Amino acid dipepetide frequency for Bacillus akibai (strain ATCC 43226 / DSM 21942 / JCM 9157 / 1139)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.046AlaAla: 5.046 ± 0.079	0.584AlaCys: 0.584 ± 0.021	3.18AlaAsp: 3.18 ± 0.045	4.608AlaGlu: 4.608 ± 0.069	3.241AlaPhe: 3.241 ± 0.055	4.862AlaGly: 4.862 ± 0.075	1.256AlaHis: 1.256 ± 0.033	5.885AlaIle: 5.885 ± 0.069	4.342AlaLys: 4.342 ± 0.062	7.138AlaLeu: 7.138 ± 0.087	1.933AlaMet: 1.933 ± 0.037	2.879AlaAsn: 2.879 ± 0.05	2.031AlaPro: 2.031 ± 0.04	2.151AlaGln: 2.151 ± 0.041	2.671AlaArg: 2.671 ± 0.049	3.983AlaSer: 3.983 ± 0.055	3.77AlaThr: 3.77 ± 0.065	5.087AlaVal: 5.087 ± 0.068	0.577AlaTrp: 0.577 ± 0.023	2.192AlaTyr: 2.192 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.409CysAla: 0.409 ± 0.02	0.099CysCys: 0.099 ± 0.009	0.373CysAsp: 0.373 ± 0.019	0.454CysGlu: 0.454 ± 0.02	0.334CysPhe: 0.334 ± 0.014	0.627CysGly: 0.627 ± 0.023	0.185CysHis: 0.185 ± 0.013	0.491CysIle: 0.491 ± 0.018	0.378CysLys: 0.378 ± 0.019	0.729CysLeu: 0.729 ± 0.027	0.178CysMet: 0.178 ± 0.013	0.29CysAsn: 0.29 ± 0.015	0.353CysPro: 0.353 ± 0.017	0.265CysGln: 0.265 ± 0.013	0.284CysArg: 0.284 ± 0.015	0.503CysSer: 0.503 ± 0.018	0.369CysThr: 0.369 ± 0.015	0.417CysVal: 0.417 ± 0.018	0.066CysTrp: 0.066 ± 0.008	0.276CysTyr: 0.276 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	2.915AspAla: 2.915 ± 0.052	0.382AspCys: 0.382 ± 0.017	2.442AspAsp: 2.442 ± 0.053	4.112AspGlu: 4.112 ± 0.062	2.484AspPhe: 2.484 ± 0.045	3.327AspGly: 3.327 ± 0.059	1.271AspHis: 1.271 ± 0.034	3.935AspIle: 3.935 ± 0.051	2.791AspLys: 2.791 ± 0.05	5.335AspLeu: 5.335 ± 0.065	1.234AspMet: 1.234 ± 0.028	1.716AspAsn: 1.716 ± 0.043	2.024AspPro: 2.024 ± 0.041	2.371AspGln: 2.371 ± 0.041	2.262AspArg: 2.262 ± 0.048	2.554AspSer: 2.554 ± 0.047	2.332AspThr: 2.332 ± 0.042	3.927AspVal: 3.927 ± 0.063	0.676AspTrp: 0.676 ± 0.024	2.097AspTyr: 2.097 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	5.472GluAla: 5.472 ± 0.071	0.38GluCys: 0.38 ± 0.019	3.737GluAsp: 3.737 ± 0.058	7.549GluGlu: 7.549 ± 0.095	2.758GluPhe: 2.758 ± 0.047	4.445GluGly: 4.445 ± 0.068	1.605GluHis: 1.605 ± 0.035	5.736GluIle: 5.736 ± 0.077	6.18GluLys: 6.18 ± 0.078	7.71GluLeu: 7.71 ± 0.09	2.265GluMet: 2.265 ± 0.046	3.619GluAsn: 3.619 ± 0.049	2.007GluPro: 2.007 ± 0.043	4.004GluGln: 4.004 ± 0.066	3.786GluArg: 3.786 ± 0.061	3.623GluSer: 3.623 ± 0.057	4.158GluThr: 4.158 ± 0.061	5.436GluVal: 5.436 ± 0.065	0.867GluTrp: 0.867 ± 0.028	2.154GluTyr: 2.154 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.041PheAla: 3.041 ± 0.056	0.36PheCys: 0.36 ± 0.016	2.426PheAsp: 2.426 ± 0.042	3.125PheGlu: 3.125 ± 0.05	2.479PhePhe: 2.479 ± 0.057	3.21PheGly: 3.21 ± 0.054	1.0PheHis: 1.0 ± 0.03	3.991PheIle: 3.991 ± 0.067	2.469PheLys: 2.469 ± 0.046	4.781PheLeu: 4.781 ± 0.072	1.171PheMet: 1.171 ± 0.03	1.952PheAsn: 1.952 ± 0.039	1.613PhePro: 1.613 ± 0.035	1.745PheGln: 1.745 ± 0.039	1.511PheArg: 1.511 ± 0.029	3.361PheSer: 3.361 ± 0.051	2.559PheThr: 2.559 ± 0.047	3.231PheVal: 3.231 ± 0.054	0.468PheTrp: 0.468 ± 0.022	1.798PheTyr: 1.798 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	4.631GlyAla: 4.631 ± 0.077	0.606GlyCys: 0.606 ± 0.025	3.113GlyAsp: 3.113 ± 0.052	4.56GlyGlu: 4.56 ± 0.054	3.463GlyPhe: 3.463 ± 0.058	4.584GlyGly: 4.584 ± 0.074	1.459GlyHis: 1.459 ± 0.04	5.548GlyIle: 5.548 ± 0.076	4.407GlyLys: 4.407 ± 0.068	6.554GlyLeu: 6.554 ± 0.082	1.989GlyMet: 1.989 ± 0.043	2.673GlyAsn: 2.673 ± 0.047	1.691GlyPro: 1.691 ± 0.041	2.3GlyGln: 2.3 ± 0.044	2.613GlyArg: 2.613 ± 0.046	3.834GlySer: 3.834 ± 0.055	3.885GlyThr: 3.885 ± 0.059	5.15GlyVal: 5.15 ± 0.077	0.818GlyTrp: 0.818 ± 0.028	2.665GlyTyr: 2.665 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.31HisAla: 1.31 ± 0.032	0.206HisCys: 0.206 ± 0.012	1.077HisAsp: 1.077 ± 0.031	1.516HisGlu: 1.516 ± 0.037	1.167HisPhe: 1.167 ± 0.031	1.381HisGly: 1.381 ± 0.036	0.719HisHis: 0.719 ± 0.025	1.487HisIle: 1.487 ± 0.034	0.982HisLys: 0.982 ± 0.028	2.277HisLeu: 2.277 ± 0.04	0.518HisMet: 0.518 ± 0.019	0.808HisAsn: 0.808 ± 0.026	1.084HisPro: 1.084 ± 0.03	0.928HisGln: 0.928 ± 0.027	0.844HisArg: 0.844 ± 0.025	1.398HisSer: 1.398 ± 0.038	1.068HisThr: 1.068 ± 0.032	1.555HisVal: 1.555 ± 0.035	0.251HisTrp: 0.251 ± 0.013	0.875HisTyr: 0.875 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.769IleAla: 5.769 ± 0.075	0.623IleCys: 0.623 ± 0.022	4.27IleAsp: 4.27 ± 0.059	6.154IleGlu: 6.154 ± 0.075	3.152IlePhe: 3.152 ± 0.064	5.962IleGly: 5.962 ± 0.076	1.706IleHis: 1.706 ± 0.038	5.879IleIle: 5.879 ± 0.082	4.553IleLys: 4.553 ± 0.057	7.005IleLeu: 7.005 ± 0.095	1.751IleMet: 1.751 ± 0.04	3.455IleAsn: 3.455 ± 0.063	3.311IlePro: 3.311 ± 0.06	2.98IleGln: 2.98 ± 0.051	3.156IleArg: 3.156 ± 0.048	5.139IleSer: 5.139 ± 0.061	4.42IleThr: 4.42 ± 0.058	5.531IleVal: 5.531 ± 0.078	0.703IleTrp: 0.703 ± 0.024	2.422IleTyr: 2.422 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	4.376LysAla: 4.376 ± 0.066	0.31LysCys: 0.31 ± 0.017	3.349LysAsp: 3.349 ± 0.05	6.565LysGlu: 6.565 ± 0.083	1.778LysPhe: 1.778 ± 0.038	4.132LysGly: 4.132 ± 0.06	1.4LysHis: 1.4 ± 0.037	4.16LysIle: 4.16 ± 0.059	5.6LysLys: 5.6 ± 0.085	5.795LysLeu: 5.795 ± 0.065	2.043LysMet: 2.043 ± 0.036	2.959LysAsn: 2.959 ± 0.049	2.112LysPro: 2.112 ± 0.044	3.496LysGln: 3.496 ± 0.056	3.34LysArg: 3.34 ± 0.055	3.279LysSer: 3.279 ± 0.053	3.342LysThr: 3.342 ± 0.045	4.622LysVal: 4.622 ± 0.066	0.785LysTrp: 0.785 ± 0.023	1.862LysTyr: 1.862 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	7.359LeuAla: 7.359 ± 0.08	0.684LeuCys: 0.684 ± 0.025	4.934LeuAsp: 4.934 ± 0.061	7.196LeuGlu: 7.196 ± 0.084	5.07LeuPhe: 5.07 ± 0.084	6.302LeuGly: 6.302 ± 0.088	2.019LeuHis: 2.019 ± 0.039	7.624LeuIle: 7.624 ± 0.108	6.482LeuLys: 6.482 ± 0.074	10.49LeuLeu: 10.49 ± 0.137	2.579LeuMet: 2.579 ± 0.049	4.445LeuAsn: 4.445 ± 0.053	3.889LeuPro: 3.889 ± 0.059	3.692LeuGln: 3.692 ± 0.063	3.768LeuArg: 3.768 ± 0.058	6.676LeuSer: 6.676 ± 0.087	6.016LeuThr: 6.016 ± 0.074	6.715LeuVal: 6.715 ± 0.083	0.857LeuTrp: 0.857 ± 0.024	3.19LeuTyr: 3.19 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	1.886MetAla: 1.886 ± 0.039	0.138MetCys: 0.138 ± 0.011	1.345MetAsp: 1.345 ± 0.035	1.857MetGlu: 1.857 ± 0.038	1.136MetPhe: 1.136 ± 0.034	1.657MetGly: 1.657 ± 0.036	0.405MetHis: 0.405 ± 0.017	2.234MetIle: 2.234 ± 0.044	2.329MetLys: 2.329 ± 0.04	2.528MetLeu: 2.528 ± 0.051	0.857MetMet: 0.857 ± 0.025	1.618MetAsn: 1.618 ± 0.035	0.955MetPro: 0.955 ± 0.029	0.881MetGln: 0.881 ± 0.027	1.058MetArg: 1.058 ± 0.024	1.735MetSer: 1.735 ± 0.033	1.741MetThr: 1.741 ± 0.036	1.786MetVal: 1.786 ± 0.04	0.222MetTrp: 0.222 ± 0.013	0.759MetTyr: 0.759 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.483AsnAla: 2.483 ± 0.045	0.304AsnCys: 0.304 ± 0.016	2.245AsnAsp: 2.245 ± 0.043	3.776AsnGlu: 3.776 ± 0.059	1.602AsnPhe: 1.602 ± 0.037	3.289AsnGly: 3.289 ± 0.061	1.153AsnHis: 1.153 ± 0.032	3.109AsnIle: 3.109 ± 0.051	2.864AsnLys: 2.864 ± 0.052	3.977AsnLeu: 3.977 ± 0.059	1.253AsnMet: 1.253 ± 0.031	2.041AsnAsn: 2.041 ± 0.051	2.105AsnPro: 2.105 ± 0.044	2.314AsnGln: 2.314 ± 0.045	2.037AsnArg: 2.037 ± 0.044	2.411AsnSer: 2.411 ± 0.053	2.036AsnThr: 2.036 ± 0.041	3.171AsnVal: 3.171 ± 0.054	0.638AsnTrp: 0.638 ± 0.023	1.572AsnTyr: 1.572 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	2.273ProAla: 2.273 ± 0.046	0.226ProCys: 0.226 ± 0.014	1.926ProAsp: 1.926 ± 0.048	2.892ProGlu: 2.892 ± 0.048	2.021ProPhe: 2.021 ± 0.039	2.158ProGly: 2.158 ± 0.047	0.758ProHis: 0.758 ± 0.021	2.941ProIle: 2.941 ± 0.049	1.993ProLys: 1.993 ± 0.042	3.493ProLeu: 3.493 ± 0.056	0.836ProMet: 0.836 ± 0.029	1.746ProAsn: 1.746 ± 0.041	1.008ProPro: 1.008 ± 0.028	1.035ProGln: 1.035 ± 0.032	1.113ProArg: 1.113 ± 0.031	2.177ProSer: 2.177 ± 0.038	2.185ProThr: 2.185 ± 0.044	2.697ProVal: 2.697 ± 0.046	0.394ProTrp: 0.394 ± 0.016	1.373ProTyr: 1.373 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.02GlnAla: 3.02 ± 0.05	0.201GlnCys: 0.201 ± 0.013	1.715GlnAsp: 1.715 ± 0.035	3.068GlnGlu: 3.068 ± 0.057	1.806GlnPhe: 1.806 ± 0.036	2.261GlnGly: 2.261 ± 0.045	0.837GlnHis: 0.837 ± 0.022	2.93GlnIle: 2.93 ± 0.048	2.636GlnLys: 2.636 ± 0.043	4.559GlnLeu: 4.559 ± 0.07	1.201GlnMet: 1.201 ± 0.029	1.588GlnAsn: 1.588 ± 0.035	1.322GlnPro: 1.322 ± 0.042	2.045GlnGln: 2.045 ± 0.063	1.557GlnArg: 1.557 ± 0.038	2.269GlnSer: 2.269 ± 0.04	2.375GlnThr: 2.375 ± 0.043	2.91GlnVal: 2.91 ± 0.049	0.445GlnTrp: 0.445 ± 0.02	1.331GlnTyr: 1.331 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	2.489ArgAla: 2.489 ± 0.047	0.259ArgCys: 0.259 ± 0.013	2.105ArgAsp: 2.105 ± 0.042	3.223ArgGlu: 3.223 ± 0.052	2.002ArgPhe: 2.002 ± 0.038	2.411ArgGly: 2.411 ± 0.047	0.787ArgHis: 0.787 ± 0.025	3.049ArgIle: 3.049 ± 0.048	3.109ArgLys: 3.109 ± 0.044	4.106ArgLeu: 4.106 ± 0.064	1.272ArgMet: 1.272 ± 0.029	2.012ArgAsn: 2.012 ± 0.041	1.307ArgPro: 1.307 ± 0.034	1.552ArgGln: 1.552 ± 0.033	1.817ArgArg: 1.817 ± 0.039	2.339ArgSer: 2.339 ± 0.037	2.19ArgThr: 2.19 ± 0.04	2.784ArgVal: 2.784 ± 0.045	0.449ArgTrp: 0.449 ± 0.019	1.582ArgTyr: 1.582 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	3.466SerAla: 3.466 ± 0.052	0.412SerCys: 0.412 ± 0.017	2.787SerAsp: 2.787 ± 0.042	4.174SerGlu: 4.174 ± 0.053	3.469SerPhe: 3.469 ± 0.059	4.043SerGly: 4.043 ± 0.053	1.247SerHis: 1.247 ± 0.035	5.108SerIle: 5.108 ± 0.072	3.681SerLys: 3.681 ± 0.058	6.263SerLeu: 6.263 ± 0.08	1.628SerMet: 1.628 ± 0.036	2.728SerAsn: 2.728 ± 0.047	2.017SerPro: 2.017 ± 0.035	2.122SerGln: 2.122 ± 0.041	2.348SerArg: 2.348 ± 0.046	3.893SerSer: 3.893 ± 0.056	3.21SerThr: 3.21 ± 0.052	4.248SerVal: 4.248 ± 0.059	0.71SerTrp: 0.71 ± 0.025	2.402SerTyr: 2.402 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	3.774ThrAla: 3.774 ± 0.052	0.361ThrCys: 0.361 ± 0.019	2.785ThrAsp: 2.785 ± 0.047	3.917ThrGlu: 3.917 ± 0.058	2.781ThrPhe: 2.781 ± 0.047	4.054ThrGly: 4.054 ± 0.065	1.13ThrHis: 1.13 ± 0.032	4.751ThrIle: 4.751 ± 0.06	3.353ThrLys: 3.353 ± 0.052	5.523ThrLeu: 5.523 ± 0.066	1.371ThrMet: 1.371 ± 0.031	2.618ThrAsn: 2.618 ± 0.048	2.177ThrPro: 2.177 ± 0.04	1.567ThrGln: 1.567 ± 0.03	1.897ThrArg: 1.897 ± 0.037	3.395ThrSer: 3.395 ± 0.049	3.233ThrThr: 3.233 ± 0.058	4.31ThrVal: 4.31 ± 0.069	0.554ThrTrp: 0.554 ± 0.02	1.949ThrTyr: 1.949 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	5.161ValAla: 5.161 ± 0.067	0.562ValCys: 0.562 ± 0.024	3.878ValAsp: 3.878 ± 0.06	5.498ValGlu: 5.498 ± 0.087	3.217ValPhe: 3.217 ± 0.062	4.769ValGly: 4.769 ± 0.067	1.389ValHis: 1.389 ± 0.03	5.856ValIle: 5.856 ± 0.063	4.456ValLys: 4.456 ± 0.063	6.915ValLeu: 6.915 ± 0.084	1.851ValMet: 1.851 ± 0.04	3.191ValAsn: 3.191 ± 0.055	2.607ValPro: 2.607 ± 0.047	2.472ValGln: 2.472 ± 0.04	2.804ValArg: 2.804 ± 0.055	4.58ValSer: 4.58 ± 0.056	4.349ValThr: 4.349 ± 0.062	5.299ValVal: 5.299 ± 0.071	0.665ValTrp: 0.665 ± 0.028	2.325ValTyr: 2.325 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	0.617TrpAla: 0.617 ± 0.022	0.076TrpCys: 0.076 ± 0.008	0.551TrpAsp: 0.551 ± 0.024	0.743TrpGlu: 0.743 ± 0.025	0.561TrpPhe: 0.561 ± 0.023	0.706TrpGly: 0.706 ± 0.023	0.217TrpHis: 0.217 ± 0.013	0.832TrpIle: 0.832 ± 0.027	0.747TrpLys: 0.747 ± 0.025	1.244TrpLeu: 1.244 ± 0.032	0.343TrpMet: 0.343 ± 0.015	0.591TrpAsn: 0.591 ± 0.022	0.272TrpPro: 0.272 ± 0.014	0.409TrpGln: 0.409 ± 0.017	0.414TrpArg: 0.414 ± 0.017	0.69TrpSer: 0.69 ± 0.023	0.532TrpThr: 0.532 ± 0.021	0.682TrpVal: 0.682 ± 0.024	0.158TrpTrp: 0.158 ± 0.013	0.339TrpTyr: 0.339 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.918TyrAla: 1.918 ± 0.038	0.306TyrCys: 0.306 ± 0.016	1.948TyrAsp: 1.948 ± 0.04	2.507TyrGlu: 2.507 ± 0.047	1.771TyrPhe: 1.771 ± 0.04	2.363TyrGly: 2.363 ± 0.043	0.905TyrHis: 0.905 ± 0.03	2.397TyrIle: 2.397 ± 0.042	1.955TyrLys: 1.955 ± 0.04	3.563TyrLeu: 3.563 ± 0.051	0.856TyrMet: 0.856 ± 0.023	1.452TyrAsn: 1.452 ± 0.039	1.359TyrPro: 1.359 ± 0.033	1.749TyrGln: 1.749 ± 0.04	1.562TyrArg: 1.562 ± 0.036	2.118TyrSer: 2.118 ± 0.04	1.731TyrThr: 1.731 ± 0.035	2.286TyrVal: 2.286 ± 0.042	0.42TyrTrp: 0.42 ± 0.022	1.453TyrTyr: 1.453 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4710 proteins (1307598 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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