetGly: 1.705 ± 0.061
0.361MetHis: 0.361 ± 0.026
1.928MetIle: 1.928 ± 0.067
2.032MetLys: 2.032 ± 0.057
2.343MetLeu: 2.343 ± 0.074
0.829MetMet: 0.829 ± 0.047
1.261MetAsn: 1.261 ± 0.049
0.837MetPro: 0.837 ± 0.038
0.892MetGln: 0.892 ± 0.037
1.049MetArg: 1.049 ± 0.043
1.592MetSer: 1.592 ± 0.055
1.969MetThr: 1.969 ± 0.064
1.812MetVal: 1.812 ± 0.063
0.187MetTrp: 0.187 ± 0.016
0.69MetTyr: 0.69 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
2.74AsnAla: 2.74 ± 0.064
0.215AsnCys: 0.215 ± 0.023
2.05AsnAsp: 2.05 ± 0.075
2.272AsnGlu: 2.272 ± 0.071
1.683AsnPhe: 1.683 ± 0.058
3.076AsnGly: 3.076 ± 0.093
0.983AsnHis: 0.983 ± 0.043
2.808AsnIle: 2.808 ± 0.074
2.186AsnLys: 2.186 ± 0.059
3.897AsnLeu: 3.897 ± 0.083
0.98AsnMet: 0.98 ± 0.037
1.471AsnAsn: 1.471 ± 0.056
2.189AsnPro: 2.189 ± 0.076
2.077AsnGln: 2.077 ± 0.059
1.966AsnArg: 1.966 ± 0.059
2.064AsnSer: 2.064 ± 0.065
1.956AsnThr: 1.956 ± 0.07
2.701AsnVal: 2.701 ± 0.077
0.505AsnTrp: 0.505 ± 0.029
1.501AsnTyr: 1.501 ± 0.055
0.0AsnXaa: 0.0 ± 0.0
Pro
2.952ProAla: 2.952 ± 0.086
0.156ProCys: 0.156 ± 0.016
2.232ProAsp: 2.232 ± 0.09
2.81ProGlu: 2.81 ± 0.096
1.691ProPhe: 1.691 ± 0.052
1.782ProGly: 1.782 ± 0.063
0.854ProHis: 0.854 ± 0.038
2.544ProIle: 2.544 ± 0.072
1.935ProLys: 1.935 ± 0.065
3.277ProLeu: 3.277 ± 0.072
0.776ProMet: 0.776 ± 0.039
1.552ProAsn: 1.552 ± 0.055
0.723ProPro: 0.723 ± 0.049
1.324ProGln: 1.324 ± 0.048
1.17ProArg: 1.17 ± 0.043
2.188ProSer: 2.188 ± 0.082
2.179ProThr: 2.179 ± 0.083
2.765ProVal: 2.765 ± 0.089
0.29ProTrp: 0.29 ± 0.021
1.367ProTyr: 1.367 ± 0.057
0.0ProXaa: 0.0 ± 0.0
Gln
4.142GlnAla: 4.142 ± 0.101
0.142GlnCys: 0.142 ± 0.015
2.092GlnAsp: 2.092 ± 0.068
3.536GlnGlu: 3.536 ± 0.067
1.791GlnPhe: 1.791 ± 0.055
2.38GlnGly: 2.38 ± 0.077
0.894GlnHis: 0.894 ± 0.041
2.828GlnIle: 2.828 ± 0.063
2.648GlnLys: 2.648 ± 0.065
4.705GlnLeu: 4.705 ± 0.098
1.046GlnMet: 1.046 ± 0.048
1.41GlnAsn: 1.41 ± 0.046
1.337GlnPro: 1.337 ± 0.049
1.991GlnGln: 1.991 ± 0.068
1.557GlnArg: 1.557 ± 0.057
2.175GlnSer: 2.175 ± 0.065
2.482GlnThr: 2.482 ± 0.068
3.498GlnVal: 3.498 ± 0.08
0.328GlnTrp: 0.328 ± 0.024
1.425GlnTyr: 1.425 ± 0.046
0.0GlnXaa: 0.0 ± 0.0
Arg
2.851ArgAla: 2.851 ± 0.068
0.204ArgCys: 0.204 ± 0.018
2.203ArgAsp: 2.203 ± 0.071
3.28ArgGlu: 3.28 ± 0.084
2.143ArgPhe: 2.143 ± 0.06
2.418ArgGly: 2.418 ± 0.074
0.923ArgHis: 0.923 ± 0.039
3.01ArgIle: 3.01 ± 0.069
2.889ArgLys: 2.889 ± 0.079
4.541ArgLeu: 4.541 ± 0.107
1.223ArgMet: 1.223 ± 0.046
1.642ArgAsn: 1.642 ± 0.057
1.38ArgPro: 1.38 ± 0.049
2.047ArgGln: 2.047 ± 0.058
1.94ArgArg: 1.94 ± 0.071
2.092ArgSer: 2.092 ± 0.063
2.161ArgThr: 2.161 ± 0.061
2.84ArgVal: 2.84 ± 0.071
0.331ArgTrp: 0.331 ± 0.025
1.936ArgTyr: 1.936 ± 0.066
0.0ArgXaa: 0.0 ± 0.0
Ser
3.884SerAla: 3.884 ± 0.084
0.295SerCys: 0.295 ± 0.023
3.232SerAsp: 3.232 ± 0.132
3.488SerGlu: 3.488 ± 0.097
2.82SerPhe: 2.82 ± 0.075
4.17SerGly: 4.17 ± 0.092
1.278SerHis: 1.278 ± 0.054
4.122SerIle: 4.122 ± 0.095
3.51SerLys: 3.51 ± 0.082
6.428SerLeu: 6.428 ± 0.136
1.456SerMet: 1.456 ± 0.056
2.275SerAsn: 2.275 ± 0.073
2.083SerPro: 2.083 ± 0.076
2.691SerGln: 2.691 ± 0.061
2.494SerArg: 2.494 ± 0.067
4.24SerSer: 4.24 ± 0.15
3.242SerThr: 3.242 ± 0.1
4.036SerVal: 4.036 ± 0.081
0.631SerTrp: 0.631 ± 0.032
2.451SerTyr: 2.451 ± 0.071
0.0SerXaa: 0.0 ± 0.0
Thr
4.647ThrAla: 4.647 ± 0.109
0.316ThrCys: 0.316 ± 0.023
3.561ThrAsp: 3.561 ± 0.156
3.68ThrGlu: 3.68 ± 0.11
2.666ThrPhe: 2.666 ± 0.07
4.308ThrGly: 4.308 ± 0.094
1.044ThrHis: 1.044 ± 0.046
4.759ThrIle: 4.759 ± 0.104
3.177ThrLys: 3.177 ± 0.078
5.635ThrLeu: 5.635 ± 0.104
1.307ThrMet: 1.307 ± 0.048
2.355ThrAsn: 2.355 ± 0.073
2.416ThrPro: 2.416 ± 0.099
1.741ThrGln: 1.741 ± 0.056
2.074ThrArg: 2.074 ± 0.057
3.704ThrSer: 3.704 ± 0.089
3.209ThrThr: 3.209 ± 0.104
4.549ThrVal: 4.549 ± 0.124
0.473ThrTrp: 0.473 ± 0.03
2.229ThrTyr: 2.229 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
6.749ValAla: 6.749 ± 0.122
0.478ValCys: 0.478 ± 0.027
4.107ValAsp: 4.107 ± 0.088
5.198ValGlu: 5.198 ± 0.112
3.048ValPhe: 3.048 ± 0.077
4.783ValGly: 4.783 ± 0.097
1.231ValHis: 1.231 ± 0.052
4.812ValIle: 4.812 ± 0.106
4.296ValLys: 4.296 ± 0.096
7.197ValLeu: 7.197 ± 0.124
1.792ValMet: 1.792 ± 0.049
2.853ValAsn: 2.853 ± 0.078
2.585ValPro: 2.585 ± 0.079
2.405ValGln: 2.405 ± 0.064
2.904ValArg: 2.904 ± 0.079
4.576ValSer: 4.576 ± 0.094
4.989ValThr: 4.989 ± 0.139
5.602ValVal: 5.602 ± 0.125
0.544ValTrp: 0.544 ± 0.035
2.448ValTyr: 2.448 ± 0.065
0.0ValXaa: 0.0 ± 0.0
Trp
0.535TrpAla: 0.535 ± 0.031
0.06TrpCys: 0.06 ± 0.011
0.48TrpAsp: 0.48 ± 0.031
0.596TrpGlu: 0.596 ± 0.035
0.405TrpPhe: 0.405 ± 0.029
0.64TrpGly: 0.64 ± 0.033
0.162TrpHis: 0.162 ± 0.017
0.637TrpIle: 0.637 ± 0.033
0.586TrpLys: 0.586 ± 0.033
1.144TrpLeu: 1.144 ± 0.044
0.26TrpMet: 0.26 ± 0.02
0.5TrpAsn: 0.5 ± 0.033
0.189TrpPro: 0.189 ± 0.019
0.505TrpGln: 0.505 ± 0.028
0.374TrpArg: 0.374 ± 0.025
0.594TrpSer: 0.594 ± 0.033
0.592TrpThr: 0.592 ± 0.032
0.535TrpVal: 0.535 ± 0.033
0.127TrpTrp: 0.127 ± 0.014
0.366TrpTyr: 0.366 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.77TyrAla: 2.77 ± 0.062
0.253TyrCys: 0.253 ± 0.023
2.237TyrAsp: 2.237 ± 0.062
2.36TyrGlu: 2.36 ± 0.057
1.857TyrPhe: 1.857 ± 0.062
2.529TyrGly: 2.529 ± 0.061
0.998TyrHis: 0.998 ± 0.044
2.375TyrIle: 2.375 ± 0.073
1.847TyrLys: 1.847 ± 0.069
4.18TyrLeu: 4.18 ± 0.097
0.818TyrMet: 0.818 ± 0.039
1.418TyrAsn: 1.418 ± 0.049
1.489TyrPro: 1.489 ± 0.06
2.375TyrGln: 2.375 ± 0.069
1.918TyrArg: 1.918 ± 0.065
2.044TyrSer: 2.044 ± 0.058
1.963TyrThr: 1.963 ± 0.065
2.315TyrVal: 2.315 ± 0.068
0.389TyrTrp: 0.389 ± 0.026
1.617TyrTyr: 1.617 ± 0.06
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1969 proteins (604276 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski