Amino acid dipepetide frequency for Mastigocladus laminosus WC112

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.645AlaAla: 6.645 ± 0.274
0.97AlaCys: 0.97 ± 0.088
3.296AlaAsp: 3.296 ± 0.173
4.928AlaGlu: 4.928 ± 0.226
2.818AlaPhe: 2.818 ± 0.151
4.397AlaGly: 4.397 ± 0.222
1.17AlaHis: 1.17 ± 0.112
6.745AlaIle: 6.745 ± 0.258
4.235AlaLys: 4.235 ± 0.19
7.893AlaLeu: 7.893 ± 0.296
1.794AlaMet: 1.794 ± 0.114
3.627AlaAsn: 3.627 ± 0.194
2.256AlaPro: 2.256 ± 0.14
3.588AlaGln: 3.588 ± 0.184
3.28AlaArg: 3.28 ± 0.18
4.389AlaSer: 4.389 ± 0.179
4.489AlaThr: 4.489 ± 0.212
5.552AlaVal: 5.552 ± 0.234
1.093AlaTrp: 1.093 ± 0.094
2.295AlaTyr: 2.295 ± 0.141
0.039AlaXaa: 0.039 ± 0.019
Cys
0.755CysAla: 0.755 ± 0.073
0.231CysCys: 0.231 ± 0.051
0.778CysAsp: 0.778 ± 0.074
0.716CysGlu: 0.716 ± 0.076
0.4CysPhe: 0.4 ± 0.055
0.87CysGly: 0.87 ± 0.085
0.323CysHis: 0.323 ± 0.05
0.755CysIle: 0.755 ± 0.078
0.539CysLys: 0.539 ± 0.063
1.255CysLeu: 1.255 ± 0.11
0.216CysMet: 0.216 ± 0.042
0.385CysAsn: 0.385 ± 0.054
0.747CysPro: 0.747 ± 0.076
0.647CysGln: 0.647 ± 0.067
0.793CysArg: 0.793 ± 0.08
0.732CysSer: 0.732 ± 0.076
0.601CysThr: 0.601 ± 0.074
0.693CysVal: 0.693 ± 0.079
0.246CysTrp: 0.246 ± 0.043
0.4CysTyr: 0.4 ± 0.053
0.0CysXaa: 0.0 ± 0.0
Asp
3.096AspAla: 3.096 ± 0.155
0.47AspCys: 0.47 ± 0.062
2.233AspAsp: 2.233 ± 0.157
2.61AspGlu: 2.61 ± 0.143
2.395AspPhe: 2.395 ± 0.144
2.995AspGly: 2.995 ± 0.201
0.662AspHis: 0.662 ± 0.07
3.327AspIle: 3.327 ± 0.183
2.056AspLys: 2.056 ± 0.136
5.236AspLeu: 5.236 ± 0.24
1.07AspMet: 1.07 ± 0.087
1.979AspAsn: 1.979 ± 0.139
2.187AspPro: 2.187 ± 0.113
1.717AspGln: 1.717 ± 0.109
2.841AspArg: 2.841 ± 0.152
2.603AspSer: 2.603 ± 0.15
2.541AspThr: 2.541 ± 0.142
2.942AspVal: 2.942 ± 0.151
0.855AspTrp: 0.855 ± 0.083
1.825AspTyr: 1.825 ± 0.127
0.0AspXaa: 0.0 ± 0.0
Glu
4.936GluAla: 4.936 ± 0.23
0.562GluCys: 0.562 ± 0.068
2.888GluAsp: 2.888 ± 0.164
4.428GluGlu: 4.428 ± 0.245
2.318GluPhe: 2.318 ± 0.136
3.257GluGly: 3.257 ± 0.167
0.97GluHis: 0.97 ± 0.074
5.082GluIle: 5.082 ± 0.234
3.511GluLys: 3.511 ± 0.159
6.615GluLeu: 6.615 ± 0.245
1.625GluMet: 1.625 ± 0.118
2.849GluAsn: 2.849 ± 0.155
2.503GluPro: 2.503 ± 0.137
3.75GluGln: 3.75 ± 0.19
3.18GluArg: 3.18 ± 0.175
3.411GluSer: 3.411 ± 0.158
3.434GluThr: 3.434 ± 0.152
4.397GluVal: 4.397 ± 0.172
0.893GluTrp: 0.893 ± 0.091
1.848GluTyr: 1.848 ± 0.115
0.0GluXaa: 0.0 ± 0.0
Phe
2.942PheAla: 2.942 ± 0.151
0.724PheCys: 0.724 ± 0.088
1.848PheAsp: 1.848 ± 0.127
1.948PheGlu: 1.948 ± 0.127
1.74PhePhe: 1.74 ± 0.127
2.749PheGly: 2.749 ± 0.148
0.762PheHis: 0.762 ± 0.077
2.641PheIle: 2.641 ± 0.162
1.694PheLys: 1.694 ± 0.114
4.666PheLeu: 4.666 ± 0.205
0.886PheMet: 0.886 ± 0.087
1.871PheAsn: 1.871 ± 0.115
1.756PhePro: 1.756 ± 0.133
1.917PheGln: 1.917 ± 0.126
1.733PheArg: 1.733 ± 0.106
3.111PheSer: 3.111 ± 0.161
2.356PheThr: 2.356 ± 0.12
2.811PheVal: 2.811 ± 0.14
0.785PheTrp: 0.785 ± 0.072
1.409PheTyr: 1.409 ± 0.1
0.0PheXaa: 0.0 ± 0.0
Gly
4.02GlyAla: 4.02 ± 0.229
0.978GlyCys: 0.978 ± 0.085
2.826GlyAsp: 2.826 ± 0.152
3.55GlyGlu: 3.55 ± 0.163
2.926GlyPhe: 2.926 ± 0.151
3.727GlyGly: 3.727 ± 0.185
1.101GlyHis: 1.101 ± 0.104
4.797GlyIle: 4.797 ± 0.203
4.112GlyLys: 4.112 ± 0.2
6.314GlyLeu: 6.314 ± 0.233
1.671GlyMet: 1.671 ± 0.124
2.603GlyAsn: 2.603 ± 0.143
1.101GlyPro: 1.101 ± 0.089
2.541GlyGln: 2.541 ± 0.15
3.25GlyArg: 3.25 ± 0.16
3.781GlySer: 3.781 ± 0.173
2.965GlyThr: 2.965 ± 0.162
4.451GlyVal: 4.451 ± 0.189
1.032GlyTrp: 1.032 ± 0.095
2.503GlyTyr: 2.503 ± 0.135
0.069GlyXaa: 0.069 ± 0.026
His
0.886HisAla: 0.886 ± 0.086
0.3HisCys: 0.3 ± 0.05
0.647HisAsp: 0.647 ± 0.075
0.816HisGlu: 0.816 ± 0.082
0.809HisPhe: 0.809 ± 0.07
0.932HisGly: 0.932 ± 0.098
0.485HisHis: 0.485 ± 0.065
1.278HisIle: 1.278 ± 0.099
1.001HisLys: 1.001 ± 0.09
2.171HisLeu: 2.171 ± 0.141
0.393HisMet: 0.393 ± 0.057
0.816HisAsn: 0.816 ± 0.078
1.201HisPro: 1.201 ± 0.107
1.232HisGln: 1.232 ± 0.11
1.271HisArg: 1.271 ± 0.107
1.155HisSer: 1.155 ± 0.1
1.063HisThr: 1.063 ± 0.094
0.978HisVal: 0.978 ± 0.08
0.239HisTrp: 0.239 ± 0.046
0.824HisTyr: 0.824 ± 0.079
0.0HisXaa: 0.0 ± 0.0
Ile
7.007IleAla: 7.007 ± 0.245
0.886IleCys: 0.886 ± 0.069
3.742IleAsp: 3.742 ± 0.177
4.543IleGlu: 4.543 ± 0.165
2.926IlePhe: 2.926 ± 0.161
4.066IleGly: 4.066 ± 0.213
1.232IleHis: 1.232 ± 0.097
4.535IleIle: 4.535 ± 0.23
3.635IleLys: 3.635 ± 0.189
7.392IleLeu: 7.392 ± 0.301
1.063IleMet: 1.063 ± 0.097
3.234IleAsn: 3.234 ± 0.145
3.565IlePro: 3.565 ± 0.15
3.542IleGln: 3.542 ± 0.186
3.273IleArg: 3.273 ± 0.157
4.566IleSer: 4.566 ± 0.199
3.542IleThr: 3.542 ± 0.156
4.813IleVal: 4.813 ± 0.218
0.986IleTrp: 0.986 ± 0.113
2.187IleTyr: 2.187 ± 0.137
0.0IleXaa: 0.0 ± 0.0
Lys
4.212LysAla: 4.212 ± 0.212
0.447LysCys: 0.447 ± 0.061
2.272LysAsp: 2.272 ± 0.148
3.642LysGlu: 3.642 ± 0.186
2.064LysPhe: 2.064 ± 0.132
2.803LysGly: 2.803 ± 0.136
0.824LysHis: 0.824 ± 0.08
3.812LysIle: 3.812 ± 0.185
2.903LysLys: 2.903 ± 0.153
6.16LysLeu: 6.16 ± 0.223
1.401LysMet: 1.401 ± 0.105
2.349LysAsn: 2.349 ± 0.147
2.456LysPro: 2.456 ± 0.139
3.188LysGln: 3.188 ± 0.188
2.872LysArg: 2.872 ± 0.153
3.234LysSer: 3.234 ± 0.179
3.026LysThr: 3.026 ± 0.185
3.096LysVal: 3.096 ± 0.163
0.639LysTrp: 0.639 ± 0.068
1.571LysTyr: 1.571 ± 0.116
0.0LysXaa: 0.0 ± 0.0
Leu
9.148LeuAla: 9.148 ± 0.292
1.132LeuCys: 1.132 ± 0.084
4.997LeuAsp: 4.997 ± 0.195
7.369LeuGlu: 7.369 ± 0.281
3.927LeuPhe: 3.927 ± 0.183
6.961LeuGly: 6.961 ± 0.271
2.01LeuHis: 2.01 ± 0.133
7.6LeuIle: 7.6 ± 0.286
5.806LeuLys: 5.806 ± 0.231
12.436LeuLeu: 12.436 ± 0.399
2.372LeuMet: 2.372 ± 0.151
4.366LeuAsn: 4.366 ± 0.181
5.483LeuPro: 5.483 ± 0.201
5.529LeuGln: 5.529 ± 0.23
5.729LeuArg: 5.729 ± 0.194
7.585LeuSer: 7.585 ± 0.266
6.237LeuThr: 6.237 ± 0.227
7.315LeuVal: 7.315 ± 0.271
1.671LeuTrp: 1.671 ± 0.143
2.865LeuTyr: 2.865 ± 0.163
0.092LeuXaa: 0.092 ± 0.024
Met
1.733MetAla: 1.733 ± 0.127
0.177MetCys: 0.177 ± 0.04
0.855MetAsp: 0.855 ± 0.083
1.271MetGlu: 1.271 ± 0.094
0.762MetPhe: 0.762 ± 0.077
1.455MetGly: 1.455 ± 0.115
0.385MetHis: 0.385 ± 0.057
1.34MetIle: 1.34 ± 0.097
1.217MetLys: 1.217 ± 0.094
2.402MetLeu: 2.402 ± 0.135
0.554MetMet: 0.554 ± 0.066
1.186MetAsn: 1.186 ± 0.09
1.04MetPro: 1.04 ± 0.092
1.301MetGln: 1.301 ± 0.097
1.178MetArg: 1.178 ± 0.091
1.64MetSer: 1.64 ± 0.092
1.448MetThr: 1.448 ± 0.111
1.363MetVal: 1.363 ± 0.113
0.108MetTrp: 0.108 ± 0.026
0.462MetTyr: 0.462 ± 0.063
0.0MetXaa: 0.0 ± 0.0
Asn
2.834AsnAla: 2.834 ± 0.148
0.578AsnCys: 0.578 ± 0.071
1.486AsnAsp: 1.486 ± 0.111
1.825AsnGlu: 1.825 ± 0.125
2.171AsnPhe: 2.171 ± 0.136
2.195AsnGly: 2.195 ± 0.152
0.986AsnHis: 0.986 ± 0.084
3.18AsnIle: 3.18 ± 0.144
2.318AsnLys: 2.318 ± 0.145
5.837AsnLeu: 5.837 ± 0.25
0.678AsnMet: 0.678 ± 0.072
2.133AsnAsn: 2.133 ± 0.167
2.865AsnPro: 2.865 ± 0.14
2.841AsnGln: 2.841 ± 0.15
2.356AsnArg: 2.356 ± 0.123
3.072AsnSer: 3.072 ± 0.162
2.479AsnThr: 2.479 ± 0.139
2.102AsnVal: 2.102 ± 0.118
0.739AsnTrp: 0.739 ± 0.08
1.779AsnTyr: 1.779 ± 0.108
0.0AsnXaa: 0.0 ± 0.0
Pro
2.726ProAla: 2.726 ± 0.161
0.454ProCys: 0.454 ± 0.063
2.495ProAsp: 2.495 ± 0.14
3.804ProGlu: 3.804 ± 0.179
1.64ProPhe: 1.64 ± 0.121
2.657ProGly: 2.657 ± 0.132
0.893ProHis: 0.893 ± 0.089
2.803ProIle: 2.803 ± 0.159
2.472ProLys: 2.472 ± 0.141
4.566ProLeu: 4.566 ± 0.199
0.832ProMet: 0.832 ± 0.088
2.31ProAsn: 2.31 ± 0.136
2.225ProPro: 2.225 ± 0.141
2.418ProGln: 2.418 ± 0.146
1.856ProArg: 1.856 ± 0.125
2.603ProSer: 2.603 ± 0.142
3.134ProThr: 3.134 ± 0.172
3.088ProVal: 3.088 ± 0.144
0.57ProTrp: 0.57 ± 0.064
1.317ProTyr: 1.317 ± 0.111
0.046ProXaa: 0.046 ± 0.02
Gln
4.358GlnAla: 4.358 ± 0.183
0.516GlnCys: 0.516 ± 0.07
2.295GlnAsp: 2.295 ± 0.142
3.658GlnGlu: 3.658 ± 0.176
1.532GlnPhe: 1.532 ± 0.106
3.38GlnGly: 3.38 ± 0.176
0.847GlnHis: 0.847 ± 0.078
3.866GlnIle: 3.866 ± 0.169
3.257GlnLys: 3.257 ± 0.148
5.845GlnLeu: 5.845 ± 0.215
1.294GlnMet: 1.294 ± 0.119
2.418GlnAsn: 2.418 ± 0.143
2.51GlnPro: 2.51 ± 0.162
4.235GlnGln: 4.235 ± 0.222
2.741GlnArg: 2.741 ± 0.153
2.849GlnSer: 2.849 ± 0.143
2.98GlnThr: 2.98 ± 0.187
3.835GlnVal: 3.835 ± 0.162
0.601GlnTrp: 0.601 ± 0.067
1.317GlnTyr: 1.317 ± 0.08
0.0GlnXaa: 0.0 ± 0.0
Arg
3.057ArgAla: 3.057 ± 0.176
0.739ArgCys: 0.739 ± 0.084
2.379ArgAsp: 2.379 ± 0.149
3.288ArgGlu: 3.288 ± 0.166
2.118ArgPhe: 2.118 ± 0.129
2.818ArgGly: 2.818 ± 0.149
1.147ArgHis: 1.147 ± 0.09
3.534ArgIle: 3.534 ± 0.149
2.618ArgLys: 2.618 ± 0.15
5.783ArgLeu: 5.783 ± 0.23
1.263ArgMet: 1.263 ± 0.11
2.11ArgAsn: 2.11 ± 0.128
2.01ArgPro: 2.01 ± 0.138
3.265ArgGln: 3.265 ± 0.165
3.38ArgArg: 3.38 ± 0.17
3.065ArgSer: 3.065 ± 0.155
2.325ArgThr: 2.325 ± 0.133
3.196ArgVal: 3.196 ± 0.159
0.901ArgTrp: 0.901 ± 0.076
2.179ArgTyr: 2.179 ± 0.124
0.039ArgXaa: 0.039 ± 0.018
Ser
4.451SerAla: 4.451 ± 0.164
0.701SerCys: 0.701 ± 0.086
2.988SerAsp: 2.988 ± 0.157
3.565SerGlu: 3.565 ± 0.157
2.618SerPhe: 2.618 ± 0.145
4.066SerGly: 4.066 ± 0.208
1.401SerHis: 1.401 ± 0.115
4.15SerIle: 4.15 ± 0.187
3.072SerLys: 3.072 ± 0.142
7.03SerLeu: 7.03 ± 0.255
1.332SerMet: 1.332 ± 0.114
3.08SerAsn: 3.08 ± 0.154
3.157SerPro: 3.157 ± 0.176
3.373SerGln: 3.373 ± 0.172
3.08SerArg: 3.08 ± 0.156
4.505SerSer: 4.505 ± 0.228
3.396SerThr: 3.396 ± 0.197
4.02SerVal: 4.02 ± 0.173
0.978SerTrp: 0.978 ± 0.09
2.071SerTyr: 2.071 ± 0.123
0.023SerXaa: 0.023 ± 0.012
Thr
4.166ThrAla: 4.166 ± 0.174
0.631ThrCys: 0.631 ± 0.067
2.695ThrAsp: 2.695 ± 0.143
3.35ThrGlu: 3.35 ± 0.17
2.087ThrPhe: 2.087 ± 0.122
3.658ThrGly: 3.658 ± 0.174
1.124ThrHis: 1.124 ± 0.096
3.765ThrIle: 3.765 ± 0.207
2.68ThrLys: 2.68 ± 0.143
6.076ThrLeu: 6.076 ± 0.248
0.901ThrMet: 0.901 ± 0.082
2.187ThrAsn: 2.187 ± 0.133
3.334ThrPro: 3.334 ± 0.177
2.718ThrGln: 2.718 ± 0.149
2.456ThrArg: 2.456 ± 0.162
3.604ThrSer: 3.604 ± 0.162
3.65ThrThr: 3.65 ± 0.191
4.166ThrVal: 4.166 ± 0.174
0.732ThrTrp: 0.732 ± 0.081
1.756ThrTyr: 1.756 ± 0.121
0.085ThrXaa: 0.085 ± 0.025
Val
5.444ValAla: 5.444 ± 0.233
0.816ValCys: 0.816 ± 0.081
2.98ValAsp: 2.98 ± 0.169
4.458ValGlu: 4.458 ± 0.191
2.749ValPhe: 2.749 ± 0.162
4.312ValGly: 4.312 ± 0.207
1.078ValHis: 1.078 ± 0.092
4.612ValIle: 4.612 ± 0.218
3.65ValLys: 3.65 ± 0.164
6.792ValLeu: 6.792 ± 0.223
1.486ValMet: 1.486 ± 0.116
3.119ValAsn: 3.119 ± 0.165
2.618ValPro: 2.618 ± 0.131
3.042ValGln: 3.042 ± 0.149
3.003ValArg: 3.003 ± 0.153
4.435ValSer: 4.435 ± 0.212
3.781ValThr: 3.781 ± 0.186
4.997ValVal: 4.997 ± 0.24
0.862ValTrp: 0.862 ± 0.093
2.171ValTyr: 2.171 ± 0.129
0.062ValXaa: 0.062 ± 0.021
Trp
0.893TrpAla: 0.893 ± 0.083
0.193TrpCys: 0.193 ± 0.042
0.639TrpAsp: 0.639 ± 0.069
0.839TrpGlu: 0.839 ± 0.084
0.739TrpPhe: 0.739 ± 0.08
0.839TrpGly: 0.839 ± 0.076
0.424TrpHis: 0.424 ± 0.053
0.916TrpIle: 0.916 ± 0.086
0.477TrpLys: 0.477 ± 0.06
2.241TrpLeu: 2.241 ± 0.15
0.408TrpMet: 0.408 ± 0.054
0.477TrpAsn: 0.477 ± 0.063
0.223TrpPro: 0.223 ± 0.044
1.348TrpGln: 1.348 ± 0.111
1.016TrpArg: 1.016 ± 0.085
0.839TrpSer: 0.839 ± 0.096
0.639TrpThr: 0.639 ± 0.071
0.963TrpVal: 0.963 ± 0.085
0.285TrpTrp: 0.285 ± 0.037
0.47TrpTyr: 0.47 ± 0.062
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.156TyrAla: 2.156 ± 0.13
0.562TyrCys: 0.562 ± 0.065
1.301TyrAsp: 1.301 ± 0.111
1.833TyrGlu: 1.833 ± 0.125
1.586TyrPhe: 1.586 ± 0.113
2.125TyrGly: 2.125 ± 0.12
0.662TyrHis: 0.662 ± 0.071
1.987TyrIle: 1.987 ± 0.125
1.709TyrLys: 1.709 ± 0.116
3.881TyrLeu: 3.881 ± 0.187
0.593TyrMet: 0.593 ± 0.057
1.348TyrAsn: 1.348 ± 0.094
1.648TyrPro: 1.648 ± 0.124
2.11TyrGln: 2.11 ± 0.131
1.925TyrArg: 1.925 ± 0.115
1.848TyrSer: 1.848 ± 0.106
1.694TyrThr: 1.694 ± 0.114
1.648TyrVal: 1.648 ± 0.123
0.647TyrTrp: 0.647 ± 0.071
1.194TyrTyr: 1.194 ± 0.099
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.046XaaAla: 0.046 ± 0.017
0.015XaaCys: 0.015 ± 0.011
0.0XaaAsp: 0.0 ± 0.001
0.015XaaGlu: 0.015 ± 0.011
0.023XaaPhe: 0.023 ± 0.012
0.054XaaGly: 0.054 ± 0.017
0.008XaaHis: 0.008 ± 0.008
0.008XaaIle: 0.008 ± 0.008
0.008XaaLys: 0.008 ± 0.007
0.039XaaLeu: 0.039 ± 0.016
0.039XaaMet: 0.039 ± 0.017
0.008XaaAsn: 0.008 ± 0.007
0.023XaaPro: 0.023 ± 0.014
0.031XaaGln: 0.031 ± 0.015
0.0XaaArg: 0.0 ± 0.001
0.031XaaSer: 0.031 ± 0.016
0.039XaaThr: 0.039 ± 0.016
0.046XaaVal: 0.046 ± 0.019
0.008XaaTrp: 0.008 ± 0.008
0.015XaaTyr: 0.015 ± 0.01
0.909XaaXaa: 0.909 ± 0.112
Statistics based on 954 proteins (129866 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski