Amino acid dipepetide frequency for Candidatus Electrothrix marina

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.877AlaAla: 8.877 ± 0.171
1.082AlaCys: 1.082 ± 0.051
5.224AlaAsp: 5.224 ± 0.111
6.833AlaGlu: 6.833 ± 0.155
3.04AlaPhe: 3.04 ± 0.07
7.123AlaGly: 7.123 ± 0.123
1.441AlaHis: 1.441 ± 0.047
4.15AlaIle: 4.15 ± 0.086
3.879AlaLys: 3.879 ± 0.084
8.752AlaLeu: 8.752 ± 0.127
2.256AlaMet: 2.256 ± 0.069
2.246AlaAsn: 2.246 ± 0.071
2.933AlaPro: 2.933 ± 0.078
2.835AlaGln: 2.835 ± 0.086
4.338AlaArg: 4.338 ± 0.089
4.239AlaSer: 4.239 ± 0.088
3.788AlaThr: 3.788 ± 0.101
7.165AlaVal: 7.165 ± 0.117
0.84AlaTrp: 0.84 ± 0.034
1.931AlaTyr: 1.931 ± 0.058
0.0AlaXaa: 0.0 ± 0.0
Cys
0.911CysAla: 0.911 ± 0.04
0.285CysCys: 0.285 ± 0.024
0.683CysAsp: 0.683 ± 0.034
0.715CysGlu: 0.715 ± 0.034
0.584CysPhe: 0.584 ± 0.033
1.221CysGly: 1.221 ± 0.051
0.391CysHis: 0.391 ± 0.036
0.68CysIle: 0.68 ± 0.038
0.502CysLys: 0.502 ± 0.038
1.394CysLeu: 1.394 ± 0.054
0.308CysMet: 0.308 ± 0.022
0.476CysAsn: 0.476 ± 0.031
0.828CysPro: 0.828 ± 0.044
0.5CysGln: 0.5 ± 0.032
0.965CysArg: 0.965 ± 0.047
0.998CysSer: 0.998 ± 0.049
0.732CysThr: 0.732 ± 0.034
0.646CysVal: 0.646 ± 0.035
0.177CysTrp: 0.177 ± 0.019
0.382CysTyr: 0.382 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
4.136AspAla: 4.136 ± 0.095
0.769AspCys: 0.769 ± 0.043
3.034AspAsp: 3.034 ± 0.085
3.86AspGlu: 3.86 ± 0.09
2.7AspPhe: 2.7 ± 0.066
3.791AspGly: 3.791 ± 0.094
1.064AspHis: 1.064 ± 0.044
3.991AspIle: 3.991 ± 0.094
3.008AspLys: 3.008 ± 0.076
5.656AspLeu: 5.656 ± 0.102
1.47AspMet: 1.47 ± 0.053
2.119AspAsn: 2.119 ± 0.068
2.641AspPro: 2.641 ± 0.074
2.212AspGln: 2.212 ± 0.063
3.222AspArg: 3.222 ± 0.077
3.209AspSer: 3.209 ± 0.067
2.859AspThr: 2.859 ± 0.085
3.288AspVal: 3.288 ± 0.075
0.768AspTrp: 0.768 ± 0.038
1.801AspTyr: 1.801 ± 0.06
0.0AspXaa: 0.0 ± 0.0
Glu
5.609GluAla: 5.609 ± 0.13
0.658GluCys: 0.658 ± 0.036
3.347GluAsp: 3.347 ± 0.075
5.998GluGlu: 5.998 ± 0.131
2.36GluPhe: 2.36 ± 0.056
4.094GluGly: 4.094 ± 0.101
1.529GluHis: 1.529 ± 0.053
4.778GluIle: 4.778 ± 0.089
5.534GluLys: 5.534 ± 0.103
7.289GluLeu: 7.289 ± 0.132
1.938GluMet: 1.938 ± 0.053
2.877GluAsn: 2.877 ± 0.077
2.254GluPro: 2.254 ± 0.067
4.529GluGln: 4.529 ± 0.111
3.963GluArg: 3.963 ± 0.074
3.185GluSer: 3.185 ± 0.078
3.226GluThr: 3.226 ± 0.066
4.321GluVal: 4.321 ± 0.092
0.65GluTrp: 0.65 ± 0.036
2.002GluTyr: 2.002 ± 0.058
0.0GluXaa: 0.0 ± 0.0
Phe
3.273PheAla: 3.273 ± 0.078
0.695PheCys: 0.695 ± 0.037
2.483PheAsp: 2.483 ± 0.063
2.059PheGlu: 2.059 ± 0.057
2.638PhePhe: 2.638 ± 0.069
3.04PheGly: 3.04 ± 0.079
0.909PheHis: 0.909 ± 0.037
2.683PheIle: 2.683 ± 0.071
1.705PheLys: 1.705 ± 0.054
4.951PheLeu: 4.951 ± 0.108
0.934PheMet: 0.934 ± 0.049
1.419PheAsn: 1.419 ± 0.054
1.833PhePro: 1.833 ± 0.061
1.515PheGln: 1.515 ± 0.053
2.163PheArg: 2.163 ± 0.057
3.547PheSer: 3.547 ± 0.081
2.463PheThr: 2.463 ± 0.071
2.411PheVal: 2.411 ± 0.068
0.52PheTrp: 0.52 ± 0.031
1.384PheTyr: 1.384 ± 0.053
0.0PheXaa: 0.0 ± 0.0
Gly
5.3GlyAla: 5.3 ± 0.107
1.227GlyCys: 1.227 ± 0.047
3.677GlyAsp: 3.677 ± 0.081
4.613GlyGlu: 4.613 ± 0.104
3.227GlyPhe: 3.227 ± 0.073
5.33GlyGly: 5.33 ± 0.11
1.545GlyHis: 1.545 ± 0.055
5.039GlyIle: 5.039 ± 0.097
4.894GlyLys: 4.894 ± 0.101
7.023GlyLeu: 7.023 ± 0.115
2.183GlyMet: 2.183 ± 0.072
2.742GlyAsn: 2.742 ± 0.084
2.079GlyPro: 2.079 ± 0.059
2.739GlyGln: 2.739 ± 0.065
4.49GlyArg: 4.49 ± 0.083
4.38GlySer: 4.38 ± 0.087
4.14GlyThr: 4.14 ± 0.095
4.786GlyVal: 4.786 ± 0.095
0.877GlyTrp: 0.877 ± 0.038
2.391GlyTyr: 2.391 ± 0.059
0.0GlyXaa: 0.0 ± 0.0
His
1.638HisAla: 1.638 ± 0.054
0.354HisCys: 0.354 ± 0.024
1.086HisAsp: 1.086 ± 0.038
1.276HisGlu: 1.276 ± 0.044
1.002HisPhe: 1.002 ± 0.044
1.582HisGly: 1.582 ± 0.06
0.594HisHis: 0.594 ± 0.031
1.3HisIle: 1.3 ± 0.052
0.926HisLys: 0.926 ± 0.039
2.333HisLeu: 2.333 ± 0.062
0.384HisMet: 0.384 ± 0.029
0.774HisAsn: 0.774 ± 0.039
1.291HisPro: 1.291 ± 0.047
0.842HisGln: 0.842 ± 0.042
1.251HisArg: 1.251 ± 0.05
1.101HisSer: 1.101 ± 0.045
1.049HisThr: 1.049 ± 0.043
1.148HisVal: 1.148 ± 0.044
0.278HisTrp: 0.278 ± 0.02
0.68HisTyr: 0.68 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
5.148IleAla: 5.148 ± 0.105
0.88IleCys: 0.88 ± 0.04
3.508IleAsp: 3.508 ± 0.071
3.885IleGlu: 3.885 ± 0.079
2.727IlePhe: 2.727 ± 0.07
4.485IleGly: 4.485 ± 0.087
1.337IleHis: 1.337 ± 0.042
4.247IleIle: 4.247 ± 0.101
3.081IleLys: 3.081 ± 0.07
6.308IleLeu: 6.308 ± 0.106
1.421IleMet: 1.421 ± 0.047
2.524IleAsn: 2.524 ± 0.074
2.85IlePro: 2.85 ± 0.068
2.084IleGln: 2.084 ± 0.06
3.997IleArg: 3.997 ± 0.087
4.291IleSer: 4.291 ± 0.089
3.643IleThr: 3.643 ± 0.086
3.734IleVal: 3.734 ± 0.084
0.547IleTrp: 0.547 ± 0.037
1.599IleTyr: 1.599 ± 0.062
0.0IleXaa: 0.0 ± 0.0
Lys
4.416LysAla: 4.416 ± 0.109
0.495LysCys: 0.495 ± 0.033
2.828LysAsp: 2.828 ± 0.081
4.707LysGlu: 4.707 ± 0.102
1.584LysPhe: 1.584 ± 0.053
3.892LysGly: 3.892 ± 0.085
0.987LysHis: 0.987 ± 0.04
3.946LysIle: 3.946 ± 0.079
5.441LysLys: 5.441 ± 0.12
4.614LysLeu: 4.614 ± 0.097
1.475LysMet: 1.475 ± 0.053
2.771LysAsn: 2.771 ± 0.066
2.024LysPro: 2.024 ± 0.069
2.286LysGln: 2.286 ± 0.069
2.882LysArg: 2.882 ± 0.07
2.658LysSer: 2.658 ± 0.07
3.131LysThr: 3.131 ± 0.08
3.36LysVal: 3.36 ± 0.074
0.407LysTrp: 0.407 ± 0.025
1.734LysTyr: 1.734 ± 0.058
0.0LysXaa: 0.0 ± 0.0
Leu
9.688LeuAla: 9.688 ± 0.145
1.34LeuCys: 1.34 ± 0.056
5.776LeuAsp: 5.776 ± 0.086
6.491LeuGlu: 6.491 ± 0.12
4.833LeuPhe: 4.833 ± 0.106
6.39LeuGly: 6.39 ± 0.118
2.561LeuHis: 2.561 ± 0.071
6.151LeuIle: 6.151 ± 0.103
5.32LeuLys: 5.32 ± 0.098
12.165LeuLeu: 12.165 ± 0.2
2.13LeuMet: 2.13 ± 0.068
3.458LeuAsn: 3.458 ± 0.081
5.175LeuPro: 5.175 ± 0.092
4.057LeuGln: 4.057 ± 0.083
5.894LeuArg: 5.894 ± 0.116
7.081LeuSer: 7.081 ± 0.124
5.776LeuThr: 5.776 ± 0.117
6.431LeuVal: 6.431 ± 0.095
0.929LeuTrp: 0.929 ± 0.047
2.909LeuTyr: 2.909 ± 0.076
0.0LeuXaa: 0.0 ± 0.0
Met
2.136MetAla: 2.136 ± 0.066
0.219MetCys: 0.219 ± 0.02
1.281MetAsp: 1.281 ± 0.055
1.749MetGlu: 1.749 ± 0.055
0.742MetPhe: 0.742 ± 0.039
1.657MetGly: 1.657 ± 0.062
0.487MetHis: 0.487 ± 0.031
1.535MetIle: 1.535 ± 0.044
1.727MetLys: 1.727 ± 0.061
2.524MetLeu: 2.524 ± 0.075
0.672MetMet: 0.672 ± 0.037
1.074MetAsn: 1.074 ± 0.045
1.162MetPro: 1.162 ± 0.04
1.239MetGln: 1.239 ± 0.049
1.298MetArg: 1.298 ± 0.049
1.431MetSer: 1.431 ± 0.049
1.577MetThr: 1.577 ± 0.052
1.638MetVal: 1.638 ± 0.053
0.152MetTrp: 0.152 ± 0.017
0.544MetTyr: 0.544 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
2.478AsnAla: 2.478 ± 0.065
0.456AsnCys: 0.456 ± 0.028
1.914AsnAsp: 1.914 ± 0.062
2.069AsnGlu: 2.069 ± 0.063
1.505AsnPhe: 1.505 ± 0.047
2.663AsnGly: 2.663 ± 0.075
0.729AsnHis: 0.729 ± 0.036
2.781AsnIle: 2.781 ± 0.071
1.885AsnLys: 1.885 ± 0.052
3.67AsnLeu: 3.67 ± 0.084
0.939AsnMet: 0.939 ± 0.038
1.522AsnAsn: 1.522 ± 0.059
1.953AsnPro: 1.953 ± 0.058
1.414AsnGln: 1.414 ± 0.049
2.33AsnArg: 2.33 ± 0.067
2.146AsnSer: 2.146 ± 0.063
1.896AsnThr: 1.896 ± 0.063
1.981AsnVal: 1.981 ± 0.06
0.439AsnTrp: 0.439 ± 0.032
1.118AsnTyr: 1.118 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
3.722ProAla: 3.722 ± 0.096
0.525ProCys: 0.525 ± 0.029
3.347ProAsp: 3.347 ± 0.079
4.077ProGlu: 4.077 ± 0.092
1.99ProPhe: 1.99 ± 0.06
3.461ProGly: 3.461 ± 0.088
0.774ProHis: 0.774 ± 0.034
1.939ProIle: 1.939 ± 0.056
1.869ProLys: 1.869 ± 0.053
4.347ProLeu: 4.347 ± 0.093
0.948ProMet: 0.948 ± 0.036
1.199ProAsn: 1.199 ± 0.045
1.963ProPro: 1.963 ± 0.07
1.421ProGln: 1.421 ± 0.058
1.589ProArg: 1.589 ± 0.052
2.236ProSer: 2.236 ± 0.061
1.859ProThr: 1.859 ± 0.052
3.845ProVal: 3.845 ± 0.089
0.544ProTrp: 0.544 ± 0.038
1.242ProTyr: 1.242 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
3.907GlnAla: 3.907 ± 0.087
0.434GlnCys: 0.434 ± 0.03
2.039GlnAsp: 2.039 ± 0.061
3.715GlnGlu: 3.715 ± 0.091
1.365GlnPhe: 1.365 ± 0.044
3.34GlnGly: 3.34 ± 0.09
0.833GlnHis: 0.833 ± 0.035
2.03GlnIle: 2.03 ± 0.062
2.384GlnLys: 2.384 ± 0.067
3.985GlnLeu: 3.985 ± 0.091
0.867GlnMet: 0.867 ± 0.042
1.214GlnAsn: 1.214 ± 0.047
1.702GlnPro: 1.702 ± 0.059
2.468GlnGln: 2.468 ± 0.09
2.311GlnArg: 2.311 ± 0.065
1.926GlnSer: 1.926 ± 0.064
1.756GlnThr: 1.756 ± 0.068
2.859GlnVal: 2.859 ± 0.072
0.439GlnTrp: 0.439 ± 0.027
1.258GlnTyr: 1.258 ± 0.046
0.0GlnXaa: 0.0 ± 0.0
Arg
3.655ArgAla: 3.655 ± 0.081
0.742ArgCys: 0.742 ± 0.039
2.995ArgAsp: 2.995 ± 0.077
4.093ArgGlu: 4.093 ± 0.092
2.729ArgPhe: 2.729 ± 0.066
3.071ArgGly: 3.071 ± 0.072
1.332ArgHis: 1.332 ± 0.048
4.165ArgIle: 4.165 ± 0.089
3.726ArgLys: 3.726 ± 0.078
6.141ArgLeu: 6.141 ± 0.118
1.561ArgMet: 1.561 ± 0.049
2.192ArgAsn: 2.192 ± 0.062
2.215ArgPro: 2.215 ± 0.063
2.764ArgGln: 2.764 ± 0.074
3.566ArgArg: 3.566 ± 0.089
3.138ArgSer: 3.138 ± 0.073
2.699ArgThr: 2.699 ± 0.065
3.598ArgVal: 3.598 ± 0.079
0.549ArgTrp: 0.549 ± 0.036
1.833ArgTyr: 1.833 ± 0.061
0.0ArgXaa: 0.0 ± 0.0
Ser
4.433SerAla: 4.433 ± 0.081
0.995SerCys: 0.995 ± 0.045
3.012SerAsp: 3.012 ± 0.074
3.688SerGlu: 3.688 ± 0.084
2.939SerPhe: 2.939 ± 0.077
5.488SerGly: 5.488 ± 0.093
1.035SerHis: 1.035 ± 0.044
3.419SerIle: 3.419 ± 0.088
2.579SerLys: 2.579 ± 0.069
6.382SerLeu: 6.382 ± 0.117
1.626SerMet: 1.626 ± 0.052
1.732SerAsn: 1.732 ± 0.062
2.719SerPro: 2.719 ± 0.078
1.86SerGln: 1.86 ± 0.058
3.431SerArg: 3.431 ± 0.069
4.126SerSer: 4.126 ± 0.092
2.917SerThr: 2.917 ± 0.072
4.086SerVal: 4.086 ± 0.086
0.864SerTrp: 0.864 ± 0.045
1.867SerTyr: 1.867 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
5.13ThrAla: 5.13 ± 0.114
0.707ThrCys: 0.707 ± 0.041
3.192ThrAsp: 3.192 ± 0.089
3.584ThrGlu: 3.584 ± 0.076
1.85ThrPhe: 1.85 ± 0.056
5.013ThrGly: 5.013 ± 0.094
0.931ThrHis: 0.931 ± 0.041
2.838ThrIle: 2.838 ± 0.08
2.067ThrLys: 2.067 ± 0.063
5.374ThrLeu: 5.374 ± 0.112
1.195ThrMet: 1.195 ± 0.043
1.49ThrAsn: 1.49 ± 0.047
2.576ThrPro: 2.576 ± 0.06
1.475ThrGln: 1.475 ± 0.053
2.502ThrArg: 2.502 ± 0.073
2.885ThrSer: 2.885 ± 0.08
2.742ThrThr: 2.742 ± 0.08
4.557ThrVal: 4.557 ± 0.096
0.547ThrTrp: 0.547 ± 0.033
1.385ThrTyr: 1.385 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
5.678ValAla: 5.678 ± 0.104
0.956ValCys: 0.956 ± 0.044
3.899ValAsp: 3.899 ± 0.096
4.404ValGlu: 4.404 ± 0.087
2.897ValPhe: 2.897 ± 0.064
4.257ValGly: 4.257 ± 0.089
1.453ValHis: 1.453 ± 0.05
4.271ValIle: 4.271 ± 0.076
3.175ValLys: 3.175 ± 0.064
7.092ValLeu: 7.092 ± 0.116
1.663ValMet: 1.663 ± 0.064
2.453ValAsn: 2.453 ± 0.066
2.86ValPro: 2.86 ± 0.073
2.653ValGln: 2.653 ± 0.068
3.986ValArg: 3.986 ± 0.082
4.055ValSer: 4.055 ± 0.092
3.675ValThr: 3.675 ± 0.088
4.71ValVal: 4.71 ± 0.095
0.62ValTrp: 0.62 ± 0.032
1.923ValTyr: 1.923 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
0.731TrpAla: 0.731 ± 0.036
0.14TrpCys: 0.14 ± 0.017
0.576TrpAsp: 0.576 ± 0.038
0.64TrpGlu: 0.64 ± 0.032
0.535TrpPhe: 0.535 ± 0.032
0.655TrpGly: 0.655 ± 0.034
0.239TrpHis: 0.239 ± 0.02
0.591TrpIle: 0.591 ± 0.035
0.586TrpLys: 0.586 ± 0.034
1.31TrpLeu: 1.31 ± 0.058
0.268TrpMet: 0.268 ± 0.021
0.456TrpAsn: 0.456 ± 0.031
0.421TrpPro: 0.421 ± 0.026
0.709TrpGln: 0.709 ± 0.036
0.64TrpArg: 0.64 ± 0.037
0.586TrpSer: 0.586 ± 0.032
0.468TrpThr: 0.468 ± 0.03
0.616TrpVal: 0.616 ± 0.033
0.175TrpTrp: 0.175 ± 0.017
0.333TrpTyr: 0.333 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.106TyrAla: 2.106 ± 0.06
0.417TyrCys: 0.417 ± 0.029
1.7TyrAsp: 1.7 ± 0.066
1.682TyrGlu: 1.682 ± 0.053
1.377TyrPhe: 1.377 ± 0.058
2.128TyrGly: 2.128 ± 0.067
0.719TyrHis: 0.719 ± 0.038
1.761TyrIle: 1.761 ± 0.054
1.352TyrLys: 1.352 ± 0.056
3.244TyrLeu: 3.244 ± 0.076
0.604TyrMet: 0.604 ± 0.033
1.151TyrAsn: 1.151 ± 0.044
1.417TyrPro: 1.417 ± 0.054
1.231TyrGln: 1.231 ± 0.049
1.944TyrArg: 1.944 ± 0.054
1.98TyrSer: 1.98 ± 0.061
1.648TyrThr: 1.648 ± 0.056
1.502TyrVal: 1.502 ± 0.053
0.352TyrTrp: 0.352 ± 0.024
1.089TyrTyr: 1.089 ± 0.048
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2161 proteins (594014 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski