Amino acid dipepetide frequency for Grapevine associated tymo-like virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.077AlaAla: 4.077 ± 0.796
1.529AlaCys: 1.529 ± 0.708
3.568AlaAsp: 3.568 ± 1.032
6.626AlaGlu: 6.626 ± 0.383
2.548AlaPhe: 2.548 ± 1.179
4.077AlaGly: 4.077 ± 1.887
0.0AlaHis: 0.0 ± 0.0
4.587AlaIle: 4.587 ± 0.56
5.097AlaLys: 5.097 ± 2.358
6.116AlaLeu: 6.116 ± 2.83
1.529AlaMet: 1.529 ± 0.778
3.568AlaAsn: 3.568 ± 1.651
1.019AlaPro: 1.019 ± 2.211
2.039AlaGln: 2.039 ± 4.421
5.607AlaArg: 5.607 ± 2.771
3.568AlaSer: 3.568 ± 1.651
3.058AlaThr: 3.058 ± 1.415
6.116AlaVal: 6.116 ± 2.535
2.548AlaTrp: 2.548 ± 1.179
2.039AlaTyr: 2.039 ± 1.739
0.0AlaXaa: 0.0 ± 0.0
Cys
2.039CysAla: 2.039 ± 0.943
0.0CysCys: 0.0 ± 0.0
1.529CysAsp: 1.529 ± 0.708
1.529CysGlu: 1.529 ± 4.657
1.019CysPhe: 1.019 ± 2.211
0.51CysGly: 0.51 ± 0.236
0.0CysHis: 0.0 ± 0.0
0.51CysIle: 0.51 ± 0.236
0.0CysLys: 0.0 ± 0.0
1.529CysLeu: 1.529 ± 0.708
0.0CysMet: 0.0 ± 0.0
0.51CysAsn: 0.51 ± 0.236
1.019CysPro: 1.019 ± 0.472
0.0CysGln: 0.0 ± 0.0
1.529CysArg: 1.529 ± 0.708
1.529CysSer: 1.529 ± 0.708
1.529CysThr: 1.529 ± 0.708
1.529CysVal: 1.529 ± 0.708
1.019CysTrp: 1.019 ± 0.472
0.51CysTyr: 0.51 ± 0.236
0.0CysXaa: 0.0 ± 0.0
Asp
4.077AspAla: 4.077 ± 1.887
2.039AspCys: 2.039 ± 0.943
4.077AspAsp: 4.077 ± 1.887
3.568AspGlu: 3.568 ± 1.651
3.568AspPhe: 3.568 ± 1.032
5.097AspGly: 5.097 ± 0.324
1.019AspHis: 1.019 ± 0.472
3.058AspIle: 3.058 ± 1.267
1.529AspLys: 1.529 ± 0.708
4.587AspLeu: 4.587 ± 0.56
3.058AspMet: 3.058 ± 1.267
1.529AspAsn: 1.529 ± 0.708
2.548AspPro: 2.548 ± 1.179
2.548AspGln: 2.548 ± 4.186
2.548AspArg: 2.548 ± 1.179
4.587AspSer: 4.587 ± 2.123
2.548AspThr: 2.548 ± 1.179
3.058AspVal: 3.058 ± 1.415
2.548AspTrp: 2.548 ± 1.179
1.529AspTyr: 1.529 ± 0.708
0.0AspXaa: 0.0 ± 0.0
Glu
2.039GluAla: 2.039 ± 0.943
0.0GluCys: 0.0 ± 0.0
1.529GluAsp: 1.529 ± 0.708
4.587GluGlu: 4.587 ± 2.123
1.529GluPhe: 1.529 ± 1.975
5.607GluGly: 5.607 ± 0.088
1.529GluHis: 1.529 ± 1.975
4.077GluIle: 4.077 ± 0.796
4.587GluLys: 4.587 ± 2.123
6.626GluLeu: 6.626 ± 2.299
1.019GluMet: 1.019 ± 0.472
3.568GluAsn: 3.568 ± 1.032
4.077GluPro: 4.077 ± 0.796
1.019GluGln: 1.019 ± 0.472
5.607GluArg: 5.607 ± 0.088
2.548GluSer: 2.548 ± 1.179
2.039GluThr: 2.039 ± 0.943
6.626GluVal: 6.626 ± 3.066
1.019GluTrp: 1.019 ± 0.472
0.51GluTyr: 0.51 ± 0.236
0.0GluXaa: 0.0 ± 0.0
Phe
2.548PheAla: 2.548 ± 6.868
2.548PheCys: 2.548 ± 1.179
4.077PheAsp: 4.077 ± 0.796
2.039PheGlu: 2.039 ± 0.943
1.529PhePhe: 1.529 ± 1.975
4.587PheGly: 4.587 ± 3.242
1.019PheHis: 1.019 ± 0.472
1.019PheIle: 1.019 ± 0.472
1.529PheLys: 1.529 ± 1.975
3.058PheLeu: 3.058 ± 1.415
0.51PheMet: 0.51 ± 0.236
2.548PheAsn: 2.548 ± 1.503
3.058PhePro: 3.058 ± 1.267
1.019PheGln: 1.019 ± 0.472
3.058PheArg: 3.058 ± 1.267
2.548PheSer: 2.548 ± 1.179
3.058PheThr: 3.058 ± 1.415
3.568PheVal: 3.568 ± 1.651
0.51PheTrp: 0.51 ± 0.236
1.019PheTyr: 1.019 ± 0.472
0.0PheXaa: 0.0 ± 0.0
Gly
5.607GlyAla: 5.607 ± 2.594
0.51GlyCys: 0.51 ± 0.236
4.077GlyAsp: 4.077 ± 1.887
4.077GlyGlu: 4.077 ± 0.796
4.587GlyPhe: 4.587 ± 0.56
5.097GlyGly: 5.097 ± 5.689
3.058GlyHis: 3.058 ± 1.267
3.058GlyIle: 3.058 ± 1.415
2.548GlyLys: 2.548 ± 1.503
4.587GlyLeu: 4.587 ± 2.123
0.0GlyMet: 0.0 ± 0.0
1.529GlyAsn: 1.529 ± 0.708
3.058GlyPro: 3.058 ± 1.415
3.058GlyGln: 3.058 ± 1.415
4.077GlyArg: 4.077 ± 0.796
3.568GlySer: 3.568 ± 1.651
2.039GlyThr: 2.039 ± 0.943
5.097GlyVal: 5.097 ± 2.358
1.529GlyTrp: 1.529 ± 1.975
2.548GlyTyr: 2.548 ± 1.503
0.0GlyXaa: 0.0 ± 0.0
His
3.058HisAla: 3.058 ± 1.267
0.51HisCys: 0.51 ± 2.447
1.529HisAsp: 1.529 ± 0.708
1.529HisGlu: 1.529 ± 0.708
1.019HisPhe: 1.019 ± 0.472
1.529HisGly: 1.529 ± 0.708
1.019HisHis: 1.019 ± 0.472
0.51HisIle: 0.51 ± 0.236
1.529HisLys: 1.529 ± 0.708
2.548HisLeu: 2.548 ± 1.179
0.0HisMet: 0.0 ± 0.0
1.019HisAsn: 1.019 ± 4.893
1.529HisPro: 1.529 ± 0.708
1.019HisGln: 1.019 ± 0.472
1.529HisArg: 1.529 ± 0.708
0.51HisSer: 0.51 ± 0.236
2.548HisThr: 2.548 ± 1.503
3.058HisVal: 3.058 ± 1.415
0.51HisTrp: 0.51 ± 0.236
1.529HisTyr: 1.529 ± 0.708
0.0HisXaa: 0.0 ± 0.0
Ile
3.568IleAla: 3.568 ± 1.651
1.019IleCys: 1.019 ± 0.472
1.529IleAsp: 1.529 ± 0.708
2.039IleGlu: 2.039 ± 0.943
0.51IlePhe: 0.51 ± 0.236
0.51IleGly: 0.51 ± 0.236
0.51IleHis: 0.51 ± 0.236
1.529IleIle: 1.529 ± 0.708
0.0IleLys: 0.0 ± 0.0
8.665IleLeu: 8.665 ± 1.327
0.51IleMet: 0.51 ± 0.236
2.548IleAsn: 2.548 ± 1.179
3.568IlePro: 3.568 ± 1.032
0.0IleGln: 0.0 ± 0.0
2.039IleArg: 2.039 ± 0.943
5.607IleSer: 5.607 ± 0.088
3.568IleThr: 3.568 ± 3.714
4.587IleVal: 4.587 ± 3.242
1.019IleTrp: 1.019 ± 0.472
2.548IleTyr: 2.548 ± 1.179
0.0IleXaa: 0.0 ± 0.0
Lys
3.568LysAla: 3.568 ± 1.651
0.51LysCys: 0.51 ± 0.236
1.529LysAsp: 1.529 ± 0.708
2.039LysGlu: 2.039 ± 1.739
2.548LysPhe: 2.548 ± 1.503
2.548LysGly: 2.548 ± 1.179
1.529LysHis: 1.529 ± 0.708
2.548LysIle: 2.548 ± 1.179
4.587LysLys: 4.587 ± 2.123
5.097LysLeu: 5.097 ± 0.324
0.51LysMet: 0.51 ± 0.236
3.058LysAsn: 3.058 ± 1.415
3.058LysPro: 3.058 ± 1.267
2.039LysGln: 2.039 ± 0.943
6.626LysArg: 6.626 ± 3.066
5.097LysSer: 5.097 ± 2.358
1.019LysThr: 1.019 ± 0.472
5.097LysVal: 5.097 ± 3.006
0.51LysTrp: 0.51 ± 0.236
2.039LysTyr: 2.039 ± 0.943
0.0LysXaa: 0.0 ± 0.0
Leu
9.174LeuAla: 9.174 ± 1.563
1.529LeuCys: 1.529 ± 0.708
4.077LeuAsp: 4.077 ± 1.887
4.077LeuGlu: 4.077 ± 3.478
5.097LeuPhe: 5.097 ± 3.006
8.155LeuGly: 8.155 ± 3.773
2.548LeuHis: 2.548 ± 1.503
5.097LeuIle: 5.097 ± 2.358
5.607LeuLys: 5.607 ± 0.088
9.174LeuLeu: 9.174 ± 1.563
2.548LeuMet: 2.548 ± 1.179
6.116LeuAsn: 6.116 ± 2.83
4.587LeuPro: 4.587 ± 3.242
3.058LeuGln: 3.058 ± 1.415
6.116LeuArg: 6.116 ± 2.83
6.626LeuSer: 6.626 ± 0.383
7.645LeuThr: 7.645 ± 0.855
8.155LeuVal: 8.155 ± 1.591
1.019LeuTrp: 1.019 ± 0.472
4.587LeuTyr: 4.587 ± 0.56
0.0LeuXaa: 0.0 ± 0.0
Met
1.019MetAla: 1.019 ± 0.472
0.0MetCys: 0.0 ± 0.0
2.039MetAsp: 2.039 ± 0.943
1.019MetGlu: 1.019 ± 0.472
1.529MetPhe: 1.529 ± 0.708
1.529MetGly: 1.529 ± 0.708
1.529MetHis: 1.529 ± 0.708
1.529MetIle: 1.529 ± 0.708
1.529MetLys: 1.529 ± 0.708
3.568MetLeu: 3.568 ± 1.651
0.51MetMet: 0.51 ± 0.236
1.529MetAsn: 1.529 ± 1.975
1.019MetPro: 1.019 ± 0.472
0.0MetGln: 0.0 ± 0.0
1.529MetArg: 1.529 ± 0.708
3.568MetSer: 3.568 ± 9.079
0.0MetThr: 0.0 ± 0.0
1.529MetVal: 1.529 ± 0.708
0.51MetTrp: 0.51 ± 0.236
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.019AsnAla: 1.019 ± 0.472
2.548AsnCys: 2.548 ± 1.179
4.077AsnAsp: 4.077 ± 1.887
5.607AsnGlu: 5.607 ± 2.594
2.548AsnPhe: 2.548 ± 1.179
2.548AsnGly: 2.548 ± 1.179
1.019AsnHis: 1.019 ± 2.211
2.039AsnIle: 2.039 ± 0.943
4.077AsnLys: 4.077 ± 1.887
6.116AsnLeu: 6.116 ± 2.535
2.039AsnMet: 2.039 ± 1.739
1.019AsnAsn: 1.019 ± 0.472
1.529AsnPro: 1.529 ± 0.708
0.0AsnGln: 0.0 ± 0.0
1.529AsnArg: 1.529 ± 0.708
3.058AsnSer: 3.058 ± 1.267
1.529AsnThr: 1.529 ± 0.708
3.568AsnVal: 3.568 ± 11.761
0.51AsnTrp: 0.51 ± 0.236
0.51AsnTyr: 0.51 ± 0.236
0.0AsnXaa: 0.0 ± 0.0
Pro
4.077ProAla: 4.077 ± 0.796
1.529ProCys: 1.529 ± 1.975
4.077ProAsp: 4.077 ± 1.887
2.548ProGlu: 2.548 ± 1.503
2.548ProPhe: 2.548 ± 1.179
2.548ProGly: 2.548 ± 1.179
0.51ProHis: 0.51 ± 0.236
2.039ProIle: 2.039 ± 1.739
3.568ProLys: 3.568 ± 1.032
6.116ProLeu: 6.116 ± 2.535
2.039ProMet: 2.039 ± 0.943
1.529ProAsn: 1.529 ± 0.708
0.51ProPro: 0.51 ± 0.236
0.0ProGln: 0.0 ± 0.0
2.548ProArg: 2.548 ± 1.179
2.548ProSer: 2.548 ± 1.503
2.039ProThr: 2.039 ± 0.943
3.058ProVal: 3.058 ± 3.95
0.0ProTrp: 0.0 ± 0.0
1.529ProTyr: 1.529 ± 0.708
0.0ProXaa: 0.0 ± 0.0
Gln
1.019GlnAla: 1.019 ± 0.472
0.0GlnCys: 0.0 ± 0.0
1.529GlnAsp: 1.529 ± 0.708
2.039GlnGlu: 2.039 ± 0.943
1.019GlnPhe: 1.019 ± 0.472
1.019GlnGly: 1.019 ± 2.211
2.039GlnHis: 2.039 ± 1.739
1.019GlnIle: 1.019 ± 0.472
0.0GlnLys: 0.0 ± 0.0
3.058GlnLeu: 3.058 ± 6.632
0.51GlnMet: 0.51 ± 0.236
0.51GlnAsn: 0.51 ± 0.236
0.51GlnPro: 0.51 ± 0.236
1.019GlnGln: 1.019 ± 0.472
1.019GlnArg: 1.019 ± 0.472
3.568GlnSer: 3.568 ± 1.651
2.039GlnThr: 2.039 ± 0.943
3.058GlnVal: 3.058 ± 1.267
0.51GlnTrp: 0.51 ± 0.236
0.51GlnTyr: 0.51 ± 0.236
0.0GlnXaa: 0.0 ± 0.0
Arg
4.077ArgAla: 4.077 ± 1.887
1.019ArgCys: 1.019 ± 0.472
5.097ArgAsp: 5.097 ± 0.324
3.058ArgGlu: 3.058 ± 1.415
3.058ArgPhe: 3.058 ± 1.415
3.568ArgGly: 3.568 ± 1.651
2.548ArgHis: 2.548 ± 1.179
3.568ArgIle: 3.568 ± 3.714
4.587ArgLys: 4.587 ± 2.123
8.665ArgLeu: 8.665 ± 4.009
1.019ArgMet: 1.019 ± 0.621
3.058ArgAsn: 3.058 ± 1.415
2.548ArgPro: 2.548 ± 1.503
0.51ArgGln: 0.51 ± 0.236
3.568ArgArg: 3.568 ± 1.651
3.058ArgSer: 3.058 ± 1.415
1.529ArgThr: 1.529 ± 1.975
6.626ArgVal: 6.626 ± 2.299
0.51ArgTrp: 0.51 ± 0.236
2.039ArgTyr: 2.039 ± 0.943
0.0ArgXaa: 0.0 ± 0.0
Ser
4.587SerAla: 4.587 ± 3.242
0.51SerCys: 0.51 ± 0.236
5.097SerAsp: 5.097 ± 0.324
4.587SerGlu: 4.587 ± 0.56
1.529SerPhe: 1.529 ± 0.708
3.568SerGly: 3.568 ± 1.651
1.529SerHis: 1.529 ± 0.708
1.019SerIle: 1.019 ± 2.211
3.058SerLys: 3.058 ± 1.267
7.645SerLeu: 7.645 ± 3.538
2.548SerMet: 2.548 ± 1.179
6.116SerAsn: 6.116 ± 7.9
3.058SerPro: 3.058 ± 1.415
1.529SerGln: 1.529 ± 0.708
4.077SerArg: 4.077 ± 0.796
4.077SerSer: 4.077 ± 8.843
4.587SerThr: 4.587 ± 2.123
3.568SerVal: 3.568 ± 3.714
0.0SerTrp: 0.0 ± 0.0
2.039SerTyr: 2.039 ± 0.943
0.0SerXaa: 0.0 ± 0.0
Thr
3.568ThrAla: 3.568 ± 1.032
0.51ThrCys: 0.51 ± 0.236
1.529ThrAsp: 1.529 ± 0.708
1.529ThrGlu: 1.529 ± 0.708
3.568ThrPhe: 3.568 ± 1.651
2.548ThrGly: 2.548 ± 1.179
1.529ThrHis: 1.529 ± 0.708
3.568ThrIle: 3.568 ± 1.651
3.058ThrLys: 3.058 ± 1.415
3.058ThrLeu: 3.058 ± 1.415
2.039ThrMet: 2.039 ± 0.943
1.019ThrAsn: 1.019 ± 0.472
2.039ThrPro: 2.039 ± 1.739
2.548ThrGln: 2.548 ± 1.179
2.548ThrArg: 2.548 ± 1.179
2.039ThrSer: 2.039 ± 7.104
1.019ThrThr: 1.019 ± 0.472
5.607ThrVal: 5.607 ± 2.594
2.039ThrTrp: 2.039 ± 0.943
1.529ThrTyr: 1.529 ± 0.708
0.0ThrXaa: 0.0 ± 0.0
Val
8.665ValAla: 8.665 ± 4.038
0.51ValCys: 0.51 ± 2.447
6.626ValAsp: 6.626 ± 2.299
5.097ValGlu: 5.097 ± 2.358
4.587ValPhe: 4.587 ± 5.925
6.116ValGly: 6.116 ± 0.148
2.548ValHis: 2.548 ± 1.179
3.568ValIle: 3.568 ± 1.651
4.077ValLys: 4.077 ± 0.796
8.155ValLeu: 8.155 ± 1.591
2.548ValMet: 2.548 ± 4.186
4.587ValAsn: 4.587 ± 0.56
3.568ValPro: 3.568 ± 1.032
3.568ValGln: 3.568 ± 3.714
4.077ValArg: 4.077 ± 0.796
3.568ValSer: 3.568 ± 1.651
3.568ValThr: 3.568 ± 1.651
4.077ValVal: 4.077 ± 0.796
0.51ValTrp: 0.51 ± 0.236
2.548ValTyr: 2.548 ± 1.503
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.019TrpGlu: 1.019 ± 0.472
0.0TrpPhe: 0.0 ± 0.0
1.019TrpGly: 1.019 ± 2.211
2.039TrpHis: 2.039 ± 0.943
1.019TrpIle: 1.019 ± 0.472
2.039TrpLys: 2.039 ± 0.943
2.548TrpLeu: 2.548 ± 1.179
0.51TrpMet: 0.51 ± 0.236
0.51TrpAsn: 0.51 ± 0.236
1.019TrpPro: 1.019 ± 0.472
0.51TrpGln: 0.51 ± 0.236
3.058TrpArg: 3.058 ± 1.415
0.0TrpSer: 0.0 ± 0.0
0.51TrpThr: 0.51 ± 0.236
2.039TrpVal: 2.039 ± 0.943
0.51TrpTrp: 0.51 ± 0.236
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.529TyrAla: 1.529 ± 0.708
1.019TyrCys: 1.019 ± 0.472
1.529TyrAsp: 1.529 ± 1.975
1.529TyrGlu: 1.529 ± 0.708
0.51TyrPhe: 0.51 ± 0.236
1.529TyrGly: 1.529 ± 0.708
0.51TyrHis: 0.51 ± 0.236
0.51TyrIle: 0.51 ± 0.236
2.548TyrLys: 2.548 ± 1.179
4.077TyrLeu: 4.077 ± 1.887
1.529TyrMet: 1.529 ± 0.708
1.019TyrAsn: 1.019 ± 0.472
2.039TyrPro: 2.039 ± 0.943
0.51TyrGln: 0.51 ± 0.236
1.529TyrArg: 1.529 ± 0.708
3.058TyrSer: 3.058 ± 3.95
1.019TyrThr: 1.019 ± 0.472
2.548TyrVal: 2.548 ± 1.503
1.019TyrTrp: 1.019 ± 0.472
1.019TyrTyr: 1.019 ± 0.472
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (1963 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski