Amino acid dipepetide frequency for Arsukibacterium sp. MJ3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.454AlaAla: 11.454 ± 0.135
1.056AlaCys: 1.056 ± 0.032
5.971AlaAsp: 5.971 ± 0.069
6.656AlaGlu: 6.656 ± 0.086
3.641AlaPhe: 3.641 ± 0.058
7.5AlaGly: 7.5 ± 0.084
1.694AlaHis: 1.694 ± 0.04
6.498AlaIle: 6.498 ± 0.086
4.728AlaLys: 4.728 ± 0.079
12.015AlaLeu: 12.015 ± 0.144
2.671AlaMet: 2.671 ± 0.049
4.12AlaAsn: 4.12 ± 0.066
3.381AlaPro: 3.381 ± 0.058
4.592AlaGln: 4.592 ± 0.071
4.485AlaArg: 4.485 ± 0.074
6.001AlaSer: 6.001 ± 0.072
5.232AlaThr: 5.232 ± 0.071
6.842AlaVal: 6.842 ± 0.077
1.079AlaTrp: 1.079 ± 0.034
2.579AlaTyr: 2.579 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
0.864CysAla: 0.864 ± 0.026
0.168CysCys: 0.168 ± 0.014
0.508CysAsp: 0.508 ± 0.021
0.394CysGlu: 0.394 ± 0.02
0.458CysPhe: 0.458 ± 0.021
0.783CysGly: 0.783 ± 0.028
0.321CysHis: 0.321 ± 0.02
0.504CysIle: 0.504 ± 0.017
0.355CysLys: 0.355 ± 0.02
0.979CysLeu: 0.979 ± 0.027
0.179CysMet: 0.179 ± 0.013
0.353CysAsn: 0.353 ± 0.018
0.451CysPro: 0.451 ± 0.024
0.68CysGln: 0.68 ± 0.027
0.503CysArg: 0.503 ± 0.023
0.681CysSer: 0.681 ± 0.024
0.433CysThr: 0.433 ± 0.02
0.51CysVal: 0.51 ± 0.023
0.169CysTrp: 0.169 ± 0.013
0.351CysTyr: 0.351 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
4.711AspAla: 4.711 ± 0.065
0.472AspCys: 0.472 ± 0.022
2.745AspAsp: 2.745 ± 0.063
2.947AspGlu: 2.947 ± 0.058
2.32AspPhe: 2.32 ± 0.049
3.49AspGly: 3.49 ± 0.07
0.921AspHis: 0.921 ± 0.032
4.022AspIle: 4.022 ± 0.064
2.697AspLys: 2.697 ± 0.053
4.729AspLeu: 4.729 ± 0.061
1.252AspMet: 1.252 ± 0.033
2.679AspAsn: 2.679 ± 0.059
1.984AspPro: 1.984 ± 0.042
1.856AspGln: 1.856 ± 0.041
1.993AspArg: 1.993 ± 0.04
3.081AspSer: 3.081 ± 0.057
2.626AspThr: 2.626 ± 0.052
3.429AspVal: 3.429 ± 0.067
0.874AspTrp: 0.874 ± 0.028
2.017AspTyr: 2.017 ± 0.049
0.0AspXaa: 0.0 ± 0.0
Glu
4.366GluAla: 4.366 ± 0.067
0.32GluCys: 0.32 ± 0.018
2.036GluAsp: 2.036 ± 0.047
2.051GluGlu: 2.051 ± 0.06
2.076GluPhe: 2.076 ± 0.043
2.635GluGly: 2.635 ± 0.058
1.549GluHis: 1.549 ± 0.036
2.735GluIle: 2.735 ± 0.053
2.448GluLys: 2.448 ± 0.056
6.952GluLeu: 6.952 ± 0.103
1.34GluMet: 1.34 ± 0.039
1.869GluAsn: 1.869 ± 0.043
2.124GluPro: 2.124 ± 0.046
5.045GluGln: 5.045 ± 0.084
3.066GluArg: 3.066 ± 0.057
2.188GluSer: 2.188 ± 0.049
2.361GluThr: 2.361 ± 0.045
3.475GluVal: 3.475 ± 0.063
0.546GluTrp: 0.546 ± 0.024
1.377GluTyr: 1.377 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
4.204PheAla: 4.204 ± 0.067
0.501PheCys: 0.501 ± 0.022
2.358PheAsp: 2.358 ± 0.044
1.958PheGlu: 1.958 ± 0.049
1.635PhePhe: 1.635 ± 0.046
3.175PheGly: 3.175 ± 0.069
0.742PheHis: 0.742 ± 0.028
2.697PheIle: 2.697 ± 0.052
1.715PheLys: 1.715 ± 0.041
3.248PheLeu: 3.248 ± 0.05
0.984PheMet: 0.984 ± 0.034
2.183PheAsn: 2.183 ± 0.047
1.275PhePro: 1.275 ± 0.037
1.328PheGln: 1.328 ± 0.032
1.597PheArg: 1.597 ± 0.034
3.567PheSer: 3.567 ± 0.062
2.336PheThr: 2.336 ± 0.044
2.568PheVal: 2.568 ± 0.053
0.585PheTrp: 0.585 ± 0.024
1.497PheTyr: 1.497 ± 0.044
0.0PheXaa: 0.0 ± 0.0
Gly
5.642GlyAla: 5.642 ± 0.091
0.837GlyCys: 0.837 ± 0.027
3.282GlyAsp: 3.282 ± 0.061
3.471GlyGlu: 3.471 ± 0.058
3.292GlyPhe: 3.292 ± 0.066
4.665GlyGly: 4.665 ± 0.081
1.492GlyHis: 1.492 ± 0.035
4.35GlyIle: 4.35 ± 0.073
3.504GlyLys: 3.504 ± 0.069
7.238GlyLeu: 7.238 ± 0.096
1.85GlyMet: 1.85 ± 0.042
2.753GlyAsn: 2.753 ± 0.061
1.884GlyPro: 1.884 ± 0.045
3.224GlyGln: 3.224 ± 0.057
3.286GlyArg: 3.286 ± 0.06
4.405GlySer: 4.405 ± 0.062
3.26GlyThr: 3.26 ± 0.062
4.799GlyVal: 4.799 ± 0.066
1.058GlyTrp: 1.058 ± 0.03
2.554GlyTyr: 2.554 ± 0.052
0.0GlyXaa: 0.0 ± 0.0
His
1.948HisAla: 1.948 ± 0.045
0.351HisCys: 0.351 ± 0.02
1.004HisAsp: 1.004 ± 0.032
0.887HisGlu: 0.887 ± 0.027
1.123HisPhe: 1.123 ± 0.03
1.53HisGly: 1.53 ± 0.042
0.633HisHis: 0.633 ± 0.029
1.406HisIle: 1.406 ± 0.04
0.916HisLys: 0.916 ± 0.033
2.182HisLeu: 2.182 ± 0.039
0.439HisMet: 0.439 ± 0.021
0.942HisAsn: 0.942 ± 0.031
1.122HisPro: 1.122 ± 0.032
1.341HisGln: 1.341 ± 0.04
1.064HisArg: 1.064 ± 0.03
1.495HisSer: 1.495 ± 0.036
1.108HisThr: 1.108 ± 0.033
1.146HisVal: 1.146 ± 0.035
0.446HisTrp: 0.446 ± 0.022
1.066HisTyr: 1.066 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
6.69IleAla: 6.69 ± 0.079
0.579IleCys: 0.579 ± 0.023
3.568IleAsp: 3.568 ± 0.06
3.389IleGlu: 3.389 ± 0.056
1.955IlePhe: 1.955 ± 0.039
4.164IleGly: 4.164 ± 0.068
0.952IleHis: 0.952 ± 0.028
3.466IleIle: 3.466 ± 0.057
2.87IleLys: 2.87 ± 0.05
4.975IleLeu: 4.975 ± 0.076
1.241IleMet: 1.241 ± 0.03
3.071IleAsn: 3.071 ± 0.064
2.325IlePro: 2.325 ± 0.045
1.991IleGln: 1.991 ± 0.043
2.701IleArg: 2.701 ± 0.05
4.514IleSer: 4.514 ± 0.065
3.624IleThr: 3.624 ± 0.062
3.8IleVal: 3.8 ± 0.067
0.648IleTrp: 0.648 ± 0.027
1.497IleTyr: 1.497 ± 0.042
0.0IleXaa: 0.0 ± 0.0
Lys
4.665LysAla: 4.665 ± 0.078
0.254LysCys: 0.254 ± 0.018
2.084LysAsp: 2.084 ± 0.052
1.879LysGlu: 1.879 ± 0.048
1.275LysPhe: 1.275 ± 0.032
2.568LysGly: 2.568 ± 0.058
1.076LysHis: 1.076 ± 0.034
2.427LysIle: 2.427 ± 0.045
2.092LysLys: 2.092 ± 0.052
5.093LysLeu: 5.093 ± 0.067
1.111LysMet: 1.111 ± 0.035
1.604LysAsn: 1.604 ± 0.044
2.288LysPro: 2.288 ± 0.051
2.964LysGln: 2.964 ± 0.063
2.332LysArg: 2.332 ± 0.051
2.263LysSer: 2.263 ± 0.052
2.634LysThr: 2.634 ± 0.055
3.323LysVal: 3.323 ± 0.064
0.413LysTrp: 0.413 ± 0.02
1.035LysTyr: 1.035 ± 0.029
0.0LysXaa: 0.0 ± 0.0
Leu
13.767LeuAla: 13.767 ± 0.153
1.168LeuCys: 1.168 ± 0.038
5.581LeuAsp: 5.581 ± 0.073
5.163LeuGlu: 5.163 ± 0.08
4.332LeuPhe: 4.332 ± 0.071
7.072LeuGly: 7.072 ± 0.095
2.434LeuHis: 2.434 ± 0.046
5.983LeuIle: 5.983 ± 0.089
4.784LeuLys: 4.784 ± 0.079
14.715LeuLeu: 14.715 ± 0.176
2.583LeuMet: 2.583 ± 0.061
4.691LeuAsn: 4.691 ± 0.074
5.724LeuPro: 5.724 ± 0.085
6.711LeuGln: 6.711 ± 0.112
5.174LeuArg: 5.174 ± 0.073
8.032LeuSer: 8.032 ± 0.09
7.009LeuThr: 7.009 ± 0.085
7.384LeuVal: 7.384 ± 0.091
1.389LeuTrp: 1.389 ± 0.039
2.95LeuTyr: 2.95 ± 0.054
0.0LeuXaa: 0.0 ± 0.0
Met
2.791MetAla: 2.791 ± 0.057
0.153MetCys: 0.153 ± 0.012
0.926MetAsp: 0.926 ± 0.027
0.881MetGlu: 0.881 ± 0.032
0.769MetPhe: 0.769 ± 0.027
1.41MetGly: 1.41 ± 0.039
0.475MetHis: 0.475 ± 0.021
1.092MetIle: 1.092 ± 0.035
0.968MetLys: 0.968 ± 0.03
3.37MetLeu: 3.37 ± 0.059
0.561MetMet: 0.561 ± 0.025
0.8MetAsn: 0.8 ± 0.026
1.294MetPro: 1.294 ± 0.037
1.566MetGln: 1.566 ± 0.037
1.207MetArg: 1.207 ± 0.033
1.541MetSer: 1.541 ± 0.04
1.375MetThr: 1.375 ± 0.041
1.587MetVal: 1.587 ± 0.041
0.191MetTrp: 0.191 ± 0.014
0.484MetTyr: 0.484 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
3.808AsnAla: 3.808 ± 0.063
0.334AsnCys: 0.334 ± 0.019
2.118AsnAsp: 2.118 ± 0.048
1.989AsnGlu: 1.989 ± 0.044
1.502AsnPhe: 1.502 ± 0.047
3.009AsnGly: 3.009 ± 0.062
0.87AsnHis: 0.87 ± 0.03
2.541AsnIle: 2.541 ± 0.051
1.817AsnLys: 1.817 ± 0.043
3.865AsnLeu: 3.865 ± 0.056
0.97AsnMet: 0.97 ± 0.03
2.052AsnAsn: 2.052 ± 0.052
2.124AsnPro: 2.124 ± 0.041
2.102AsnGln: 2.102 ± 0.05
2.077AsnArg: 2.077 ± 0.048
2.824AsnSer: 2.824 ± 0.054
2.299AsnThr: 2.299 ± 0.056
2.541AsnVal: 2.541 ± 0.049
0.783AsnTrp: 0.783 ± 0.029
1.276AsnTyr: 1.276 ± 0.039
0.0AsnXaa: 0.0 ± 0.0
Pro
4.896ProAla: 4.896 ± 0.072
0.324ProCys: 0.324 ± 0.018
2.565ProAsp: 2.565 ± 0.054
2.974ProGlu: 2.974 ± 0.057
1.78ProPhe: 1.78 ± 0.045
2.875ProGly: 2.875 ± 0.053
0.828ProHis: 0.828 ± 0.031
2.004ProIle: 2.004 ± 0.043
1.598ProLys: 1.598 ± 0.04
5.151ProLeu: 5.151 ± 0.08
0.974ProMet: 0.974 ± 0.03
1.367ProAsn: 1.367 ± 0.037
1.295ProPro: 1.295 ± 0.044
2.031ProGln: 2.031 ± 0.047
1.566ProArg: 1.566 ± 0.041
2.013ProSer: 2.013 ± 0.04
2.027ProThr: 2.027 ± 0.044
3.421ProVal: 3.421 ± 0.053
0.516ProTrp: 0.516 ± 0.024
1.227ProTyr: 1.227 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
5.765GlnAla: 5.765 ± 0.094
0.428GlnCys: 0.428 ± 0.022
2.005GlnAsp: 2.005 ± 0.041
1.82GlnGlu: 1.82 ± 0.046
2.176GlnPhe: 2.176 ± 0.039
3.245GlnGly: 3.245 ± 0.05
2.217GlnHis: 2.217 ± 0.052
2.642GlnIle: 2.642 ± 0.053
1.92GlnLys: 1.92 ± 0.051
8.785GlnLeu: 8.785 ± 0.135
1.136GlnMet: 1.136 ± 0.032
1.654GlnAsn: 1.654 ± 0.044
2.692GlnPro: 2.692 ± 0.057
7.785GlnGln: 7.785 ± 0.196
3.544GlnArg: 3.544 ± 0.071
2.93GlnSer: 2.93 ± 0.057
2.406GlnThr: 2.406 ± 0.055
3.547GlnVal: 3.547 ± 0.062
0.806GlnTrp: 0.806 ± 0.032
1.685GlnTyr: 1.685 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
4.045ArgAla: 4.045 ± 0.063
0.471ArgCys: 0.471 ± 0.019
2.423ArgAsp: 2.423 ± 0.047
2.57ArgGlu: 2.57 ± 0.056
2.47ArgPhe: 2.47 ± 0.053
2.772ArgGly: 2.772 ± 0.046
1.216ArgHis: 1.216 ± 0.035
2.897ArgIle: 2.897 ± 0.055
1.912ArgLys: 1.912 ± 0.049
6.026ArgLeu: 6.026 ± 0.081
1.128ArgMet: 1.128 ± 0.033
1.869ArgAsn: 1.869 ± 0.043
1.768ArgPro: 1.768 ± 0.042
3.462ArgGln: 3.462 ± 0.064
2.617ArgArg: 2.617 ± 0.057
2.837ArgSer: 2.837 ± 0.056
1.983ArgThr: 1.983 ± 0.046
3.059ArgVal: 3.059 ± 0.065
0.758ArgTrp: 0.758 ± 0.027
2.065ArgTyr: 2.065 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
6.384SerAla: 6.384 ± 0.078
0.645SerCys: 0.645 ± 0.025
3.094SerAsp: 3.094 ± 0.056
3.23SerGlu: 3.23 ± 0.048
2.697SerPhe: 2.697 ± 0.054
5.022SerGly: 5.022 ± 0.075
1.42SerHis: 1.42 ± 0.036
3.388SerIle: 3.388 ± 0.059
2.744SerLys: 2.744 ± 0.047
6.971SerLeu: 6.971 ± 0.08
1.452SerMet: 1.452 ± 0.034
2.585SerAsn: 2.585 ± 0.058
2.401SerPro: 2.401 ± 0.055
3.174SerGln: 3.174 ± 0.056
3.385SerArg: 3.385 ± 0.059
4.266SerSer: 4.266 ± 0.071
3.063SerThr: 3.063 ± 0.059
4.194SerVal: 4.194 ± 0.067
1.023SerTrp: 1.023 ± 0.031
2.004SerTyr: 2.004 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
5.857ThrAla: 5.857 ± 0.069
0.356ThrCys: 0.356 ± 0.018
3.169ThrAsp: 3.169 ± 0.055
3.508ThrGlu: 3.508 ± 0.066
1.796ThrPhe: 1.796 ± 0.047
4.056ThrGly: 4.056 ± 0.069
0.889ThrHis: 0.889 ± 0.026
3.024ThrIle: 3.024 ± 0.058
1.867ThrLys: 1.867 ± 0.047
6.711ThrLeu: 6.711 ± 0.081
1.054ThrMet: 1.054 ± 0.033
1.904ThrAsn: 1.904 ± 0.041
2.654ThrPro: 2.654 ± 0.052
1.994ThrGln: 1.994 ± 0.043
2.109ThrArg: 2.109 ± 0.045
3.088ThrSer: 3.088 ± 0.062
2.968ThrThr: 2.968 ± 0.055
4.022ThrVal: 4.022 ± 0.068
0.417ThrTrp: 0.417 ± 0.018
1.228ThrTyr: 1.228 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
7.057ValAla: 7.057 ± 0.084
0.685ValCys: 0.685 ± 0.026
3.402ValAsp: 3.402 ± 0.065
3.295ValGlu: 3.295 ± 0.063
2.754ValPhe: 2.754 ± 0.055
4.131ValGly: 4.131 ± 0.065
1.217ValHis: 1.217 ± 0.03
4.299ValIle: 4.299 ± 0.077
3.118ValLys: 3.118 ± 0.054
7.611ValLeu: 7.611 ± 0.101
1.74ValMet: 1.74 ± 0.043
2.932ValAsn: 2.932 ± 0.055
2.588ValPro: 2.588 ± 0.04
2.875ValGln: 2.875 ± 0.051
2.95ValArg: 2.95 ± 0.059
4.79ValSer: 4.79 ± 0.066
4.047ValThr: 4.047 ± 0.064
4.969ValVal: 4.969 ± 0.077
0.772ValTrp: 0.772 ± 0.028
1.81ValTyr: 1.81 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
0.826TrpAla: 0.826 ± 0.028
0.135TrpCys: 0.135 ± 0.011
0.516TrpAsp: 0.516 ± 0.023
0.356TrpGlu: 0.356 ± 0.019
0.67TrpPhe: 0.67 ± 0.023
0.678TrpGly: 0.678 ± 0.024
0.437TrpHis: 0.437 ± 0.02
0.493TrpIle: 0.493 ± 0.021
0.252TrpLys: 0.252 ± 0.017
2.372TrpLeu: 2.372 ± 0.058
0.264TrpMet: 0.264 ± 0.015
0.361TrpAsn: 0.361 ± 0.018
0.666TrpPro: 0.666 ± 0.029
1.819TrpGln: 1.819 ± 0.049
0.871TrpArg: 0.871 ± 0.03
0.621TrpSer: 0.621 ± 0.025
0.48TrpThr: 0.48 ± 0.023
0.747TrpVal: 0.747 ± 0.027
0.23TrpTrp: 0.23 ± 0.015
0.414TrpTyr: 0.414 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.454TyrAla: 2.454 ± 0.051
0.406TyrCys: 0.406 ± 0.018
1.487TyrAsp: 1.487 ± 0.04
1.143TyrGlu: 1.143 ± 0.038
1.432TyrPhe: 1.432 ± 0.04
2.068TyrGly: 2.068 ± 0.048
0.766TyrHis: 0.766 ± 0.027
1.551TyrIle: 1.551 ± 0.036
1.077TyrLys: 1.077 ± 0.036
3.662TyrLeu: 3.662 ± 0.07
0.511TyrMet: 0.511 ± 0.021
1.112TyrAsn: 1.112 ± 0.036
1.392TyrPro: 1.392 ± 0.033
2.648TyrGln: 2.648 ± 0.058
1.822TyrArg: 1.822 ± 0.039
2.007TyrSer: 2.007 ± 0.048
1.4TyrThr: 1.4 ± 0.037
1.676TyrVal: 1.676 ± 0.041
0.503TyrTrp: 0.503 ± 0.022
1.073TyrTyr: 1.073 ± 0.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3329 proteins (1092290 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski