Amino acid dipepetide frequency for Crenobacter sp. GY 70310

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.627AlaAla: 18.627 ± 0.207	1.732AlaCys: 1.732 ± 0.048	7.173AlaAsp: 7.173 ± 0.093	7.583AlaGlu: 7.583 ± 0.111	4.376AlaPhe: 4.376 ± 0.075	12.302AlaGly: 12.302 ± 0.147	2.735AlaHis: 2.735 ± 0.056	5.198AlaIle: 5.198 ± 0.077	3.614AlaLys: 3.614 ± 0.076	17.426AlaLeu: 17.426 ± 0.203	3.397AlaMet: 3.397 ± 0.062	2.829AlaAsn: 2.829 ± 0.051	5.849AlaPro: 5.849 ± 0.094	4.937AlaGln: 4.937 ± 0.072	10.676AlaArg: 10.676 ± 0.145	6.796AlaSer: 6.796 ± 0.09	5.326AlaThr: 5.326 ± 0.083	8.615AlaVal: 8.615 ± 0.101	2.048AlaTrp: 2.048 ± 0.048	2.775AlaTyr: 2.775 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	1.383CysAla: 1.383 ± 0.039	0.154CysCys: 0.154 ± 0.013	0.625CysAsp: 0.625 ± 0.025	0.603CysGlu: 0.603 ± 0.025	0.331CysPhe: 0.331 ± 0.018	1.099CysGly: 1.099 ± 0.037	0.313CysHis: 0.313 ± 0.019	0.345CysIle: 0.345 ± 0.021	0.257CysLys: 0.257 ± 0.014	1.056CysLeu: 1.056 ± 0.033	0.209CysMet: 0.209 ± 0.014	0.279CysAsn: 0.279 ± 0.015	0.622CysPro: 0.622 ± 0.027	0.374CysGln: 0.374 ± 0.019	0.853CysArg: 0.853 ± 0.029	0.5CysSer: 0.5 ± 0.023	0.446CysThr: 0.446 ± 0.021	0.864CysVal: 0.864 ± 0.031	0.152CysTrp: 0.152 ± 0.011	0.295CysTyr: 0.295 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	8.476AspAla: 8.476 ± 0.105	0.522AspCys: 0.522 ± 0.024	2.854AspAsp: 2.854 ± 0.054	3.622AspGlu: 3.622 ± 0.068	2.154AspPhe: 2.154 ± 0.043	4.791AspGly: 4.791 ± 0.085	0.923AspHis: 0.923 ± 0.032	2.392AspIle: 2.392 ± 0.044	2.002AspLys: 2.002 ± 0.046	4.682AspLeu: 4.682 ± 0.067	1.144AspMet: 1.144 ± 0.036	1.297AspAsn: 1.297 ± 0.042	2.547AspPro: 2.547 ± 0.054	1.193AspGln: 1.193 ± 0.036	2.855AspArg: 2.855 ± 0.067	2.333AspSer: 2.333 ± 0.048	2.747AspThr: 2.747 ± 0.049	3.857AspVal: 3.857 ± 0.062	0.905AspTrp: 0.905 ± 0.031	1.626AspTyr: 1.626 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	7.887GluAla: 7.887 ± 0.133	0.479GluCys: 0.479 ± 0.021	2.365GluAsp: 2.365 ± 0.054	2.811GluGlu: 2.811 ± 0.06	1.68GluPhe: 1.68 ± 0.04	4.079GluGly: 4.079 ± 0.074	1.438GluHis: 1.438 ± 0.044	2.677GluIle: 2.677 ± 0.061	1.998GluLys: 1.998 ± 0.053	6.497GluLeu: 6.497 ± 0.094	1.364GluMet: 1.364 ± 0.035	1.386GluAsn: 1.386 ± 0.039	2.343GluPro: 2.343 ± 0.056	2.528GluGln: 2.528 ± 0.056	4.77GluArg: 4.77 ± 0.083	2.287GluSer: 2.287 ± 0.042	2.776GluThr: 2.776 ± 0.056	4.485GluVal: 4.485 ± 0.077	0.761GluTrp: 0.761 ± 0.028	1.153GluTyr: 1.153 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	5.204PheAla: 5.204 ± 0.089	0.471PheCys: 0.471 ± 0.023	2.52PheAsp: 2.52 ± 0.048	2.11PheGlu: 2.11 ± 0.046	1.414PhePhe: 1.414 ± 0.044	3.566PheGly: 3.566 ± 0.058	0.689PheHis: 0.689 ± 0.026	1.546PheIle: 1.546 ± 0.041	1.098PheLys: 1.098 ± 0.033	2.951PheLeu: 2.951 ± 0.061	0.864PheMet: 0.864 ± 0.028	1.149PheAsn: 1.149 ± 0.037	1.403PhePro: 1.403 ± 0.036	0.809PheGln: 0.809 ± 0.029	1.755PheArg: 1.755 ± 0.04	2.326PheSer: 2.326 ± 0.055	1.778PheThr: 1.778 ± 0.042	2.918PheVal: 2.918 ± 0.06	0.554PheTrp: 0.554 ± 0.027	1.02PheTyr: 1.02 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.527GlyAla: 9.527 ± 0.129	1.079GlyCys: 1.079 ± 0.029	4.238GlyAsp: 4.238 ± 0.071	5.518GlyGlu: 5.518 ± 0.086	3.472GlyPhe: 3.472 ± 0.061	7.361GlyGly: 7.361 ± 0.135	1.94GlyHis: 1.94 ± 0.043	3.564GlyIle: 3.564 ± 0.071	3.614GlyLys: 3.614 ± 0.068	8.451GlyLeu: 8.451 ± 0.099	2.342GlyMet: 2.342 ± 0.05	2.202GlyAsn: 2.202 ± 0.058	2.377GlyPro: 2.377 ± 0.048	3.224GlyGln: 3.224 ± 0.058	6.005GlyArg: 6.005 ± 0.084	4.417GlySer: 4.417 ± 0.086	3.702GlyThr: 3.702 ± 0.07	7.488GlyVal: 7.488 ± 0.102	1.435GlyTrp: 1.435 ± 0.036	2.448GlyTyr: 2.448 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.902HisAla: 2.902 ± 0.06	0.277HisCys: 0.277 ± 0.016	1.156HisAsp: 1.156 ± 0.037	1.096HisGlu: 1.096 ± 0.039	0.956HisPhe: 0.956 ± 0.033	2.008HisGly: 2.008 ± 0.046	0.612HisHis: 0.612 ± 0.028	0.814HisIle: 0.814 ± 0.029	0.629HisLys: 0.629 ± 0.026	2.203HisLeu: 2.203 ± 0.051	0.422HisMet: 0.422 ± 0.02	0.545HisAsn: 0.545 ± 0.021	1.468HisPro: 1.468 ± 0.037	0.665HisGln: 0.665 ± 0.026	1.296HisArg: 1.296 ± 0.04	0.912HisSer: 0.912 ± 0.032	0.918HisThr: 0.918 ± 0.027	1.384HisVal: 1.384 ± 0.039	0.389HisTrp: 0.389 ± 0.02	0.72HisTyr: 0.72 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.825IleAla: 5.825 ± 0.082	0.442IleCys: 0.442 ± 0.02	2.835IleAsp: 2.835 ± 0.049	2.963IleGlu: 2.963 ± 0.057	1.198IlePhe: 1.198 ± 0.043	4.208IleGly: 4.208 ± 0.071	0.86IleHis: 0.86 ± 0.028	1.466IleIle: 1.466 ± 0.047	1.434IleLys: 1.434 ± 0.036	3.431IleLeu: 3.431 ± 0.067	0.695IleMet: 0.695 ± 0.024	1.253IleAsn: 1.253 ± 0.043	1.887IlePro: 1.887 ± 0.05	1.023IleGln: 1.023 ± 0.039	2.862IleArg: 2.862 ± 0.054	2.155IleSer: 2.155 ± 0.052	1.961IleThr: 1.961 ± 0.046	3.426IleVal: 3.426 ± 0.065	0.393IleTrp: 0.393 ± 0.019	0.899IleTyr: 0.899 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.967LysAla: 3.967 ± 0.082	0.183LysCys: 0.183 ± 0.015	1.544LysAsp: 1.544 ± 0.043	1.535LysGlu: 1.535 ± 0.042	0.882LysPhe: 0.882 ± 0.03	2.516LysGly: 2.516 ± 0.056	0.642LysHis: 0.642 ± 0.027	1.508LysIle: 1.508 ± 0.043	1.463LysLys: 1.463 ± 0.053	3.913LysLeu: 3.913 ± 0.065	0.79LysMet: 0.79 ± 0.031	0.978LysAsn: 0.978 ± 0.033	1.969LysPro: 1.969 ± 0.045	1.317LysGln: 1.317 ± 0.039	2.132LysArg: 2.132 ± 0.048	1.707LysSer: 1.707 ± 0.039	1.79LysThr: 1.79 ± 0.047	2.659LysVal: 2.659 ± 0.055	0.352LysTrp: 0.352 ± 0.02	0.707LysTyr: 0.707 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	18.278LeuAla: 18.278 ± 0.213	1.243LeuCys: 1.243 ± 0.041	5.962LeuAsp: 5.962 ± 0.08	5.732LeuGlu: 5.732 ± 0.096	4.154LeuPhe: 4.154 ± 0.081	8.959LeuGly: 8.959 ± 0.104	1.928LeuHis: 1.928 ± 0.047	4.895LeuIle: 4.895 ± 0.075	3.942LeuLys: 3.942 ± 0.065	12.517LeuLeu: 12.517 ± 0.17	2.843LeuMet: 2.843 ± 0.054	2.597LeuAsn: 2.597 ± 0.054	6.897LeuPro: 6.897 ± 0.104	3.373LeuGln: 3.373 ± 0.063	6.502LeuArg: 6.502 ± 0.087	7.187LeuSer: 7.187 ± 0.098	6.065LeuThr: 6.065 ± 0.082	8.069LeuVal: 8.069 ± 0.119	1.497LeuTrp: 1.497 ± 0.042	2.43LeuTyr: 2.43 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.98MetAla: 2.98 ± 0.057	0.172MetCys: 0.172 ± 0.012	1.092MetAsp: 1.092 ± 0.035	0.921MetGlu: 0.921 ± 0.034	0.736MetPhe: 0.736 ± 0.03	1.823MetGly: 1.823 ± 0.042	0.537MetHis: 0.537 ± 0.024	0.97MetIle: 0.97 ± 0.031	1.081MetLys: 1.081 ± 0.04	2.976MetLeu: 2.976 ± 0.055	0.653MetMet: 0.653 ± 0.026	0.728MetAsn: 0.728 ± 0.025	1.358MetPro: 1.358 ± 0.035	1.137MetGln: 1.137 ± 0.037	1.582MetArg: 1.582 ± 0.046	1.49MetSer: 1.49 ± 0.04	1.237MetThr: 1.237 ± 0.034	1.784MetVal: 1.784 ± 0.045	0.218MetTrp: 0.218 ± 0.015	0.406MetTyr: 0.406 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.023AsnAla: 3.023 ± 0.065	0.247AsnCys: 0.247 ± 0.016	1.219AsnAsp: 1.219 ± 0.033	1.265AsnGlu: 1.265 ± 0.037	0.878AsnPhe: 0.878 ± 0.032	2.033AsnGly: 2.033 ± 0.055	0.499AsnHis: 0.499 ± 0.023	1.193AsnIle: 1.193 ± 0.036	0.878AsnLys: 0.878 ± 0.03	2.656AsnLeu: 2.656 ± 0.051	0.597AsnMet: 0.597 ± 0.028	0.723AsnAsn: 0.723 ± 0.031	1.817AsnPro: 1.817 ± 0.046	0.796AsnGln: 0.796 ± 0.028	1.768AsnArg: 1.768 ± 0.04	1.141AsnSer: 1.141 ± 0.043	1.298AsnThr: 1.298 ± 0.039	1.892AsnVal: 1.892 ± 0.05	0.432AsnTrp: 0.432 ± 0.021	0.664AsnTyr: 0.664 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	7.276ProAla: 7.276 ± 0.12	0.468ProCys: 0.468 ± 0.018	3.057ProAsp: 3.057 ± 0.054	3.213ProGlu: 3.213 ± 0.073	1.843ProPhe: 1.843 ± 0.042	3.882ProGly: 3.882 ± 0.061	1.017ProHis: 1.017 ± 0.034	1.626ProIle: 1.626 ± 0.04	1.375ProLys: 1.375 ± 0.046	5.664ProLeu: 5.664 ± 0.081	1.162ProMet: 1.162 ± 0.034	1.167ProAsn: 1.167 ± 0.034	2.257ProPro: 2.257 ± 0.056	1.927ProGln: 1.927 ± 0.041	2.605ProArg: 2.605 ± 0.051	2.21ProSer: 2.21 ± 0.052	2.033ProThr: 2.033 ± 0.047	4.086ProVal: 4.086 ± 0.069	0.772ProTrp: 0.772 ± 0.031	1.223ProTyr: 1.223 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	5.018GlnAla: 5.018 ± 0.077	0.314GlnCys: 0.314 ± 0.015	1.611GlnAsp: 1.611 ± 0.046	1.425GlnGlu: 1.425 ± 0.047	1.033GlnPhe: 1.033 ± 0.03	3.136GlnGly: 3.136 ± 0.055	0.822GlnHis: 0.822 ± 0.028	1.449GlnIle: 1.449 ± 0.036	1.22GlnLys: 1.22 ± 0.04	4.389GlnLeu: 4.389 ± 0.081	0.939GlnMet: 0.939 ± 0.031	0.812GlnAsn: 0.812 ± 0.038	1.847GlnPro: 1.847 ± 0.049	1.91GlnGln: 1.91 ± 0.056	2.613GlnArg: 2.613 ± 0.055	1.773GlnSer: 1.773 ± 0.045	1.701GlnThr: 1.701 ± 0.049	2.728GlnVal: 2.728 ± 0.056	0.532GlnTrp: 0.532 ± 0.027	0.732GlnTyr: 0.732 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	8.37ArgAla: 8.37 ± 0.115	0.654ArgCys: 0.654 ± 0.028	3.529ArgAsp: 3.529 ± 0.069	4.587ArgGlu: 4.587 ± 0.08	2.976ArgPhe: 2.976 ± 0.058	4.228ArgGly: 4.228 ± 0.064	1.933ArgHis: 1.933 ± 0.048	3.059ArgIle: 3.059 ± 0.065	2.062ArgLys: 2.062 ± 0.048	8.759ArgLeu: 8.759 ± 0.127	1.711ArgMet: 1.711 ± 0.041	1.565ArgAsn: 1.565 ± 0.04	2.88ArgPro: 2.88 ± 0.054	3.039ArgGln: 3.039 ± 0.056	5.022ArgArg: 5.022 ± 0.102	2.75ArgSer: 2.75 ± 0.052	2.822ArgThr: 2.822 ± 0.056	5.742ArgVal: 5.742 ± 0.089	1.123ArgTrp: 1.123 ± 0.037	2.178ArgTyr: 2.178 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	6.37SerAla: 6.37 ± 0.093	0.529SerCys: 0.529 ± 0.024	2.451SerAsp: 2.451 ± 0.044	2.689SerGlu: 2.689 ± 0.059	2.025SerPhe: 2.025 ± 0.045	5.099SerGly: 5.099 ± 0.096	1.116SerHis: 1.116 ± 0.032	2.072SerIle: 2.072 ± 0.048	1.47SerLys: 1.47 ± 0.039	5.982SerLeu: 5.982 ± 0.075	1.195SerMet: 1.195 ± 0.039	1.328SerAsn: 1.328 ± 0.037	2.518SerPro: 2.518 ± 0.052	1.828SerGln: 1.828 ± 0.049	3.591SerArg: 3.591 ± 0.06	2.469SerSer: 2.469 ± 0.051	2.474SerThr: 2.474 ± 0.053	3.961SerVal: 3.961 ± 0.069	0.688SerTrp: 0.688 ± 0.028	1.254SerTyr: 1.254 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	5.105ThrAla: 5.105 ± 0.076	0.44ThrCys: 0.44 ± 0.02	2.377ThrAsp: 2.377 ± 0.046	2.136ThrGlu: 2.136 ± 0.043	1.618ThrPhe: 1.618 ± 0.044	4.276ThrGly: 4.276 ± 0.076	0.944ThrHis: 0.944 ± 0.032	1.843ThrIle: 1.843 ± 0.045	0.864ThrLys: 0.864 ± 0.033	7.285ThrLeu: 7.285 ± 0.106	0.955ThrMet: 0.955 ± 0.029	0.987ThrAsn: 0.987 ± 0.031	3.116ThrPro: 3.116 ± 0.058	1.627ThrGln: 1.627 ± 0.046	3.473ThrArg: 3.473 ± 0.061	2.173ThrSer: 2.173 ± 0.055	2.144ThrThr: 2.144 ± 0.063	3.977ThrVal: 3.977 ± 0.07	0.479ThrTrp: 0.479 ± 0.023	0.89ThrTyr: 0.89 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	9.562ValAla: 9.562 ± 0.102	0.909ValCys: 0.909 ± 0.029	4.474ValAsp: 4.474 ± 0.064	4.366ValGlu: 4.366 ± 0.076	2.862ValPhe: 2.862 ± 0.052	6.044ValGly: 6.044 ± 0.079	1.489ValHis: 1.489 ± 0.036	3.285ValIle: 3.285 ± 0.061	2.474ValLys: 2.474 ± 0.056	8.82ValLeu: 8.82 ± 0.097	1.8ValMet: 1.8 ± 0.046	2.237ValAsn: 2.237 ± 0.057	3.606ValPro: 3.606 ± 0.063	2.188ValGln: 2.188 ± 0.053	5.178ValArg: 5.178 ± 0.083	4.684ValSer: 4.684 ± 0.078	3.714ValThr: 3.714 ± 0.059	6.262ValVal: 6.262 ± 0.101	1.043ValTrp: 1.043 ± 0.037	1.725ValTyr: 1.725 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.372TrpAla: 1.372 ± 0.035	0.181TrpCys: 0.181 ± 0.012	0.58TrpAsp: 0.58 ± 0.026	0.463TrpGlu: 0.463 ± 0.022	0.554TrpPhe: 0.554 ± 0.025	0.923TrpGly: 0.923 ± 0.03	0.402TrpHis: 0.402 ± 0.022	0.527TrpIle: 0.527 ± 0.023	0.398TrpLys: 0.398 ± 0.021	2.438TrpLeu: 2.438 ± 0.052	0.368TrpMet: 0.368 ± 0.017	0.328TrpAsn: 0.328 ± 0.019	0.731TrpPro: 0.731 ± 0.031	1.088TrpGln: 1.088 ± 0.037	1.375TrpArg: 1.375 ± 0.038	0.601TrpSer: 0.601 ± 0.027	0.533TrpThr: 0.533 ± 0.022	1.015TrpVal: 1.015 ± 0.031	0.262TrpTrp: 0.262 ± 0.016	0.267TrpTyr: 0.267 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.865TyrAla: 2.865 ± 0.053	0.265TyrCys: 0.265 ± 0.017	1.259TyrAsp: 1.259 ± 0.034	1.122TyrGlu: 1.122 ± 0.034	1.001TyrPhe: 1.001 ± 0.033	2.071TyrGly: 2.071 ± 0.051	0.534TyrHis: 0.534 ± 0.024	0.787TyrIle: 0.787 ± 0.032	0.682TyrLys: 0.682 ± 0.031	2.975TyrLeu: 2.975 ± 0.06	0.429TyrMet: 0.429 ± 0.022	0.632TyrAsn: 0.632 ± 0.028	1.372TyrPro: 1.372 ± 0.036	1.021TyrGln: 1.021 ± 0.032	2.076TyrArg: 2.076 ± 0.04	1.195TyrSer: 1.195 ± 0.037	1.245TyrThr: 1.245 ± 0.033	1.51TyrVal: 1.51 ± 0.038	0.371TyrTrp: 0.371 ± 0.02	0.668TyrTyr: 0.668 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3190 proteins (1028072 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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