Amino acid dipepetide frequency for Vagococcus coleopterorum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.674AlaAla: 5.674 ± 0.191
0.499AlaCys: 0.499 ± 0.036
4.264AlaAsp: 4.264 ± 0.112
5.275AlaGlu: 5.275 ± 0.133
3.072AlaPhe: 3.072 ± 0.089
5.206AlaGly: 5.206 ± 0.146
1.101AlaHis: 1.101 ± 0.049
5.807AlaIle: 5.807 ± 0.108
5.27AlaLys: 5.27 ± 0.111
6.762AlaLeu: 6.762 ± 0.135
2.082AlaMet: 2.082 ± 0.074
3.095AlaAsn: 3.095 ± 0.076
2.109AlaPro: 2.109 ± 0.079
2.446AlaGln: 2.446 ± 0.075
2.366AlaArg: 2.366 ± 0.082
4.12AlaSer: 4.12 ± 0.102
4.238AlaThr: 4.238 ± 0.106
5.221AlaVal: 5.221 ± 0.14
0.517AlaTrp: 0.517 ± 0.032
2.358AlaTyr: 2.358 ± 0.079
0.0AlaXaa: 0.0 ± 0.0
Cys
0.388CysAla: 0.388 ± 0.027
0.075CysCys: 0.075 ± 0.011
0.406CysAsp: 0.406 ± 0.032
0.417CysGlu: 0.417 ± 0.035
0.32CysPhe: 0.32 ± 0.024
0.568CysGly: 0.568 ± 0.037
0.173CysHis: 0.173 ± 0.02
0.404CysIle: 0.404 ± 0.029
0.253CysLys: 0.253 ± 0.028
0.624CysLeu: 0.624 ± 0.038
0.131CysMet: 0.131 ± 0.018
0.233CysAsn: 0.233 ± 0.024
0.266CysPro: 0.266 ± 0.025
0.364CysGln: 0.364 ± 0.03
0.231CysArg: 0.231 ± 0.02
0.393CysSer: 0.393 ± 0.031
0.295CysThr: 0.295 ± 0.025
0.42CysVal: 0.42 ± 0.032
0.051CysTrp: 0.051 ± 0.012
0.246CysTyr: 0.246 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
3.532AspAla: 3.532 ± 0.096
0.386AspCys: 0.386 ± 0.031
2.89AspAsp: 2.89 ± 0.102
4.622AspGlu: 4.622 ± 0.11
2.913AspPhe: 2.913 ± 0.078
3.798AspGly: 3.798 ± 0.121
1.063AspHis: 1.063 ± 0.047
4.327AspIle: 4.327 ± 0.093
4.009AspLys: 4.009 ± 0.106
5.732AspLeu: 5.732 ± 0.123
1.634AspMet: 1.634 ± 0.062
2.435AspAsn: 2.435 ± 0.081
1.791AspPro: 1.791 ± 0.073
2.193AspGln: 2.193 ± 0.075
1.936AspArg: 1.936 ± 0.063
2.957AspSer: 2.957 ± 0.079
2.671AspThr: 2.671 ± 0.071
4.145AspVal: 4.145 ± 0.095
0.602AspTrp: 0.602 ± 0.031
2.526AspTyr: 2.526 ± 0.074
0.0AspXaa: 0.0 ± 0.0
Glu
5.845GluAla: 5.845 ± 0.152
0.388GluCys: 0.388 ± 0.032
3.9GluAsp: 3.9 ± 0.092
6.689GluGlu: 6.689 ± 0.128
2.93GluPhe: 2.93 ± 0.085
4.178GluGly: 4.178 ± 0.091
1.145GluHis: 1.145 ± 0.053
5.665GluIle: 5.665 ± 0.136
6.322GluLys: 6.322 ± 0.136
8.083GluLeu: 8.083 ± 0.145
2.544GluMet: 2.544 ± 0.07
3.803GluAsn: 3.803 ± 0.108
2.1GluPro: 2.1 ± 0.094
3.152GluGln: 3.152 ± 0.112
3.039GluArg: 3.039 ± 0.102
4.042GluSer: 4.042 ± 0.094
4.651GluThr: 4.651 ± 0.118
5.583GluVal: 5.583 ± 0.131
0.635GluTrp: 0.635 ± 0.042
2.058GluTyr: 2.058 ± 0.066
0.0GluXaa: 0.0 ± 0.0
Phe
2.746PheAla: 2.746 ± 0.082
0.324PheCys: 0.324 ± 0.028
2.773PheAsp: 2.773 ± 0.08
3.035PheGlu: 3.035 ± 0.089
2.278PhePhe: 2.278 ± 0.079
3.396PheGly: 3.396 ± 0.104
0.706PheHis: 0.706 ± 0.042
3.461PheIle: 3.461 ± 0.114
2.935PheLys: 2.935 ± 0.089
4.085PheLeu: 4.085 ± 0.119
1.208PheMet: 1.208 ± 0.06
2.249PheAsn: 2.249 ± 0.065
1.543PhePro: 1.543 ± 0.054
1.345PheGln: 1.345 ± 0.052
1.219PheArg: 1.219 ± 0.054
3.143PheSer: 3.143 ± 0.095
2.449PheThr: 2.449 ± 0.079
3.106PheVal: 3.106 ± 0.099
0.404PheTrp: 0.404 ± 0.032
1.7PheTyr: 1.7 ± 0.062
0.0PheXaa: 0.0 ± 0.0
Gly
4.537GlyAla: 4.537 ± 0.128
0.526GlyCys: 0.526 ± 0.037
3.448GlyAsp: 3.448 ± 0.095
4.462GlyGlu: 4.462 ± 0.125
3.214GlyPhe: 3.214 ± 0.1
4.438GlyGly: 4.438 ± 0.127
1.319GlyHis: 1.319 ± 0.057
5.354GlyIle: 5.354 ± 0.125
4.964GlyLys: 4.964 ± 0.111
7.033GlyLeu: 7.033 ± 0.144
2.24GlyMet: 2.24 ± 0.089
2.819GlyAsn: 2.819 ± 0.083
1.523GlyPro: 1.523 ± 0.06
2.513GlyGln: 2.513 ± 0.075
2.606GlyArg: 2.606 ± 0.094
3.94GlySer: 3.94 ± 0.096
3.976GlyThr: 3.976 ± 0.104
5.179GlyVal: 5.179 ± 0.112
0.65GlyTrp: 0.65 ± 0.052
2.586GlyTyr: 2.586 ± 0.077
0.0GlyXaa: 0.0 ± 0.0
His
1.101HisAla: 1.101 ± 0.053
0.104HisCys: 0.104 ± 0.015
1.059HisAsp: 1.059 ± 0.049
1.141HisGlu: 1.141 ± 0.047
0.868HisPhe: 0.868 ± 0.045
1.288HisGly: 1.288 ± 0.055
0.511HisHis: 0.511 ± 0.035
1.108HisIle: 1.108 ± 0.048
0.948HisLys: 0.948 ± 0.045
1.774HisLeu: 1.774 ± 0.067
0.462HisMet: 0.462 ± 0.032
0.706HisAsn: 0.706 ± 0.042
0.864HisPro: 0.864 ± 0.047
0.804HisGln: 0.804 ± 0.039
0.768HisArg: 0.768 ± 0.046
0.946HisSer: 0.946 ± 0.046
0.879HisThr: 0.879 ± 0.051
1.13HisVal: 1.13 ± 0.05
0.142HisTrp: 0.142 ± 0.019
0.786HisTyr: 0.786 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
5.712IleAla: 5.712 ± 0.133
0.577IleCys: 0.577 ± 0.035
4.298IleAsp: 4.298 ± 0.097
5.541IleGlu: 5.541 ± 0.103
3.101IlePhe: 3.101 ± 0.113
5.388IleGly: 5.388 ± 0.128
1.201IleHis: 1.201 ± 0.06
5.718IleIle: 5.718 ± 0.161
5.066IleLys: 5.066 ± 0.104
6.842IleLeu: 6.842 ± 0.168
1.949IleMet: 1.949 ± 0.073
3.527IleAsn: 3.527 ± 0.1
3.117IlePro: 3.117 ± 0.071
2.668IleGln: 2.668 ± 0.086
2.566IleArg: 2.566 ± 0.082
5.181IleSer: 5.181 ± 0.113
4.486IleThr: 4.486 ± 0.113
5.164IleVal: 5.164 ± 0.118
0.539IleTrp: 0.539 ± 0.044
2.255IleTyr: 2.255 ± 0.075
0.0IleXaa: 0.0 ± 0.0
Lys
4.877LysAla: 4.877 ± 0.103
0.262LysCys: 0.262 ± 0.028
4.22LysAsp: 4.22 ± 0.108
7.264LysGlu: 7.264 ± 0.16
2.124LysPhe: 2.124 ± 0.074
4.169LysGly: 4.169 ± 0.095
1.088LysHis: 1.088 ± 0.05
4.948LysIle: 4.948 ± 0.103
5.905LysLys: 5.905 ± 0.136
5.807LysLeu: 5.807 ± 0.115
2.668LysMet: 2.668 ± 0.066
3.885LysAsn: 3.885 ± 0.105
2.34LysPro: 2.34 ± 0.081
2.897LysGln: 2.897 ± 0.094
3.01LysArg: 3.01 ± 0.08
3.532LysSer: 3.532 ± 0.088
4.049LysThr: 4.049 ± 0.108
4.935LysVal: 4.935 ± 0.11
0.553LysTrp: 0.553 ± 0.033
2.293LysTyr: 2.293 ± 0.083
0.0LysXaa: 0.0 ± 0.0
Leu
8.149LeuAla: 8.149 ± 0.15
0.548LeuCys: 0.548 ± 0.033
5.423LeuAsp: 5.423 ± 0.118
6.624LeuGlu: 6.624 ± 0.15
4.577LeuPhe: 4.577 ± 0.143
6.58LeuGly: 6.58 ± 0.162
1.403LeuHis: 1.403 ± 0.062
7.339LeuIle: 7.339 ± 0.143
6.638LeuLys: 6.638 ± 0.128
9.599LeuLeu: 9.599 ± 0.214
2.593LeuMet: 2.593 ± 0.083
4.677LeuAsn: 4.677 ± 0.119
3.863LeuPro: 3.863 ± 0.09
2.848LeuGln: 2.848 ± 0.082
3.123LeuArg: 3.123 ± 0.09
7.057LeuSer: 7.057 ± 0.143
6.291LeuThr: 6.291 ± 0.127
7.272LeuVal: 7.272 ± 0.125
0.666LeuTrp: 0.666 ± 0.037
2.668LeuTyr: 2.668 ± 0.097
0.0LeuXaa: 0.0 ± 0.0
Met
2.211MetAla: 2.211 ± 0.073
0.158MetCys: 0.158 ± 0.019
1.518MetAsp: 1.518 ± 0.066
1.807MetGlu: 1.807 ± 0.074
1.132MetPhe: 1.132 ± 0.059
1.818MetGly: 1.818 ± 0.058
0.357MetHis: 0.357 ± 0.026
2.215MetIle: 2.215 ± 0.08
2.195MetLys: 2.195 ± 0.064
2.717MetLeu: 2.717 ± 0.082
1.03MetMet: 1.03 ± 0.045
1.423MetAsn: 1.423 ± 0.059
1.123MetPro: 1.123 ± 0.051
0.852MetGln: 0.852 ± 0.042
0.961MetArg: 0.961 ± 0.047
1.951MetSer: 1.951 ± 0.077
2.309MetThr: 2.309 ± 0.07
2.02MetVal: 2.02 ± 0.073
0.222MetTrp: 0.222 ± 0.024
0.735MetTyr: 0.735 ± 0.045
0.0MetXaa: 0.0 ± 0.0
Asn
2.777AsnAla: 2.777 ± 0.089
0.317AsnCys: 0.317 ± 0.033
2.704AsnAsp: 2.704 ± 0.085
3.319AsnGlu: 3.319 ± 0.095
2.029AsnPhe: 2.029 ± 0.073
3.177AsnGly: 3.177 ± 0.1
1.041AsnHis: 1.041 ± 0.048
3.219AsnIle: 3.219 ± 0.099
3.55AsnLys: 3.55 ± 0.111
4.145AsnLeu: 4.145 ± 0.094
1.296AsnMet: 1.296 ± 0.064
2.315AsnAsn: 2.315 ± 0.094
2.191AsnPro: 2.191 ± 0.072
2.364AsnGln: 2.364 ± 0.086
1.665AsnArg: 1.665 ± 0.062
2.422AsnSer: 2.422 ± 0.092
2.169AsnThr: 2.169 ± 0.065
3.037AsnVal: 3.037 ± 0.091
0.471AsnTrp: 0.471 ± 0.029
1.885AsnTyr: 1.885 ± 0.067
0.0AsnXaa: 0.0 ± 0.0
Pro
2.386ProAla: 2.386 ± 0.083
0.173ProCys: 0.173 ± 0.022
2.009ProAsp: 2.009 ± 0.069
3.137ProGlu: 3.137 ± 0.088
1.689ProPhe: 1.689 ± 0.062
2.131ProGly: 2.131 ± 0.07
0.597ProHis: 0.597 ± 0.034
2.546ProIle: 2.546 ± 0.08
2.415ProLys: 2.415 ± 0.078
3.161ProLeu: 3.161 ± 0.088
0.759ProMet: 0.759 ± 0.039
1.754ProAsn: 1.754 ± 0.071
0.571ProPro: 0.571 ± 0.036
1.132ProGln: 1.132 ± 0.053
0.981ProArg: 0.981 ± 0.046
1.894ProSer: 1.894 ± 0.064
2.548ProThr: 2.548 ± 0.107
2.813ProVal: 2.813 ± 0.077
0.295ProTrp: 0.295 ± 0.027
1.276ProTyr: 1.276 ± 0.055
0.0ProXaa: 0.0 ± 0.0
Gln
3.001GlnAla: 3.001 ± 0.091
0.158GlnCys: 0.158 ± 0.017
1.86GlnAsp: 1.86 ± 0.06
3.188GlnGlu: 3.188 ± 0.095
1.47GlnPhe: 1.47 ± 0.058
2.313GlnGly: 2.313 ± 0.072
0.648GlnHis: 0.648 ± 0.035
2.382GlnIle: 2.382 ± 0.069
2.648GlnLys: 2.648 ± 0.076
4.307GlnLeu: 4.307 ± 0.12
1.125GlnMet: 1.125 ± 0.053
1.532GlnAsn: 1.532 ± 0.061
1.339GlnPro: 1.339 ± 0.057
1.749GlnGln: 1.749 ± 0.078
1.549GlnArg: 1.549 ± 0.059
2.156GlnSer: 2.156 ± 0.063
2.389GlnThr: 2.389 ± 0.075
2.857GlnVal: 2.857 ± 0.083
0.315GlnTrp: 0.315 ± 0.029
1.068GlnTyr: 1.068 ± 0.051
0.0GlnXaa: 0.0 ± 0.0
Arg
2.08ArgAla: 2.08 ± 0.066
0.206ArgCys: 0.206 ± 0.025
1.982ArgAsp: 1.982 ± 0.071
2.79ArgGlu: 2.79 ± 0.085
1.758ArgPhe: 1.758 ± 0.06
2.244ArgGly: 2.244 ± 0.079
0.706ArgHis: 0.706 ± 0.047
2.644ArgIle: 2.644 ± 0.076
2.573ArgLys: 2.573 ± 0.072
3.734ArgLeu: 3.734 ± 0.096
1.121ArgMet: 1.121 ± 0.049
1.552ArgAsn: 1.552 ± 0.062
1.192ArgPro: 1.192 ± 0.063
1.854ArgGln: 1.854 ± 0.058
1.66ArgArg: 1.66 ± 0.068
1.834ArgSer: 1.834 ± 0.07
1.738ArgThr: 1.738 ± 0.063
2.557ArgVal: 2.557 ± 0.077
0.235ArgTrp: 0.235 ± 0.025
1.387ArgTyr: 1.387 ± 0.056
0.0ArgXaa: 0.0 ± 0.0
Ser
3.863SerAla: 3.863 ± 0.106
0.34SerCys: 0.34 ± 0.031
3.512SerAsp: 3.512 ± 0.103
4.731SerGlu: 4.731 ± 0.123
2.961SerPhe: 2.961 ± 0.09
4.407SerGly: 4.407 ± 0.108
1.25SerHis: 1.25 ± 0.053
4.349SerIle: 4.349 ± 0.107
4.007SerLys: 4.007 ± 0.11
6.207SerLeu: 6.207 ± 0.137
1.538SerMet: 1.538 ± 0.062
2.551SerAsn: 2.551 ± 0.086
1.738SerPro: 1.738 ± 0.06
2.566SerGln: 2.566 ± 0.082
2.209SerArg: 2.209 ± 0.068
3.574SerSer: 3.574 ± 0.116
3.077SerThr: 3.077 ± 0.086
4.309SerVal: 4.309 ± 0.091
0.59SerTrp: 0.59 ± 0.043
2.355SerTyr: 2.355 ± 0.084
0.0SerXaa: 0.0 ± 0.0
Thr
4.229ThrAla: 4.229 ± 0.108
0.369ThrCys: 0.369 ± 0.026
3.472ThrAsp: 3.472 ± 0.086
4.564ThrGlu: 4.564 ± 0.145
2.584ThrPhe: 2.584 ± 0.075
4.256ThrGly: 4.256 ± 0.099
1.072ThrHis: 1.072 ± 0.049
4.848ThrIle: 4.848 ± 0.095
3.923ThrLys: 3.923 ± 0.088
5.501ThrLeu: 5.501 ± 0.127
1.39ThrMet: 1.39 ± 0.055
2.622ThrAsn: 2.622 ± 0.081
2.495ThrPro: 2.495 ± 0.082
1.716ThrGln: 1.716 ± 0.063
1.669ThrArg: 1.669 ± 0.063
3.359ThrSer: 3.359 ± 0.094
3.621ThrThr: 3.621 ± 0.105
4.64ThrVal: 4.64 ± 0.111
0.491ThrTrp: 0.491 ± 0.036
1.847ThrTyr: 1.847 ± 0.063
0.0ThrXaa: 0.0 ± 0.0
Val
5.958ValAla: 5.958 ± 0.148
0.531ValCys: 0.531 ± 0.036
3.92ValAsp: 3.92 ± 0.11
5.374ValGlu: 5.374 ± 0.11
2.87ValPhe: 2.87 ± 0.077
5.212ValGly: 5.212 ± 0.125
1.07ValHis: 1.07 ± 0.051
5.832ValIle: 5.832 ± 0.124
4.797ValLys: 4.797 ± 0.12
6.857ValLeu: 6.857 ± 0.145
1.987ValMet: 1.987 ± 0.073
3.075ValAsn: 3.075 ± 0.082
2.548ValPro: 2.548 ± 0.067
2.084ValGln: 2.084 ± 0.071
2.402ValArg: 2.402 ± 0.082
5.048ValSer: 5.048 ± 0.112
4.6ValThr: 4.6 ± 0.093
5.65ValVal: 5.65 ± 0.14
0.499ValTrp: 0.499 ± 0.038
2.362ValTyr: 2.362 ± 0.081
0.0ValXaa: 0.0 ± 0.0
Trp
0.422TrpAla: 0.422 ± 0.031
0.053TrpCys: 0.053 ± 0.01
0.499TrpAsp: 0.499 ± 0.031
0.544TrpGlu: 0.544 ± 0.04
0.433TrpPhe: 0.433 ± 0.037
0.48TrpGly: 0.48 ± 0.035
0.173TrpHis: 0.173 ± 0.019
0.553TrpIle: 0.553 ± 0.037
0.446TrpLys: 0.446 ± 0.029
1.15TrpLeu: 1.15 ± 0.052
0.244TrpMet: 0.244 ± 0.021
0.408TrpAsn: 0.408 ± 0.039
0.215TrpPro: 0.215 ± 0.029
0.484TrpGln: 0.484 ± 0.034
0.344TrpArg: 0.344 ± 0.032
0.502TrpSer: 0.502 ± 0.037
0.42TrpThr: 0.42 ± 0.038
0.553TrpVal: 0.553 ± 0.043
0.078TrpTrp: 0.078 ± 0.013
0.26TrpTyr: 0.26 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.993TyrAla: 1.993 ± 0.061
0.264TyrCys: 0.264 ± 0.027
2.002TyrAsp: 2.002 ± 0.073
2.231TyrGlu: 2.231 ± 0.093
1.778TyrPhe: 1.778 ± 0.069
2.282TyrGly: 2.282 ± 0.072
0.761TyrHis: 0.761 ± 0.046
2.178TyrIle: 2.178 ± 0.073
1.965TyrLys: 1.965 ± 0.085
3.823TyrLeu: 3.823 ± 0.098
0.753TyrMet: 0.753 ± 0.04
1.432TyrAsn: 1.432 ± 0.055
1.341TyrPro: 1.341 ± 0.056
2.02TyrGln: 2.02 ± 0.078
1.543TyrArg: 1.543 ± 0.068
2.082TyrSer: 2.082 ± 0.072
1.811TyrThr: 1.811 ± 0.072
2.089TyrVal: 2.089 ± 0.071
0.304TyrTrp: 0.304 ± 0.028
1.452TyrTyr: 1.452 ± 0.071
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1442 proteins (450470 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski