Amino acid dipepetide frequency for Cephus cinctus (Wheat stem sawfly)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.632AlaAla: 3.632 ± 0.266
1.313AlaCys: 1.313 ± 0.127
1.732AlaAsp: 1.732 ± 0.169
2.249AlaGlu: 2.249 ± 0.186
3.157AlaPhe: 3.157 ± 0.2
2.682AlaGly: 2.682 ± 0.201
0.782AlaHis: 0.782 ± 0.101
4.819AlaIle: 4.819 ± 0.242
2.137AlaLys: 2.137 ± 0.171
5.113AlaLeu: 5.113 ± 0.293
1.551AlaMet: 1.551 ± 0.128
2.752AlaAsn: 2.752 ± 0.16
1.104AlaPro: 1.104 ± 0.112
1.397AlaGln: 1.397 ± 0.142
1.942AlaArg: 1.942 ± 0.163
4.023AlaSer: 4.023 ± 0.228
3.618AlaThr: 3.618 ± 0.215
3.897AlaVal: 3.897 ± 0.221
0.698AlaTrp: 0.698 ± 0.105
3.241AlaTyr: 3.241 ± 0.187
0.0AlaXaa: 0.0 ± 0.0
Cys
1.243CysAla: 1.243 ± 0.121
0.712CysCys: 0.712 ± 0.105
0.824CysAsp: 0.824 ± 0.107
1.006CysGlu: 1.006 ± 0.118
1.76CysPhe: 1.76 ± 0.146
1.187CysGly: 1.187 ± 0.158
0.587CysHis: 0.587 ± 0.086
2.123CysIle: 2.123 ± 0.161
0.866CysLys: 0.866 ± 0.104
3.059CysLeu: 3.059 ± 0.238
0.545CysMet: 0.545 ± 0.087
0.894CysAsn: 0.894 ± 0.104
0.601CysPro: 0.601 ± 0.094
0.629CysGln: 0.629 ± 0.095
0.657CysArg: 0.657 ± 0.106
1.69CysSer: 1.69 ± 0.143
1.062CysThr: 1.062 ± 0.11
1.802CysVal: 1.802 ± 0.157
0.405CysTrp: 0.405 ± 0.09
1.118CysTyr: 1.118 ± 0.128
0.0CysXaa: 0.0 ± 0.0
Asp
1.9AspAla: 1.9 ± 0.123
0.74AspCys: 0.74 ± 0.108
2.123AspAsp: 2.123 ± 0.145
2.151AspGlu: 2.151 ± 0.179
2.319AspPhe: 2.319 ± 0.183
1.62AspGly: 1.62 ± 0.167
0.838AspHis: 0.838 ± 0.102
3.59AspIle: 3.59 ± 0.186
2.277AspLys: 2.277 ± 0.165
4.414AspLeu: 4.414 ± 0.272
1.132AspMet: 1.132 ± 0.132
2.207AspAsn: 2.207 ± 0.163
1.313AspPro: 1.313 ± 0.148
0.936AspGln: 0.936 ± 0.116
2.081AspArg: 2.081 ± 0.167
2.598AspSer: 2.598 ± 0.192
2.682AspThr: 2.682 ± 0.191
2.668AspVal: 2.668 ± 0.191
0.796AspTrp: 0.796 ± 0.118
1.732AspTyr: 1.732 ± 0.153
0.0AspXaa: 0.0 ± 0.0
Glu
2.067GluAla: 2.067 ± 0.172
0.838GluCys: 0.838 ± 0.105
2.151GluAsp: 2.151 ± 0.165
2.542GluGlu: 2.542 ± 0.181
2.333GluPhe: 2.333 ± 0.179
1.397GluGly: 1.397 ± 0.147
0.726GluHis: 0.726 ± 0.097
4.903GluIle: 4.903 ± 0.255
3.157GluLys: 3.157 ± 0.216
4.54GluLeu: 4.54 ± 0.262
1.453GluMet: 1.453 ± 0.155
3.842GluAsn: 3.842 ± 0.218
0.796GluPro: 0.796 ± 0.094
1.104GluGln: 1.104 ± 0.147
2.878GluArg: 2.878 ± 0.187
3.786GluSer: 3.786 ± 0.224
2.64GluThr: 2.64 ± 0.202
2.906GluVal: 2.906 ± 0.242
0.503GluTrp: 0.503 ± 0.073
1.984GluTyr: 1.984 ± 0.156
0.0GluXaa: 0.0 ± 0.0
Phe
3.381PheAla: 3.381 ± 0.218
1.439PheCys: 1.439 ± 0.143
2.095PheAsp: 2.095 ± 0.158
2.459PheGlu: 2.459 ± 0.169
3.786PhePhe: 3.786 ± 0.216
2.78PheGly: 2.78 ± 0.208
1.132PheHis: 1.132 ± 0.113
5.239PheIle: 5.239 ± 0.252
2.612PheLys: 2.612 ± 0.192
7.669PheLeu: 7.669 ± 0.294
1.718PheMet: 1.718 ± 0.189
2.822PheAsn: 2.822 ± 0.168
1.523PhePro: 1.523 ± 0.139
2.109PheGln: 2.109 ± 0.188
2.054PheArg: 2.054 ± 0.171
5.155PheSer: 5.155 ± 0.271
4.596PheThr: 4.596 ± 0.245
4.973PheVal: 4.973 ± 0.228
0.768PheTrp: 0.768 ± 0.099
2.948PheTyr: 2.948 ± 0.197
0.0PheXaa: 0.0 ± 0.0
Gly
1.606GlyAla: 1.606 ± 0.144
0.852GlyCys: 0.852 ± 0.119
1.551GlyAsp: 1.551 ± 0.15
1.858GlyGlu: 1.858 ± 0.141
3.199GlyPhe: 3.199 ± 0.202
1.872GlyGly: 1.872 ± 0.166
0.88GlyHis: 0.88 ± 0.116
4.233GlyIle: 4.233 ± 0.205
2.556GlyLys: 2.556 ± 0.209
4.945GlyLeu: 4.945 ± 0.216
1.509GlyMet: 1.509 ± 0.15
2.598GlyAsn: 2.598 ± 0.189
0.978GlyPro: 0.978 ± 0.127
1.565GlyGln: 1.565 ± 0.143
1.69GlyArg: 1.69 ± 0.171
2.696GlySer: 2.696 ± 0.19
2.584GlyThr: 2.584 ± 0.208
2.64GlyVal: 2.64 ± 0.208
0.349GlyTrp: 0.349 ± 0.076
2.137GlyTyr: 2.137 ± 0.192
0.0GlyXaa: 0.0 ± 0.0
His
0.95HisAla: 0.95 ± 0.113
0.447HisCys: 0.447 ± 0.075
0.74HisAsp: 0.74 ± 0.09
1.257HisGlu: 1.257 ± 0.132
1.062HisPhe: 1.062 ± 0.118
1.104HisGly: 1.104 ± 0.119
0.475HisHis: 0.475 ± 0.089
1.341HisIle: 1.341 ± 0.137
0.964HisLys: 0.964 ± 0.123
2.514HisLeu: 2.514 ± 0.182
0.671HisMet: 0.671 ± 0.08
0.964HisAsn: 0.964 ± 0.118
0.559HisPro: 0.559 ± 0.087
0.992HisGln: 0.992 ± 0.124
1.132HisArg: 1.132 ± 0.116
1.299HisSer: 1.299 ± 0.141
0.894HisThr: 0.894 ± 0.114
1.732HisVal: 1.732 ± 0.164
0.391HisTrp: 0.391 ± 0.072
0.768HisTyr: 0.768 ± 0.092
0.0HisXaa: 0.0 ± 0.0
Ile
4.959IleAla: 4.959 ± 0.246
2.347IleCys: 2.347 ± 0.175
3.464IleAsp: 3.464 ± 0.222
3.367IleGlu: 3.367 ± 0.195
6.412IlePhe: 6.412 ± 0.291
4.624IleGly: 4.624 ± 0.243
1.606IleHis: 1.606 ± 0.165
8.745IleIle: 8.745 ± 0.327
3.632IleLys: 3.632 ± 0.222
13.313IleLeu: 13.313 ± 0.432
2.696IleMet: 2.696 ± 0.202
4.065IleAsn: 4.065 ± 0.243
2.501IlePro: 2.501 ± 0.193
2.459IleGln: 2.459 ± 0.188
3.786IleArg: 3.786 ± 0.236
6.845IleSer: 6.845 ± 0.324
5.378IleThr: 5.378 ± 0.249
6.119IleVal: 6.119 ± 0.295
1.229IleTrp: 1.229 ± 0.11
3.883IleTyr: 3.883 ± 0.224
0.0IleXaa: 0.0 ± 0.0
Lys
2.137LysAla: 2.137 ± 0.187
1.285LysCys: 1.285 ± 0.165
2.347LysAsp: 2.347 ± 0.168
2.445LysGlu: 2.445 ± 0.185
3.562LysPhe: 3.562 ± 0.213
1.565LysGly: 1.565 ± 0.177
1.145LysHis: 1.145 ± 0.129
5.294LysIle: 5.294 ± 0.256
3.339LysLys: 3.339 ± 0.223
5.741LysLeu: 5.741 ± 0.229
2.137LysMet: 2.137 ± 0.169
3.492LysAsn: 3.492 ± 0.243
1.481LysPro: 1.481 ± 0.155
1.411LysGln: 1.411 ± 0.139
2.808LysArg: 2.808 ± 0.225
3.688LysSer: 3.688 ± 0.205
3.031LysThr: 3.031 ± 0.201
2.878LysVal: 2.878 ± 0.194
0.768LysTrp: 0.768 ± 0.087
2.333LysTyr: 2.333 ± 0.179
0.0LysXaa: 0.0 ± 0.0
Leu
5.741LeuAla: 5.741 ± 0.237
2.612LeuCys: 2.612 ± 0.209
3.925LeuAsp: 3.925 ± 0.248
5.448LeuGlu: 5.448 ± 0.282
6.831LeuPhe: 6.831 ± 0.313
4.512LeuGly: 4.512 ± 0.236
2.668LeuHis: 2.668 ± 0.195
10.812LeuIle: 10.812 ± 0.423
6.733LeuLys: 6.733 ± 0.313
13.746LeuLeu: 13.746 ± 0.481
3.632LeuMet: 3.632 ± 0.203
4.889LeuAsn: 4.889 ± 0.226
3.897LeuPro: 3.897 ± 0.259
4.191LeuGln: 4.191 ± 0.251
6.119LeuArg: 6.119 ± 0.271
9.29LeuSer: 9.29 ± 0.44
8.2LeuThr: 8.2 ± 0.334
7.865LeuVal: 7.865 ± 0.392
1.942LeuTrp: 1.942 ± 0.16
4.568LeuTyr: 4.568 ± 0.256
0.0LeuXaa: 0.0 ± 0.0
Met
1.802MetAla: 1.802 ± 0.14
0.936MetCys: 0.936 ± 0.121
1.634MetAsp: 1.634 ± 0.135
1.509MetGlu: 1.509 ± 0.169
1.355MetPhe: 1.355 ± 0.13
0.894MetGly: 0.894 ± 0.111
0.726MetHis: 0.726 ± 0.094
2.85MetIle: 2.85 ± 0.201
2.151MetLys: 2.151 ± 0.183
3.003MetLeu: 3.003 ± 0.211
0.978MetMet: 0.978 ± 0.13
1.858MetAsn: 1.858 ± 0.158
0.782MetPro: 0.782 ± 0.11
0.992MetGln: 0.992 ± 0.107
1.495MetArg: 1.495 ± 0.137
2.403MetSer: 2.403 ± 0.175
2.193MetThr: 2.193 ± 0.154
1.69MetVal: 1.69 ± 0.149
0.405MetTrp: 0.405 ± 0.083
1.145MetTyr: 1.145 ± 0.144
0.0MetXaa: 0.0 ± 0.0
Asn
2.501AsnAla: 2.501 ± 0.198
1.397AsnCys: 1.397 ± 0.139
2.71AsnAsp: 2.71 ± 0.192
3.059AsnGlu: 3.059 ± 0.188
3.325AsnPhe: 3.325 ± 0.206
2.612AsnGly: 2.612 ± 0.167
1.132AsnHis: 1.132 ± 0.134
4.456AsnIle: 4.456 ± 0.227
2.528AsnLys: 2.528 ± 0.228
5.574AsnLeu: 5.574 ± 0.225
1.257AsnMet: 1.257 ± 0.141
2.906AsnAsn: 2.906 ± 0.202
1.509AsnPro: 1.509 ± 0.158
1.173AsnGln: 1.173 ± 0.136
2.361AsnArg: 2.361 ± 0.186
3.632AsnSer: 3.632 ± 0.242
2.528AsnThr: 2.528 ± 0.208
3.925AsnVal: 3.925 ± 0.224
0.754AsnTrp: 0.754 ± 0.098
2.193AsnTyr: 2.193 ± 0.163
0.0AsnXaa: 0.0 ± 0.0
Pro
1.187ProAla: 1.187 ± 0.133
0.796ProCys: 0.796 ± 0.121
1.159ProAsp: 1.159 ± 0.133
1.383ProGlu: 1.383 ± 0.14
2.095ProPhe: 2.095 ± 0.133
1.02ProGly: 1.02 ± 0.124
0.447ProHis: 0.447 ± 0.072
2.473ProIle: 2.473 ± 0.144
1.606ProLys: 1.606 ± 0.17
3.688ProLeu: 3.688 ± 0.24
1.062ProMet: 1.062 ± 0.112
1.159ProAsn: 1.159 ± 0.128
0.894ProPro: 0.894 ± 0.152
0.685ProGln: 0.685 ± 0.101
1.467ProArg: 1.467 ± 0.129
1.704ProSer: 1.704 ± 0.156
1.299ProThr: 1.299 ± 0.137
1.984ProVal: 1.984 ± 0.146
0.419ProTrp: 0.419 ± 0.068
1.998ProTyr: 1.998 ± 0.185
0.0ProXaa: 0.0 ± 0.0
Gln
1.509GlnAla: 1.509 ± 0.14
0.866GlnCys: 0.866 ± 0.115
1.104GlnAsp: 1.104 ± 0.113
1.201GlnGlu: 1.201 ± 0.115
1.998GlnPhe: 1.998 ± 0.163
1.09GlnGly: 1.09 ± 0.142
0.601GlnHis: 0.601 ± 0.088
2.724GlnIle: 2.724 ± 0.208
1.816GlnLys: 1.816 ± 0.152
4.386GlnLeu: 4.386 ± 0.251
1.104GlnMet: 1.104 ± 0.117
1.537GlnAsn: 1.537 ± 0.138
0.866GlnPro: 0.866 ± 0.102
1.118GlnGln: 1.118 ± 0.129
1.495GlnArg: 1.495 ± 0.138
2.235GlnSer: 2.235 ± 0.17
1.299GlnThr: 1.299 ± 0.136
1.732GlnVal: 1.732 ± 0.146
0.307GlnTrp: 0.307 ± 0.073
1.118GlnTyr: 1.118 ± 0.11
0.0GlnXaa: 0.0 ± 0.0
Arg
2.123ArgAla: 2.123 ± 0.193
0.643ArgCys: 0.643 ± 0.102
2.263ArgAsp: 2.263 ± 0.154
2.263ArgGlu: 2.263 ± 0.203
2.067ArgPhe: 2.067 ± 0.161
1.662ArgGly: 1.662 ± 0.145
1.285ArgHis: 1.285 ± 0.119
4.275ArgIle: 4.275 ± 0.264
3.367ArgLys: 3.367 ± 0.199
4.736ArgLeu: 4.736 ± 0.252
1.132ArgMet: 1.132 ± 0.123
3.297ArgAsn: 3.297 ± 0.245
1.732ArgPro: 1.732 ± 0.144
1.718ArgGln: 1.718 ± 0.145
2.626ArgArg: 2.626 ± 0.199
3.381ArgSer: 3.381 ± 0.202
2.347ArgThr: 2.347 ± 0.196
2.64ArgVal: 2.64 ± 0.197
0.517ArgTrp: 0.517 ± 0.093
1.593ArgTyr: 1.593 ± 0.141
0.0ArgXaa: 0.0 ± 0.0
Ser
4.163SerAla: 4.163 ± 0.241
1.397SerCys: 1.397 ± 0.144
2.975SerAsp: 2.975 ± 0.18
3.353SerGlu: 3.353 ± 0.214
4.261SerPhe: 4.261 ± 0.268
3.297SerGly: 3.297 ± 0.179
1.676SerHis: 1.676 ± 0.124
6.775SerIle: 6.775 ± 0.3
3.8SerLys: 3.8 ± 0.207
8.926SerLeu: 8.926 ± 0.353
2.375SerMet: 2.375 ± 0.199
3.297SerAsn: 3.297 ± 0.209
2.207SerPro: 2.207 ± 0.154
2.179SerGln: 2.179 ± 0.188
3.52SerArg: 3.52 ± 0.24
5.406SerSer: 5.406 ± 0.287
4.959SerThr: 4.959 ± 0.225
5.448SerVal: 5.448 ± 0.273
1.243SerTrp: 1.243 ± 0.124
3.632SerTyr: 3.632 ± 0.25
0.0SerXaa: 0.0 ± 0.0
Thr
3.772ThrAla: 3.772 ± 0.232
1.397ThrCys: 1.397 ± 0.118
2.501ThrAsp: 2.501 ± 0.155
3.129ThrGlu: 3.129 ± 0.214
4.009ThrPhe: 4.009 ± 0.21
2.878ThrGly: 2.878 ± 0.179
0.964ThrHis: 0.964 ± 0.116
5.252ThrIle: 5.252 ± 0.279
3.017ThrLys: 3.017 ± 0.222
7.418ThrLeu: 7.418 ± 0.262
2.123ThrMet: 2.123 ± 0.162
2.598ThrAsn: 2.598 ± 0.164
1.551ThrPro: 1.551 ± 0.173
1.159ThrGln: 1.159 ± 0.135
2.193ThrArg: 2.193 ± 0.159
5.183ThrSer: 5.183 ± 0.225
4.107ThrThr: 4.107 ± 0.239
5.155ThrVal: 5.155 ± 0.28
1.02ThrTrp: 1.02 ± 0.143
3.087ThrTyr: 3.087 ± 0.186
0.0ThrXaa: 0.0 ± 0.0
Val
4.219ValAla: 4.219 ± 0.25
1.537ValCys: 1.537 ± 0.139
2.57ValAsp: 2.57 ± 0.136
3.087ValGlu: 3.087 ± 0.217
4.205ValPhe: 4.205 ± 0.252
3.185ValGly: 3.185 ± 0.16
1.243ValHis: 1.243 ± 0.116
6.342ValIle: 6.342 ± 0.286
3.101ValLys: 3.101 ± 0.209
8.382ValLeu: 8.382 ± 0.347
2.361ValMet: 2.361 ± 0.157
2.892ValAsn: 2.892 ± 0.185
1.984ValPro: 1.984 ± 0.18
2.626ValGln: 2.626 ± 0.196
2.528ValArg: 2.528 ± 0.234
4.582ValSer: 4.582 ± 0.257
5.252ValThr: 5.252 ± 0.252
4.61ValVal: 4.61 ± 0.271
1.006ValTrp: 1.006 ± 0.125
2.878ValTyr: 2.878 ± 0.174
0.0ValXaa: 0.0 ± 0.0
Trp
0.363TrpAla: 0.363 ± 0.072
0.14TrpCys: 0.14 ± 0.041
0.461TrpAsp: 0.461 ± 0.082
0.559TrpGlu: 0.559 ± 0.094
0.531TrpPhe: 0.531 ± 0.093
0.475TrpGly: 0.475 ± 0.082
0.391TrpHis: 0.391 ± 0.083
1.495TrpIle: 1.495 ± 0.145
0.81TrpLys: 0.81 ± 0.116
1.495TrpLeu: 1.495 ± 0.113
0.349TrpMet: 0.349 ± 0.072
0.908TrpAsn: 0.908 ± 0.102
0.782TrpPro: 0.782 ± 0.09
0.335TrpGln: 0.335 ± 0.071
0.838TrpArg: 0.838 ± 0.112
1.159TrpSer: 1.159 ± 0.102
1.104TrpThr: 1.104 ± 0.113
0.657TrpVal: 0.657 ± 0.096
0.321TrpTrp: 0.321 ± 0.074
1.313TrpTyr: 1.313 ± 0.111
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.584TyrAla: 2.584 ± 0.196
1.076TyrCys: 1.076 ± 0.102
1.788TyrAsp: 1.788 ± 0.165
2.221TyrGlu: 2.221 ± 0.174
2.989TyrPhe: 2.989 ± 0.217
1.844TyrGly: 1.844 ± 0.158
0.95TyrHis: 0.95 ± 0.117
3.688TyrIle: 3.688 ± 0.221
2.431TyrLys: 2.431 ± 0.177
4.959TyrLeu: 4.959 ± 0.249
1.006TyrMet: 1.006 ± 0.121
2.556TyrAsn: 2.556 ± 0.211
1.467TyrPro: 1.467 ± 0.142
1.327TyrGln: 1.327 ± 0.147
1.998TyrArg: 1.998 ± 0.161
4.135TyrSer: 4.135 ± 0.246
2.738TyrThr: 2.738 ± 0.23
3.269TyrVal: 3.269 ± 0.239
0.643TyrTrp: 0.643 ± 0.089
2.193TyrTyr: 2.193 ± 0.166
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 160 proteins (71586 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski