Amino acid dipepetide frequency for Valsa malicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.064AlaAla: 10.064 ± 0.069	1.018AlaCys: 1.018 ± 0.014	4.609AlaAsp: 4.609 ± 0.031	5.509AlaGlu: 5.509 ± 0.043	3.039AlaPhe: 3.039 ± 0.03	6.463AlaGly: 6.463 ± 0.043	1.81AlaHis: 1.81 ± 0.017	4.014AlaIle: 4.014 ± 0.031	4.165AlaLys: 4.165 ± 0.037	7.585AlaLeu: 7.585 ± 0.047	2.153AlaMet: 2.153 ± 0.024	2.973AlaAsn: 2.973 ± 0.027	5.073AlaPro: 5.073 ± 0.048	3.461AlaGln: 3.461 ± 0.033	5.162AlaArg: 5.162 ± 0.041	7.318AlaSer: 7.318 ± 0.051	5.508AlaThr: 5.508 ± 0.036	5.728AlaVal: 5.728 ± 0.039	1.21AlaTrp: 1.21 ± 0.015	2.187AlaTyr: 2.187 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	0.881CysAla: 0.881 ± 0.016	0.228CysCys: 0.228 ± 0.007	0.65CysAsp: 0.65 ± 0.012	0.576CysGlu: 0.576 ± 0.01	0.494CysPhe: 0.494 ± 0.01	0.918CysGly: 0.918 ± 0.013	0.299CysHis: 0.299 ± 0.008	0.642CysIle: 0.642 ± 0.011	0.465CysLys: 0.465 ± 0.011	1.177CysLeu: 1.177 ± 0.018	0.259CysMet: 0.259 ± 0.008	0.407CysAsn: 0.407 ± 0.009	0.634CysPro: 0.634 ± 0.011	0.402CysGln: 0.402 ± 0.008	0.667CysArg: 0.667 ± 0.012	0.814CysSer: 0.814 ± 0.015	0.621CysThr: 0.621 ± 0.013	0.76CysVal: 0.76 ± 0.013	0.19CysTrp: 0.19 ± 0.006	0.338CysTyr: 0.338 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.981AspAla: 4.981 ± 0.036	0.619AspCys: 0.619 ± 0.012	4.99AspAsp: 4.99 ± 0.052	4.901AspGlu: 4.901 ± 0.041	2.283AspPhe: 2.283 ± 0.022	4.667AspGly: 4.667 ± 0.032	1.326AspHis: 1.326 ± 0.017	2.981AspIle: 2.981 ± 0.023	2.473AspLys: 2.473 ± 0.026	5.156AspLeu: 5.156 ± 0.035	1.438AspMet: 1.438 ± 0.017	2.004AspAsn: 2.004 ± 0.018	3.474AspPro: 3.474 ± 0.027	1.929AspGln: 1.929 ± 0.021	3.116AspArg: 3.116 ± 0.03	4.077AspSer: 4.077 ± 0.031	3.114AspThr: 3.114 ± 0.023	3.96AspVal: 3.96 ± 0.028	0.944AspTrp: 0.944 ± 0.014	1.656AspTyr: 1.656 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	5.904GluAla: 5.904 ± 0.04	0.592GluCys: 0.592 ± 0.011	4.711GluAsp: 4.711 ± 0.04	5.783GluGlu: 5.783 ± 0.058	1.882GluPhe: 1.882 ± 0.02	4.198GluGly: 4.198 ± 0.038	1.401GluHis: 1.401 ± 0.02	2.796GluIle: 2.796 ± 0.025	3.654GluLys: 3.654 ± 0.032	5.201GluLeu: 5.201 ± 0.041	1.536GluMet: 1.536 ± 0.02	2.129GluAsn: 2.129 ± 0.022	2.947GluPro: 2.947 ± 0.032	2.479GluGln: 2.479 ± 0.026	3.938GluArg: 3.938 ± 0.036	3.963GluSer: 3.963 ± 0.028	3.516GluThr: 3.516 ± 0.03	3.866GluVal: 3.866 ± 0.029	0.898GluTrp: 0.898 ± 0.014	1.654GluTyr: 1.654 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	2.912PheAla: 2.912 ± 0.027	0.492PheCys: 0.492 ± 0.01	2.277PheAsp: 2.277 ± 0.021	2.148PheGlu: 2.148 ± 0.019	1.496PhePhe: 1.496 ± 0.022	2.841PheGly: 2.841 ± 0.031	0.842PheHis: 0.842 ± 0.013	1.682PheIle: 1.682 ± 0.023	1.446PheLys: 1.446 ± 0.019	3.218PheLeu: 3.218 ± 0.028	0.82PheMet: 0.82 ± 0.013	1.336PheAsn: 1.336 ± 0.017	1.88PhePro: 1.88 ± 0.021	1.323PheGln: 1.323 ± 0.015	1.883PheArg: 1.883 ± 0.022	2.76PheSer: 2.76 ± 0.024	2.089PheThr: 2.089 ± 0.021	2.334PheVal: 2.334 ± 0.021	0.62PheTrp: 0.62 ± 0.012	1.056PheTyr: 1.056 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.897GlyAla: 5.897 ± 0.046	0.848GlyCys: 0.848 ± 0.014	4.2GlyAsp: 4.2 ± 0.03	4.067GlyGlu: 4.067 ± 0.033	2.782GlyPhe: 2.782 ± 0.026	7.207GlyGly: 7.207 ± 0.061	1.858GlyHis: 1.858 ± 0.022	3.384GlyIle: 3.384 ± 0.029	3.523GlyLys: 3.523 ± 0.029	6.393GlyLeu: 6.393 ± 0.045	1.754GlyMet: 1.754 ± 0.021	2.674GlyAsn: 2.674 ± 0.025	3.733GlyPro: 3.733 ± 0.031	2.743GlyGln: 2.743 ± 0.027	4.419GlyArg: 4.419 ± 0.034	6.085GlySer: 6.085 ± 0.044	4.291GlyThr: 4.291 ± 0.035	4.639GlyVal: 4.639 ± 0.036	1.219GlyTrp: 1.219 ± 0.018	2.163GlyTyr: 2.163 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.826HisAla: 1.826 ± 0.019	0.315HisCys: 0.315 ± 0.007	1.385HisAsp: 1.385 ± 0.017	1.352HisGlu: 1.352 ± 0.015	0.87HisPhe: 0.87 ± 0.012	1.812HisGly: 1.812 ± 0.018	0.924HisHis: 0.924 ± 0.019	1.149HisIle: 1.149 ± 0.016	0.936HisLys: 0.936 ± 0.014	2.13HisLeu: 2.13 ± 0.024	0.528HisMet: 0.528 ± 0.01	0.851HisAsn: 0.851 ± 0.011	1.615HisPro: 1.615 ± 0.019	0.979HisGln: 0.979 ± 0.017	1.476HisArg: 1.476 ± 0.019	1.665HisSer: 1.665 ± 0.021	1.215HisThr: 1.215 ± 0.016	1.467HisVal: 1.467 ± 0.018	0.341HisTrp: 0.341 ± 0.008	0.679HisTyr: 0.679 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	3.869IleAla: 3.869 ± 0.034	0.689IleCys: 0.689 ± 0.012	2.755IleAsp: 2.755 ± 0.021	2.682IleGlu: 2.682 ± 0.026	1.789IlePhe: 1.789 ± 0.022	3.01IleGly: 3.01 ± 0.029	1.087IleHis: 1.087 ± 0.014	2.293IleIle: 2.293 ± 0.026	2.06IleLys: 2.06 ± 0.021	4.142IleLeu: 4.142 ± 0.032	1.059IleMet: 1.059 ± 0.017	1.702IleAsn: 1.702 ± 0.016	2.871IlePro: 2.871 ± 0.025	1.755IleGln: 1.755 ± 0.017	2.606IleArg: 2.606 ± 0.024	3.409IleSer: 3.409 ± 0.031	2.759IleThr: 2.759 ± 0.024	3.007IleVal: 3.007 ± 0.027	0.713IleTrp: 0.713 ± 0.013	1.287IleTyr: 1.287 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	4.448LysAla: 4.448 ± 0.035	0.454LysCys: 0.454 ± 0.01	2.845LysAsp: 2.845 ± 0.028	3.381LysGlu: 3.381 ± 0.029	1.382LysPhe: 1.382 ± 0.017	3.126LysGly: 3.126 ± 0.026	1.094LysHis: 1.094 ± 0.016	2.041LysIle: 2.041 ± 0.02	3.39LysLys: 3.39 ± 0.049	3.846LysLeu: 3.846 ± 0.032	1.04LysMet: 1.04 ± 0.013	1.626LysAsn: 1.626 ± 0.017	2.728LysPro: 2.728 ± 0.027	1.806LysGln: 1.806 ± 0.021	3.276LysArg: 3.276 ± 0.039	3.302LysSer: 3.302 ± 0.028	2.852LysThr: 2.852 ± 0.026	2.87LysVal: 2.87 ± 0.026	0.672LysTrp: 0.672 ± 0.013	1.339LysTyr: 1.339 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	7.903LeuAla: 7.903 ± 0.046	1.129LeuCys: 1.129 ± 0.015	5.294LeuAsp: 5.294 ± 0.036	5.415LeuGlu: 5.415 ± 0.039	3.053LeuPhe: 3.053 ± 0.028	6.167LeuGly: 6.167 ± 0.044	2.073LeuHis: 2.073 ± 0.024	3.548LeuIle: 3.548 ± 0.031	4.012LeuLys: 4.012 ± 0.032	7.887LeuLeu: 7.887 ± 0.056	1.813LeuMet: 1.813 ± 0.019	2.964LeuAsn: 2.964 ± 0.025	5.268LeuPro: 5.268 ± 0.037	3.61LeuGln: 3.61 ± 0.034	5.597LeuArg: 5.597 ± 0.041	6.689LeuSer: 6.689 ± 0.038	4.631LeuThr: 4.631 ± 0.033	5.52LeuVal: 5.52 ± 0.042	1.196LeuTrp: 1.196 ± 0.017	2.238LeuTyr: 2.238 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.508MetAla: 2.508 ± 0.02	0.248MetCys: 0.248 ± 0.007	1.416MetAsp: 1.416 ± 0.017	1.362MetGlu: 1.362 ± 0.017	0.77MetPhe: 0.77 ± 0.015	1.633MetGly: 1.633 ± 0.017	0.477MetHis: 0.477 ± 0.009	0.966MetIle: 0.966 ± 0.013	1.013MetLys: 1.013 ± 0.017	1.858MetLeu: 1.858 ± 0.02	0.642MetMet: 0.642 ± 0.013	0.806MetAsn: 0.806 ± 0.013	1.387MetPro: 1.387 ± 0.019	0.848MetGln: 0.848 ± 0.014	1.32MetArg: 1.32 ± 0.016	1.986MetSer: 1.986 ± 0.02	1.352MetThr: 1.352 ± 0.016	1.42MetVal: 1.42 ± 0.018	0.301MetTrp: 0.301 ± 0.008	0.552MetTyr: 0.552 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.993AsnAla: 2.993 ± 0.029	0.418AsnCys: 0.418 ± 0.01	1.969AsnAsp: 1.969 ± 0.019	1.937AsnGlu: 1.937 ± 0.021	1.324AsnPhe: 1.324 ± 0.016	3.056AsnGly: 3.056 ± 0.031	0.838AsnHis: 0.838 ± 0.012	1.905AsnIle: 1.905 ± 0.023	1.592AsnLys: 1.592 ± 0.017	3.098AsnLeu: 3.098 ± 0.026	0.861AsnMet: 0.861 ± 0.014	1.713AsnAsn: 1.713 ± 0.025	2.331AsnPro: 2.331 ± 0.021	1.227AsnGln: 1.227 ± 0.017	1.821AsnArg: 1.821 ± 0.02	2.656AsnSer: 2.656 ± 0.024	2.215AsnThr: 2.215 ± 0.023	2.258AsnVal: 2.258 ± 0.024	0.545AsnTrp: 0.545 ± 0.011	1.041AsnTyr: 1.041 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	5.56ProAla: 5.56 ± 0.047	0.465ProCys: 0.465 ± 0.008	3.414ProAsp: 3.414 ± 0.025	3.997ProGlu: 3.997 ± 0.033	1.996ProPhe: 1.996 ± 0.019	4.414ProGly: 4.414 ± 0.041	1.296ProHis: 1.296 ± 0.018	2.356ProIle: 2.356 ± 0.023	2.654ProLys: 2.654 ± 0.028	4.532ProLeu: 4.532 ± 0.034	1.195ProMet: 1.195 ± 0.019	2.087ProAsn: 2.087 ± 0.023	5.358ProPro: 5.358 ± 0.063	2.534ProGln: 2.534 ± 0.034	3.561ProArg: 3.561 ± 0.033	5.764ProSer: 5.764 ± 0.049	3.968ProThr: 3.968 ± 0.04	3.75ProVal: 3.75 ± 0.032	0.744ProTrp: 0.744 ± 0.011	1.519ProTyr: 1.519 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.583GlnAla: 3.583 ± 0.03	0.407GlnCys: 0.407 ± 0.01	2.17GlnAsp: 2.17 ± 0.022	2.45GlnGlu: 2.45 ± 0.028	1.161GlnPhe: 1.161 ± 0.014	2.57GlnGly: 2.57 ± 0.025	1.103GlnHis: 1.103 ± 0.018	1.678GlnIle: 1.678 ± 0.021	1.885GlnLys: 1.885 ± 0.021	3.276GlnLeu: 3.276 ± 0.032	0.914GlnMet: 0.914 ± 0.015	1.449GlnAsn: 1.449 ± 0.022	2.596GlnPro: 2.596 ± 0.03	2.721GlnGln: 2.721 ± 0.052	2.597GlnArg: 2.597 ± 0.026	2.882GlnSer: 2.882 ± 0.03	2.2GlnThr: 2.2 ± 0.023	2.252GlnVal: 2.252 ± 0.02	0.572GlnTrp: 0.572 ± 0.012	1.132GlnTyr: 1.132 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.767ArgAla: 4.767 ± 0.036	0.641ArgCys: 0.641 ± 0.011	3.516ArgAsp: 3.516 ± 0.033	3.88ArgGlu: 3.88 ± 0.035	2.028ArgPhe: 2.028 ± 0.021	4.006ArgGly: 4.006 ± 0.035	1.56ArgHis: 1.56 ± 0.019	2.674ArgIle: 2.674 ± 0.025	3.381ArgLys: 3.381 ± 0.036	5.409ArgLeu: 5.409 ± 0.034	1.372ArgMet: 1.372 ± 0.017	2.181ArgAsn: 2.181 ± 0.021	3.671ArgPro: 3.671 ± 0.031	2.608ArgGln: 2.608 ± 0.024	5.206ArgArg: 5.206 ± 0.046	4.504ArgSer: 4.504 ± 0.039	3.211ArgThr: 3.211 ± 0.025	3.418ArgVal: 3.418 ± 0.028	0.931ArgTrp: 0.931 ± 0.013	1.607ArgTyr: 1.607 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.581SerAla: 6.581 ± 0.045	0.778SerCys: 0.778 ± 0.014	4.131SerAsp: 4.131 ± 0.038	3.958SerGlu: 3.958 ± 0.031	2.767SerPhe: 2.767 ± 0.025	5.92SerGly: 5.92 ± 0.049	1.801SerHis: 1.801 ± 0.021	3.627SerIle: 3.627 ± 0.027	3.524SerLys: 3.524 ± 0.03	6.602SerLeu: 6.602 ± 0.044	1.796SerMet: 1.796 ± 0.018	2.86SerAsn: 2.86 ± 0.026	5.433SerPro: 5.433 ± 0.052	3.148SerGln: 3.148 ± 0.029	4.76SerArg: 4.76 ± 0.037	8.841SerSer: 8.841 ± 0.086	5.445SerThr: 5.445 ± 0.047	4.516SerVal: 4.516 ± 0.037	1.087SerTrp: 1.087 ± 0.015	2.029SerTyr: 2.029 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	5.508ThrAla: 5.508 ± 0.038	0.693ThrCys: 0.693 ± 0.011	2.997ThrAsp: 2.997 ± 0.025	3.144ThrGlu: 3.144 ± 0.031	2.19ThrPhe: 2.19 ± 0.026	4.449ThrGly: 4.449 ± 0.032	1.236ThrHis: 1.236 ± 0.017	2.963ThrIle: 2.963 ± 0.026	2.596ThrLys: 2.596 ± 0.023	4.9ThrLeu: 4.9 ± 0.029	1.263ThrMet: 1.263 ± 0.017	2.115ThrAsn: 2.115 ± 0.023	4.331ThrPro: 4.331 ± 0.039	2.05ThrGln: 2.05 ± 0.022	3.143ThrArg: 3.143 ± 0.025	5.309ThrSer: 5.309 ± 0.046	4.741ThrThr: 4.741 ± 0.056	3.876ThrVal: 3.876 ± 0.032	0.875ThrTrp: 0.875 ± 0.014	1.621ThrTyr: 1.621 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	5.541ValAla: 5.541 ± 0.038	0.791ValCys: 0.791 ± 0.013	4.082ValAsp: 4.082 ± 0.029	4.03ValGlu: 4.03 ± 0.03	2.459ValPhe: 2.459 ± 0.023	4.287ValGly: 4.287 ± 0.036	1.398ValHis: 1.398 ± 0.017	2.845ValIle: 2.845 ± 0.029	2.906ValLys: 2.906 ± 0.024	5.718ValLeu: 5.718 ± 0.042	1.385ValMet: 1.385 ± 0.017	2.182ValAsn: 2.182 ± 0.022	3.756ValPro: 3.756 ± 0.026	2.376ValGln: 2.376 ± 0.022	3.5ValArg: 3.5 ± 0.026	4.555ValSer: 4.555 ± 0.033	3.711ValThr: 3.711 ± 0.034	4.654ValVal: 4.654 ± 0.039	0.902ValTrp: 0.902 ± 0.016	1.782ValTyr: 1.782 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	1.198TrpAla: 1.198 ± 0.016	0.2TrpCys: 0.2 ± 0.007	0.97TrpAsp: 0.97 ± 0.014	0.887TrpGlu: 0.887 ± 0.013	0.544TrpPhe: 0.544 ± 0.01	0.981TrpGly: 0.981 ± 0.016	0.352TrpHis: 0.352 ± 0.009	0.687TrpIle: 0.687 ± 0.013	0.766TrpLys: 0.766 ± 0.011	1.355TrpLeu: 1.355 ± 0.02	0.394TrpMet: 0.394 ± 0.008	0.612TrpAsn: 0.612 ± 0.011	0.636TrpPro: 0.636 ± 0.01	0.558TrpGln: 0.558 ± 0.01	0.952TrpArg: 0.952 ± 0.013	1.031TrpSer: 1.031 ± 0.016	0.949TrpThr: 0.949 ± 0.014	0.906TrpVal: 0.906 ± 0.015	0.278TrpTrp: 0.278 ± 0.008	0.444TrpTyr: 0.444 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.128TyrAla: 2.128 ± 0.023	0.398TyrCys: 0.398 ± 0.009	1.709TyrAsp: 1.709 ± 0.02	1.59TyrGlu: 1.59 ± 0.017	1.144TyrPhe: 1.144 ± 0.016	2.151TyrGly: 2.151 ± 0.028	0.741TyrHis: 0.741 ± 0.012	1.316TyrIle: 1.316 ± 0.019	1.077TyrLys: 1.077 ± 0.014	2.524TyrLeu: 2.524 ± 0.022	0.64TyrMet: 0.64 ± 0.011	1.126TyrAsn: 1.126 ± 0.017	1.442TyrPro: 1.442 ± 0.017	1.04TyrGln: 1.04 ± 0.016	1.571TyrArg: 1.571 ± 0.018	1.995TyrSer: 1.995 ± 0.021	1.61TyrThr: 1.61 ± 0.019	1.658TyrVal: 1.658 ± 0.02	0.464TyrTrp: 0.464 ± 0.01	0.965TyrTyr: 0.965 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.023XaaXaa: 0.023 ± 0.009

Statistics based on 10560 proteins (5240010 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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