Amino acid dipepetide frequency for Oxalobacteraceae bacterium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.057AlaAla: 13.057 ± 0.242	0.957AlaCys: 0.957 ± 0.041	6.371AlaAsp: 6.371 ± 0.101	6.254AlaGlu: 6.254 ± 0.113	4.006AlaPhe: 4.006 ± 0.077	9.268AlaGly: 9.268 ± 0.128	2.152AlaHis: 2.152 ± 0.065	5.686AlaIle: 5.686 ± 0.099	4.916AlaLys: 4.916 ± 0.108	10.735AlaLeu: 10.735 ± 0.158	3.171AlaMet: 3.171 ± 0.074	3.706AlaAsn: 3.706 ± 0.085	4.931AlaPro: 4.931 ± 0.117	4.381AlaGln: 4.381 ± 0.083	6.571AlaArg: 6.571 ± 0.114	5.869AlaSer: 5.869 ± 0.117	5.893AlaThr: 5.893 ± 0.105	7.688AlaVal: 7.688 ± 0.128	1.277AlaTrp: 1.277 ± 0.049	2.625AlaTyr: 2.625 ± 0.074	0.0AlaXaa: 0.0 ± 0.0
Cys	0.903CysAla: 0.903 ± 0.041	0.098CysCys: 0.098 ± 0.012	0.513CysAsp: 0.513 ± 0.03	0.42CysGlu: 0.42 ± 0.027	0.285CysPhe: 0.285 ± 0.024	0.85CysGly: 0.85 ± 0.051	0.247CysHis: 0.247 ± 0.024	0.443CysIle: 0.443 ± 0.029	0.262CysLys: 0.262 ± 0.021	0.673CysLeu: 0.673 ± 0.034	0.178CysMet: 0.178 ± 0.019	0.245CysAsn: 0.245 ± 0.022	0.412CysPro: 0.412 ± 0.026	0.222CysGln: 0.222 ± 0.019	0.395CysArg: 0.395 ± 0.028	0.473CysSer: 0.473 ± 0.031	0.55CysThr: 0.55 ± 0.03	0.622CysVal: 0.622 ± 0.032	0.095CysTrp: 0.095 ± 0.014	0.222CysTyr: 0.222 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	6.75AspAla: 6.75 ± 0.107	0.37AspCys: 0.37 ± 0.024	3.137AspAsp: 3.137 ± 0.084	3.561AspGlu: 3.561 ± 0.09	2.434AspPhe: 2.434 ± 0.058	5.008AspGly: 5.008 ± 0.111	1.244AspHis: 1.244 ± 0.051	3.396AspIle: 3.396 ± 0.08	2.79AspLys: 2.79 ± 0.068	5.576AspLeu: 5.576 ± 0.103	1.479AspMet: 1.479 ± 0.049	1.787AspAsn: 1.787 ± 0.053	2.844AspPro: 2.844 ± 0.069	2.004AspGln: 2.004 ± 0.067	3.241AspArg: 3.241 ± 0.074	2.604AspSer: 2.604 ± 0.073	2.929AspThr: 2.929 ± 0.062	4.711AspVal: 4.711 ± 0.086	0.947AspTrp: 0.947 ± 0.042	1.882AspTyr: 1.882 ± 0.059	0.0AspXaa: 0.0 ± 0.0
Glu	5.981GluAla: 5.981 ± 0.118	0.378GluCys: 0.378 ± 0.026	2.642GluAsp: 2.642 ± 0.068	3.287GluGlu: 3.287 ± 0.105	2.29GluPhe: 2.29 ± 0.067	4.197GluGly: 4.197 ± 0.092	1.352GluHis: 1.352 ± 0.046	3.267GluIle: 3.267 ± 0.07	2.667GluLys: 2.667 ± 0.069	5.631GluLeu: 5.631 ± 0.114	1.597GluMet: 1.597 ± 0.058	1.914GluAsn: 1.914 ± 0.051	2.122GluPro: 2.122 ± 0.056	2.535GluGln: 2.535 ± 0.066	4.121GluArg: 4.121 ± 0.092	2.587GluSer: 2.587 ± 0.067	2.839GluThr: 2.839 ± 0.067	4.124GluVal: 4.124 ± 0.086	0.735GluTrp: 0.735 ± 0.031	1.479GluTyr: 1.479 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	4.141PheAla: 4.141 ± 0.077	0.393PheCys: 0.393 ± 0.028	2.951PheAsp: 2.951 ± 0.069	2.26PheGlu: 2.26 ± 0.057	1.597PhePhe: 1.597 ± 0.053	3.926PheGly: 3.926 ± 0.095	0.812PheHis: 0.812 ± 0.037	1.965PheIle: 1.965 ± 0.059	1.602PheLys: 1.602 ± 0.054	3.022PheLeu: 3.022 ± 0.087	1.05PheMet: 1.05 ± 0.044	1.575PheAsn: 1.575 ± 0.059	1.455PhePro: 1.455 ± 0.05	1.194PheGln: 1.194 ± 0.041	2.03PheArg: 2.03 ± 0.056	2.464PheSer: 2.464 ± 0.074	2.382PheThr: 2.382 ± 0.066	2.921PheVal: 2.921 ± 0.078	0.505PheTrp: 0.505 ± 0.032	1.165PheTyr: 1.165 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	8.69GlyAla: 8.69 ± 0.129	0.758GlyCys: 0.758 ± 0.045	4.347GlyAsp: 4.347 ± 0.087	4.539GlyGlu: 4.539 ± 0.096	3.526GlyPhe: 3.526 ± 0.08	6.791GlyGly: 6.791 ± 0.131	1.845GlyHis: 1.845 ± 0.062	4.779GlyIle: 4.779 ± 0.105	4.609GlyLys: 4.609 ± 0.099	7.631GlyLeu: 7.631 ± 0.133	2.48GlyMet: 2.48 ± 0.075	2.997GlyAsn: 2.997 ± 0.09	2.674GlyPro: 2.674 ± 0.073	3.044GlyGln: 3.044 ± 0.076	4.564GlyArg: 4.564 ± 0.089	4.642GlySer: 4.642 ± 0.093	4.924GlyThr: 4.924 ± 0.115	6.715GlyVal: 6.715 ± 0.127	1.16GlyTrp: 1.16 ± 0.041	2.604GlyTyr: 2.604 ± 0.078	0.0GlyXaa: 0.0 ± 0.0
His	2.175HisAla: 2.175 ± 0.071	0.238HisCys: 0.238 ± 0.02	1.212HisAsp: 1.212 ± 0.046	1.097HisGlu: 1.097 ± 0.044	0.959HisPhe: 0.959 ± 0.04	2.012HisGly: 2.012 ± 0.066	0.548HisHis: 0.548 ± 0.034	1.174HisIle: 1.174 ± 0.049	0.753HisLys: 0.753 ± 0.034	1.867HisLeu: 1.867 ± 0.052	0.54HisMet: 0.54 ± 0.032	0.65HisAsn: 0.65 ± 0.036	1.16HisPro: 1.16 ± 0.042	0.728HisGln: 0.728 ± 0.035	1.16HisArg: 1.16 ± 0.039	1.007HisSer: 1.007 ± 0.041	1.125HisThr: 1.125 ± 0.043	1.582HisVal: 1.582 ± 0.053	0.317HisTrp: 0.317 ± 0.025	0.728HisTyr: 0.728 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.166IleAla: 6.166 ± 0.098	0.432IleCys: 0.432 ± 0.026	3.986IleAsp: 3.986 ± 0.092	3.676IleGlu: 3.676 ± 0.088	1.632IlePhe: 1.632 ± 0.053	4.913IleGly: 4.913 ± 0.104	1.014IleHis: 1.014 ± 0.044	2.535IleIle: 2.535 ± 0.077	2.519IleLys: 2.519 ± 0.078	4.314IleLeu: 4.314 ± 0.095	1.237IleMet: 1.237 ± 0.043	2.009IleAsn: 2.009 ± 0.055	2.395IlePro: 2.395 ± 0.058	1.444IleGln: 1.444 ± 0.051	2.764IleArg: 2.764 ± 0.068	2.894IleSer: 2.894 ± 0.069	3.201IleThr: 3.201 ± 0.082	4.181IleVal: 4.181 ± 0.096	0.507IleTrp: 0.507 ± 0.027	1.305IleTyr: 1.305 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.984LysAla: 4.984 ± 0.101	0.228LysCys: 0.228 ± 0.021	2.547LysAsp: 2.547 ± 0.064	2.367LysGlu: 2.367 ± 0.078	1.484LysPhe: 1.484 ± 0.05	3.286LysGly: 3.286 ± 0.08	0.87LysHis: 0.87 ± 0.033	2.44LysIle: 2.44 ± 0.073	2.182LysLys: 2.182 ± 0.071	4.417LysLeu: 4.417 ± 0.088	1.349LysMet: 1.349 ± 0.046	1.66LysAsn: 1.66 ± 0.052	2.432LysPro: 2.432 ± 0.077	1.672LysGln: 1.672 ± 0.05	2.607LysArg: 2.607 ± 0.064	2.409LysSer: 2.409 ± 0.063	2.552LysThr: 2.552 ± 0.07	3.571LysVal: 3.571 ± 0.076	0.415LysTrp: 0.415 ± 0.028	1.095LysTyr: 1.095 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	11.067LeuAla: 11.067 ± 0.167	0.83LeuCys: 0.83 ± 0.034	5.958LeuAsp: 5.958 ± 0.104	5.139LeuGlu: 5.139 ± 0.092	3.462LeuPhe: 3.462 ± 0.077	7.568LeuGly: 7.568 ± 0.122	1.925LeuHis: 1.925 ± 0.056	4.529LeuIle: 4.529 ± 0.086	4.159LeuLys: 4.159 ± 0.085	8.358LeuLeu: 8.358 ± 0.155	2.285LeuMet: 2.285 ± 0.067	3.421LeuAsn: 3.421 ± 0.076	4.681LeuPro: 4.681 ± 0.086	3.324LeuGln: 3.324 ± 0.075	5.958LeuArg: 5.958 ± 0.107	5.586LeuSer: 5.586 ± 0.095	5.359LeuThr: 5.359 ± 0.093	7.063LeuVal: 7.063 ± 0.117	0.922LeuTrp: 0.922 ± 0.044	2.24LeuTyr: 2.24 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	3.074MetAla: 3.074 ± 0.074	0.182MetCys: 0.182 ± 0.017	1.33MetAsp: 1.33 ± 0.052	1.299MetGlu: 1.299 ± 0.048	0.95MetPhe: 0.95 ± 0.042	1.95MetGly: 1.95 ± 0.067	0.607MetHis: 0.607 ± 0.032	1.37MetIle: 1.37 ± 0.046	1.407MetLys: 1.407 ± 0.051	2.59MetLeu: 2.59 ± 0.063	0.778MetMet: 0.778 ± 0.041	1.137MetAsn: 1.137 ± 0.042	1.479MetPro: 1.479 ± 0.05	1.135MetGln: 1.135 ± 0.039	1.714MetArg: 1.714 ± 0.052	1.69MetSer: 1.69 ± 0.055	1.772MetThr: 1.772 ± 0.056	1.884MetVal: 1.884 ± 0.055	0.185MetTrp: 0.185 ± 0.018	0.583MetTyr: 0.583 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	3.646AsnAla: 3.646 ± 0.099	0.375AsnCys: 0.375 ± 0.027	1.814AsnAsp: 1.814 ± 0.058	1.739AsnGlu: 1.739 ± 0.059	1.575AsnPhe: 1.575 ± 0.053	3.282AsnGly: 3.282 ± 0.073	0.682AsnHis: 0.682 ± 0.029	1.949AsnIle: 1.949 ± 0.059	1.489AsnLys: 1.489 ± 0.05	3.464AsnLeu: 3.464 ± 0.084	0.944AsnMet: 0.944 ± 0.038	1.382AsnAsn: 1.382 ± 0.067	2.224AsnPro: 2.224 ± 0.059	1.199AsnGln: 1.199 ± 0.045	1.909AsnArg: 1.909 ± 0.062	1.682AsnSer: 1.682 ± 0.061	2.055AsnThr: 2.055 ± 0.071	2.866AsnVal: 2.866 ± 0.067	0.492AsnTrp: 0.492 ± 0.03	1.159AsnTyr: 1.159 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	5.286ProAla: 5.286 ± 0.111	0.298ProCys: 0.298 ± 0.022	3.084ProAsp: 3.084 ± 0.07	2.964ProGlu: 2.964 ± 0.07	1.857ProPhe: 1.857 ± 0.058	3.992ProGly: 3.992 ± 0.087	0.915ProHis: 0.915 ± 0.041	2.244ProIle: 2.244 ± 0.058	1.829ProLys: 1.829 ± 0.054	4.134ProLeu: 4.134 ± 0.085	1.199ProMet: 1.199 ± 0.044	1.71ProAsn: 1.71 ± 0.049	1.704ProPro: 1.704 ± 0.06	1.715ProGln: 1.715 ± 0.059	2.23ProArg: 2.23 ± 0.068	2.554ProSer: 2.554 ± 0.065	2.56ProThr: 2.56 ± 0.077	3.972ProVal: 3.972 ± 0.078	0.503ProTrp: 0.503 ± 0.031	1.302ProTyr: 1.302 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	4.174GlnAla: 4.174 ± 0.1	0.295GlnCys: 0.295 ± 0.022	1.695GlnAsp: 1.695 ± 0.05	1.752GlnGlu: 1.752 ± 0.059	1.467GlnPhe: 1.467 ± 0.042	2.7GlnGly: 2.7 ± 0.072	0.818GlnHis: 0.818 ± 0.035	2.069GlnIle: 2.069 ± 0.056	1.514GlnLys: 1.514 ± 0.049	3.491GlnLeu: 3.491 ± 0.072	1.074GlnMet: 1.074 ± 0.04	1.272GlnAsn: 1.272 ± 0.053	1.789GlnPro: 1.789 ± 0.052	1.674GlnGln: 1.674 ± 0.058	2.535GlnArg: 2.535 ± 0.074	1.795GlnSer: 1.795 ± 0.059	1.915GlnThr: 1.915 ± 0.055	3.026GlnVal: 3.026 ± 0.076	0.447GlnTrp: 0.447 ± 0.031	1.009GlnTyr: 1.009 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	6.013ArgAla: 6.013 ± 0.103	0.397ArgCys: 0.397 ± 0.023	3.492ArgAsp: 3.492 ± 0.085	3.546ArgGlu: 3.546 ± 0.078	2.65ArgPhe: 2.65 ± 0.08	4.197ArgGly: 4.197 ± 0.085	1.364ArgHis: 1.364 ± 0.052	3.311ArgIle: 3.311 ± 0.07	2.419ArgLys: 2.419 ± 0.054	5.838ArgLeu: 5.838 ± 0.11	1.719ArgMet: 1.719 ± 0.053	2.179ArgAsn: 2.179 ± 0.058	2.515ArgPro: 2.515 ± 0.063	2.269ArgGln: 2.269 ± 0.062	3.516ArgArg: 3.516 ± 0.075	3.072ArgSer: 3.072 ± 0.071	3.154ArgThr: 3.154 ± 0.082	4.341ArgVal: 4.341 ± 0.078	0.703ArgTrp: 0.703 ± 0.028	1.959ArgTyr: 1.959 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	5.589SerAla: 5.589 ± 0.102	0.448SerCys: 0.448 ± 0.033	2.936SerAsp: 2.936 ± 0.062	2.532SerGlu: 2.532 ± 0.061	2.35SerPhe: 2.35 ± 0.064	5.253SerGly: 5.253 ± 0.097	1.164SerHis: 1.164 ± 0.044	2.932SerIle: 2.932 ± 0.068	2.245SerLys: 2.245 ± 0.057	5.131SerLeu: 5.131 ± 0.096	1.469SerMet: 1.469 ± 0.054	1.924SerAsn: 1.924 ± 0.068	2.437SerPro: 2.437 ± 0.067	1.825SerGln: 1.825 ± 0.063	2.956SerArg: 2.956 ± 0.072	3.316SerSer: 3.316 ± 0.084	3.429SerThr: 3.429 ± 0.068	4.026SerVal: 4.026 ± 0.072	0.66SerTrp: 0.66 ± 0.035	1.577SerTyr: 1.577 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	5.819ThrAla: 5.819 ± 0.102	0.407ThrCys: 0.407 ± 0.03	3.292ThrAsp: 3.292 ± 0.074	2.745ThrGlu: 2.745 ± 0.075	2.267ThrPhe: 2.267 ± 0.063	5.254ThrGly: 5.254 ± 0.11	1.169ThrHis: 1.169 ± 0.042	3.004ThrIle: 3.004 ± 0.068	2.03ThrLys: 2.03 ± 0.06	5.853ThrLeu: 5.853 ± 0.092	1.402ThrMet: 1.402 ± 0.045	1.862ThrAsn: 1.862 ± 0.068	3.401ThrPro: 3.401 ± 0.077	1.997ThrGln: 1.997 ± 0.074	3.196ThrArg: 3.196 ± 0.07	2.982ThrSer: 2.982 ± 0.081	3.479ThrThr: 3.479 ± 0.093	4.854ThrVal: 4.854 ± 0.091	0.618ThrTrp: 0.618 ± 0.037	1.52ThrTyr: 1.52 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	8.36ValAla: 8.36 ± 0.127	0.642ValCys: 0.642 ± 0.035	4.919ValAsp: 4.919 ± 0.102	4.586ValGlu: 4.586 ± 0.085	2.877ValPhe: 2.877 ± 0.073	5.624ValGly: 5.624 ± 0.102	1.41ValHis: 1.41 ± 0.049	4.214ValIle: 4.214 ± 0.091	3.456ValLys: 3.456 ± 0.082	7.283ValLeu: 7.283 ± 0.117	2.057ValMet: 2.057 ± 0.067	2.934ValAsn: 2.934 ± 0.077	3.651ValPro: 3.651 ± 0.089	2.53ValGln: 2.53 ± 0.067	4.688ValArg: 4.688 ± 0.1	4.296ValSer: 4.296 ± 0.087	4.656ValThr: 4.656 ± 0.09	6.573ValVal: 6.573 ± 0.118	0.833ValTrp: 0.833 ± 0.044	1.942ValTyr: 1.942 ± 0.06	0.0ValXaa: 0.0 ± 0.0
Trp	0.945TrpAla: 0.945 ± 0.046	0.143TrpCys: 0.143 ± 0.017	0.72TrpAsp: 0.72 ± 0.038	0.53TrpGlu: 0.53 ± 0.027	0.573TrpPhe: 0.573 ± 0.038	0.825TrpGly: 0.825 ± 0.046	0.305TrpHis: 0.305 ± 0.024	0.613TrpIle: 0.613 ± 0.03	0.542TrpLys: 0.542 ± 0.031	1.319TrpLeu: 1.319 ± 0.053	0.41TrpMet: 0.41 ± 0.026	0.515TrpAsn: 0.515 ± 0.031	0.427TrpPro: 0.427 ± 0.027	0.502TrpGln: 0.502 ± 0.029	0.777TrpArg: 0.777 ± 0.041	0.693TrpSer: 0.693 ± 0.034	0.677TrpThr: 0.677 ± 0.035	0.803TrpVal: 0.803 ± 0.038	0.192TrpTrp: 0.192 ± 0.021	0.355TrpTyr: 0.355 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.694TyrAla: 2.694 ± 0.078	0.238TyrCys: 0.238 ± 0.02	1.744TyrAsp: 1.744 ± 0.057	1.454TyrGlu: 1.454 ± 0.05	1.169TyrPhe: 1.169 ± 0.044	2.424TyrGly: 2.424 ± 0.063	0.592TyrHis: 0.592 ± 0.031	1.2TyrIle: 1.2 ± 0.044	1.179TyrLys: 1.179 ± 0.044	2.507TyrLeu: 2.507 ± 0.067	0.698TyrMet: 0.698 ± 0.032	1.045TyrAsn: 1.045 ± 0.044	1.322TyrPro: 1.322 ± 0.048	1.117TyrGln: 1.117 ± 0.045	1.722TyrArg: 1.722 ± 0.058	1.584TyrSer: 1.584 ± 0.052	1.7TyrThr: 1.7 ± 0.055	2.01TyrVal: 2.01 ± 0.046	0.353TyrTrp: 0.353 ± 0.026	0.895TyrTyr: 0.895 ± 0.045	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2416 proteins (599894 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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