Amino acid dipepetide frequency for Salinivirga cyanobacteriivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.819AlaAla: 4.819 ± 0.087	0.543AlaCys: 0.543 ± 0.023	3.842AlaAsp: 3.842 ± 0.062	4.326AlaGlu: 4.326 ± 0.073	3.327AlaPhe: 3.327 ± 0.057	4.951AlaGly: 4.951 ± 0.09	1.327AlaHis: 1.327 ± 0.031	5.168AlaIle: 5.168 ± 0.079	3.983AlaLys: 3.983 ± 0.067	6.231AlaLeu: 6.231 ± 0.077	1.659AlaMet: 1.659 ± 0.035	3.393AlaAsn: 3.393 ± 0.051	1.991AlaPro: 1.991 ± 0.042	2.708AlaGln: 2.708 ± 0.05	2.699AlaArg: 2.699 ± 0.05	3.852AlaSer: 3.852 ± 0.054	3.611AlaThr: 3.611 ± 0.07	4.034AlaVal: 4.034 ± 0.068	0.729AlaTrp: 0.729 ± 0.022	2.63AlaTyr: 2.63 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.412CysAla: 0.412 ± 0.02	0.071CysCys: 0.071 ± 0.007	0.42CysAsp: 0.42 ± 0.025	0.416CysGlu: 0.416 ± 0.018	0.329CysPhe: 0.329 ± 0.016	0.58CysGly: 0.58 ± 0.024	0.186CysHis: 0.186 ± 0.015	0.503CysIle: 0.503 ± 0.021	0.476CysLys: 0.476 ± 0.018	0.493CysLeu: 0.493 ± 0.02	0.146CysMet: 0.146 ± 0.01	0.429CysAsn: 0.429 ± 0.021	0.346CysPro: 0.346 ± 0.02	0.218CysGln: 0.218 ± 0.013	0.307CysArg: 0.307 ± 0.017	0.392CysSer: 0.392 ± 0.016	0.404CysThr: 0.404 ± 0.024	0.366CysVal: 0.366 ± 0.016	0.066CysTrp: 0.066 ± 0.007	0.252CysTyr: 0.252 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.521AspAla: 3.521 ± 0.06	0.393AspCys: 0.393 ± 0.019	3.176AspAsp: 3.176 ± 0.063	4.191AspGlu: 4.191 ± 0.061	3.291AspPhe: 3.291 ± 0.055	3.85AspGly: 3.85 ± 0.102	1.034AspHis: 1.034 ± 0.029	4.692AspIle: 4.692 ± 0.053	4.082AspLys: 4.082 ± 0.076	5.125AspLeu: 5.125 ± 0.066	1.381AspMet: 1.381 ± 0.032	3.141AspAsn: 3.141 ± 0.057	1.969AspPro: 1.969 ± 0.042	2.057AspGln: 2.057 ± 0.044	2.109AspArg: 2.109 ± 0.038	3.49AspSer: 3.49 ± 0.072	2.977AspThr: 2.977 ± 0.059	3.543AspVal: 3.543 ± 0.066	0.685AspTrp: 0.685 ± 0.026	2.88AspTyr: 2.88 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	4.537GluAla: 4.537 ± 0.069	0.315GluCys: 0.315 ± 0.016	3.45GluAsp: 3.45 ± 0.059	4.686GluGlu: 4.686 ± 0.093	2.852GluPhe: 2.852 ± 0.047	3.716GluGly: 3.716 ± 0.065	1.363GluHis: 1.363 ± 0.033	5.507GluIle: 5.507 ± 0.076	6.088GluLys: 6.088 ± 0.093	6.476GluLeu: 6.476 ± 0.069	1.947GluMet: 1.947 ± 0.039	4.33GluAsn: 4.33 ± 0.067	1.978GluPro: 1.978 ± 0.041	3.011GluGln: 3.011 ± 0.059	2.675GluArg: 2.675 ± 0.049	3.432GluSer: 3.432 ± 0.049	3.499GluThr: 3.499 ± 0.05	4.069GluVal: 4.069 ± 0.059	0.692GluTrp: 0.692 ± 0.024	2.586GluTyr: 2.586 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.021PheAla: 3.021 ± 0.049	0.369PheCys: 0.369 ± 0.017	3.21PheAsp: 3.21 ± 0.053	3.353PheGlu: 3.353 ± 0.051	2.664PhePhe: 2.664 ± 0.049	3.213PheGly: 3.213 ± 0.05	0.969PheHis: 0.969 ± 0.029	3.773PheIle: 3.773 ± 0.06	3.086PheLys: 3.086 ± 0.055	4.292PheLeu: 4.292 ± 0.066	1.272PheMet: 1.272 ± 0.035	3.081PheAsn: 3.081 ± 0.061	1.623PhePro: 1.623 ± 0.03	1.46PheGln: 1.46 ± 0.032	1.961PheArg: 1.961 ± 0.046	3.662PheSer: 3.662 ± 0.059	2.997PheThr: 2.997 ± 0.053	2.859PheVal: 2.859 ± 0.052	0.534PheTrp: 0.534 ± 0.021	2.316PheTyr: 2.316 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	4.327GlyAla: 4.327 ± 0.076	0.623GlyCys: 0.623 ± 0.038	3.569GlyAsp: 3.569 ± 0.082	3.974GlyGlu: 3.974 ± 0.064	3.415GlyPhe: 3.415 ± 0.05	4.589GlyGly: 4.589 ± 0.09	1.283GlyHis: 1.283 ± 0.031	5.121GlyIle: 5.121 ± 0.075	4.762GlyLys: 4.762 ± 0.063	5.611GlyLeu: 5.611 ± 0.074	1.703GlyMet: 1.703 ± 0.047	3.61GlyAsn: 3.61 ± 0.06	1.41GlyPro: 1.41 ± 0.033	2.206GlyGln: 2.206 ± 0.041	2.326GlyArg: 2.326 ± 0.051	3.874GlySer: 3.874 ± 0.074	3.949GlyThr: 3.949 ± 0.099	4.029GlyVal: 4.029 ± 0.061	0.801GlyTrp: 0.801 ± 0.027	3.089GlyTyr: 3.089 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.153HisAla: 1.153 ± 0.033	0.181HisCys: 0.181 ± 0.01	1.088HisAsp: 1.088 ± 0.031	1.296HisGlu: 1.296 ± 0.032	1.215HisPhe: 1.215 ± 0.03	1.233HisGly: 1.233 ± 0.031	0.496HisHis: 0.496 ± 0.02	1.644HisIle: 1.644 ± 0.035	1.538HisLys: 1.538 ± 0.039	1.877HisLeu: 1.877 ± 0.033	0.409HisMet: 0.409 ± 0.016	1.136HisAsn: 1.136 ± 0.031	0.939HisPro: 0.939 ± 0.03	0.793HisGln: 0.793 ± 0.026	0.836HisArg: 0.836 ± 0.027	1.084HisSer: 1.084 ± 0.03	1.154HisThr: 1.154 ± 0.03	1.082HisVal: 1.082 ± 0.029	0.25HisTrp: 0.25 ± 0.012	1.05HisTyr: 1.05 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.483IleAla: 5.483 ± 0.072	0.536IleCys: 0.536 ± 0.025	5.215IleAsp: 5.215 ± 0.064	5.686IleGlu: 5.686 ± 0.068	3.444IlePhe: 3.444 ± 0.055	4.588IleGly: 4.588 ± 0.082	1.519IleHis: 1.519 ± 0.037	5.953IleIle: 5.953 ± 0.086	5.599IleLys: 5.599 ± 0.081	6.222IleLeu: 6.222 ± 0.09	1.574IleMet: 1.574 ± 0.035	4.67IleAsn: 4.67 ± 0.069	3.041IlePro: 3.041 ± 0.046	2.584IleGln: 2.584 ± 0.052	2.978IleArg: 2.978 ± 0.05	5.374IleSer: 5.374 ± 0.07	4.646IleThr: 4.646 ± 0.065	4.59IleVal: 4.59 ± 0.058	0.711IleTrp: 0.711 ± 0.025	3.126IleTyr: 3.126 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	5.149LysAla: 5.149 ± 0.075	0.372LysCys: 0.372 ± 0.019	3.874LysAsp: 3.874 ± 0.062	5.279LysGlu: 5.279 ± 0.081	2.648LysPhe: 2.648 ± 0.051	4.142LysGly: 4.142 ± 0.051	1.649LysHis: 1.649 ± 0.041	5.706LysIle: 5.706 ± 0.084	6.41LysLys: 6.41 ± 0.103	6.276LysLeu: 6.276 ± 0.077	1.868LysMet: 1.868 ± 0.037	4.595LysAsn: 4.595 ± 0.07	2.709LysPro: 2.709 ± 0.047	3.124LysGln: 3.124 ± 0.057	3.105LysArg: 3.105 ± 0.058	4.058LysSer: 4.058 ± 0.057	4.205LysThr: 4.205 ± 0.061	4.284LysVal: 4.284 ± 0.062	0.771LysTrp: 0.771 ± 0.027	3.172LysTyr: 3.172 ± 0.053	0.0LysXaa: 0.0 ± 0.0
Leu	5.836LeuAla: 5.836 ± 0.072	0.496LeuCys: 0.496 ± 0.022	4.586LeuAsp: 4.586 ± 0.061	5.699LeuGlu: 5.699 ± 0.068	4.664LeuPhe: 4.664 ± 0.068	5.012LeuGly: 5.012 ± 0.07	1.818LeuHis: 1.818 ± 0.04	6.892LeuIle: 6.892 ± 0.092	7.281LeuLys: 7.281 ± 0.083	8.496LeuLeu: 8.496 ± 0.124	2.188LeuMet: 2.188 ± 0.038	5.532LeuAsn: 5.532 ± 0.077	3.678LeuPro: 3.678 ± 0.051	3.416LeuGln: 3.416 ± 0.056	3.581LeuArg: 3.581 ± 0.061	6.31LeuSer: 6.31 ± 0.084	5.083LeuThr: 5.083 ± 0.069	4.908LeuVal: 4.908 ± 0.065	0.869LeuTrp: 0.869 ± 0.03	3.35LeuTyr: 3.35 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	1.821MetAla: 1.821 ± 0.039	0.13MetCys: 0.13 ± 0.011	1.285MetAsp: 1.285 ± 0.033	1.522MetGlu: 1.522 ± 0.034	0.949MetPhe: 0.949 ± 0.031	1.564MetGly: 1.564 ± 0.036	0.554MetHis: 0.554 ± 0.02	1.514MetIle: 1.514 ± 0.035	1.9MetLys: 1.9 ± 0.044	2.343MetLeu: 2.343 ± 0.041	0.569MetMet: 0.569 ± 0.022	1.428MetAsn: 1.428 ± 0.031	1.078MetPro: 1.078 ± 0.036	1.14MetGln: 1.14 ± 0.034	1.172MetArg: 1.172 ± 0.027	1.383MetSer: 1.383 ± 0.031	1.168MetThr: 1.168 ± 0.026	1.549MetVal: 1.549 ± 0.034	0.212MetTrp: 0.212 ± 0.012	0.766MetTyr: 0.766 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.707AsnAla: 3.707 ± 0.064	0.413AsnCys: 0.413 ± 0.023	3.302AsnAsp: 3.302 ± 0.064	3.832AsnGlu: 3.832 ± 0.06	2.624AsnPhe: 2.624 ± 0.048	3.842AsnGly: 3.842 ± 0.079	1.18AsnHis: 1.18 ± 0.031	4.665AsnIle: 4.665 ± 0.064	3.997AsnLys: 3.997 ± 0.066	5.106AsnLeu: 5.106 ± 0.071	1.396AsnMet: 1.396 ± 0.033	3.533AsnAsn: 3.533 ± 0.066	2.711AsnPro: 2.711 ± 0.051	2.482AsnGln: 2.482 ± 0.045	2.439AsnArg: 2.439 ± 0.046	3.362AsnSer: 3.362 ± 0.062	3.258AsnThr: 3.258 ± 0.055	3.19AsnVal: 3.19 ± 0.055	0.728AsnTrp: 0.728 ± 0.026	2.962AsnTyr: 2.962 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	2.479ProAla: 2.479 ± 0.047	0.199ProCys: 0.199 ± 0.012	2.67ProAsp: 2.67 ± 0.05	3.356ProGlu: 3.356 ± 0.054	1.852ProPhe: 1.852 ± 0.041	2.625ProGly: 2.625 ± 0.047	0.717ProHis: 0.717 ± 0.024	2.219ProIle: 2.219 ± 0.039	2.018ProLys: 2.018 ± 0.043	2.889ProLeu: 2.889 ± 0.043	0.749ProMet: 0.749 ± 0.023	1.771ProAsn: 1.771 ± 0.044	0.963ProPro: 0.963 ± 0.032	1.311ProGln: 1.311 ± 0.032	1.153ProArg: 1.153 ± 0.03	1.74ProSer: 1.74 ± 0.041	1.675ProThr: 1.675 ± 0.038	2.959ProVal: 2.959 ± 0.048	0.388ProTrp: 0.388 ± 0.018	1.565ProTyr: 1.565 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	2.207GlnAla: 2.207 ± 0.039	0.228GlnCys: 0.228 ± 0.015	1.711GlnAsp: 1.711 ± 0.032	2.44GlnGlu: 2.44 ± 0.047	1.69GlnPhe: 1.69 ± 0.038	1.959GlnGly: 1.959 ± 0.038	0.816GlnHis: 0.816 ± 0.025	3.082GlnIle: 3.082 ± 0.049	3.526GlnLys: 3.526 ± 0.067	3.575GlnLeu: 3.575 ± 0.058	0.989GlnMet: 0.989 ± 0.028	2.52GlnAsn: 2.52 ± 0.049	1.285GlnPro: 1.285 ± 0.035	1.873GlnGln: 1.873 ± 0.045	1.604GlnArg: 1.604 ± 0.042	2.116GlnSer: 2.116 ± 0.039	2.175GlnThr: 2.175 ± 0.042	2.194GlnVal: 2.194 ± 0.036	0.457GlnTrp: 0.457 ± 0.018	1.726GlnTyr: 1.726 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.183ArgAla: 2.183 ± 0.04	0.268ArgCys: 0.268 ± 0.016	2.034ArgAsp: 2.034 ± 0.044	2.602ArgGlu: 2.602 ± 0.05	2.276ArgPhe: 2.276 ± 0.036	2.089ArgGly: 2.089 ± 0.042	0.862ArgHis: 0.862 ± 0.027	3.475ArgIle: 3.475 ± 0.05	3.631ArgLys: 3.631 ± 0.059	3.729ArgLeu: 3.729 ± 0.06	1.061ArgMet: 1.061 ± 0.029	2.371ArgAsn: 2.371 ± 0.046	1.21ArgPro: 1.21 ± 0.031	1.618ArgGln: 1.618 ± 0.038	1.729ArgArg: 1.729 ± 0.041	2.09ArgSer: 2.09 ± 0.039	1.91ArgThr: 1.91 ± 0.042	2.25ArgVal: 2.25 ± 0.049	0.445ArgTrp: 0.445 ± 0.018	1.913ArgTyr: 1.913 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	3.998SerAla: 3.998 ± 0.072	0.456SerCys: 0.456 ± 0.02	3.556SerAsp: 3.556 ± 0.061	3.642SerGlu: 3.642 ± 0.055	3.343SerPhe: 3.343 ± 0.047	4.94SerGly: 4.94 ± 0.081	1.172SerHis: 1.172 ± 0.026	4.804SerIle: 4.804 ± 0.063	3.849SerLys: 3.849 ± 0.056	5.461SerLeu: 5.461 ± 0.069	1.43SerMet: 1.43 ± 0.033	3.287SerAsn: 3.287 ± 0.053	2.015SerPro: 2.015 ± 0.04	2.084SerGln: 2.084 ± 0.04	2.324SerArg: 2.324 ± 0.042	3.748SerSer: 3.748 ± 0.067	3.331SerThr: 3.331 ± 0.068	3.976SerVal: 3.976 ± 0.063	0.691SerTrp: 0.691 ± 0.023	2.579SerTyr: 2.579 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	3.806ThrAla: 3.806 ± 0.076	0.384ThrCys: 0.384 ± 0.024	3.479ThrAsp: 3.479 ± 0.075	3.457ThrGlu: 3.457 ± 0.053	2.754ThrPhe: 2.754 ± 0.05	4.436ThrGly: 4.436 ± 0.069	1.191ThrHis: 1.191 ± 0.034	4.7ThrIle: 4.7 ± 0.07	3.132ThrLys: 3.132 ± 0.052	5.051ThrLeu: 5.051 ± 0.062	1.079ThrMet: 1.079 ± 0.031	3.025ThrAsn: 3.025 ± 0.057	2.203ThrPro: 2.203 ± 0.045	1.848ThrGln: 1.848 ± 0.04	2.033ThrArg: 2.033 ± 0.041	3.418ThrSer: 3.418 ± 0.058	3.297ThrThr: 3.297 ± 0.065	3.497ThrVal: 3.497 ± 0.072	0.642ThrTrp: 0.642 ± 0.033	2.432ThrTyr: 2.432 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	4.056ValAla: 4.056 ± 0.065	0.429ValCys: 0.429 ± 0.018	3.745ValAsp: 3.745 ± 0.059	3.928ValGlu: 3.928 ± 0.065	3.394ValPhe: 3.394 ± 0.055	3.514ValGly: 3.514 ± 0.065	1.088ValHis: 1.088 ± 0.027	4.459ValIle: 4.459 ± 0.056	4.358ValLys: 4.358 ± 0.057	5.353ValLeu: 5.353 ± 0.075	1.421ValMet: 1.421 ± 0.033	3.543ValAsn: 3.543 ± 0.051	2.197ValPro: 2.197 ± 0.047	1.991ValGln: 1.991 ± 0.04	2.295ValArg: 2.295 ± 0.041	3.939ValSer: 3.939 ± 0.063	3.42ValThr: 3.42 ± 0.075	4.084ValVal: 4.084 ± 0.061	0.624ValTrp: 0.624 ± 0.021	2.589ValTyr: 2.589 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.638TrpAla: 0.638 ± 0.024	0.08TrpCys: 0.08 ± 0.008	0.664TrpAsp: 0.664 ± 0.026	0.711TrpGlu: 0.711 ± 0.025	0.586TrpPhe: 0.586 ± 0.023	0.677TrpGly: 0.677 ± 0.023	0.253TrpHis: 0.253 ± 0.014	0.818TrpIle: 0.818 ± 0.027	0.742TrpLys: 0.742 ± 0.023	1.077TrpLeu: 1.077 ± 0.029	0.293TrpMet: 0.293 ± 0.014	0.599TrpAsn: 0.599 ± 0.019	0.288TrpPro: 0.288 ± 0.014	0.499TrpGln: 0.499 ± 0.023	0.439TrpArg: 0.439 ± 0.018	0.676TrpSer: 0.676 ± 0.024	0.602TrpThr: 0.602 ± 0.028	0.693TrpVal: 0.693 ± 0.022	0.149TrpTrp: 0.149 ± 0.012	0.465TrpTyr: 0.465 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.67TyrAla: 2.67 ± 0.053	0.326TyrCys: 0.326 ± 0.016	2.711TyrAsp: 2.711 ± 0.056	2.813TyrGlu: 2.813 ± 0.04	2.395TyrPhe: 2.395 ± 0.048	2.751TyrGly: 2.751 ± 0.053	0.977TyrHis: 0.977 ± 0.024	2.846TyrIle: 2.846 ± 0.046	2.939TyrLys: 2.939 ± 0.052	4.013TyrLeu: 4.013 ± 0.061	0.914TyrMet: 0.914 ± 0.026	2.734TyrAsn: 2.734 ± 0.048	1.663TyrPro: 1.663 ± 0.036	1.75TyrGln: 1.75 ± 0.044	1.98TyrArg: 1.98 ± 0.044	2.686TyrSer: 2.686 ± 0.05	2.504TyrThr: 2.504 ± 0.056	2.271TyrVal: 2.271 ± 0.039	0.507TyrTrp: 0.507 ± 0.02	2.132TyrTyr: 2.132 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3717 proteins (1369904 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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