Amino acid dipepetide frequency for Streptococcus satellite phage Javan603

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.438AlaCys: 0.438 ± 0.329
2.628AlaAsp: 2.628 ± 1.047
3.942AlaGlu: 3.942 ± 1.029
2.628AlaPhe: 2.628 ± 1.138
3.066AlaGly: 3.066 ± 0.8
0.0AlaHis: 0.0 ± 0.0
4.818AlaIle: 4.818 ± 0.876
4.818AlaLys: 4.818 ± 1.158
4.818AlaLeu: 4.818 ± 1.277
0.876AlaMet: 0.876 ± 0.712
5.256AlaAsn: 5.256 ± 2.115
1.314AlaPro: 1.314 ± 0.822
3.066AlaGln: 3.066 ± 1.218
2.19AlaArg: 2.19 ± 0.75
2.19AlaSer: 2.19 ± 0.861
3.066AlaThr: 3.066 ± 1.13
2.628AlaVal: 2.628 ± 0.716
0.876AlaTrp: 0.876 ± 0.546
3.066AlaTyr: 3.066 ± 0.872
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.876CysAsp: 0.876 ± 0.773
0.0CysGlu: 0.0 ± 0.0
0.438CysPhe: 0.438 ± 0.413
0.438CysGly: 0.438 ± 0.329
0.0CysHis: 0.0 ± 0.0
0.438CysIle: 0.438 ± 0.421
0.438CysLys: 0.438 ± 0.329
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
0.438CysAsn: 0.438 ± 0.329
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.438CysArg: 0.438 ± 0.411
0.438CysSer: 0.438 ± 0.552
0.0CysThr: 0.0 ± 0.0
0.438CysVal: 0.438 ± 0.421
0.0CysTrp: 0.0 ± 0.0
0.438CysTyr: 0.438 ± 0.544
0.0CysXaa: 0.0 ± 0.0
Asp
0.0AspAla: 0.0 ± 0.0
0.438AspCys: 0.438 ± 0.544
3.504AspAsp: 3.504 ± 1.692
7.446AspGlu: 7.446 ± 1.777
4.38AspPhe: 4.38 ± 1.006
2.19AspGly: 2.19 ± 0.746
0.438AspHis: 0.438 ± 0.552
4.818AspIle: 4.818 ± 1.805
5.694AspLys: 5.694 ± 1.231
5.256AspLeu: 5.256 ± 1.536
2.628AspMet: 2.628 ± 0.983
6.132AspAsn: 6.132 ± 1.229
1.314AspPro: 1.314 ± 0.589
0.438AspGln: 0.438 ± 0.45
1.314AspArg: 1.314 ± 0.697
4.818AspSer: 4.818 ± 1.676
3.066AspThr: 3.066 ± 0.93
3.504AspVal: 3.504 ± 1.028
0.876AspTrp: 0.876 ± 0.659
3.942AspTyr: 3.942 ± 1.698
0.0AspXaa: 0.0 ± 0.0
Glu
5.256GluAla: 5.256 ± 1.365
0.438GluCys: 0.438 ± 0.449
3.066GluAsp: 3.066 ± 1.474
5.256GluGlu: 5.256 ± 1.542
4.38GluPhe: 4.38 ± 0.85
3.066GluGly: 3.066 ± 0.983
0.876GluHis: 0.876 ± 0.568
4.818GluIle: 4.818 ± 1.157
6.57GluLys: 6.57 ± 1.717
12.703GluLeu: 12.703 ± 1.889
1.314GluMet: 1.314 ± 0.578
4.38GluAsn: 4.38 ± 1.358
2.628GluPro: 2.628 ± 0.971
1.314GluGln: 1.314 ± 0.866
3.504GluArg: 3.504 ± 1.38
3.504GluSer: 3.504 ± 0.941
5.694GluThr: 5.694 ± 1.497
1.752GluVal: 1.752 ± 1.092
0.0GluTrp: 0.0 ± 0.0
3.504GluTyr: 3.504 ± 1.046
0.0GluXaa: 0.0 ± 0.0
Phe
0.876PheAla: 0.876 ± 0.523
0.0PheCys: 0.0 ± 0.0
4.818PheAsp: 4.818 ± 1.047
4.818PheGlu: 4.818 ± 1.763
0.438PhePhe: 0.438 ± 0.45
2.19PheGly: 2.19 ± 0.985
0.438PheHis: 0.438 ± 0.411
3.066PheIle: 3.066 ± 1.183
3.066PheLys: 3.066 ± 0.938
5.694PheLeu: 5.694 ± 1.588
0.438PheMet: 0.438 ± 0.507
3.942PheAsn: 3.942 ± 1.729
0.438PhePro: 0.438 ± 0.421
0.876PheGln: 0.876 ± 0.535
1.752PheArg: 1.752 ± 0.98
1.752PheSer: 1.752 ± 0.782
2.19PheThr: 2.19 ± 0.987
0.876PheVal: 0.876 ± 0.609
0.876PheTrp: 0.876 ± 0.523
1.314PheTyr: 1.314 ± 0.578
0.0PheXaa: 0.0 ± 0.0
Gly
2.19GlyAla: 2.19 ± 0.7
0.876GlyCys: 0.876 ± 0.629
3.942GlyAsp: 3.942 ± 1.232
3.066GlyGlu: 3.066 ± 0.851
2.628GlyPhe: 2.628 ± 0.997
1.752GlyGly: 1.752 ± 0.695
0.438GlyHis: 0.438 ± 0.411
4.818GlyIle: 4.818 ± 0.993
3.942GlyLys: 3.942 ± 1.443
6.57GlyLeu: 6.57 ± 1.906
0.876GlyMet: 0.876 ± 0.626
4.38GlyAsn: 4.38 ± 1.816
0.0GlyPro: 0.0 ± 0.0
0.876GlyGln: 0.876 ± 0.552
1.752GlyArg: 1.752 ± 0.774
1.314GlySer: 1.314 ± 0.871
2.19GlyThr: 2.19 ± 0.679
5.256GlyVal: 5.256 ± 1.281
0.876GlyTrp: 0.876 ± 0.659
5.694GlyTyr: 5.694 ± 2.047
0.0GlyXaa: 0.0 ± 0.0
His
2.19HisAla: 2.19 ± 0.911
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
1.752HisGlu: 1.752 ± 0.753
1.314HisPhe: 1.314 ± 0.815
1.314HisGly: 1.314 ± 0.832
0.0HisHis: 0.0 ± 0.0
0.438HisIle: 0.438 ± 0.411
0.438HisLys: 0.438 ± 0.411
0.876HisLeu: 0.876 ± 0.504
0.0HisMet: 0.0 ± 0.0
0.876HisAsn: 0.876 ± 0.621
0.438HisPro: 0.438 ± 0.418
0.876HisGln: 0.876 ± 0.64
0.438HisArg: 0.438 ± 0.411
0.438HisSer: 0.438 ± 0.411
1.752HisThr: 1.752 ± 1.031
0.876HisVal: 0.876 ± 0.622
0.0HisTrp: 0.0 ± 0.0
1.314HisTyr: 1.314 ± 0.649
0.0HisXaa: 0.0 ± 0.0
Ile
5.694IleAla: 5.694 ± 1.759
0.438IleCys: 0.438 ± 0.413
5.256IleAsp: 5.256 ± 1.386
4.38IleGlu: 4.38 ± 1.378
1.314IlePhe: 1.314 ± 0.685
3.066IleGly: 3.066 ± 0.65
1.752IleHis: 1.752 ± 0.953
3.942IleIle: 3.942 ± 1.493
4.818IleLys: 4.818 ± 1.091
7.446IleLeu: 7.446 ± 1.923
1.314IleMet: 1.314 ± 0.662
3.066IleAsn: 3.066 ± 1.03
2.628IlePro: 2.628 ± 1.39
1.752IleGln: 1.752 ± 0.788
1.314IleArg: 1.314 ± 0.534
4.38IleSer: 4.38 ± 1.445
5.694IleThr: 5.694 ± 0.834
2.19IleVal: 2.19 ± 1.123
0.876IleTrp: 0.876 ± 0.826
5.256IleTyr: 5.256 ± 1.196
0.0IleXaa: 0.0 ± 0.0
Lys
4.818LysAla: 4.818 ± 1.814
0.438LysCys: 0.438 ± 0.421
4.818LysAsp: 4.818 ± 1.365
7.446LysGlu: 7.446 ± 1.657
3.504LysPhe: 3.504 ± 1.153
4.38LysGly: 4.38 ± 1.086
2.628LysHis: 2.628 ± 1.104
6.132LysIle: 6.132 ± 1.087
9.636LysLys: 9.636 ± 2.662
7.884LysLeu: 7.884 ± 2.202
1.314LysMet: 1.314 ± 0.519
6.132LysAsn: 6.132 ± 1.23
3.942LysPro: 3.942 ± 1.664
4.818LysGln: 4.818 ± 1.116
6.57LysArg: 6.57 ± 1.669
4.38LysSer: 4.38 ± 1.412
4.38LysThr: 4.38 ± 1.337
3.942LysVal: 3.942 ± 0.982
0.0LysTrp: 0.0 ± 0.0
2.19LysTyr: 2.19 ± 0.737
0.0LysXaa: 0.0 ± 0.0
Leu
7.884LeuAla: 7.884 ± 1.818
0.438LeuCys: 0.438 ± 0.329
7.884LeuAsp: 7.884 ± 1.56
8.76LeuGlu: 8.76 ± 2.859
3.066LeuPhe: 3.066 ± 0.77
7.884LeuGly: 7.884 ± 2.139
1.752LeuHis: 1.752 ± 0.877
4.38LeuIle: 4.38 ± 1.258
8.322LeuLys: 8.322 ± 1.482
7.884LeuLeu: 7.884 ± 1.537
2.19LeuMet: 2.19 ± 0.898
5.256LeuAsn: 5.256 ± 2.058
3.504LeuPro: 3.504 ± 1.21
3.942LeuGln: 3.942 ± 1.253
3.066LeuArg: 3.066 ± 1.675
7.446LeuSer: 7.446 ± 2.235
4.818LeuThr: 4.818 ± 1.052
4.38LeuVal: 4.38 ± 1.346
0.876LeuTrp: 0.876 ± 0.535
2.628LeuTyr: 2.628 ± 0.888
0.0LeuXaa: 0.0 ± 0.0
Met
0.876MetAla: 0.876 ± 0.613
0.0MetCys: 0.0 ± 0.0
2.19MetAsp: 2.19 ± 0.805
0.876MetGlu: 0.876 ± 0.659
0.0MetPhe: 0.0 ± 0.0
1.314MetGly: 1.314 ± 0.656
0.0MetHis: 0.0 ± 0.0
1.314MetIle: 1.314 ± 0.758
1.752MetLys: 1.752 ± 1.288
1.314MetLeu: 1.314 ± 0.831
0.876MetMet: 0.876 ± 0.466
1.314MetAsn: 1.314 ± 0.668
0.438MetPro: 0.438 ± 0.421
0.438MetGln: 0.438 ± 0.442
0.876MetArg: 0.876 ± 0.721
2.19MetSer: 2.19 ± 0.943
2.19MetThr: 2.19 ± 0.879
2.628MetVal: 2.628 ± 1.243
0.438MetTrp: 0.438 ± 0.544
0.876MetTyr: 0.876 ± 0.419
0.0MetXaa: 0.0 ± 0.0
Asn
3.942AsnAla: 3.942 ± 1.589
0.0AsnCys: 0.0 ± 0.0
3.504AsnAsp: 3.504 ± 1.199
4.38AsnGlu: 4.38 ± 0.92
1.314AsnPhe: 1.314 ± 0.799
6.132AsnGly: 6.132 ± 1.189
0.438AsnHis: 0.438 ± 0.411
3.504AsnIle: 3.504 ± 1.439
6.132AsnLys: 6.132 ± 1.237
4.818AsnLeu: 4.818 ± 1.402
1.752AsnMet: 1.752 ± 1.073
4.38AsnAsn: 4.38 ± 1.468
4.38AsnPro: 4.38 ± 1.353
0.876AsnGln: 0.876 ± 0.495
2.19AsnArg: 2.19 ± 1.111
5.694AsnSer: 5.694 ± 2.103
7.008AsnThr: 7.008 ± 1.258
3.942AsnVal: 3.942 ± 0.795
0.438AsnTrp: 0.438 ± 0.45
4.818AsnTyr: 4.818 ± 1.085
0.0AsnXaa: 0.0 ± 0.0
Pro
2.19ProAla: 2.19 ± 0.832
0.0ProCys: 0.0 ± 0.0
1.314ProAsp: 1.314 ± 0.699
0.876ProGlu: 0.876 ± 0.624
2.628ProPhe: 2.628 ± 1.168
0.0ProGly: 0.0 ± 0.0
0.438ProHis: 0.438 ± 0.421
3.066ProIle: 3.066 ± 1.413
3.066ProLys: 3.066 ± 1.521
2.628ProLeu: 2.628 ± 0.72
0.0ProMet: 0.0 ± 0.0
3.942ProAsn: 3.942 ± 2.158
2.19ProPro: 2.19 ± 1.011
0.876ProGln: 0.876 ± 0.552
1.752ProArg: 1.752 ± 0.774
1.314ProSer: 1.314 ± 0.822
1.314ProThr: 1.314 ± 0.743
3.066ProVal: 3.066 ± 1.346
0.438ProTrp: 0.438 ± 0.329
1.752ProTyr: 1.752 ± 0.43
0.0ProXaa: 0.0 ± 0.0
Gln
1.314GlnAla: 1.314 ± 0.514
0.0GlnCys: 0.0 ± 0.0
2.19GlnAsp: 2.19 ± 1.346
5.256GlnGlu: 5.256 ± 1.136
1.752GlnPhe: 1.752 ± 0.925
1.314GlnGly: 1.314 ± 0.791
1.314GlnHis: 1.314 ± 0.871
2.19GlnIle: 2.19 ± 0.952
2.628GlnLys: 2.628 ± 0.782
1.314GlnLeu: 1.314 ± 0.791
0.438GlnMet: 0.438 ± 0.413
0.876GlnAsn: 0.876 ± 0.514
1.314GlnPro: 1.314 ± 0.802
0.876GlnGln: 0.876 ± 0.53
0.876GlnArg: 0.876 ± 0.659
3.504GlnSer: 3.504 ± 0.977
3.066GlnThr: 3.066 ± 0.974
1.752GlnVal: 1.752 ± 0.703
0.0GlnTrp: 0.0 ± 0.0
0.438GlnTyr: 0.438 ± 0.411
0.0GlnXaa: 0.0 ± 0.0
Arg
3.066ArgAla: 3.066 ± 1.319
0.0ArgCys: 0.0 ± 0.0
1.314ArgAsp: 1.314 ± 0.59
1.752ArgGlu: 1.752 ± 0.849
0.0ArgPhe: 0.0 ± 0.0
2.19ArgGly: 2.19 ± 1.059
0.876ArgHis: 0.876 ± 0.629
3.942ArgIle: 3.942 ± 1.234
2.628ArgLys: 2.628 ± 0.878
3.066ArgLeu: 3.066 ± 1.06
0.438ArgMet: 0.438 ± 0.534
5.694ArgAsn: 5.694 ± 1.154
1.314ArgPro: 1.314 ± 0.685
0.876ArgGln: 0.876 ± 0.638
0.876ArgArg: 0.876 ± 0.488
2.19ArgSer: 2.19 ± 0.786
2.628ArgThr: 2.628 ± 1.149
3.504ArgVal: 3.504 ± 1.735
0.438ArgTrp: 0.438 ± 0.442
3.504ArgTyr: 3.504 ± 1.015
0.0ArgXaa: 0.0 ± 0.0
Ser
2.628SerAla: 2.628 ± 1.051
0.0SerCys: 0.0 ± 0.0
4.818SerAsp: 4.818 ± 0.747
3.504SerGlu: 3.504 ± 1.673
1.752SerPhe: 1.752 ± 0.818
3.066SerGly: 3.066 ± 0.85
0.438SerHis: 0.438 ± 0.411
3.942SerIle: 3.942 ± 1.228
7.884SerLys: 7.884 ± 2.009
5.256SerLeu: 5.256 ± 1.299
0.876SerMet: 0.876 ± 0.466
4.38SerAsn: 4.38 ± 1.54
1.314SerPro: 1.314 ± 0.863
3.066SerGln: 3.066 ± 1.459
2.19SerArg: 2.19 ± 0.918
3.066SerSer: 3.066 ± 1.595
3.066SerThr: 3.066 ± 1.455
3.504SerVal: 3.504 ± 1.316
2.19SerTrp: 2.19 ± 1.047
3.504SerTyr: 3.504 ± 1.251
0.0SerXaa: 0.0 ± 0.0
Thr
2.628ThrAla: 2.628 ± 0.721
0.0ThrCys: 0.0 ± 0.0
3.504ThrAsp: 3.504 ± 1.664
1.752ThrGlu: 1.752 ± 0.836
3.942ThrPhe: 3.942 ± 1.77
3.504ThrGly: 3.504 ± 1.417
1.752ThrHis: 1.752 ± 0.925
3.942ThrIle: 3.942 ± 2.024
6.57ThrLys: 6.57 ± 1.369
7.008ThrLeu: 7.008 ± 1.637
3.066ThrMet: 3.066 ± 1.242
3.504ThrAsn: 3.504 ± 1.144
1.752ThrPro: 1.752 ± 0.653
1.752ThrGln: 1.752 ± 1.092
5.256ThrArg: 5.256 ± 1.724
3.066ThrSer: 3.066 ± 1.135
3.942ThrThr: 3.942 ± 1.641
7.884ThrVal: 7.884 ± 1.43
0.438ThrTrp: 0.438 ± 0.421
2.19ThrTyr: 2.19 ± 1.032
0.0ThrXaa: 0.0 ± 0.0
Val
4.38ValAla: 4.38 ± 1.301
0.876ValCys: 0.876 ± 0.547
1.752ValAsp: 1.752 ± 0.884
2.628ValGlu: 2.628 ± 1.236
3.066ValPhe: 3.066 ± 1.081
3.066ValGly: 3.066 ± 0.812
0.438ValHis: 0.438 ± 0.411
3.504ValIle: 3.504 ± 0.799
5.694ValLys: 5.694 ± 1.434
7.008ValLeu: 7.008 ± 1.483
0.438ValMet: 0.438 ± 0.409
2.628ValAsn: 2.628 ± 1.232
2.19ValPro: 2.19 ± 1.021
2.19ValGln: 2.19 ± 0.88
0.876ValArg: 0.876 ± 0.659
3.504ValSer: 3.504 ± 1.47
8.76ValThr: 8.76 ± 1.602
4.38ValVal: 4.38 ± 1.29
0.0ValTrp: 0.0 ± 0.0
1.752ValTyr: 1.752 ± 0.94
0.0ValXaa: 0.0 ± 0.0
Trp
0.438TrpAla: 0.438 ± 0.45
0.0TrpCys: 0.0 ± 0.0
0.876TrpAsp: 0.876 ± 0.504
0.438TrpGlu: 0.438 ± 0.442
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.438TrpHis: 0.438 ± 0.329
0.438TrpIle: 0.438 ± 0.329
1.314TrpLys: 1.314 ± 0.476
2.19TrpLeu: 2.19 ± 0.972
0.438TrpMet: 0.438 ± 0.544
0.438TrpAsn: 0.438 ± 0.413
0.0TrpPro: 0.0 ± 0.0
0.438TrpGln: 0.438 ± 0.329
0.438TrpArg: 0.438 ± 0.329
1.314TrpSer: 1.314 ± 0.495
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.438TrpTrp: 0.438 ± 0.411
0.876TrpTyr: 0.876 ± 0.523
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.314TyrAla: 1.314 ± 0.673
0.438TyrCys: 0.438 ± 0.421
3.942TyrAsp: 3.942 ± 1.1
5.694TyrGlu: 5.694 ± 1.704
1.314TyrPhe: 1.314 ± 0.769
3.504TyrGly: 3.504 ± 1.059
0.876TyrHis: 0.876 ± 0.535
3.066TyrIle: 3.066 ± 1.03
3.942TyrLys: 3.942 ± 1.885
2.628TyrLeu: 2.628 ± 1.243
2.19TyrMet: 2.19 ± 1.028
3.066TyrAsn: 3.066 ± 1.507
1.752TyrPro: 1.752 ± 0.948
3.066TyrGln: 3.066 ± 1.136
2.628TyrArg: 2.628 ± 0.922
3.942TyrSer: 3.942 ± 1.699
2.628TyrThr: 2.628 ± 0.968
2.628TyrVal: 2.628 ± 1.154
0.438TyrTrp: 0.438 ± 0.45
2.628TyrTyr: 2.628 ± 1.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 14 proteins (2284 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski