Amino acid dipepetide frequency for Erwinia phage vB_EamP-L1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.274AlaAla: 10.274 ± 1.405
0.383AlaCys: 0.383 ± 0.177
5.367AlaAsp: 5.367 ± 0.734
5.751AlaGlu: 5.751 ± 0.802
3.144AlaPhe: 3.144 ± 0.405
8.051AlaGly: 8.051 ± 0.916
1.38AlaHis: 1.38 ± 0.31
3.987AlaIle: 3.987 ± 0.615
6.671AlaLys: 6.671 ± 0.773
8.434AlaLeu: 8.434 ± 0.864
3.757AlaMet: 3.757 ± 0.908
4.294AlaAsn: 4.294 ± 0.508
3.144AlaPro: 3.144 ± 0.645
5.597AlaGln: 5.597 ± 1.093
4.601AlaArg: 4.601 ± 0.601
5.904AlaSer: 5.904 ± 0.829
4.907AlaThr: 4.907 ± 0.675
6.671AlaVal: 6.671 ± 0.886
1.073AlaTrp: 1.073 ± 0.344
3.297AlaTyr: 3.297 ± 0.578
0.0AlaXaa: 0.0 ± 0.0
Cys
0.997CysAla: 0.997 ± 0.345
0.0CysCys: 0.0 ± 0.0
0.613CysAsp: 0.613 ± 0.308
0.537CysGlu: 0.537 ± 0.21
0.307CysPhe: 0.307 ± 0.177
0.613CysGly: 0.613 ± 0.216
0.307CysHis: 0.307 ± 0.158
0.46CysIle: 0.46 ± 0.195
0.383CysLys: 0.383 ± 0.222
0.613CysLeu: 0.613 ± 0.255
0.307CysMet: 0.307 ± 0.149
0.46CysAsn: 0.46 ± 0.245
0.613CysPro: 0.613 ± 0.247
0.153CysGln: 0.153 ± 0.109
1.303CysArg: 1.303 ± 0.473
0.613CysSer: 0.613 ± 0.247
0.23CysThr: 0.23 ± 0.129
0.69CysVal: 0.69 ± 0.231
0.23CysTrp: 0.23 ± 0.133
0.537CysTyr: 0.537 ± 0.235
0.0CysXaa: 0.0 ± 0.0
Asp
6.211AspAla: 6.211 ± 0.624
0.46AspCys: 0.46 ± 0.161
4.064AspAsp: 4.064 ± 0.675
3.987AspGlu: 3.987 ± 0.552
2.76AspPhe: 2.76 ± 0.402
6.364AspGly: 6.364 ± 0.52
1.38AspHis: 1.38 ± 0.258
3.374AspIle: 3.374 ± 0.417
4.294AspLys: 4.294 ± 0.59
3.757AspLeu: 3.757 ± 0.585
1.687AspMet: 1.687 ± 0.309
2.224AspAsn: 2.224 ± 0.335
2.684AspPro: 2.684 ± 0.547
3.144AspGln: 3.144 ± 0.497
2.684AspArg: 2.684 ± 0.522
4.37AspSer: 4.37 ± 0.726
3.834AspThr: 3.834 ± 0.385
3.91AspVal: 3.91 ± 0.66
0.767AspTrp: 0.767 ± 0.273
2.607AspTyr: 2.607 ± 0.441
0.0AspXaa: 0.0 ± 0.0
Glu
5.904GluAla: 5.904 ± 0.76
1.073GluCys: 1.073 ± 0.345
3.91GluAsp: 3.91 ± 0.497
4.677GluGlu: 4.677 ± 0.873
2.914GluPhe: 2.914 ± 0.624
5.061GluGly: 5.061 ± 0.695
0.92GluHis: 0.92 ± 0.436
3.374GluIle: 3.374 ± 0.42
2.607GluLys: 2.607 ± 0.442
4.831GluLeu: 4.831 ± 0.697
1.61GluMet: 1.61 ± 0.41
2.224GluAsn: 2.224 ± 0.433
1.38GluPro: 1.38 ± 0.401
3.297GluGln: 3.297 ± 0.511
4.064GluArg: 4.064 ± 0.504
3.987GluSer: 3.987 ± 0.427
3.527GluThr: 3.527 ± 0.546
4.294GluVal: 4.294 ± 0.598
0.69GluTrp: 0.69 ± 0.211
2.377GluTyr: 2.377 ± 0.425
0.0GluXaa: 0.0 ± 0.0
Phe
4.064PheAla: 4.064 ± 0.488
0.23PheCys: 0.23 ± 0.174
3.374PheAsp: 3.374 ± 0.678
1.457PheGlu: 1.457 ± 0.452
0.767PhePhe: 0.767 ± 0.22
3.527PheGly: 3.527 ± 0.452
0.767PheHis: 0.767 ± 0.289
1.457PheIle: 1.457 ± 0.42
2.377PheLys: 2.377 ± 0.46
3.374PheLeu: 3.374 ± 0.472
1.303PheMet: 1.303 ± 0.264
2.607PheAsn: 2.607 ± 0.459
1.457PhePro: 1.457 ± 0.352
1.073PheGln: 1.073 ± 0.359
1.917PheArg: 1.917 ± 0.349
2.224PheSer: 2.224 ± 0.366
2.3PheThr: 2.3 ± 0.476
1.764PheVal: 1.764 ± 0.511
0.153PheTrp: 0.153 ± 0.108
0.997PheTyr: 0.997 ± 0.266
0.0PheXaa: 0.0 ± 0.0
Gly
8.128GlyAla: 8.128 ± 0.987
0.69GlyCys: 0.69 ± 0.275
5.904GlyAsp: 5.904 ± 0.711
5.444GlyGlu: 5.444 ± 0.496
3.22GlyPhe: 3.22 ± 0.62
5.827GlyGly: 5.827 ± 0.755
1.38GlyHis: 1.38 ± 0.407
4.754GlyIle: 4.754 ± 0.577
5.981GlyLys: 5.981 ± 0.579
7.438GlyLeu: 7.438 ± 0.739
1.917GlyMet: 1.917 ± 0.377
2.837GlyAsn: 2.837 ± 0.416
0.997GlyPro: 0.997 ± 0.266
2.99GlyGln: 2.99 ± 0.428
4.294GlyArg: 4.294 ± 0.548
5.674GlySer: 5.674 ± 0.742
3.374GlyThr: 3.374 ± 0.598
4.447GlyVal: 4.447 ± 0.561
1.457GlyTrp: 1.457 ± 0.345
2.454GlyTyr: 2.454 ± 0.571
0.0GlyXaa: 0.0 ± 0.0
His
1.38HisAla: 1.38 ± 0.331
0.46HisCys: 0.46 ± 0.226
0.69HisAsp: 0.69 ± 0.259
1.15HisGlu: 1.15 ± 0.293
0.843HisPhe: 0.843 ± 0.277
1.303HisGly: 1.303 ± 0.311
0.613HisHis: 0.613 ± 0.19
0.843HisIle: 0.843 ± 0.25
1.073HisLys: 1.073 ± 0.283
1.84HisLeu: 1.84 ± 0.452
1.073HisMet: 1.073 ± 0.257
0.537HisAsn: 0.537 ± 0.264
0.537HisPro: 0.537 ± 0.181
0.153HisGln: 0.153 ± 0.092
0.613HisArg: 0.613 ± 0.199
1.15HisSer: 1.15 ± 0.33
1.61HisThr: 1.61 ± 0.346
1.073HisVal: 1.073 ± 0.329
0.537HisTrp: 0.537 ± 0.19
0.613HisTyr: 0.613 ± 0.217
0.0HisXaa: 0.0 ± 0.0
Ile
4.677IleAla: 4.677 ± 0.532
0.46IleCys: 0.46 ± 0.199
4.064IleAsp: 4.064 ± 0.548
2.607IleGlu: 2.607 ± 0.457
1.073IlePhe: 1.073 ± 0.254
3.987IleGly: 3.987 ± 0.433
1.38IleHis: 1.38 ± 0.368
2.76IleIle: 2.76 ± 0.49
4.14IleLys: 4.14 ± 0.447
3.604IleLeu: 3.604 ± 0.578
1.227IleMet: 1.227 ± 0.262
2.684IleAsn: 2.684 ± 0.6
2.684IlePro: 2.684 ± 0.5
1.687IleGln: 1.687 ± 0.471
2.76IleArg: 2.76 ± 0.361
2.76IleSer: 2.76 ± 0.464
2.53IleThr: 2.53 ± 0.396
3.067IleVal: 3.067 ± 0.487
0.613IleTrp: 0.613 ± 0.213
1.227IleTyr: 1.227 ± 0.304
0.0IleXaa: 0.0 ± 0.0
Lys
7.744LysAla: 7.744 ± 0.855
0.69LysCys: 0.69 ± 0.226
4.601LysAsp: 4.601 ± 0.731
3.374LysGlu: 3.374 ± 0.537
2.607LysPhe: 2.607 ± 0.517
4.524LysGly: 4.524 ± 0.672
1.534LysHis: 1.534 ± 0.357
2.377LysIle: 2.377 ± 0.367
3.297LysLys: 3.297 ± 0.613
4.907LysLeu: 4.907 ± 0.706
2.224LysMet: 2.224 ± 0.43
1.764LysAsn: 1.764 ± 0.305
3.067LysPro: 3.067 ± 0.618
2.53LysGln: 2.53 ± 0.454
3.297LysArg: 3.297 ± 0.484
3.604LysSer: 3.604 ± 0.489
3.374LysThr: 3.374 ± 0.395
5.137LysVal: 5.137 ± 0.651
0.383LysTrp: 0.383 ± 0.197
2.224LysTyr: 2.224 ± 0.369
0.0LysXaa: 0.0 ± 0.0
Leu
6.901LeuAla: 6.901 ± 0.789
0.383LeuCys: 0.383 ± 0.222
4.677LeuAsp: 4.677 ± 0.561
6.057LeuGlu: 6.057 ± 0.979
2.224LeuPhe: 2.224 ± 0.595
5.137LeuGly: 5.137 ± 0.701
0.613LeuHis: 0.613 ± 0.232
4.37LeuIle: 4.37 ± 0.682
6.517LeuLys: 6.517 ± 0.724
5.827LeuLeu: 5.827 ± 0.907
2.377LeuMet: 2.377 ± 0.493
3.604LeuAsn: 3.604 ± 0.468
3.297LeuPro: 3.297 ± 0.54
3.527LeuGln: 3.527 ± 0.485
5.981LeuArg: 5.981 ± 0.67
5.214LeuSer: 5.214 ± 0.538
5.597LeuThr: 5.597 ± 0.806
4.754LeuVal: 4.754 ± 0.771
1.227LeuTrp: 1.227 ± 0.379
1.687LeuTyr: 1.687 ± 0.394
0.0LeuXaa: 0.0 ± 0.0
Met
3.604MetAla: 3.604 ± 0.433
0.153MetCys: 0.153 ± 0.109
1.61MetAsp: 1.61 ± 0.338
1.994MetGlu: 1.994 ± 0.464
1.38MetPhe: 1.38 ± 0.329
1.534MetGly: 1.534 ± 0.396
0.46MetHis: 0.46 ± 0.165
1.38MetIle: 1.38 ± 0.316
1.457MetLys: 1.457 ± 0.318
3.067MetLeu: 3.067 ± 0.436
0.843MetMet: 0.843 ± 0.254
1.457MetAsn: 1.457 ± 0.355
1.15MetPro: 1.15 ± 0.261
1.534MetGln: 1.534 ± 0.393
1.227MetArg: 1.227 ± 0.373
1.994MetSer: 1.994 ± 0.367
2.07MetThr: 2.07 ± 0.453
1.917MetVal: 1.917 ± 0.453
0.0MetTrp: 0.0 ± 0.0
0.46MetTyr: 0.46 ± 0.177
0.0MetXaa: 0.0 ± 0.0
Asn
3.834AsnAla: 3.834 ± 0.52
0.46AsnCys: 0.46 ± 0.196
2.454AsnAsp: 2.454 ± 0.295
2.607AsnGlu: 2.607 ± 0.401
1.84AsnPhe: 1.84 ± 0.317
3.757AsnGly: 3.757 ± 0.504
0.767AsnHis: 0.767 ± 0.319
2.224AsnIle: 2.224 ± 0.374
2.377AsnLys: 2.377 ± 0.536
3.144AsnLeu: 3.144 ± 0.572
1.38AsnMet: 1.38 ± 0.319
1.917AsnAsn: 1.917 ± 0.358
2.454AsnPro: 2.454 ± 0.359
1.994AsnGln: 1.994 ± 0.371
2.377AsnArg: 2.377 ± 0.513
2.07AsnSer: 2.07 ± 0.382
2.224AsnThr: 2.224 ± 0.48
2.837AsnVal: 2.837 ± 0.341
0.537AsnTrp: 0.537 ± 0.248
1.687AsnTyr: 1.687 ± 0.469
0.0AsnXaa: 0.0 ± 0.0
Pro
3.604ProAla: 3.604 ± 0.42
0.537ProCys: 0.537 ± 0.222
3.144ProAsp: 3.144 ± 0.366
3.144ProGlu: 3.144 ± 0.607
1.84ProPhe: 1.84 ± 0.452
1.917ProGly: 1.917 ± 0.408
0.613ProHis: 0.613 ± 0.222
1.38ProIle: 1.38 ± 0.297
1.764ProLys: 1.764 ± 0.435
2.76ProLeu: 2.76 ± 0.476
0.613ProMet: 0.613 ± 0.264
2.07ProAsn: 2.07 ± 0.375
0.767ProPro: 0.767 ± 0.317
1.687ProGln: 1.687 ± 0.415
1.457ProArg: 1.457 ± 0.301
2.377ProSer: 2.377 ± 0.527
2.07ProThr: 2.07 ± 0.391
2.607ProVal: 2.607 ± 0.432
0.843ProTrp: 0.843 ± 0.17
1.457ProTyr: 1.457 ± 0.389
0.0ProXaa: 0.0 ± 0.0
Gln
4.831GlnAla: 4.831 ± 0.814
0.537GlnCys: 0.537 ± 0.232
2.684GlnAsp: 2.684 ± 0.415
2.914GlnGlu: 2.914 ± 0.416
1.687GlnPhe: 1.687 ± 0.325
3.68GlnGly: 3.68 ± 0.497
0.767GlnHis: 0.767 ± 0.224
2.07GlnIle: 2.07 ± 0.352
2.607GlnLys: 2.607 ± 0.4
4.447GlnLeu: 4.447 ± 0.585
1.534GlnMet: 1.534 ± 0.455
1.457GlnAsn: 1.457 ± 0.327
1.687GlnPro: 1.687 ± 0.413
2.53GlnGln: 2.53 ± 0.484
2.224GlnArg: 2.224 ± 0.572
2.607GlnSer: 2.607 ± 0.45
1.38GlnThr: 1.38 ± 0.353
3.067GlnVal: 3.067 ± 0.386
0.843GlnTrp: 0.843 ± 0.287
1.15GlnTyr: 1.15 ± 0.268
0.0GlnXaa: 0.0 ± 0.0
Arg
4.217ArgAla: 4.217 ± 0.681
0.92ArgCys: 0.92 ± 0.314
3.374ArgAsp: 3.374 ± 0.513
3.757ArgGlu: 3.757 ± 0.66
1.994ArgPhe: 1.994 ± 0.362
4.217ArgGly: 4.217 ± 0.435
0.997ArgHis: 0.997 ± 0.196
2.76ArgIle: 2.76 ± 0.559
3.757ArgLys: 3.757 ± 0.681
4.677ArgLeu: 4.677 ± 0.559
1.457ArgMet: 1.457 ± 0.305
2.147ArgAsn: 2.147 ± 0.503
1.994ArgPro: 1.994 ± 0.448
2.914ArgGln: 2.914 ± 0.601
2.377ArgArg: 2.377 ± 0.445
3.527ArgSer: 3.527 ± 0.611
3.067ArgThr: 3.067 ± 0.397
3.91ArgVal: 3.91 ± 0.506
0.69ArgTrp: 0.69 ± 0.242
1.534ArgTyr: 1.534 ± 0.323
0.0ArgXaa: 0.0 ± 0.0
Ser
5.981SerAla: 5.981 ± 0.485
0.767SerCys: 0.767 ± 0.251
3.987SerAsp: 3.987 ± 0.714
2.76SerGlu: 2.76 ± 0.413
2.377SerPhe: 2.377 ± 0.349
5.981SerGly: 5.981 ± 0.688
0.997SerHis: 0.997 ± 0.32
3.68SerIle: 3.68 ± 0.785
3.757SerLys: 3.757 ± 0.559
4.601SerLeu: 4.601 ± 0.645
1.534SerMet: 1.534 ± 0.404
2.914SerAsn: 2.914 ± 0.502
2.224SerPro: 2.224 ± 0.358
2.607SerGln: 2.607 ± 0.445
3.45SerArg: 3.45 ± 0.43
3.22SerSer: 3.22 ± 0.574
2.76SerThr: 2.76 ± 0.437
4.294SerVal: 4.294 ± 0.54
1.073SerTrp: 1.073 ± 0.248
2.53SerTyr: 2.53 ± 0.455
0.0SerXaa: 0.0 ± 0.0
Thr
5.444ThrAla: 5.444 ± 0.664
0.843ThrCys: 0.843 ± 0.268
3.68ThrAsp: 3.68 ± 0.499
3.527ThrGlu: 3.527 ± 0.445
2.07ThrPhe: 2.07 ± 0.283
5.137ThrGly: 5.137 ± 0.491
1.15ThrHis: 1.15 ± 0.287
2.99ThrIle: 2.99 ± 0.465
4.14ThrLys: 4.14 ± 0.6
4.907ThrLeu: 4.907 ± 0.722
1.073ThrMet: 1.073 ± 0.322
2.147ThrAsn: 2.147 ± 0.461
2.76ThrPro: 2.76 ± 0.441
2.3ThrGln: 2.3 ± 0.51
2.684ThrArg: 2.684 ± 0.372
3.527ThrSer: 3.527 ± 0.613
3.604ThrThr: 3.604 ± 0.511
3.68ThrVal: 3.68 ± 0.481
0.69ThrTrp: 0.69 ± 0.234
0.92ThrTyr: 0.92 ± 0.213
0.0ThrXaa: 0.0 ± 0.0
Val
5.367ValAla: 5.367 ± 0.679
0.383ValCys: 0.383 ± 0.173
3.22ValAsp: 3.22 ± 0.39
4.37ValGlu: 4.37 ± 0.556
2.53ValPhe: 2.53 ± 0.485
4.984ValGly: 4.984 ± 0.677
1.303ValHis: 1.303 ± 0.352
3.527ValIle: 3.527 ± 0.426
3.527ValLys: 3.527 ± 0.474
4.601ValLeu: 4.601 ± 0.624
1.917ValMet: 1.917 ± 0.298
3.144ValAsn: 3.144 ± 0.398
2.607ValPro: 2.607 ± 0.403
2.76ValGln: 2.76 ± 0.472
4.064ValArg: 4.064 ± 0.445
4.754ValSer: 4.754 ± 0.589
4.984ValThr: 4.984 ± 0.637
5.827ValVal: 5.827 ± 0.921
1.227ValTrp: 1.227 ± 0.229
1.994ValTyr: 1.994 ± 0.417
0.0ValXaa: 0.0 ± 0.0
Trp
0.69TrpAla: 0.69 ± 0.226
0.153TrpCys: 0.153 ± 0.098
0.767TrpAsp: 0.767 ± 0.257
0.613TrpGlu: 0.613 ± 0.194
0.69TrpPhe: 0.69 ± 0.24
0.69TrpGly: 0.69 ± 0.25
0.383TrpHis: 0.383 ± 0.187
0.69TrpIle: 0.69 ± 0.252
0.843TrpLys: 0.843 ± 0.233
1.303TrpLeu: 1.303 ± 0.31
0.307TrpMet: 0.307 ± 0.151
1.38TrpAsn: 1.38 ± 0.361
0.077TrpPro: 0.077 ± 0.08
0.767TrpGln: 0.767 ± 0.224
0.767TrpArg: 0.767 ± 0.298
0.92TrpSer: 0.92 ± 0.264
0.997TrpThr: 0.997 ± 0.327
1.303TrpVal: 1.303 ± 0.563
0.153TrpTrp: 0.153 ± 0.155
0.383TrpTyr: 0.383 ± 0.162
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.837TyrAla: 2.837 ± 0.434
0.383TyrCys: 0.383 ± 0.161
2.454TyrAsp: 2.454 ± 0.688
1.994TyrGlu: 1.994 ± 0.409
0.92TyrPhe: 0.92 ± 0.239
2.914TyrGly: 2.914 ± 0.498
0.383TyrHis: 0.383 ± 0.16
1.534TyrIle: 1.534 ± 0.314
1.687TyrLys: 1.687 ± 0.348
1.84TyrLeu: 1.84 ± 0.499
1.073TyrMet: 1.073 ± 0.2
1.073TyrAsn: 1.073 ± 0.275
1.073TyrPro: 1.073 ± 0.253
1.457TyrGln: 1.457 ± 0.243
2.147TyrArg: 2.147 ± 0.339
0.997TyrSer: 0.997 ± 0.329
2.837TyrThr: 2.837 ± 0.561
1.84TyrVal: 1.84 ± 0.366
0.69TyrTrp: 0.69 ± 0.232
0.613TyrTyr: 0.613 ± 0.256
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 51 proteins (13043 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski