Amino acid dipepetide frequency for Solitalea longa

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.604AlaAla: 5.604 ± 0.089	0.698AlaCys: 0.698 ± 0.025	3.908AlaAsp: 3.908 ± 0.06	4.456AlaGlu: 4.456 ± 0.079	3.448AlaPhe: 3.448 ± 0.056	5.126AlaGly: 5.126 ± 0.092	1.108AlaHis: 1.108 ± 0.03	5.569AlaIle: 5.569 ± 0.079	4.73AlaLys: 4.73 ± 0.07	6.55AlaLeu: 6.55 ± 0.081	1.59AlaMet: 1.59 ± 0.033	3.942AlaAsn: 3.942 ± 0.071	2.368AlaPro: 2.368 ± 0.064	2.809AlaGln: 2.809 ± 0.057	2.207AlaArg: 2.207 ± 0.041	4.566AlaSer: 4.566 ± 0.089	4.224AlaThr: 4.224 ± 0.126	4.575AlaVal: 4.575 ± 0.069	0.732AlaTrp: 0.732 ± 0.025	2.646AlaTyr: 2.646 ± 0.051	0.001AlaXaa: 0.001 ± 0.001
Cys	0.534CysAla: 0.534 ± 0.022	0.136CysCys: 0.136 ± 0.011	0.457CysAsp: 0.457 ± 0.022	0.454CysGlu: 0.454 ± 0.022	0.448CysPhe: 0.448 ± 0.019	0.667CysGly: 0.667 ± 0.025	0.198CysHis: 0.198 ± 0.014	0.655CysIle: 0.655 ± 0.022	0.529CysLys: 0.529 ± 0.02	0.814CysLeu: 0.814 ± 0.031	0.18CysMet: 0.18 ± 0.012	0.526CysAsn: 0.526 ± 0.038	0.366CysPro: 0.366 ± 0.025	0.27CysGln: 0.27 ± 0.024	0.28CysArg: 0.28 ± 0.016	0.714CysSer: 0.714 ± 0.031	0.463CysThr: 0.463 ± 0.021	0.485CysVal: 0.485 ± 0.032	0.078CysTrp: 0.078 ± 0.007	0.339CysTyr: 0.339 ± 0.015	0.001CysXaa: 0.001 ± 0.001
Asp	3.718AspAla: 3.718 ± 0.068	0.421AspCys: 0.421 ± 0.02	2.578AspAsp: 2.578 ± 0.062	3.459AspGlu: 3.459 ± 0.061	3.175AspPhe: 3.175 ± 0.053	3.433AspGly: 3.433 ± 0.07	0.925AspHis: 0.925 ± 0.031	3.795AspIle: 3.795 ± 0.057	4.077AspLys: 4.077 ± 0.064	5.182AspLeu: 5.182 ± 0.073	1.085AspMet: 1.085 ± 0.03	2.768AspAsn: 2.768 ± 0.059	2.113AspPro: 2.113 ± 0.058	1.863AspGln: 1.863 ± 0.042	1.94AspArg: 1.94 ± 0.052	2.996AspSer: 2.996 ± 0.059	2.317AspThr: 2.317 ± 0.045	3.172AspVal: 3.172 ± 0.057	0.717AspTrp: 0.717 ± 0.025	2.484AspTyr: 2.484 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	4.156GluAla: 4.156 ± 0.066	0.378GluCys: 0.378 ± 0.017	2.798GluAsp: 2.798 ± 0.062	4.079GluGlu: 4.079 ± 0.067	2.773GluPhe: 2.773 ± 0.051	3.498GluGly: 3.498 ± 0.059	1.15GluHis: 1.15 ± 0.037	4.641GluIle: 4.641 ± 0.074	5.085GluLys: 5.085 ± 0.078	6.293GluLeu: 6.293 ± 0.081	1.534GluMet: 1.534 ± 0.038	3.718GluAsn: 3.718 ± 0.06	1.742GluPro: 1.742 ± 0.044	2.551GluGln: 2.551 ± 0.045	2.504GluArg: 2.504 ± 0.049	3.192GluSer: 3.192 ± 0.048	3.253GluThr: 3.253 ± 0.061	3.998GluVal: 3.998 ± 0.068	0.651GluTrp: 0.651 ± 0.02	2.153GluTyr: 2.153 ± 0.046	0.001GluXaa: 0.001 ± 0.001
Phe	3.335PheAla: 3.335 ± 0.058	0.499PheCys: 0.499 ± 0.024	3.02PheAsp: 3.02 ± 0.052	3.075PheGlu: 3.075 ± 0.056	2.566PhePhe: 2.566 ± 0.059	3.5PheGly: 3.5 ± 0.062	0.797PheHis: 0.797 ± 0.025	3.9PheIle: 3.9 ± 0.067	3.529PheLys: 3.529 ± 0.062	4.442PheLeu: 4.442 ± 0.075	1.116PheMet: 1.116 ± 0.03	3.331PheAsn: 3.331 ± 0.062	1.692PhePro: 1.692 ± 0.038	1.471PheGln: 1.471 ± 0.037	1.716PheArg: 1.716 ± 0.039	3.925PheSer: 3.925 ± 0.071	3.12PheThr: 3.12 ± 0.06	3.023PheVal: 3.023 ± 0.056	0.608PheTrp: 0.608 ± 0.023	2.141PheTyr: 2.141 ± 0.046	0.001PheXaa: 0.001 ± 0.001
Gly	4.587GlyAla: 4.587 ± 0.089	0.745GlyCys: 0.745 ± 0.043	3.158GlyAsp: 3.158 ± 0.057	3.461GlyGlu: 3.461 ± 0.058	3.671GlyPhe: 3.671 ± 0.057	4.754GlyGly: 4.754 ± 0.085	1.124GlyHis: 1.124 ± 0.036	5.097GlyIle: 5.097 ± 0.068	5.144GlyLys: 5.144 ± 0.078	6.126GlyLeu: 6.126 ± 0.084	1.597GlyMet: 1.597 ± 0.038	3.659GlyAsn: 3.659 ± 0.07	1.636GlyPro: 1.636 ± 0.047	2.21GlyGln: 2.21 ± 0.048	2.237GlyArg: 2.237 ± 0.045	4.522GlySer: 4.522 ± 0.082	4.299GlyThr: 4.299 ± 0.107	4.47GlyVal: 4.47 ± 0.072	0.869GlyTrp: 0.869 ± 0.026	2.901GlyTyr: 2.901 ± 0.053	0.002GlyXaa: 0.002 ± 0.001
His	0.992HisAla: 0.992 ± 0.028	0.186HisCys: 0.186 ± 0.013	0.759HisAsp: 0.759 ± 0.023	0.98HisGlu: 0.98 ± 0.028	1.141HisPhe: 1.141 ± 0.027	1.077HisGly: 1.077 ± 0.031	0.457HisHis: 0.457 ± 0.019	1.231HisIle: 1.231 ± 0.035	1.095HisLys: 1.095 ± 0.023	1.857HisLeu: 1.857 ± 0.041	0.335HisMet: 0.335 ± 0.017	0.888HisAsn: 0.888 ± 0.03	0.897HisPro: 0.897 ± 0.03	0.722HisGln: 0.722 ± 0.023	0.654HisArg: 0.654 ± 0.022	1.116HisSer: 1.116 ± 0.031	0.939HisThr: 0.939 ± 0.031	0.887HisVal: 0.887 ± 0.025	0.228HisTrp: 0.228 ± 0.015	0.821HisTyr: 0.821 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.649IleAla: 5.649 ± 0.07	0.726IleCys: 0.726 ± 0.025	4.615IleAsp: 4.615 ± 0.068	4.726IleGlu: 4.726 ± 0.068	3.047IlePhe: 3.047 ± 0.061	4.964IleGly: 4.964 ± 0.078	1.237IleHis: 1.237 ± 0.033	5.396IleIle: 5.396 ± 0.073	5.476IleLys: 5.476 ± 0.076	6.126IleLeu: 6.126 ± 0.083	1.373IleMet: 1.373 ± 0.036	4.753IleAsn: 4.753 ± 0.068	3.033IlePro: 3.033 ± 0.048	2.386IleGln: 2.386 ± 0.049	2.656IleArg: 2.656 ± 0.054	5.373IleSer: 5.373 ± 0.075	4.728IleThr: 4.728 ± 0.092	4.531IleVal: 4.531 ± 0.078	0.701IleTrp: 0.701 ± 0.027	2.606IleTyr: 2.606 ± 0.053	0.001IleXaa: 0.001 ± 0.001
Lys	5.354LysAla: 5.354 ± 0.066	0.367LysCys: 0.367 ± 0.018	3.946LysAsp: 3.946 ± 0.064	5.228LysGlu: 5.228 ± 0.083	2.962LysPhe: 2.962 ± 0.051	4.608LysGly: 4.608 ± 0.073	1.3LysHis: 1.3 ± 0.032	5.284LysIle: 5.284 ± 0.081	5.661LysLys: 5.661 ± 0.088	6.612LysLeu: 6.612 ± 0.087	1.9LysMet: 1.9 ± 0.041	4.442LysAsn: 4.442 ± 0.073	2.718LysPro: 2.718 ± 0.061	2.934LysGln: 2.934 ± 0.051	2.724LysArg: 2.724 ± 0.048	4.272LysSer: 4.272 ± 0.057	4.306LysThr: 4.306 ± 0.062	5.026LysVal: 5.026 ± 0.073	0.865LysTrp: 0.865 ± 0.027	2.895LysTyr: 2.895 ± 0.057	0.001LysXaa: 0.001 ± 0.001
Leu	6.506LeuAla: 6.506 ± 0.082	0.774LeuCys: 0.774 ± 0.027	4.412LeuAsp: 4.412 ± 0.066	5.023LeuGlu: 5.023 ± 0.08	4.837LeuPhe: 4.837 ± 0.084	5.81LeuGly: 5.81 ± 0.073	1.563LeuHis: 1.563 ± 0.04	7.04LeuIle: 7.04 ± 0.094	7.656LeuLys: 7.656 ± 0.094	9.32LeuLeu: 9.32 ± 0.133	2.233LeuMet: 2.233 ± 0.043	5.992LeuAsn: 5.992 ± 0.078	3.847LeuPro: 3.847 ± 0.045	3.312LeuGln: 3.312 ± 0.058	3.336LeuArg: 3.336 ± 0.058	7.165LeuSer: 7.165 ± 0.079	5.835LeuThr: 5.835 ± 0.105	5.56LeuVal: 5.56 ± 0.073	0.824LeuTrp: 0.824 ± 0.03	3.134LeuTyr: 3.134 ± 0.061	0.002LeuXaa: 0.002 ± 0.001
Met	1.771MetAla: 1.771 ± 0.039	0.144MetCys: 0.144 ± 0.01	1.169MetAsp: 1.169 ± 0.029	1.341MetGlu: 1.341 ± 0.028	0.841MetPhe: 0.841 ± 0.029	1.528MetGly: 1.528 ± 0.034	0.435MetHis: 0.435 ± 0.02	1.528MetIle: 1.528 ± 0.041	2.077MetLys: 2.077 ± 0.047	2.003MetLeu: 2.003 ± 0.048	0.585MetMet: 0.585 ± 0.022	1.354MetAsn: 1.354 ± 0.033	0.961MetPro: 0.961 ± 0.03	0.906MetGln: 0.906 ± 0.028	0.883MetArg: 0.883 ± 0.026	1.323MetSer: 1.323 ± 0.031	1.055MetThr: 1.055 ± 0.028	1.469MetVal: 1.469 ± 0.033	0.176MetTrp: 0.176 ± 0.011	0.686MetTyr: 0.686 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	4.068AsnAla: 4.068 ± 0.066	0.548AsnCys: 0.548 ± 0.039	3.213AsnAsp: 3.213 ± 0.053	3.612AsnGlu: 3.612 ± 0.054	2.875AsnPhe: 2.875 ± 0.056	4.353AsnGly: 4.353 ± 0.091	1.01AsnHis: 1.01 ± 0.028	4.059AsnIle: 4.059 ± 0.067	4.031AsnLys: 4.031 ± 0.058	5.16AsnLeu: 5.16 ± 0.072	1.236AsnMet: 1.236 ± 0.028	3.717AsnAsn: 3.717 ± 0.077	2.737AsnPro: 2.737 ± 0.063	2.232AsnGln: 2.232 ± 0.048	2.277AsnArg: 2.277 ± 0.048	3.817AsnSer: 3.817 ± 0.064	3.305AsnThr: 3.305 ± 0.061	3.646AsnVal: 3.646 ± 0.056	0.776AsnTrp: 0.776 ± 0.024	2.861AsnTyr: 2.861 ± 0.054	0.0AsnXaa: 0.0 ± 0.0
Pro	2.856ProAla: 2.856 ± 0.068	0.248ProCys: 0.248 ± 0.013	2.229ProAsp: 2.229 ± 0.047	2.736ProGlu: 2.736 ± 0.045	1.931ProPhe: 1.931 ± 0.042	2.423ProGly: 2.423 ± 0.044	0.633ProHis: 0.633 ± 0.022	2.561ProIle: 2.561 ± 0.041	2.325ProLys: 2.325 ± 0.049	3.189ProLeu: 3.189 ± 0.058	0.74ProMet: 0.74 ± 0.022	2.054ProAsn: 2.054 ± 0.04	0.985ProPro: 0.985 ± 0.038	1.395ProGln: 1.395 ± 0.033	1.008ProArg: 1.008 ± 0.03	2.355ProSer: 2.355 ± 0.045	2.155ProThr: 2.155 ± 0.066	3.01ProVal: 3.01 ± 0.061	0.382ProTrp: 0.382 ± 0.018	1.593ProTyr: 1.593 ± 0.046	0.001ProXaa: 0.001 ± 0.001
Gln	2.41GlnAla: 2.41 ± 0.058	0.197GlnCys: 0.197 ± 0.011	1.459GlnAsp: 1.459 ± 0.033	1.923GlnGlu: 1.923 ± 0.044	1.804GlnPhe: 1.804 ± 0.038	2.04GlnGly: 2.04 ± 0.052	0.667GlnHis: 0.667 ± 0.022	2.438GlnIle: 2.438 ± 0.05	2.867GlnLys: 2.867 ± 0.05	4.059GlnLeu: 4.059 ± 0.067	0.876GlnMet: 0.876 ± 0.026	2.222GlnAsn: 2.222 ± 0.044	1.423GlnPro: 1.423 ± 0.057	1.946GlnGln: 1.946 ± 0.049	1.41GlnArg: 1.41 ± 0.039	2.384GlnSer: 2.384 ± 0.052	2.176GlnThr: 2.176 ± 0.04	2.201GlnVal: 2.201 ± 0.046	0.448GlnTrp: 0.448 ± 0.023	1.493GlnTyr: 1.493 ± 0.041	0.002GlnXaa: 0.002 ± 0.001
Arg	2.137ArgAla: 2.137 ± 0.046	0.243ArgCys: 0.243 ± 0.014	1.551ArgAsp: 1.551 ± 0.036	2.197ArgGlu: 2.197 ± 0.051	2.135ArgPhe: 2.135 ± 0.046	1.906ArgGly: 1.906 ± 0.049	0.627ArgHis: 0.627 ± 0.026	2.997ArgIle: 2.997 ± 0.056	2.822ArgLys: 2.822 ± 0.055	3.483ArgLeu: 3.483 ± 0.055	0.952ArgMet: 0.952 ± 0.026	2.151ArgAsn: 2.151 ± 0.046	1.191ArgPro: 1.191 ± 0.029	1.24ArgGln: 1.24 ± 0.033	1.324ArgArg: 1.324 ± 0.036	2.191ArgSer: 2.191 ± 0.044	1.831ArgThr: 1.831 ± 0.038	2.274ArgVal: 2.274 ± 0.048	0.417ArgTrp: 0.417 ± 0.019	1.598ArgTyr: 1.598 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	4.694SerAla: 4.694 ± 0.07	0.686SerCys: 0.686 ± 0.036	3.291SerAsp: 3.291 ± 0.056	3.466SerGlu: 3.466 ± 0.05	4.007SerPhe: 4.007 ± 0.068	4.919SerGly: 4.919 ± 0.1	1.011SerHis: 1.011 ± 0.027	5.276SerIle: 5.276 ± 0.079	4.463SerLys: 4.463 ± 0.06	6.452SerLeu: 6.452 ± 0.077	1.417SerMet: 1.417 ± 0.037	3.677SerAsn: 3.677 ± 0.063	2.387SerPro: 2.387 ± 0.046	2.071SerGln: 2.071 ± 0.045	2.172SerArg: 2.172 ± 0.048	4.71SerSer: 4.71 ± 0.074	3.989SerThr: 3.989 ± 0.075	4.524SerVal: 4.524 ± 0.07	0.821SerTrp: 0.821 ± 0.037	2.841SerTyr: 2.841 ± 0.054	0.002SerXaa: 0.002 ± 0.001
Thr	4.642ThrAla: 4.642 ± 0.121	0.475ThrCys: 0.475 ± 0.035	3.339ThrAsp: 3.339 ± 0.069	3.419ThrGlu: 3.419 ± 0.065	2.77ThrPhe: 2.77 ± 0.058	4.443ThrGly: 4.443 ± 0.082	1.016ThrHis: 1.016 ± 0.028	4.688ThrIle: 4.688 ± 0.102	3.325ThrLys: 3.325 ± 0.049	5.457ThrLeu: 5.457 ± 0.095	0.997ThrMet: 0.997 ± 0.025	3.082ThrAsn: 3.082 ± 0.066	2.506ThrPro: 2.506 ± 0.057	1.958ThrGln: 1.958 ± 0.039	1.69ThrArg: 1.69 ± 0.041	3.817ThrSer: 3.817 ± 0.076	3.535ThrThr: 3.535 ± 0.087	4.518ThrVal: 4.518 ± 0.152	0.602ThrTrp: 0.602 ± 0.024	2.415ThrTyr: 2.415 ± 0.07	0.002ThrXaa: 0.002 ± 0.001
Val	4.488ValAla: 4.488 ± 0.069	0.618ValCys: 0.618 ± 0.023	3.515ValAsp: 3.515 ± 0.057	3.808ValGlu: 3.808 ± 0.063	3.482ValPhe: 3.482 ± 0.063	3.893ValGly: 3.893 ± 0.056	1.009ValHis: 1.009 ± 0.029	4.781ValIle: 4.781 ± 0.069	4.826ValLys: 4.826 ± 0.066	6.071ValLeu: 6.071 ± 0.081	1.405ValMet: 1.405 ± 0.034	4.053ValAsn: 4.053 ± 0.073	2.361ValPro: 2.361 ± 0.052	2.022ValGln: 2.022 ± 0.047	2.167ValArg: 2.167 ± 0.045	4.615ValSer: 4.615 ± 0.065	4.039ValThr: 4.039 ± 0.161	4.332ValVal: 4.332 ± 0.072	0.654ValTrp: 0.654 ± 0.023	2.485ValTyr: 2.485 ± 0.047	0.001ValXaa: 0.001 ± 0.001
Trp	0.763TrpAla: 0.763 ± 0.028	0.13TrpCys: 0.13 ± 0.01	0.594TrpAsp: 0.594 ± 0.029	0.623TrpGlu: 0.623 ± 0.021	0.596TrpPhe: 0.596 ± 0.021	0.782TrpGly: 0.782 ± 0.029	0.216TrpHis: 0.216 ± 0.012	0.751TrpIle: 0.751 ± 0.027	0.825TrpLys: 0.825 ± 0.025	1.092TrpLeu: 1.092 ± 0.03	0.324TrpMet: 0.324 ± 0.016	0.687TrpAsn: 0.687 ± 0.025	0.274TrpPro: 0.274 ± 0.014	0.488TrpGln: 0.488 ± 0.022	0.426TrpArg: 0.426 ± 0.018	0.746TrpSer: 0.746 ± 0.042	0.602TrpThr: 0.602 ± 0.021	0.7TrpVal: 0.7 ± 0.021	0.187TrpTrp: 0.187 ± 0.011	0.443TrpTyr: 0.443 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.59TyrAla: 2.59 ± 0.042	0.374TyrCys: 0.374 ± 0.016	2.208TyrAsp: 2.208 ± 0.048	2.085TyrGlu: 2.085 ± 0.038	2.296TyrPhe: 2.296 ± 0.053	2.544TyrGly: 2.544 ± 0.056	0.776TyrHis: 0.776 ± 0.026	2.414TyrIle: 2.414 ± 0.045	2.859TyrLys: 2.859 ± 0.048	3.891TyrLeu: 3.891 ± 0.06	0.757TyrMet: 0.757 ± 0.028	2.517TyrAsn: 2.517 ± 0.054	1.57TyrPro: 1.57 ± 0.033	1.658TyrGln: 1.658 ± 0.043	1.658TyrArg: 1.658 ± 0.041	3.076TyrSer: 3.076 ± 0.065	2.525TyrThr: 2.525 ± 0.077	2.221TyrVal: 2.221 ± 0.041	0.516TyrTrp: 0.516 ± 0.023	1.878TyrTyr: 1.878 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.001	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.002XaaThr: 0.002 ± 0.001	0.002XaaVal: 0.002 ± 0.001	0.002XaaTrp: 0.002 ± 0.001	0.001XaaTyr: 0.001 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3780 proteins (1322964 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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