Amino acid dipepetide frequency for Bacteriovorax sp. Seq25_V

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.87AlaAla: 3.87 ± 0.085	0.73AlaCys: 0.73 ± 0.028	3.105AlaAsp: 3.105 ± 0.052	3.524AlaGlu: 3.524 ± 0.07	2.757AlaPhe: 2.757 ± 0.056	3.958AlaGly: 3.958 ± 0.078	1.174AlaHis: 1.174 ± 0.037	4.767AlaIle: 4.767 ± 0.079	5.36AlaLys: 5.36 ± 0.086	6.255AlaLeu: 6.255 ± 0.081	1.591AlaMet: 1.591 ± 0.04	2.977AlaAsn: 2.977 ± 0.066	2.052AlaPro: 2.052 ± 0.053	2.145AlaGln: 2.145 ± 0.06	2.396AlaArg: 2.396 ± 0.051	4.511AlaSer: 4.511 ± 0.075	3.447AlaThr: 3.447 ± 0.084	3.403AlaVal: 3.403 ± 0.061	0.464AlaTrp: 0.464 ± 0.021	1.981AlaTyr: 1.981 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.688CysAla: 0.688 ± 0.029	0.118CysCys: 0.118 ± 0.013	0.689CysAsp: 0.689 ± 0.023	0.769CysGlu: 0.769 ± 0.024	0.626CysPhe: 0.626 ± 0.024	0.751CysGly: 0.751 ± 0.03	0.33CysHis: 0.33 ± 0.022	0.7CysIle: 0.7 ± 0.025	0.663CysLys: 0.663 ± 0.023	1.04CysLeu: 1.04 ± 0.034	0.235CysMet: 0.235 ± 0.014	0.517CysAsn: 0.517 ± 0.024	0.492CysPro: 0.492 ± 0.025	0.369CysGln: 0.369 ± 0.021	0.395CysArg: 0.395 ± 0.022	0.914CysSer: 0.914 ± 0.033	0.635CysThr: 0.635 ± 0.036	0.594CysVal: 0.594 ± 0.025	0.103CysTrp: 0.103 ± 0.011	0.348CysTyr: 0.348 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.189AspAla: 3.189 ± 0.06	0.631AspCys: 0.631 ± 0.026	3.179AspAsp: 3.179 ± 0.06	4.334AspGlu: 4.334 ± 0.077	3.49AspPhe: 3.49 ± 0.064	3.569AspGly: 3.569 ± 0.087	1.18AspHis: 1.18 ± 0.034	4.849AspIle: 4.849 ± 0.065	4.313AspLys: 4.313 ± 0.075	5.949AspLeu: 5.949 ± 0.085	1.203AspMet: 1.203 ± 0.028	2.632AspAsn: 2.632 ± 0.05	1.761AspPro: 1.761 ± 0.042	1.841AspGln: 1.841 ± 0.037	2.164AspArg: 2.164 ± 0.049	3.972AspSer: 3.972 ± 0.069	2.518AspThr: 2.518 ± 0.059	3.453AspVal: 3.453 ± 0.059	0.505AspTrp: 0.505 ± 0.022	2.668AspTyr: 2.668 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	4.237GluAla: 4.237 ± 0.08	0.646GluCys: 0.646 ± 0.026	3.906GluAsp: 3.906 ± 0.081	5.435GluGlu: 5.435 ± 0.113	3.443GluPhe: 3.443 ± 0.064	3.716GluGly: 3.716 ± 0.059	1.2GluHis: 1.2 ± 0.038	5.988GluIle: 5.988 ± 0.09	6.559GluLys: 6.559 ± 0.11	7.258GluLeu: 7.258 ± 0.103	1.719GluMet: 1.719 ± 0.041	4.177GluAsn: 4.177 ± 0.071	1.297GluPro: 1.297 ± 0.034	2.064GluGln: 2.064 ± 0.051	2.907GluArg: 2.907 ± 0.059	4.443GluSer: 4.443 ± 0.072	3.335GluThr: 3.335 ± 0.056	5.17GluVal: 5.17 ± 0.084	0.527GluTrp: 0.527 ± 0.023	2.569GluTyr: 2.569 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	3.086PheAla: 3.086 ± 0.049	0.642PheCys: 0.642 ± 0.026	3.333PheAsp: 3.333 ± 0.069	3.672PheGlu: 3.672 ± 0.059	2.917PhePhe: 2.917 ± 0.066	3.15PheGly: 3.15 ± 0.054	0.977PheHis: 0.977 ± 0.033	3.966PheIle: 3.966 ± 0.069	4.236PheLys: 4.236 ± 0.07	5.043PheLeu: 5.043 ± 0.086	1.147PheMet: 1.147 ± 0.035	3.079PheAsn: 3.079 ± 0.065	1.659PhePro: 1.659 ± 0.046	1.475PheGln: 1.475 ± 0.031	1.641PheArg: 1.641 ± 0.047	4.395PheSer: 4.395 ± 0.074	2.653PheThr: 2.653 ± 0.06	2.98PheVal: 2.98 ± 0.054	0.508PheTrp: 0.508 ± 0.026	2.224PheTyr: 2.224 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	3.992GlyAla: 3.992 ± 0.074	0.72GlyCys: 0.72 ± 0.028	3.394GlyAsp: 3.394 ± 0.069	4.153GlyGlu: 4.153 ± 0.069	2.93GlyPhe: 2.93 ± 0.056	4.031GlyGly: 4.031 ± 0.096	1.474GlyHis: 1.474 ± 0.038	4.649GlyIle: 4.649 ± 0.072	4.793GlyLys: 4.793 ± 0.081	5.903GlyLeu: 5.903 ± 0.081	1.466GlyMet: 1.466 ± 0.044	2.914GlyAsn: 2.914 ± 0.07	1.637GlyPro: 1.637 ± 0.042	2.056GlyGln: 2.056 ± 0.048	2.289GlyArg: 2.289 ± 0.054	4.015GlySer: 4.015 ± 0.09	3.409GlyThr: 3.409 ± 0.086	4.312GlyVal: 4.312 ± 0.071	0.459GlyTrp: 0.459 ± 0.028	2.174GlyTyr: 2.174 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.02HisAla: 1.02 ± 0.03	0.248HisCys: 0.248 ± 0.015	1.036HisAsp: 1.036 ± 0.033	1.288HisGlu: 1.288 ± 0.031	1.12HisPhe: 1.12 ± 0.029	1.306HisGly: 1.306 ± 0.038	0.51HisHis: 0.51 ± 0.027	1.422HisIle: 1.422 ± 0.035	1.074HisLys: 1.074 ± 0.034	1.831HisLeu: 1.831 ± 0.048	0.396HisMet: 0.396 ± 0.023	0.807HisAsn: 0.807 ± 0.028	0.864HisPro: 0.864 ± 0.032	0.659HisGln: 0.659 ± 0.022	0.762HisArg: 0.762 ± 0.027	1.238HisSer: 1.238 ± 0.036	0.858HisThr: 0.858 ± 0.03	0.961HisVal: 0.961 ± 0.028	0.147HisTrp: 0.147 ± 0.012	0.747HisTyr: 0.747 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	4.803IleAla: 4.803 ± 0.07	0.875IleCys: 0.875 ± 0.031	5.075IleAsp: 5.075 ± 0.068	5.739IleGlu: 5.739 ± 0.087	4.141IlePhe: 4.141 ± 0.074	4.567IleGly: 4.567 ± 0.089	1.364IleHis: 1.364 ± 0.045	5.555IleIle: 5.555 ± 0.097	6.191IleLys: 6.191 ± 0.077	7.175IleLeu: 7.175 ± 0.109	1.362IleMet: 1.362 ± 0.039	4.42IleAsn: 4.42 ± 0.069	2.883IlePro: 2.883 ± 0.05	2.218IleGln: 2.218 ± 0.047	2.693IleArg: 2.693 ± 0.051	6.658IleSer: 6.658 ± 0.089	4.145IleThr: 4.145 ± 0.075	4.505IleVal: 4.505 ± 0.076	0.544IleTrp: 0.544 ± 0.023	2.736IleTyr: 2.736 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	4.772LysAla: 4.772 ± 0.094	0.652LysCys: 0.652 ± 0.025	4.93LysAsp: 4.93 ± 0.078	6.7LysGlu: 6.7 ± 0.108	3.827LysPhe: 3.827 ± 0.069	4.09LysGly: 4.09 ± 0.073	1.268LysHis: 1.268 ± 0.032	6.938LysIle: 6.938 ± 0.084	7.896LysLys: 7.896 ± 0.135	7.753LysLeu: 7.753 ± 0.093	2.072LysMet: 2.072 ± 0.049	5.326LysAsn: 5.326 ± 0.077	1.88LysPro: 1.88 ± 0.045	2.153LysGln: 2.153 ± 0.055	3.255LysArg: 3.255 ± 0.069	5.74LysSer: 5.74 ± 0.094	4.235LysThr: 4.235 ± 0.07	5.399LysVal: 5.399 ± 0.072	0.661LysTrp: 0.661 ± 0.027	3.221LysTyr: 3.221 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	6.104LeuAla: 6.104 ± 0.085	1.062LeuCys: 1.062 ± 0.03	5.571LeuAsp: 5.571 ± 0.08	6.941LeuGlu: 6.941 ± 0.1	4.799LeuPhe: 4.799 ± 0.087	6.22LeuGly: 6.22 ± 0.087	1.478LeuHis: 1.478 ± 0.037	6.979LeuIle: 6.979 ± 0.093	8.504LeuLys: 8.504 ± 0.102	8.763LeuLeu: 8.763 ± 0.117	2.21LeuMet: 2.21 ± 0.047	5.578LeuAsn: 5.578 ± 0.079	3.18LeuPro: 3.18 ± 0.061	2.742LeuGln: 2.742 ± 0.049	3.783LeuArg: 3.783 ± 0.068	8.173LeuSer: 8.173 ± 0.098	5.217LeuThr: 5.217 ± 0.079	5.79LeuVal: 5.79 ± 0.078	0.73LeuTrp: 0.73 ± 0.025	3.029LeuTyr: 3.029 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	1.687MetAla: 1.687 ± 0.038	0.19MetCys: 0.19 ± 0.013	1.137MetAsp: 1.137 ± 0.034	1.251MetGlu: 1.251 ± 0.039	0.895MetPhe: 0.895 ± 0.032	1.441MetGly: 1.441 ± 0.043	0.309MetHis: 0.309 ± 0.019	1.715MetIle: 1.715 ± 0.038	2.512MetLys: 2.512 ± 0.053	1.839MetLeu: 1.839 ± 0.045	0.596MetMet: 0.596 ± 0.026	1.364MetAsn: 1.364 ± 0.033	0.819MetPro: 0.819 ± 0.029	0.627MetGln: 0.627 ± 0.025	0.95MetArg: 0.95 ± 0.025	1.771MetSer: 1.771 ± 0.041	1.387MetThr: 1.387 ± 0.034	1.25MetVal: 1.25 ± 0.038	0.153MetTrp: 0.153 ± 0.012	0.54MetTyr: 0.54 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.753AsnAla: 2.753 ± 0.057	0.642AsnCys: 0.642 ± 0.029	2.971AsnAsp: 2.971 ± 0.054	3.696AsnGlu: 3.696 ± 0.067	3.385AsnPhe: 3.385 ± 0.058	3.267AsnGly: 3.267 ± 0.072	0.957AsnHis: 0.957 ± 0.029	4.751AsnIle: 4.751 ± 0.065	4.088AsnLys: 4.088 ± 0.071	5.513AsnLeu: 5.513 ± 0.072	1.101AsnMet: 1.101 ± 0.034	2.806AsnAsn: 2.806 ± 0.078	2.008AsnPro: 2.008 ± 0.052	1.787AsnGln: 1.787 ± 0.043	1.915AsnArg: 1.915 ± 0.044	4.037AsnSer: 4.037 ± 0.071	2.688AsnThr: 2.688 ± 0.062	2.993AsnVal: 2.993 ± 0.048	0.54AsnTrp: 0.54 ± 0.021	2.407AsnTyr: 2.407 ± 0.057	0.0AsnXaa: 0.0 ± 0.0
Pro	1.852ProAla: 1.852 ± 0.051	0.293ProCys: 0.293 ± 0.016	1.601ProAsp: 1.601 ± 0.043	2.48ProGlu: 2.48 ± 0.058	1.769ProPhe: 1.769 ± 0.038	1.957ProGly: 1.957 ± 0.051	0.61ProHis: 0.61 ± 0.023	2.401ProIle: 2.401 ± 0.053	2.343ProLys: 2.343 ± 0.042	2.988ProLeu: 2.988 ± 0.059	0.749ProMet: 0.749 ± 0.028	1.59ProAsn: 1.59 ± 0.04	0.796ProPro: 0.796 ± 0.035	0.934ProGln: 0.934 ± 0.032	1.044ProArg: 1.044 ± 0.034	2.308ProSer: 2.308 ± 0.058	1.797ProThr: 1.797 ± 0.059	2.255ProVal: 2.255 ± 0.054	0.327ProTrp: 0.327 ± 0.018	1.204ProTyr: 1.204 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	2.155GlnAla: 2.155 ± 0.048	0.296GlnCys: 0.296 ± 0.02	1.661GlnAsp: 1.661 ± 0.041	2.116GlnGlu: 2.116 ± 0.048	1.427GlnPhe: 1.427 ± 0.032	1.77GlnGly: 1.77 ± 0.039	0.407GlnHis: 0.407 ± 0.02	2.508GlnIle: 2.508 ± 0.055	2.741GlnLys: 2.741 ± 0.058	2.646GlnLeu: 2.646 ± 0.053	0.82GlnMet: 0.82 ± 0.031	1.722GlnAsn: 1.722 ± 0.044	0.611GlnPro: 0.611 ± 0.027	0.871GlnGln: 0.871 ± 0.037	1.367GlnArg: 1.367 ± 0.039	2.015GlnSer: 2.015 ± 0.047	1.686GlnThr: 1.686 ± 0.04	2.053GlnVal: 2.053 ± 0.044	0.26GlnTrp: 0.26 ± 0.015	1.076GlnTyr: 1.076 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.476ArgAla: 2.476 ± 0.053	0.317ArgCys: 0.317 ± 0.02	2.348ArgAsp: 2.348 ± 0.046	3.031ArgGlu: 3.031 ± 0.056	1.958ArgPhe: 1.958 ± 0.046	2.155ArgGly: 2.155 ± 0.046	0.624ArgHis: 0.624 ± 0.026	2.894ArgIle: 2.894 ± 0.056	2.994ArgLys: 2.994 ± 0.057	3.501ArgLeu: 3.501 ± 0.052	0.881ArgMet: 0.881 ± 0.033	2.054ArgAsn: 2.054 ± 0.046	1.371ArgPro: 1.371 ± 0.038	1.025ArgGln: 1.025 ± 0.033	1.597ArgArg: 1.597 ± 0.04	2.536ArgSer: 2.536 ± 0.049	1.846ArgThr: 1.846 ± 0.045	2.627ArgVal: 2.627 ± 0.056	0.326ArgTrp: 0.326 ± 0.018	1.467ArgTyr: 1.467 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	4.088SerAla: 4.088 ± 0.077	1.063SerCys: 1.063 ± 0.039	4.054SerAsp: 4.054 ± 0.069	4.832SerGlu: 4.832 ± 0.075	4.657SerPhe: 4.657 ± 0.066	4.662SerGly: 4.662 ± 0.09	1.431SerHis: 1.431 ± 0.043	5.613SerIle: 5.613 ± 0.093	6.188SerLys: 6.188 ± 0.08	7.841SerLeu: 7.841 ± 0.109	1.57SerMet: 1.57 ± 0.039	3.932SerAsn: 3.932 ± 0.08	2.255SerPro: 2.255 ± 0.05	2.236SerGln: 2.236 ± 0.049	2.781SerArg: 2.781 ± 0.057	6.052SerSer: 6.052 ± 0.105	3.934SerThr: 3.934 ± 0.089	4.278SerVal: 4.278 ± 0.072	0.69SerTrp: 0.69 ± 0.03	2.991SerTyr: 2.991 ± 0.061	0.0SerXaa: 0.0 ± 0.0
Thr	3.156ThrAla: 3.156 ± 0.067	0.603ThrCys: 0.603 ± 0.032	2.926ThrAsp: 2.926 ± 0.066	3.215ThrGlu: 3.215 ± 0.057	2.793ThrPhe: 2.793 ± 0.049	3.533ThrGly: 3.533 ± 0.072	0.986ThrHis: 0.986 ± 0.03	4.023ThrIle: 4.023 ± 0.07	4.021ThrLys: 4.021 ± 0.071	5.252ThrLeu: 5.252 ± 0.078	1.019ThrMet: 1.019 ± 0.031	2.766ThrAsn: 2.766 ± 0.063	2.202ThrPro: 2.202 ± 0.059	1.517ThrGln: 1.517 ± 0.045	1.946ThrArg: 1.946 ± 0.04	3.935ThrSer: 3.935 ± 0.091	3.182ThrThr: 3.182 ± 0.089	3.172ThrVal: 3.172 ± 0.073	0.455ThrTrp: 0.455 ± 0.022	2.006ThrTyr: 2.006 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	4.006ValAla: 4.006 ± 0.074	0.717ValCys: 0.717 ± 0.028	3.881ValAsp: 3.881 ± 0.076	4.457ValGlu: 4.457 ± 0.079	3.064ValPhe: 3.064 ± 0.059	3.808ValGly: 3.808 ± 0.065	1.048ValHis: 1.048 ± 0.035	4.75ValIle: 4.75 ± 0.065	4.862ValLys: 4.862 ± 0.077	5.739ValLeu: 5.739 ± 0.078	1.285ValMet: 1.285 ± 0.04	3.232ValAsn: 3.232 ± 0.068	1.934ValPro: 1.934 ± 0.055	1.738ValGln: 1.738 ± 0.046	2.249ValArg: 2.249 ± 0.049	4.983ValSer: 4.983 ± 0.071	3.37ValThr: 3.37 ± 0.065	4.149ValVal: 4.149 ± 0.071	0.482ValTrp: 0.482 ± 0.021	2.009ValTyr: 2.009 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.563TrpAla: 0.563 ± 0.022	0.092TrpCys: 0.092 ± 0.01	0.446TrpAsp: 0.446 ± 0.018	0.491TrpGlu: 0.491 ± 0.02	0.414TrpPhe: 0.414 ± 0.022	0.596TrpGly: 0.596 ± 0.027	0.189TrpHis: 0.189 ± 0.014	0.58TrpIle: 0.58 ± 0.022	0.645TrpLys: 0.645 ± 0.025	0.767TrpLeu: 0.767 ± 0.03	0.238TrpMet: 0.238 ± 0.015	0.484TrpAsn: 0.484 ± 0.019	0.255TrpPro: 0.255 ± 0.016	0.3TrpGln: 0.3 ± 0.019	0.31TrpArg: 0.31 ± 0.019	0.568TrpSer: 0.568 ± 0.025	0.48TrpThr: 0.48 ± 0.023	0.471TrpVal: 0.471 ± 0.022	0.11TrpTrp: 0.11 ± 0.011	0.299TrpTyr: 0.299 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.969TyrAla: 1.969 ± 0.042	0.441TyrCys: 0.441 ± 0.018	2.158TyrAsp: 2.158 ± 0.051	2.47TyrGlu: 2.47 ± 0.056	2.372TyrPhe: 2.372 ± 0.061	2.223TyrGly: 2.223 ± 0.049	0.781TyrHis: 0.781 ± 0.027	2.6TyrIle: 2.6 ± 0.055	2.783TyrLys: 2.783 ± 0.058	3.795TyrLeu: 3.795 ± 0.062	0.772TyrMet: 0.772 ± 0.027	1.928TyrAsn: 1.928 ± 0.045	1.341TyrPro: 1.341 ± 0.042	1.451TyrGln: 1.451 ± 0.039	1.583TyrArg: 1.583 ± 0.041	2.883TyrSer: 2.883 ± 0.053	1.887TyrThr: 1.887 ± 0.051	1.95TyrVal: 1.95 ± 0.042	0.311TyrTrp: 0.311 ± 0.018	1.551TyrTyr: 1.551 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3292 proteins (1059612 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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