Amino acid dipepetide frequency for Lapillicoccus jejuensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.937AlaAla: 21.937 ± 0.19	0.928AlaCys: 0.928 ± 0.029	8.587AlaAsp: 8.587 ± 0.09	6.516AlaGlu: 6.516 ± 0.096	3.345AlaPhe: 3.345 ± 0.063	13.645AlaGly: 13.645 ± 0.121	2.729AlaHis: 2.729 ± 0.054	2.989AlaIle: 2.989 ± 0.05	2.083AlaLys: 2.083 ± 0.049	14.981AlaLeu: 14.981 ± 0.136	2.424AlaMet: 2.424 ± 0.044	1.674AlaAsn: 1.674 ± 0.039	7.755AlaPro: 7.755 ± 0.101	4.079AlaGln: 4.079 ± 0.056	10.809AlaArg: 10.809 ± 0.116	6.904AlaSer: 6.904 ± 0.087	8.872AlaThr: 8.872 ± 0.1	13.946AlaVal: 13.946 ± 0.127	2.02AlaTrp: 2.02 ± 0.046	2.386AlaTyr: 2.386 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.805CysAla: 0.805 ± 0.027	0.083CysCys: 0.083 ± 0.009	0.412CysAsp: 0.412 ± 0.016	0.265CysGlu: 0.265 ± 0.015	0.183CysPhe: 0.183 ± 0.014	0.789CysGly: 0.789 ± 0.024	0.163CysHis: 0.163 ± 0.01	0.124CysIle: 0.124 ± 0.01	0.074CysLys: 0.074 ± 0.009	0.603CysLeu: 0.603 ± 0.02	0.072CysMet: 0.072 ± 0.007	0.091CysAsn: 0.091 ± 0.008	0.412CysPro: 0.412 ± 0.02	0.147CysGln: 0.147 ± 0.01	0.503CysArg: 0.503 ± 0.019	0.388CysSer: 0.388 ± 0.019	0.44CysThr: 0.44 ± 0.021	0.562CysVal: 0.562 ± 0.019	0.104CysTrp: 0.104 ± 0.011	0.124CysTyr: 0.124 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.867AspAla: 8.867 ± 0.094	0.288AspCys: 0.288 ± 0.015	4.704AspAsp: 4.704 ± 0.074	4.218AspGlu: 4.218 ± 0.05	1.315AspPhe: 1.315 ± 0.038	7.031AspGly: 7.031 ± 0.092	1.45AspHis: 1.45 ± 0.033	1.264AspIle: 1.264 ± 0.035	0.838AspLys: 0.838 ± 0.026	7.488AspLeu: 7.488 ± 0.084	0.573AspMet: 0.573 ± 0.021	0.726AspAsn: 0.726 ± 0.024	5.07AspPro: 5.07 ± 0.071	1.547AspGln: 1.547 ± 0.038	5.009AspArg: 5.009 ± 0.065	1.935AspSer: 1.935 ± 0.04	2.959AspThr: 2.959 ± 0.047	6.629AspVal: 6.629 ± 0.075	0.924AspTrp: 0.924 ± 0.027	0.992AspTyr: 0.992 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	6.57GluAla: 6.57 ± 0.083	0.267GluCys: 0.267 ± 0.016	2.744GluAsp: 2.744 ± 0.046	2.698GluGlu: 2.698 ± 0.053	0.982GluPhe: 0.982 ± 0.026	4.023GluGly: 4.023 ± 0.059	1.603GluHis: 1.603 ± 0.035	1.471GluIle: 1.471 ± 0.037	1.004GluLys: 1.004 ± 0.031	5.525GluLeu: 5.525 ± 0.071	0.671GluMet: 0.671 ± 0.023	0.629GluAsn: 0.629 ± 0.022	3.061GluPro: 3.061 ± 0.077	2.157GluGln: 2.157 ± 0.044	5.212GluArg: 5.212 ± 0.07	2.02GluSer: 2.02 ± 0.039	2.421GluThr: 2.421 ± 0.047	5.142GluVal: 5.142 ± 0.064	0.675GluTrp: 0.675 ± 0.023	0.744GluTyr: 0.744 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	3.344PheAla: 3.344 ± 0.051	0.203PheCys: 0.203 ± 0.014	1.644PheAsp: 1.644 ± 0.04	1.177PheGlu: 1.177 ± 0.03	0.779PhePhe: 0.779 ± 0.031	2.635PheGly: 2.635 ± 0.05	0.547PheHis: 0.547 ± 0.019	0.544PheIle: 0.544 ± 0.02	0.338PheLys: 0.338 ± 0.015	2.351PheLeu: 2.351 ± 0.05	0.32PheMet: 0.32 ± 0.016	0.446PheAsn: 0.446 ± 0.02	1.193PhePro: 1.193 ± 0.033	0.57PheGln: 0.57 ± 0.021	1.515PheArg: 1.515 ± 0.04	1.359PheSer: 1.359 ± 0.038	1.758PheThr: 1.758 ± 0.04	2.491PheVal: 2.491 ± 0.044	0.363PheTrp: 0.363 ± 0.017	0.558PheTyr: 0.558 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	12.039GlyAla: 12.039 ± 0.113	0.723GlyCys: 0.723 ± 0.026	5.808GlyAsp: 5.808 ± 0.067	4.662GlyGlu: 4.662 ± 0.065	2.783GlyPhe: 2.783 ± 0.046	9.268GlyGly: 9.268 ± 0.116	2.157GlyHis: 2.157 ± 0.046	2.915GlyIle: 2.915 ± 0.049	1.831GlyLys: 1.831 ± 0.042	10.263GlyLeu: 10.263 ± 0.102	1.755GlyMet: 1.755 ± 0.033	1.401GlyAsn: 1.401 ± 0.038	5.379GlyPro: 5.379 ± 0.073	2.665GlyGln: 2.665 ± 0.048	8.164GlyArg: 8.164 ± 0.086	5.984GlySer: 5.984 ± 0.078	6.67GlyThr: 6.67 ± 0.084	8.903GlyVal: 8.903 ± 0.088	2.008GlyTrp: 2.008 ± 0.044	2.166GlyTyr: 2.166 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.512HisAla: 2.512 ± 0.049	0.162HisCys: 0.162 ± 0.011	1.608HisAsp: 1.608 ± 0.035	1.29HisGlu: 1.29 ± 0.035	0.49HisPhe: 0.49 ± 0.017	2.205HisGly: 2.205 ± 0.046	0.68HisHis: 0.68 ± 0.026	0.409HisIle: 0.409 ± 0.017	0.231HisLys: 0.231 ± 0.012	2.529HisLeu: 2.529 ± 0.045	0.209HisMet: 0.209 ± 0.013	0.261HisAsn: 0.261 ± 0.014	1.778HisPro: 1.778 ± 0.04	0.55HisGln: 0.55 ± 0.021	1.972HisArg: 1.972 ± 0.041	0.746HisSer: 0.746 ± 0.022	0.963HisThr: 0.963 ± 0.03	2.166HisVal: 2.166 ± 0.038	0.32HisTrp: 0.32 ± 0.015	0.397HisTyr: 0.397 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	3.577IleAla: 3.577 ± 0.057	0.208IleCys: 0.208 ± 0.012	1.684IleAsp: 1.684 ± 0.04	1.384IleGlu: 1.384 ± 0.037	0.574IlePhe: 0.574 ± 0.024	2.794IleGly: 2.794 ± 0.061	0.421IleHis: 0.421 ± 0.016	0.659IleIle: 0.659 ± 0.03	0.479IleLys: 0.479 ± 0.021	1.845IleLeu: 1.845 ± 0.04	0.323IleMet: 0.323 ± 0.019	0.468IleAsn: 0.468 ± 0.02	1.279IlePro: 1.279 ± 0.034	0.607IleGln: 0.607 ± 0.022	1.538IleArg: 1.538 ± 0.035	1.261IleSer: 1.261 ± 0.036	1.587IleThr: 1.587 ± 0.035	2.327IleVal: 2.327 ± 0.046	0.266IleTrp: 0.266 ± 0.016	0.431IleTyr: 0.431 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	2.246LysAla: 2.246 ± 0.049	0.06LysCys: 0.06 ± 0.007	1.01LysAsp: 1.01 ± 0.029	0.766LysGlu: 0.766 ± 0.027	0.3LysPhe: 0.3 ± 0.015	1.338LysGly: 1.338 ± 0.039	0.298LysHis: 0.298 ± 0.015	0.59LysIle: 0.59 ± 0.022	0.492LysLys: 0.492 ± 0.025	1.261LysLeu: 1.261 ± 0.036	0.234LysMet: 0.234 ± 0.015	0.319LysAsn: 0.319 ± 0.016	0.901LysPro: 0.901 ± 0.029	0.518LysGln: 0.518 ± 0.022	1.026LysArg: 1.026 ± 0.033	0.809LysSer: 0.809 ± 0.028	0.957LysThr: 0.957 ± 0.034	1.671LysVal: 1.671 ± 0.039	0.152LysTrp: 0.152 ± 0.01	0.317LysTyr: 0.317 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	16.073LeuAla: 16.073 ± 0.141	0.579LeuCys: 0.579 ± 0.02	7.382LeuAsp: 7.382 ± 0.085	5.233LeuGlu: 5.233 ± 0.066	2.189LeuPhe: 2.189 ± 0.047	10.37LeuGly: 10.37 ± 0.11	2.082LeuHis: 2.082 ± 0.042	1.817LeuIle: 1.817 ± 0.044	1.37LeuLys: 1.37 ± 0.041	11.72LeuLeu: 11.72 ± 0.134	1.286LeuMet: 1.286 ± 0.03	1.239LeuAsn: 1.239 ± 0.032	6.374LeuPro: 6.374 ± 0.074	2.458LeuGln: 2.458 ± 0.053	8.573LeuArg: 8.573 ± 0.098	5.002LeuSer: 5.002 ± 0.065	6.758LeuThr: 6.758 ± 0.079	12.14LeuVal: 12.14 ± 0.11	1.251LeuTrp: 1.251 ± 0.029	1.457LeuTyr: 1.457 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	1.953MetAla: 1.953 ± 0.041	0.103MetCys: 0.103 ± 0.008	0.7MetAsp: 0.7 ± 0.023	0.566MetGlu: 0.566 ± 0.021	0.346MetPhe: 0.346 ± 0.016	1.213MetGly: 1.213 ± 0.033	0.236MetHis: 0.236 ± 0.011	0.432MetIle: 0.432 ± 0.019	0.274MetLys: 0.274 ± 0.014	1.414MetLeu: 1.414 ± 0.034	0.24MetMet: 0.24 ± 0.013	0.274MetAsn: 0.274 ± 0.014	1.03MetPro: 1.03 ± 0.027	0.364MetGln: 0.364 ± 0.016	1.164MetArg: 1.164 ± 0.031	1.414MetSer: 1.414 ± 0.032	1.709MetThr: 1.709 ± 0.035	1.289MetVal: 1.289 ± 0.031	0.17MetTrp: 0.17 ± 0.011	0.233MetTyr: 0.233 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	1.779AsnAla: 1.779 ± 0.041	0.103AsnCys: 0.103 ± 0.008	0.748AsnAsp: 0.748 ± 0.028	0.572AsnGlu: 0.572 ± 0.023	0.356AsnPhe: 0.356 ± 0.018	1.419AsnGly: 1.419 ± 0.041	0.278AsnHis: 0.278 ± 0.013	0.458AsnIle: 0.458 ± 0.02	0.25AsnLys: 0.25 ± 0.016	1.517AsnLeu: 1.517 ± 0.036	0.187AsnMet: 0.187 ± 0.013	0.323AsnAsn: 0.323 ± 0.018	1.165AsnPro: 1.165 ± 0.03	0.414AsnGln: 0.414 ± 0.017	0.937AsnArg: 0.937 ± 0.029	0.602AsnSer: 0.602 ± 0.024	0.819AsnThr: 0.819 ± 0.027	1.279AsnVal: 1.279 ± 0.03	0.184AsnTrp: 0.184 ± 0.012	0.325AsnTyr: 0.325 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	8.708ProAla: 8.708 ± 0.109	0.256ProCys: 0.256 ± 0.015	4.622ProAsp: 4.622 ± 0.077	3.292ProGlu: 3.292 ± 0.059	1.421ProPhe: 1.421 ± 0.037	6.757ProGly: 6.757 ± 0.089	1.267ProHis: 1.267 ± 0.034	1.143ProIle: 1.143 ± 0.032	0.81ProLys: 0.81 ± 0.025	5.318ProLeu: 5.318 ± 0.072	0.947ProMet: 0.947 ± 0.028	0.705ProAsn: 0.705 ± 0.023	3.475ProPro: 3.475 ± 0.065	1.906ProGln: 1.906 ± 0.038	4.257ProArg: 4.257 ± 0.067	3.671ProSer: 3.671 ± 0.06	4.551ProThr: 4.551 ± 0.066	6.25ProVal: 6.25 ± 0.08	1.005ProTrp: 1.005 ± 0.032	1.399ProTyr: 1.399 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.597GlnAla: 3.597 ± 0.058	0.14GlnCys: 0.14 ± 0.011	1.591GlnAsp: 1.591 ± 0.033	1.324GlnGlu: 1.324 ± 0.033	0.579GlnPhe: 0.579 ± 0.019	2.398GlnGly: 2.398 ± 0.051	0.644GlnHis: 0.644 ± 0.021	0.72GlnIle: 0.72 ± 0.024	0.523GlnLys: 0.523 ± 0.024	2.933GlnLeu: 2.933 ± 0.048	0.421GlnMet: 0.421 ± 0.02	0.383GlnAsn: 0.383 ± 0.018	1.615GlnPro: 1.615 ± 0.036	1.309GlnGln: 1.309 ± 0.042	2.477GlnArg: 2.477 ± 0.045	1.225GlnSer: 1.225 ± 0.034	1.388GlnThr: 1.388 ± 0.033	3.263GlnVal: 3.263 ± 0.043	0.438GlnTrp: 0.438 ± 0.017	0.503GlnTyr: 0.503 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	9.957ArgAla: 9.957 ± 0.098	0.512ArgCys: 0.512 ± 0.023	4.714ArgAsp: 4.714 ± 0.064	4.475ArgGlu: 4.475 ± 0.065	2.141ArgPhe: 2.141 ± 0.04	6.264ArgGly: 6.264 ± 0.076	1.982ArgHis: 1.982 ± 0.032	2.222ArgIle: 2.222 ± 0.041	1.046ArgLys: 1.046 ± 0.029	9.219ArgLeu: 9.219 ± 0.108	1.636ArgMet: 1.636 ± 0.034	0.973ArgAsn: 0.973 ± 0.028	5.271ArgPro: 5.271 ± 0.085	1.976ArgGln: 1.976 ± 0.044	8.677ArgArg: 8.677 ± 0.101	4.078ArgSer: 4.078 ± 0.056	5.411ArgThr: 5.411 ± 0.056	7.241ArgVal: 7.241 ± 0.079	1.596ArgTrp: 1.596 ± 0.036	1.593ArgTyr: 1.593 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.698SerAla: 6.698 ± 0.083	0.346SerCys: 0.346 ± 0.017	2.757SerAsp: 2.757 ± 0.042	1.885SerGlu: 1.885 ± 0.035	1.492SerPhe: 1.492 ± 0.037	5.842SerGly: 5.842 ± 0.072	0.896SerHis: 0.896 ± 0.024	1.401SerIle: 1.401 ± 0.034	0.739SerLys: 0.739 ± 0.028	4.988SerLeu: 4.988 ± 0.058	1.071SerMet: 1.071 ± 0.029	0.789SerAsn: 0.789 ± 0.025	3.26SerPro: 3.26 ± 0.051	1.291SerGln: 1.291 ± 0.033	3.76SerArg: 3.76 ± 0.055	3.404SerSer: 3.404 ± 0.076	3.956SerThr: 3.956 ± 0.079	4.753SerVal: 4.753 ± 0.065	0.901SerTrp: 0.901 ± 0.027	1.306SerTyr: 1.306 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	8.911ThrAla: 8.911 ± 0.111	0.42ThrCys: 0.42 ± 0.02	3.804ThrAsp: 3.804 ± 0.053	2.393ThrGlu: 2.393 ± 0.047	1.637ThrPhe: 1.637 ± 0.037	6.889ThrGly: 6.889 ± 0.081	1.205ThrHis: 1.205 ± 0.033	1.776ThrIle: 1.776 ± 0.037	0.981ThrLys: 0.981 ± 0.031	6.085ThrLeu: 6.085 ± 0.068	1.002ThrMet: 1.002 ± 0.027	0.968ThrAsn: 0.968 ± 0.029	4.844ThrPro: 4.844 ± 0.077	1.556ThrGln: 1.556 ± 0.033	4.491ThrArg: 4.491 ± 0.064	4.109ThrSer: 4.109 ± 0.068	5.637ThrThr: 5.637 ± 0.098	6.774ThrVal: 6.774 ± 0.087	1.155ThrTrp: 1.155 ± 0.03	1.427ThrTyr: 1.427 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	14.809ValAla: 14.809 ± 0.127	0.676ValCys: 0.676 ± 0.025	6.785ValAsp: 6.785 ± 0.075	5.351ValGlu: 5.351 ± 0.074	2.23ValPhe: 2.23 ± 0.051	9.271ValGly: 9.271 ± 0.083	2.14ValHis: 2.14 ± 0.043	2.141ValIle: 2.141 ± 0.052	1.412ValLys: 1.412 ± 0.034	11.681ValLeu: 11.681 ± 0.101	1.348ValMet: 1.348 ± 0.034	1.439ValAsn: 1.439 ± 0.035	6.129ValPro: 6.129 ± 0.083	2.319ValGln: 2.319 ± 0.043	7.993ValArg: 7.993 ± 0.095	4.658ValSer: 4.658 ± 0.071	7.19ValThr: 7.19 ± 0.086	13.238ValVal: 13.238 ± 0.134	1.267ValTrp: 1.267 ± 0.032	1.406ValTyr: 1.406 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.747TrpAla: 1.747 ± 0.032	0.149TrpCys: 0.149 ± 0.011	0.88TrpAsp: 0.88 ± 0.029	0.661TrpGlu: 0.661 ± 0.021	0.511TrpPhe: 0.511 ± 0.02	1.217TrpGly: 1.217 ± 0.033	0.348TrpHis: 0.348 ± 0.016	0.322TrpIle: 0.322 ± 0.012	0.222TrpLys: 0.222 ± 0.013	1.719TrpLeu: 1.719 ± 0.038	0.238TrpMet: 0.238 ± 0.015	0.295TrpAsn: 0.295 ± 0.014	0.779TrpPro: 0.779 ± 0.023	0.516TrpGln: 0.516 ± 0.021	1.404TrpArg: 1.404 ± 0.038	1.146TrpSer: 1.146 ± 0.035	1.078TrpThr: 1.078 ± 0.029	1.544TrpVal: 1.544 ± 0.037	0.437TrpTrp: 0.437 ± 0.018	0.314TrpTyr: 0.314 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.48TyrAla: 2.48 ± 0.046	0.136TyrCys: 0.136 ± 0.01	1.644TyrAsp: 1.644 ± 0.033	0.894TyrGlu: 0.894 ± 0.028	0.484TyrPhe: 0.484 ± 0.022	2.175TyrGly: 2.175 ± 0.04	0.35TyrHis: 0.35 ± 0.015	0.316TyrIle: 0.316 ± 0.015	0.269TyrLys: 0.269 ± 0.015	1.912TyrLeu: 1.912 ± 0.036	0.166TyrMet: 0.166 ± 0.01	0.311TyrAsn: 0.311 ± 0.017	0.993TyrPro: 0.993 ± 0.028	0.523TyrGln: 0.523 ± 0.022	1.502TyrArg: 1.502 ± 0.031	0.822TyrSer: 0.822 ± 0.028	0.939TyrThr: 0.939 ± 0.026	1.874TyrVal: 1.874 ± 0.038	0.289TyrTrp: 0.289 ± 0.014	0.38TyrTyr: 0.38 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4122 proteins (1392142 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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