Amino acid dipepetide frequency for Sandarakinorhabdus sp. LB1R16

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.646AlaAla: 24.646 ± 0.241	1.109AlaCys: 1.109 ± 0.038	8.231AlaAsp: 8.231 ± 0.111	7.049AlaGlu: 7.049 ± 0.11	4.552AlaPhe: 4.552 ± 0.066	13.164AlaGly: 13.164 ± 0.164	2.444AlaHis: 2.444 ± 0.056	5.95AlaIle: 5.95 ± 0.089	4.093AlaLys: 4.093 ± 0.085	15.319AlaLeu: 15.319 ± 0.162	3.742AlaMet: 3.742 ± 0.072	3.203AlaAsn: 3.203 ± 0.081	7.23AlaPro: 7.23 ± 0.103	4.306AlaGln: 4.306 ± 0.068	11.21AlaArg: 11.21 ± 0.131	6.861AlaSer: 6.861 ± 0.091	8.352AlaThr: 8.352 ± 0.115	10.683AlaVal: 10.683 ± 0.121	1.943AlaTrp: 1.943 ± 0.047	2.727AlaTyr: 2.727 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	1.041CysAla: 1.041 ± 0.031	0.078CysCys: 0.078 ± 0.009	0.484CysAsp: 0.484 ± 0.024	0.377CysGlu: 0.377 ± 0.023	0.237CysPhe: 0.237 ± 0.015	0.85CysGly: 0.85 ± 0.028	0.181CysHis: 0.181 ± 0.019	0.334CysIle: 0.334 ± 0.018	0.124CysLys: 0.124 ± 0.011	0.601CysLeu: 0.601 ± 0.026	0.128CysMet: 0.128 ± 0.012	0.196CysAsn: 0.196 ± 0.014	0.415CysPro: 0.415 ± 0.02	0.161CysGln: 0.161 ± 0.011	0.517CysArg: 0.517 ± 0.025	0.377CysSer: 0.377 ± 0.022	0.417CysThr: 0.417 ± 0.022	0.582CysVal: 0.582 ± 0.028	0.081CysTrp: 0.081 ± 0.009	0.145CysTyr: 0.145 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	9.297AspAla: 9.297 ± 0.133	0.463AspCys: 0.463 ± 0.024	3.497AspAsp: 3.497 ± 0.065	2.93AspGlu: 2.93 ± 0.069	2.283AspPhe: 2.283 ± 0.054	6.022AspGly: 6.022 ± 0.089	1.071AspHis: 1.071 ± 0.032	2.669AspIle: 2.669 ± 0.055	1.384AspLys: 1.384 ± 0.039	5.963AspLeu: 5.963 ± 0.085	1.147AspMet: 1.147 ± 0.032	1.219AspAsn: 1.219 ± 0.034	3.717AspPro: 3.717 ± 0.063	1.406AspGln: 1.406 ± 0.038	4.779AspArg: 4.779 ± 0.072	2.051AspSer: 2.051 ± 0.042	3.017AspThr: 3.017 ± 0.056	4.23AspVal: 4.23 ± 0.073	1.166AspTrp: 1.166 ± 0.035	1.54AspTyr: 1.54 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	7.35GluAla: 7.35 ± 0.099	0.247GluCys: 0.247 ± 0.016	2.084GluAsp: 2.084 ± 0.046	1.811GluGlu: 1.811 ± 0.055	1.446GluPhe: 1.446 ± 0.042	3.989GluGly: 3.989 ± 0.069	0.919GluHis: 0.919 ± 0.03	2.55GluIle: 2.55 ± 0.052	1.31GluLys: 1.31 ± 0.042	4.609GluLeu: 4.609 ± 0.076	1.084GluMet: 1.084 ± 0.035	1.029GluAsn: 1.029 ± 0.033	2.414GluPro: 2.414 ± 0.056	1.48GluGln: 1.48 ± 0.039	4.348GluArg: 4.348 ± 0.068	1.673GluSer: 1.673 ± 0.041	3.01GluThr: 3.01 ± 0.053	3.563GluVal: 3.563 ± 0.065	0.669GluTrp: 0.669 ± 0.024	0.862GluTyr: 0.862 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	5.283PheAla: 5.283 ± 0.083	0.261PheCys: 0.261 ± 0.016	2.915PheAsp: 2.915 ± 0.062	1.989PheGlu: 1.989 ± 0.045	1.115PhePhe: 1.115 ± 0.037	3.897PheGly: 3.897 ± 0.082	0.611PheHis: 0.611 ± 0.026	1.387PheIle: 1.387 ± 0.037	0.88PheLys: 0.88 ± 0.028	2.653PheLeu: 2.653 ± 0.052	0.625PheMet: 0.625 ± 0.025	1.105PheAsn: 1.105 ± 0.038	1.363PhePro: 1.363 ± 0.04	0.802PheGln: 0.802 ± 0.029	2.065PheArg: 2.065 ± 0.047	1.714PheSer: 1.714 ± 0.045	2.238PheThr: 2.238 ± 0.055	2.917PheVal: 2.917 ± 0.052	0.493PheTrp: 0.493 ± 0.027	0.849PheTyr: 0.849 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	11.377GlyAla: 11.377 ± 0.148	0.85GlyCys: 0.85 ± 0.03	5.471GlyAsp: 5.471 ± 0.087	4.486GlyGlu: 4.486 ± 0.062	3.961GlyPhe: 3.961 ± 0.066	9.446GlyGly: 9.446 ± 0.175	1.78GlyHis: 1.78 ± 0.043	4.532GlyIle: 4.532 ± 0.079	2.93GlyLys: 2.93 ± 0.061	9.141GlyLeu: 9.141 ± 0.1	2.041GlyMet: 2.041 ± 0.05	2.326GlyAsn: 2.326 ± 0.087	4.086GlyPro: 4.086 ± 0.072	2.822GlyGln: 2.822 ± 0.057	6.74GlyArg: 6.74 ± 0.091	4.987GlySer: 4.987 ± 0.107	5.68GlyThr: 5.68 ± 0.173	7.546GlyVal: 7.546 ± 0.101	1.624GlyTrp: 1.624 ± 0.048	2.236GlyTyr: 2.236 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.641HisAla: 2.641 ± 0.054	0.187HisCys: 0.187 ± 0.013	1.225HisAsp: 1.225 ± 0.035	0.825HisGlu: 0.825 ± 0.028	0.675HisPhe: 0.675 ± 0.028	1.873HisGly: 1.873 ± 0.052	0.482HisHis: 0.482 ± 0.024	0.775HisIle: 0.775 ± 0.031	0.372HisLys: 0.372 ± 0.018	1.669HisLeu: 1.669 ± 0.038	0.355HisMet: 0.355 ± 0.019	0.4HisAsn: 0.4 ± 0.021	1.212HisPro: 1.212 ± 0.037	0.414HisGln: 0.414 ± 0.02	1.422HisArg: 1.422 ± 0.044	0.726HisSer: 0.726 ± 0.028	0.652HisThr: 0.652 ± 0.03	1.481HisVal: 1.481 ± 0.042	0.304HisTrp: 0.304 ± 0.016	0.458HisTyr: 0.458 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.67IleAla: 7.67 ± 0.087	0.324IleCys: 0.324 ± 0.018	3.893IleAsp: 3.893 ± 0.061	2.945IleGlu: 2.945 ± 0.055	1.318IlePhe: 1.318 ± 0.036	4.954IleGly: 4.954 ± 0.09	0.748IleHis: 0.748 ± 0.026	1.686IleIle: 1.686 ± 0.045	1.126IleLys: 1.126 ± 0.036	3.344IleLeu: 3.344 ± 0.059	0.667IleMet: 0.667 ± 0.029	1.216IleAsn: 1.216 ± 0.054	1.914IlePro: 1.914 ± 0.044	0.917IleGln: 0.917 ± 0.027	2.792IleArg: 2.792 ± 0.056	2.029IleSer: 2.029 ± 0.057	2.317IleThr: 2.317 ± 0.055	4.421IleVal: 4.421 ± 0.069	0.475IleTrp: 0.475 ± 0.021	0.905IleTyr: 0.905 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.61LysAla: 3.61 ± 0.077	0.131LysCys: 0.131 ± 0.011	1.296LysAsp: 1.296 ± 0.04	0.823LysGlu: 0.823 ± 0.037	0.852LysPhe: 0.852 ± 0.032	2.263LysGly: 2.263 ± 0.056	0.441LysHis: 0.441 ± 0.024	1.183LysIle: 1.183 ± 0.042	0.743LysLys: 0.743 ± 0.031	2.919LysLeu: 2.919 ± 0.064	0.597LysMet: 0.597 ± 0.026	0.575LysAsn: 0.575 ± 0.024	1.706LysPro: 1.706 ± 0.043	0.717LysGln: 0.717 ± 0.026	2.097LysArg: 2.097 ± 0.055	1.383LysSer: 1.383 ± 0.042	1.562LysThr: 1.562 ± 0.043	1.959LysVal: 1.959 ± 0.047	0.342LysTrp: 0.342 ± 0.018	0.612LysTyr: 0.612 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	14.943LeuAla: 14.943 ± 0.15	0.715LeuCys: 0.715 ± 0.026	6.534LeuAsp: 6.534 ± 0.086	3.858LeuGlu: 3.858 ± 0.073	3.427LeuPhe: 3.427 ± 0.06	9.0LeuGly: 9.0 ± 0.107	1.736LeuHis: 1.736 ± 0.045	4.704LeuIle: 4.704 ± 0.072	2.783LeuLys: 2.783 ± 0.057	9.563LeuLeu: 9.563 ± 0.129	1.897LeuMet: 1.897 ± 0.045	2.466LeuAsn: 2.466 ± 0.067	5.743LeuPro: 5.743 ± 0.084	2.31LeuGln: 2.31 ± 0.047	7.222LeuArg: 7.222 ± 0.093	5.52LeuSer: 5.52 ± 0.086	6.491LeuThr: 6.491 ± 0.092	7.511LeuVal: 7.511 ± 0.096	1.175LeuTrp: 1.175 ± 0.043	1.834LeuTyr: 1.834 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.814MetAla: 2.814 ± 0.055	0.129MetCys: 0.129 ± 0.01	0.843MetAsp: 0.843 ± 0.029	0.688MetGlu: 0.688 ± 0.03	0.597MetPhe: 0.597 ± 0.025	1.642MetGly: 1.642 ± 0.04	0.432MetHis: 0.432 ± 0.021	1.174MetIle: 1.174 ± 0.038	0.722MetLys: 0.722 ± 0.028	2.239MetLeu: 2.239 ± 0.053	0.511MetMet: 0.511 ± 0.024	0.512MetAsn: 0.512 ± 0.019	1.284MetPro: 1.284 ± 0.032	0.648MetGln: 0.648 ± 0.025	1.7MetArg: 1.7 ± 0.043	1.24MetSer: 1.24 ± 0.035	1.766MetThr: 1.766 ± 0.045	1.403MetVal: 1.403 ± 0.038	0.194MetTrp: 0.194 ± 0.013	0.269MetTyr: 0.269 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.255AsnAla: 3.255 ± 0.062	0.214AsnCys: 0.214 ± 0.016	1.329AsnAsp: 1.329 ± 0.045	0.935AsnGlu: 0.935 ± 0.031	0.959AsnPhe: 0.959 ± 0.036	2.347AsnGly: 2.347 ± 0.085	0.395AsnHis: 0.395 ± 0.021	1.247AsnIle: 1.247 ± 0.045	0.563AsnLys: 0.563 ± 0.025	2.392AsnLeu: 2.392 ± 0.071	0.46AsnMet: 0.46 ± 0.021	0.713AsnAsn: 0.713 ± 0.048	1.616AsnPro: 1.616 ± 0.043	0.655AsnGln: 0.655 ± 0.034	1.641AsnArg: 1.641 ± 0.037	1.167AsnSer: 1.167 ± 0.058	1.303AsnThr: 1.303 ± 0.054	1.845AsnVal: 1.845 ± 0.047	0.363AsnTrp: 0.363 ± 0.02	0.674AsnTyr: 0.674 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	8.143ProAla: 8.143 ± 0.108	0.329ProCys: 0.329 ± 0.018	3.726ProAsp: 3.726 ± 0.059	3.119ProGlu: 3.119 ± 0.047	1.861ProPhe: 1.861 ± 0.043	5.542ProGly: 5.542 ± 0.082	1.011ProHis: 1.011 ± 0.032	1.988ProIle: 1.988 ± 0.047	1.317ProLys: 1.317 ± 0.038	5.089ProLeu: 5.089 ± 0.077	1.035ProMet: 1.035 ± 0.029	1.216ProAsn: 1.216 ± 0.034	3.331ProPro: 3.331 ± 0.088	1.533ProGln: 1.533 ± 0.041	3.516ProArg: 3.516 ± 0.07	2.454ProSer: 2.454 ± 0.046	2.77ProThr: 2.77 ± 0.078	4.661ProVal: 4.661 ± 0.079	0.7ProTrp: 0.7 ± 0.024	1.089ProTyr: 1.089 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.864GlnAla: 3.864 ± 0.063	0.177GlnCys: 0.177 ± 0.014	1.135GlnAsp: 1.135 ± 0.034	0.882GlnGlu: 0.882 ± 0.026	1.023GlnPhe: 1.023 ± 0.035	2.47GlnGly: 2.47 ± 0.06	0.468GlnHis: 0.468 ± 0.024	1.478GlnIle: 1.478 ± 0.034	0.632GlnLys: 0.632 ± 0.027	2.895GlnLeu: 2.895 ± 0.059	0.587GlnMet: 0.587 ± 0.022	0.626GlnAsn: 0.626 ± 0.027	1.66GlnPro: 1.66 ± 0.036	0.89GlnGln: 0.89 ± 0.031	2.184GlnArg: 2.184 ± 0.053	1.486GlnSer: 1.486 ± 0.043	1.457GlnThr: 1.457 ± 0.038	2.254GlnVal: 2.254 ± 0.05	0.337GlnTrp: 0.337 ± 0.018	0.594GlnTyr: 0.594 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	10.206ArgAla: 10.206 ± 0.145	0.518ArgCys: 0.518 ± 0.022	4.575ArgAsp: 4.575 ± 0.082	3.419ArgGlu: 3.419 ± 0.06	3.052ArgPhe: 3.052 ± 0.059	5.694ArgGly: 5.694 ± 0.075	1.526ArgHis: 1.526 ± 0.045	3.912ArgIle: 3.912 ± 0.06	1.644ArgLys: 1.644 ± 0.044	8.511ArgLeu: 8.511 ± 0.107	1.686ArgMet: 1.686 ± 0.042	1.673ArgAsn: 1.673 ± 0.049	3.75ArgPro: 3.75 ± 0.07	2.05ArgGln: 2.05 ± 0.049	6.075ArgArg: 6.075 ± 0.105	3.481ArgSer: 3.481 ± 0.055	4.092ArgThr: 4.092 ± 0.068	5.668ArgVal: 5.668 ± 0.076	1.188ArgTrp: 1.188 ± 0.034	1.788ArgTyr: 1.788 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	6.191SerAla: 6.191 ± 0.084	0.37SerCys: 0.37 ± 0.021	2.713SerAsp: 2.713 ± 0.054	2.083SerGlu: 2.083 ± 0.049	2.097SerPhe: 2.097 ± 0.049	5.301SerGly: 5.301 ± 0.107	0.823SerHis: 0.823 ± 0.027	2.342SerIle: 2.342 ± 0.059	1.215SerLys: 1.215 ± 0.037	4.758SerLeu: 4.758 ± 0.068	0.962SerMet: 0.962 ± 0.032	1.249SerAsn: 1.249 ± 0.041	2.702SerPro: 2.702 ± 0.051	1.277SerGln: 1.277 ± 0.038	3.197SerArg: 3.197 ± 0.057	2.417SerSer: 2.417 ± 0.056	2.528SerThr: 2.528 ± 0.054	3.92SerVal: 3.92 ± 0.059	0.701SerTrp: 0.701 ± 0.031	1.271SerTyr: 1.271 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	7.953ThrAla: 7.953 ± 0.105	0.393ThrCys: 0.393 ± 0.018	3.009ThrAsp: 3.009 ± 0.054	2.226ThrGlu: 2.226 ± 0.051	1.794ThrPhe: 1.794 ± 0.053	6.21ThrGly: 6.21 ± 0.126	0.991ThrHis: 0.991 ± 0.034	2.928ThrIle: 2.928 ± 0.063	1.236ThrLys: 1.236 ± 0.043	6.533ThrLeu: 6.533 ± 0.102	1.171ThrMet: 1.171 ± 0.034	1.417ThrAsn: 1.417 ± 0.064	4.043ThrPro: 4.043 ± 0.085	1.454ThrGln: 1.454 ± 0.033	4.01ThrArg: 4.01 ± 0.062	2.737ThrSer: 2.737 ± 0.06	3.427ThrThr: 3.427 ± 0.093	4.825ThrVal: 4.825 ± 0.088	0.695ThrTrp: 0.695 ± 0.026	1.271ThrTyr: 1.271 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	12.186ValAla: 12.186 ± 0.127	0.55ValCys: 0.55 ± 0.024	4.657ValAsp: 4.657 ± 0.07	4.467ValGlu: 4.467 ± 0.063	2.549ValPhe: 2.549 ± 0.045	6.231ValGly: 6.231 ± 0.089	1.379ValHis: 1.379 ± 0.039	3.509ValIle: 3.509 ± 0.056	1.841ValLys: 1.841 ± 0.046	7.216ValLeu: 7.216 ± 0.093	1.476ValMet: 1.476 ± 0.043	1.932ValAsn: 1.932 ± 0.057	4.499ValPro: 4.499 ± 0.071	2.014ValGln: 2.014 ± 0.043	5.914ValArg: 5.914 ± 0.088	3.933ValSer: 3.933 ± 0.057	5.252ValThr: 5.252 ± 0.085	6.632ValVal: 6.632 ± 0.092	0.963ValTrp: 0.963 ± 0.027	1.401ValTyr: 1.401 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.544TrpAla: 1.544 ± 0.041	0.11TrpCys: 0.11 ± 0.01	0.72TrpAsp: 0.72 ± 0.03	0.51TrpGlu: 0.51 ± 0.023	0.504TrpPhe: 0.504 ± 0.021	1.003TrpGly: 1.003 ± 0.034	0.31TrpHis: 0.31 ± 0.017	0.536TrpIle: 0.536 ± 0.021	0.357TrpLys: 0.357 ± 0.021	1.886TrpLeu: 1.886 ± 0.049	0.285TrpMet: 0.285 ± 0.018	0.39TrpAsn: 0.39 ± 0.023	0.735TrpPro: 0.735 ± 0.029	0.604TrpGln: 0.604 ± 0.023	1.233TrpArg: 1.233 ± 0.042	0.854TrpSer: 0.854 ± 0.032	0.946TrpThr: 0.946 ± 0.032	0.911TrpVal: 0.911 ± 0.033	0.261TrpTrp: 0.261 ± 0.016	0.287TrpTyr: 0.287 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.799TyrAla: 2.799 ± 0.051	0.172TyrCys: 0.172 ± 0.013	1.513TyrAsp: 1.513 ± 0.04	1.027TyrGlu: 1.027 ± 0.033	0.858TyrPhe: 0.858 ± 0.027	2.162TyrGly: 2.162 ± 0.046	0.402TyrHis: 0.402 ± 0.021	0.779TyrIle: 0.779 ± 0.025	0.54TyrLys: 0.54 ± 0.029	2.134TyrLeu: 2.134 ± 0.047	0.35TyrMet: 0.35 ± 0.02	0.609TyrAsn: 0.609 ± 0.032	1.011TyrPro: 1.011 ± 0.032	0.635TyrGln: 0.635 ± 0.025	1.849TyrArg: 1.849 ± 0.048	1.029TyrSer: 1.029 ± 0.034	1.046TyrThr: 1.046 ± 0.032	1.585TyrVal: 1.585 ± 0.038	0.311TyrTrp: 0.311 ± 0.019	0.54TyrTyr: 0.54 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3247 proteins (1057848 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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