Amino acid dipepetide frequency for Prauserella sp. YIM 121212

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.729AlaAla: 19.729 ± 0.126	1.067AlaCys: 1.067 ± 0.021	8.193AlaAsp: 8.193 ± 0.06	9.742AlaGlu: 9.742 ± 0.078	3.686AlaPhe: 3.686 ± 0.046	13.282AlaGly: 13.282 ± 0.083	2.661AlaHis: 2.661 ± 0.038	4.388AlaIle: 4.388 ± 0.046	2.832AlaLys: 2.832 ± 0.043	14.341AlaLeu: 14.341 ± 0.1	2.535AlaMet: 2.535 ± 0.036	2.101AlaAsn: 2.101 ± 0.03	6.064AlaPro: 6.064 ± 0.065	3.484AlaGln: 3.484 ± 0.046	10.037AlaArg: 10.037 ± 0.084	5.939AlaSer: 5.939 ± 0.047	7.101AlaThr: 7.101 ± 0.049	11.932AlaVal: 11.932 ± 0.074	1.774AlaTrp: 1.774 ± 0.028	2.302AlaTyr: 2.302 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	1.073CysAla: 1.073 ± 0.024	0.096CysCys: 0.096 ± 0.007	0.443CysAsp: 0.443 ± 0.014	0.41CysGlu: 0.41 ± 0.013	0.232CysPhe: 0.232 ± 0.01	0.932CysGly: 0.932 ± 0.021	0.193CysHis: 0.193 ± 0.009	0.171CysIle: 0.171 ± 0.008	0.093CysLys: 0.093 ± 0.007	0.716CysLeu: 0.716 ± 0.018	0.101CysMet: 0.101 ± 0.006	0.114CysAsn: 0.114 ± 0.008	0.467CysPro: 0.467 ± 0.014	0.174CysGln: 0.174 ± 0.009	0.58CysArg: 0.58 ± 0.017	0.427CysSer: 0.427 ± 0.012	0.484CysThr: 0.484 ± 0.017	0.688CysVal: 0.688 ± 0.018	0.128CysTrp: 0.128 ± 0.007	0.177CysTyr: 0.177 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.413AspAla: 7.413 ± 0.057	0.397AspCys: 0.397 ± 0.014	3.651AspAsp: 3.651 ± 0.045	4.254AspGlu: 4.254 ± 0.048	1.556AspPhe: 1.556 ± 0.028	5.942AspGly: 5.942 ± 0.067	1.288AspHis: 1.288 ± 0.023	1.879AspIle: 1.879 ± 0.029	1.029AspLys: 1.029 ± 0.028	6.238AspLeu: 6.238 ± 0.059	0.754AspMet: 0.754 ± 0.018	0.971AspAsn: 0.971 ± 0.022	4.304AspPro: 4.304 ± 0.05	1.448AspGln: 1.448 ± 0.027	4.622AspArg: 4.622 ± 0.053	2.279AspSer: 2.279 ± 0.033	3.089AspThr: 3.089 ± 0.038	5.585AspVal: 5.585 ± 0.048	0.902AspTrp: 0.902 ± 0.018	1.206AspTyr: 1.206 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	6.973GluAla: 6.973 ± 0.065	0.361GluCys: 0.361 ± 0.013	2.75GluAsp: 2.75 ± 0.039	3.327GluGlu: 3.327 ± 0.044	1.746GluPhe: 1.746 ± 0.031	4.324GluGly: 4.324 ± 0.043	1.929GluHis: 1.929 ± 0.028	2.412GluIle: 2.412 ± 0.033	1.28GluLys: 1.28 ± 0.026	8.075GluLeu: 8.075 ± 0.069	0.809GluMet: 0.809 ± 0.018	1.15GluAsn: 1.15 ± 0.023	3.98GluPro: 3.98 ± 0.052	2.648GluGln: 2.648 ± 0.036	6.168GluArg: 6.168 ± 0.06	2.742GluSer: 2.742 ± 0.036	2.882GluThr: 2.882 ± 0.033	4.998GluVal: 4.998 ± 0.041	0.866GluTrp: 0.866 ± 0.017	1.158GluTyr: 1.158 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	4.132PheAla: 4.132 ± 0.048	0.281PheCys: 0.281 ± 0.011	2.034PheAsp: 2.034 ± 0.027	1.497PheGlu: 1.497 ± 0.024	0.891PhePhe: 0.891 ± 0.023	3.408PheGly: 3.408 ± 0.042	0.604PheHis: 0.604 ± 0.015	0.749PheIle: 0.749 ± 0.021	0.377PheLys: 0.377 ± 0.013	2.75PheLeu: 2.75 ± 0.039	0.345PheMet: 0.345 ± 0.014	0.553PheAsn: 0.553 ± 0.014	1.415PhePro: 1.415 ± 0.029	0.63PheGln: 0.63 ± 0.017	1.834PheArg: 1.834 ± 0.028	1.531PheSer: 1.531 ± 0.026	2.036PheThr: 2.036 ± 0.029	2.62PheVal: 2.62 ± 0.036	0.42PheTrp: 0.42 ± 0.015	0.629PheTyr: 0.629 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	10.796GlyAla: 10.796 ± 0.063	0.752GlyCys: 0.752 ± 0.018	5.147GlyAsp: 5.147 ± 0.052	5.961GlyGlu: 5.961 ± 0.055	3.068GlyPhe: 3.068 ± 0.038	8.618GlyGly: 8.618 ± 0.083	2.146GlyHis: 2.146 ± 0.034	3.8GlyIle: 3.8 ± 0.047	2.35GlyLys: 2.35 ± 0.031	9.809GlyLeu: 9.809 ± 0.079	2.014GlyMet: 2.014 ± 0.027	1.829GlyAsn: 1.829 ± 0.033	4.565GlyPro: 4.565 ± 0.044	2.715GlyGln: 2.715 ± 0.04	7.259GlyArg: 7.259 ± 0.06	5.045GlySer: 5.045 ± 0.052	5.972GlyThr: 5.972 ± 0.054	8.324GlyVal: 8.324 ± 0.055	1.748GlyTrp: 1.748 ± 0.026	2.454GlyTyr: 2.454 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.731HisAla: 2.731 ± 0.038	0.205HisCys: 0.205 ± 0.009	1.386HisAsp: 1.386 ± 0.026	1.266HisGlu: 1.266 ± 0.023	0.608HisPhe: 0.608 ± 0.017	2.345HisGly: 2.345 ± 0.037	0.63HisHis: 0.63 ± 0.02	0.62HisIle: 0.62 ± 0.018	0.325HisLys: 0.325 ± 0.011	2.256HisLeu: 2.256 ± 0.029	0.281HisMet: 0.281 ± 0.011	0.399HisAsn: 0.399 ± 0.013	1.596HisPro: 1.596 ± 0.026	0.58HisGln: 0.58 ± 0.017	1.941HisArg: 1.941 ± 0.032	0.954HisSer: 0.954 ± 0.018	1.194HisThr: 1.194 ± 0.026	1.902HisVal: 1.902 ± 0.028	0.349HisTrp: 0.349 ± 0.012	0.499HisTyr: 0.499 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	5.354IleAla: 5.354 ± 0.051	0.276IleCys: 0.276 ± 0.01	2.409IleAsp: 2.409 ± 0.033	2.269IleGlu: 2.269 ± 0.034	0.789IlePhe: 0.789 ± 0.021	3.981IleGly: 3.981 ± 0.048	0.575IleHis: 0.575 ± 0.016	1.008IleIle: 1.008 ± 0.027	0.63IleLys: 0.63 ± 0.016	2.499IleLeu: 2.499 ± 0.037	0.514IleMet: 0.514 ± 0.015	0.743IleAsn: 0.743 ± 0.022	1.824IlePro: 1.824 ± 0.029	0.726IleGln: 0.726 ± 0.019	2.278IleArg: 2.278 ± 0.03	1.761IleSer: 1.761 ± 0.027	2.332IleThr: 2.332 ± 0.032	3.301IleVal: 3.301 ± 0.034	0.364IleTrp: 0.364 ± 0.013	0.601IleTyr: 0.601 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	2.632LysAla: 2.632 ± 0.034	0.092LysCys: 0.092 ± 0.006	0.986LysAsp: 0.986 ± 0.02	1.02LysGlu: 1.02 ± 0.025	0.456LysPhe: 0.456 ± 0.015	1.541LysGly: 1.541 ± 0.03	0.421LysHis: 0.421 ± 0.014	0.83LysIle: 0.83 ± 0.021	0.536LysLys: 0.536 ± 0.021	2.029LysLeu: 2.029 ± 0.029	0.328LysMet: 0.328 ± 0.012	0.38LysAsn: 0.38 ± 0.014	1.333LysPro: 1.333 ± 0.027	0.657LysGln: 0.657 ± 0.016	1.498LysArg: 1.498 ± 0.027	0.898LysSer: 0.898 ± 0.023	1.088LysThr: 1.088 ± 0.025	1.782LysVal: 1.782 ± 0.032	0.226LysTrp: 0.226 ± 0.01	0.388LysTyr: 0.388 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	16.605LeuAla: 16.605 ± 0.111	0.835LeuCys: 0.835 ± 0.02	7.009LeuAsp: 7.009 ± 0.063	4.974LeuGlu: 4.974 ± 0.048	2.741LeuPhe: 2.741 ± 0.041	10.399LeuGly: 10.399 ± 0.079	2.176LeuHis: 2.176 ± 0.032	3.274LeuIle: 3.274 ± 0.041	1.58LeuLys: 1.58 ± 0.029	11.652LeuLeu: 11.652 ± 0.11	1.444LeuMet: 1.444 ± 0.028	1.724LeuAsn: 1.724 ± 0.027	6.407LeuPro: 6.407 ± 0.065	1.962LeuGln: 1.962 ± 0.03	9.322LeuArg: 9.322 ± 0.087	5.603LeuSer: 5.603 ± 0.052	6.691LeuThr: 6.691 ± 0.061	9.842LeuVal: 9.842 ± 0.073	1.246LeuTrp: 1.246 ± 0.025	1.708LeuTyr: 1.708 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.09MetAla: 2.09 ± 0.031	0.118MetCys: 0.118 ± 0.007	0.761MetAsp: 0.761 ± 0.018	0.649MetGlu: 0.649 ± 0.017	0.5MetPhe: 0.5 ± 0.016	1.226MetGly: 1.226 ± 0.022	0.322MetHis: 0.322 ± 0.012	0.738MetIle: 0.738 ± 0.017	0.338MetLys: 0.338 ± 0.013	1.842MetLeu: 1.842 ± 0.028	0.267MetMet: 0.267 ± 0.011	0.4MetAsn: 0.4 ± 0.013	1.084MetPro: 1.084 ± 0.02	0.398MetGln: 0.398 ± 0.012	1.425MetArg: 1.425 ± 0.021	1.356MetSer: 1.356 ± 0.025	1.524MetThr: 1.524 ± 0.022	1.28MetVal: 1.28 ± 0.021	0.198MetTrp: 0.198 ± 0.009	0.26MetTyr: 0.26 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.314AsnAla: 2.314 ± 0.034	0.143AsnCys: 0.143 ± 0.007	0.94AsnAsp: 0.94 ± 0.022	0.895AsnGlu: 0.895 ± 0.021	0.518AsnPhe: 0.518 ± 0.016	1.823AsnGly: 1.823 ± 0.032	0.386AsnHis: 0.386 ± 0.012	0.648AsnIle: 0.648 ± 0.017	0.356AsnLys: 0.356 ± 0.013	1.814AsnLeu: 1.814 ± 0.032	0.3AsnMet: 0.3 ± 0.013	0.419AsnAsn: 0.419 ± 0.014	1.458AsnPro: 1.458 ± 0.028	0.495AsnGln: 0.495 ± 0.016	1.329AsnArg: 1.329 ± 0.024	0.855AsnSer: 0.855 ± 0.022	1.09AsnThr: 1.09 ± 0.025	1.537AsnVal: 1.537 ± 0.025	0.291AsnTrp: 0.291 ± 0.012	0.42AsnTyr: 0.42 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	7.778ProAla: 7.778 ± 0.071	0.331ProCys: 0.331 ± 0.013	4.065ProAsp: 4.065 ± 0.045	4.564ProGlu: 4.564 ± 0.046	1.618ProPhe: 1.618 ± 0.03	6.401ProGly: 6.401 ± 0.053	1.248ProHis: 1.248 ± 0.022	1.667ProIle: 1.667 ± 0.027	1.185ProLys: 1.185 ± 0.023	5.218ProLeu: 5.218 ± 0.051	1.02ProMet: 1.02 ± 0.021	0.952ProAsn: 0.952 ± 0.019	3.475ProPro: 3.475 ± 0.059	1.49ProGln: 1.49 ± 0.033	3.886ProArg: 3.886 ± 0.044	3.03ProSer: 3.03 ± 0.038	2.914ProThr: 2.914 ± 0.04	5.442ProVal: 5.442 ± 0.052	0.883ProTrp: 0.883 ± 0.02	1.129ProTyr: 1.129 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.569GlnAla: 3.569 ± 0.042	0.176GlnCys: 0.176 ± 0.01	1.126GlnAsp: 1.126 ± 0.022	1.314GlnGlu: 1.314 ± 0.026	0.703GlnPhe: 0.703 ± 0.019	2.055GlnGly: 2.055 ± 0.033	0.659GlnHis: 0.659 ± 0.017	1.024GlnIle: 1.024 ± 0.02	0.442GlnLys: 0.442 ± 0.015	3.268GlnLeu: 3.268 ± 0.046	0.402GlnMet: 0.402 ± 0.015	0.474GlnAsn: 0.474 ± 0.015	1.778GlnPro: 1.778 ± 0.033	1.213GlnGln: 1.213 ± 0.031	2.636GlnArg: 2.636 ± 0.035	1.13GlnSer: 1.13 ± 0.024	1.178GlnThr: 1.178 ± 0.021	2.333GlnVal: 2.333 ± 0.03	0.437GlnTrp: 0.437 ± 0.012	0.546GlnTyr: 0.546 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	9.719ArgAla: 9.719 ± 0.083	0.618ArgCys: 0.618 ± 0.017	4.476ArgAsp: 4.476 ± 0.05	5.238ArgGlu: 5.238 ± 0.058	2.542ArgPhe: 2.542 ± 0.032	5.901ArgGly: 5.901 ± 0.054	2.002ArgHis: 2.002 ± 0.031	3.192ArgIle: 3.192 ± 0.037	1.781ArgLys: 1.781 ± 0.029	8.868ArgLeu: 8.868 ± 0.082	1.816ArgMet: 1.816 ± 0.026	1.441ArgAsn: 1.441 ± 0.028	4.605ArgPro: 4.605 ± 0.049	2.326ArgGln: 2.326 ± 0.031	7.66ArgArg: 7.66 ± 0.077	3.939ArgSer: 3.939 ± 0.045	4.822ArgThr: 4.822 ± 0.049	6.274ArgVal: 6.274 ± 0.054	1.433ArgTrp: 1.433 ± 0.024	1.931ArgTyr: 1.931 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.597SerAla: 6.597 ± 0.052	0.395SerCys: 0.395 ± 0.012	2.584SerAsp: 2.584 ± 0.034	2.612SerGlu: 2.612 ± 0.033	1.557SerPhe: 1.557 ± 0.027	5.694SerGly: 5.694 ± 0.052	0.872SerHis: 0.872 ± 0.018	1.68SerIle: 1.68 ± 0.028	0.899SerLys: 0.899 ± 0.02	4.748SerLeu: 4.748 ± 0.045	1.157SerMet: 1.157 ± 0.021	0.824SerAsn: 0.824 ± 0.021	2.968SerPro: 2.968 ± 0.034	1.194SerGln: 1.194 ± 0.023	3.636SerArg: 3.636 ± 0.037	2.634SerSer: 2.634 ± 0.041	3.165SerThr: 3.165 ± 0.041	4.454SerVal: 4.454 ± 0.044	0.857SerTrp: 0.857 ± 0.022	1.12SerTyr: 1.12 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	7.801ThrAla: 7.801 ± 0.058	0.443ThrCys: 0.443 ± 0.014	3.41ThrAsp: 3.41 ± 0.038	3.627ThrGlu: 3.627 ± 0.041	1.715ThrPhe: 1.715 ± 0.028	6.392ThrGly: 6.392 ± 0.049	1.098ThrHis: 1.098 ± 0.022	2.124ThrIle: 2.124 ± 0.031	1.083ThrLys: 1.083 ± 0.024	5.735ThrLeu: 5.735 ± 0.052	1.052ThrMet: 1.052 ± 0.021	1.006ThrAsn: 1.006 ± 0.023	3.634ThrPro: 3.634 ± 0.042	1.269ThrGln: 1.269 ± 0.022	3.914ThrArg: 3.914 ± 0.047	3.098ThrSer: 3.098 ± 0.034	3.821ThrThr: 3.821 ± 0.043	6.014ThrVal: 6.014 ± 0.052	0.853ThrTrp: 0.853 ± 0.021	1.197ThrTyr: 1.197 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	11.85ValAla: 11.85 ± 0.083	0.769ValCys: 0.769 ± 0.019	5.37ValAsp: 5.37 ± 0.048	5.149ValGlu: 5.149 ± 0.053	2.644ValPhe: 2.644 ± 0.04	7.011ValGly: 7.011 ± 0.056	2.04ValHis: 2.04 ± 0.029	3.051ValIle: 3.051 ± 0.04	1.455ValLys: 1.455 ± 0.03	11.069ValLeu: 11.069 ± 0.083	1.184ValMet: 1.184 ± 0.023	1.818ValAsn: 1.818 ± 0.03	5.398ValPro: 5.398 ± 0.046	1.896ValGln: 1.896 ± 0.03	7.301ValArg: 7.301 ± 0.053	4.624ValSer: 4.624 ± 0.047	5.866ValThr: 5.866 ± 0.056	9.07ValVal: 9.07 ± 0.073	1.064ValTrp: 1.064 ± 0.023	1.53ValTyr: 1.53 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.583TrpAla: 1.583 ± 0.027	0.168TrpCys: 0.168 ± 0.008	0.729TrpAsp: 0.729 ± 0.018	0.681TrpGlu: 0.681 ± 0.02	0.531TrpPhe: 0.531 ± 0.018	1.011TrpGly: 1.011 ± 0.024	0.359TrpHis: 0.359 ± 0.013	0.536TrpIle: 0.536 ± 0.015	0.277TrpLys: 0.277 ± 0.011	1.961TrpLeu: 1.961 ± 0.029	0.249TrpMet: 0.249 ± 0.011	0.359TrpAsn: 0.359 ± 0.011	0.826TrpPro: 0.826 ± 0.018	0.571TrpGln: 0.571 ± 0.015	1.411TrpArg: 1.411 ± 0.024	0.828TrpSer: 0.828 ± 0.021	0.914TrpThr: 0.914 ± 0.021	1.067TrpVal: 1.067 ± 0.021	0.359TrpTrp: 0.359 ± 0.014	0.307TrpTyr: 0.307 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.45TyrAla: 2.45 ± 0.033	0.179TyrCys: 0.179 ± 0.009	1.339TyrAsp: 1.339 ± 0.027	1.126TyrGlu: 1.126 ± 0.02	0.635TyrPhe: 0.635 ± 0.014	2.084TyrGly: 2.084 ± 0.03	0.46TyrHis: 0.46 ± 0.015	0.442TyrIle: 0.442 ± 0.015	0.271TyrLys: 0.271 ± 0.01	2.306TyrLeu: 2.306 ± 0.035	0.205TyrMet: 0.205 ± 0.009	0.375TyrAsn: 0.375 ± 0.012	1.114TyrPro: 1.114 ± 0.022	0.588TyrGln: 0.588 ± 0.015	1.848TyrArg: 1.848 ± 0.033	0.976TyrSer: 0.976 ± 0.021	1.122TyrThr: 1.122 ± 0.026	1.713TyrVal: 1.713 ± 0.028	0.329TyrTrp: 0.329 ± 0.012	0.466TyrTyr: 0.466 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7493 proteins (2375979 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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