Amino acid dipepetide frequency for Succiniclasticum ruminis DSM 9236

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.503AlaAla: 10.503 ± 0.185	1.187AlaCys: 1.187 ± 0.044	5.465AlaAsp: 5.465 ± 0.099	7.059AlaGlu: 7.059 ± 0.11	3.507AlaPhe: 3.507 ± 0.086	8.15AlaGly: 8.15 ± 0.153	1.404AlaHis: 1.404 ± 0.045	5.175AlaIle: 5.175 ± 0.107	5.958AlaLys: 5.958 ± 0.119	8.392AlaLeu: 8.392 ± 0.118	2.688AlaMet: 2.688 ± 0.07	2.939AlaAsn: 2.939 ± 0.082	2.598AlaPro: 2.598 ± 0.059	2.523AlaGln: 2.523 ± 0.06	3.911AlaArg: 3.911 ± 0.1	4.355AlaSer: 4.355 ± 0.109	4.049AlaThr: 4.049 ± 0.13	7.477AlaVal: 7.477 ± 0.117	0.841AlaTrp: 0.841 ± 0.045	2.823AlaTyr: 2.823 ± 0.079	0.0AlaXaa: 0.0 ± 0.0
Cys	1.067CysAla: 1.067 ± 0.042	0.295CysCys: 0.295 ± 0.022	0.673CysAsp: 0.673 ± 0.031	0.73CysGlu: 0.73 ± 0.035	0.58CysPhe: 0.58 ± 0.033	1.525CysGly: 1.525 ± 0.05	0.293CysHis: 0.293 ± 0.02	0.804CysIle: 0.804 ± 0.035	0.744CysLys: 0.744 ± 0.034	1.273CysLeu: 1.273 ± 0.051	0.362CysMet: 0.362 ± 0.023	0.532CysAsn: 0.532 ± 0.028	0.68CysPro: 0.68 ± 0.036	0.342CysGln: 0.342 ± 0.021	0.785CysArg: 0.785 ± 0.031	0.822CysSer: 0.822 ± 0.031	0.654CysThr: 0.654 ± 0.031	0.862CysVal: 0.862 ± 0.037	0.188CysTrp: 0.188 ± 0.016	0.491CysTyr: 0.491 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	4.745AspAla: 4.745 ± 0.101	0.728AspCys: 0.728 ± 0.032	2.602AspAsp: 2.602 ± 0.071	3.601AspGlu: 3.601 ± 0.077	2.597AspPhe: 2.597 ± 0.067	4.3AspGly: 4.3 ± 0.099	0.894AspHis: 0.894 ± 0.046	3.998AspIle: 3.998 ± 0.089	3.793AspLys: 3.793 ± 0.079	4.485AspLeu: 4.485 ± 0.08	1.746AspMet: 1.746 ± 0.047	2.237AspAsn: 2.237 ± 0.067	2.142AspPro: 2.142 ± 0.062	1.132AspGln: 1.132 ± 0.036	2.652AspArg: 2.652 ± 0.061	2.827AspSer: 2.827 ± 0.069	2.957AspThr: 2.957 ± 0.079	4.169AspVal: 4.169 ± 0.082	0.662AspTrp: 0.662 ± 0.031	2.307AspTyr: 2.307 ± 0.071	0.0AspXaa: 0.0 ± 0.0
Glu	6.386GluAla: 6.386 ± 0.107	0.704GluCys: 0.704 ± 0.031	3.602GluAsp: 3.602 ± 0.07	5.846GluGlu: 5.846 ± 0.119	2.333GluPhe: 2.333 ± 0.064	4.391GluGly: 4.391 ± 0.087	1.214GluHis: 1.214 ± 0.042	4.473GluIle: 4.473 ± 0.083	6.015GluLys: 6.015 ± 0.105	5.994GluLeu: 5.994 ± 0.113	2.227GluMet: 2.227 ± 0.059	3.32GluAsn: 3.32 ± 0.072	2.111GluPro: 2.111 ± 0.067	2.606GluGln: 2.606 ± 0.069	3.204GluArg: 3.204 ± 0.079	2.684GluSer: 2.684 ± 0.064	3.966GluThr: 3.966 ± 0.067	4.147GluVal: 4.147 ± 0.079	0.639GluTrp: 0.639 ± 0.029	2.323GluTyr: 2.323 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	3.663PheAla: 3.663 ± 0.087	0.841PheCys: 0.841 ± 0.038	2.232PheAsp: 2.232 ± 0.062	2.038PheGlu: 2.038 ± 0.054	1.789PhePhe: 1.789 ± 0.059	3.357PheGly: 3.357 ± 0.098	0.712PheHis: 0.712 ± 0.032	2.559PheIle: 2.559 ± 0.071	1.972PheLys: 1.972 ± 0.054	3.761PheLeu: 3.761 ± 0.087	1.198PheMet: 1.198 ± 0.042	1.656PheAsn: 1.656 ± 0.049	1.498PhePro: 1.498 ± 0.049	0.902PheGln: 0.902 ± 0.038	1.871PheArg: 1.871 ± 0.055	2.769PheSer: 2.769 ± 0.062	2.387PheThr: 2.387 ± 0.061	2.642PheVal: 2.642 ± 0.077	0.486PheTrp: 0.486 ± 0.028	1.404PheTyr: 1.404 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	6.363GlyAla: 6.363 ± 0.147	1.275GlyCys: 1.275 ± 0.044	3.898GlyAsp: 3.898 ± 0.097	4.461GlyGlu: 4.461 ± 0.084	3.205GlyPhe: 3.205 ± 0.073	6.109GlyGly: 6.109 ± 0.152	1.516GlyHis: 1.516 ± 0.057	5.666GlyIle: 5.666 ± 0.104	5.904GlyLys: 5.904 ± 0.085	6.624GlyLeu: 6.624 ± 0.098	2.455GlyMet: 2.455 ± 0.067	3.547GlyAsn: 3.547 ± 0.108	1.855GlyPro: 1.855 ± 0.058	2.244GlyGln: 2.244 ± 0.055	3.705GlyArg: 3.705 ± 0.081	4.76GlySer: 4.76 ± 0.141	4.931GlyThr: 4.931 ± 0.132	5.502GlyVal: 5.502 ± 0.107	0.831GlyTrp: 0.831 ± 0.041	3.042GlyTyr: 3.042 ± 0.079	0.0GlyXaa: 0.0 ± 0.0
His	1.424HisAla: 1.424 ± 0.045	0.337HisCys: 0.337 ± 0.022	0.945HisAsp: 0.945 ± 0.041	1.035HisGlu: 1.035 ± 0.045	0.805HisPhe: 0.805 ± 0.035	1.43HisGly: 1.43 ± 0.05	0.468HisHis: 0.468 ± 0.031	1.257HisIle: 1.257 ± 0.044	1.042HisLys: 1.042 ± 0.042	1.524HisLeu: 1.524 ± 0.049	0.563HisMet: 0.563 ± 0.025	0.818HisAsn: 0.818 ± 0.033	1.053HisPro: 1.053 ± 0.04	0.501HisGln: 0.501 ± 0.027	0.956HisArg: 0.956 ± 0.041	0.961HisSer: 0.961 ± 0.04	1.024HisThr: 1.024 ± 0.035	1.228HisVal: 1.228 ± 0.041	0.192HisTrp: 0.192 ± 0.016	0.72HisTyr: 0.72 ± 0.037	0.0HisXaa: 0.0 ± 0.0
Ile	5.914IleAla: 5.914 ± 0.11	0.973IleCys: 0.973 ± 0.036	3.371IleAsp: 3.371 ± 0.074	3.583IleGlu: 3.583 ± 0.08	2.334IlePhe: 2.334 ± 0.065	4.936IleGly: 4.936 ± 0.109	1.167IleHis: 1.167 ± 0.038	4.049IleIle: 4.049 ± 0.091	3.561IleLys: 3.561 ± 0.071	5.748IleLeu: 5.748 ± 0.099	1.648IleMet: 1.648 ± 0.05	2.542IleAsn: 2.542 ± 0.068	3.025IlePro: 3.025 ± 0.076	1.649IleGln: 1.649 ± 0.053	3.539IleArg: 3.539 ± 0.083	3.748IleSer: 3.748 ± 0.071	3.936IleThr: 3.936 ± 0.079	4.514IleVal: 4.514 ± 0.076	0.568IleTrp: 0.568 ± 0.028	1.99IleTyr: 1.99 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	6.332LysAla: 6.332 ± 0.108	0.541LysCys: 0.541 ± 0.031	3.919LysAsp: 3.919 ± 0.078	5.733LysGlu: 5.733 ± 0.112	2.002LysPhe: 2.002 ± 0.056	4.461LysGly: 4.461 ± 0.076	1.096LysHis: 1.096 ± 0.041	4.091LysIle: 4.091 ± 0.075	5.568LysLys: 5.568 ± 0.113	5.486LysLeu: 5.486 ± 0.094	2.163LysMet: 2.163 ± 0.056	3.382LysAsn: 3.382 ± 0.071	2.536LysPro: 2.536 ± 0.065	2.376LysGln: 2.376 ± 0.062	3.169LysArg: 3.169 ± 0.072	2.959LysSer: 2.959 ± 0.067	3.884LysThr: 3.884 ± 0.073	4.543LysVal: 4.543 ± 0.093	0.595LysTrp: 0.595 ± 0.028	2.28LysTyr: 2.28 ± 0.062	0.0LysXaa: 0.0 ± 0.0
Leu	8.761LeuAla: 8.761 ± 0.122	1.415LeuCys: 1.415 ± 0.05	5.009LeuAsp: 5.009 ± 0.084	5.659LeuGlu: 5.659 ± 0.114	3.779LeuPhe: 3.779 ± 0.087	6.444LeuGly: 6.444 ± 0.098	1.785LeuHis: 1.785 ± 0.061	4.847LeuIle: 4.847 ± 0.103	5.895LeuLys: 5.895 ± 0.097	9.225LeuLeu: 9.225 ± 0.165	2.477LeuMet: 2.477 ± 0.063	3.469LeuAsn: 3.469 ± 0.069	4.246LeuPro: 4.246 ± 0.097	3.769LeuGln: 3.769 ± 0.095	4.66LeuArg: 4.66 ± 0.103	5.242LeuSer: 5.242 ± 0.093	5.105LeuThr: 5.105 ± 0.08	5.744LeuVal: 5.744 ± 0.103	0.822LeuTrp: 0.822 ± 0.039	2.975LeuTyr: 2.975 ± 0.07	0.0LeuXaa: 0.0 ± 0.0
Met	2.84MetAla: 2.84 ± 0.058	0.249MetCys: 0.249 ± 0.018	1.677MetAsp: 1.677 ± 0.05	2.185MetGlu: 2.185 ± 0.058	0.984MetPhe: 0.984 ± 0.035	2.108MetGly: 2.108 ± 0.058	0.514MetHis: 0.514 ± 0.028	1.718MetIle: 1.718 ± 0.054	2.344MetLys: 2.344 ± 0.064	2.812MetLeu: 2.812 ± 0.065	0.874MetMet: 0.874 ± 0.036	1.354MetAsn: 1.354 ± 0.045	1.251MetPro: 1.251 ± 0.042	1.22MetGln: 1.22 ± 0.04	1.415MetArg: 1.415 ± 0.047	1.502MetSer: 1.502 ± 0.047	1.626MetThr: 1.626 ± 0.048	1.794MetVal: 1.794 ± 0.048	0.195MetTrp: 0.195 ± 0.015	0.82MetTyr: 0.82 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	3.8AsnAla: 3.8 ± 0.103	0.576AsnCys: 0.576 ± 0.032	1.937AsnAsp: 1.937 ± 0.062	2.33AsnGlu: 2.33 ± 0.056	1.539AsnPhe: 1.539 ± 0.047	3.492AsnGly: 3.492 ± 0.088	0.793AsnHis: 0.793 ± 0.032	2.83AsnIle: 2.83 ± 0.082	2.731AsnLys: 2.731 ± 0.074	3.618AsnLeu: 3.618 ± 0.067	1.186AsnMet: 1.186 ± 0.039	1.941AsnAsn: 1.941 ± 0.078	2.08AsnPro: 2.08 ± 0.059	1.078AsnGln: 1.078 ± 0.04	2.208AsnArg: 2.208 ± 0.06	2.092AsnSer: 2.092 ± 0.068	2.48AsnThr: 2.48 ± 0.092	3.193AsnVal: 3.193 ± 0.083	0.482AsnTrp: 0.482 ± 0.024	1.626AsnTyr: 1.626 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	3.558ProAla: 3.558 ± 0.091	0.494ProCys: 0.494 ± 0.029	2.696ProAsp: 2.696 ± 0.078	4.009ProGlu: 4.009 ± 0.082	1.642ProPhe: 1.642 ± 0.053	3.208ProGly: 3.208 ± 0.072	0.704ProHis: 0.704 ± 0.033	1.753ProIle: 1.753 ± 0.054	2.128ProLys: 2.128 ± 0.067	3.268ProLeu: 3.268 ± 0.076	0.937ProMet: 0.937 ± 0.04	1.209ProAsn: 1.209 ± 0.041	1.139ProPro: 1.139 ± 0.05	1.264ProGln: 1.264 ± 0.054	1.42ProArg: 1.42 ± 0.054	1.769ProSer: 1.769 ± 0.053	1.452ProThr: 1.452 ± 0.048	3.853ProVal: 3.853 ± 0.072	0.402ProTrp: 0.402 ± 0.023	1.422ProTyr: 1.422 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	2.873GlnAla: 2.873 ± 0.071	0.367GlnCys: 0.367 ± 0.023	1.636GlnAsp: 1.636 ± 0.045	2.305GlnGlu: 2.305 ± 0.065	1.109GlnPhe: 1.109 ± 0.044	2.089GlnGly: 2.089 ± 0.073	0.614GlnHis: 0.614 ± 0.032	2.081GlnIle: 2.081 ± 0.052	2.459GlnLys: 2.459 ± 0.058	2.723GlnLeu: 2.723 ± 0.063	1.072GlnMet: 1.072 ± 0.046	1.426GlnAsn: 1.426 ± 0.046	1.171GlnPro: 1.171 ± 0.047	1.405GlnGln: 1.405 ± 0.061	1.61GlnArg: 1.61 ± 0.057	1.442GlnSer: 1.442 ± 0.042	1.486GlnThr: 1.486 ± 0.047	2.029GlnVal: 2.029 ± 0.058	0.32GlnTrp: 0.32 ± 0.023	1.195GlnTyr: 1.195 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	3.272ArgAla: 3.272 ± 0.07	0.638ArgCys: 0.638 ± 0.031	2.459ArgAsp: 2.459 ± 0.059	3.577ArgGlu: 3.577 ± 0.076	2.197ArgPhe: 2.197 ± 0.065	2.894ArgGly: 2.894 ± 0.075	0.958ArgHis: 0.958 ± 0.04	3.566ArgIle: 3.566 ± 0.074	3.496ArgLys: 3.496 ± 0.079	4.757ArgLeu: 4.757 ± 0.107	1.603ArgMet: 1.603 ± 0.047	2.353ArgAsn: 2.353 ± 0.06	1.86ArgPro: 1.86 ± 0.062	1.894ArgGln: 1.894 ± 0.055	2.642ArgArg: 2.642 ± 0.086	2.376ArgSer: 2.376 ± 0.06	2.454ArgThr: 2.454 ± 0.059	3.134ArgVal: 3.134 ± 0.074	0.556ArgTrp: 0.556 ± 0.032	1.836ArgTyr: 1.836 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	4.454SerAla: 4.454 ± 0.094	0.681SerCys: 0.681 ± 0.034	2.723SerAsp: 2.723 ± 0.067	3.069SerGlu: 3.069 ± 0.067	2.276SerPhe: 2.276 ± 0.061	5.202SerGly: 5.202 ± 0.119	1.07SerHis: 1.07 ± 0.042	3.196SerIle: 3.196 ± 0.082	2.809SerLys: 2.809 ± 0.064	5.119SerLeu: 5.119 ± 0.095	1.525SerMet: 1.525 ± 0.045	1.988SerAsn: 1.988 ± 0.067	1.833SerPro: 1.833 ± 0.051	1.485SerGln: 1.485 ± 0.049	2.731SerArg: 2.731 ± 0.07	3.042SerSer: 3.042 ± 0.072	2.59SerThr: 2.59 ± 0.098	4.313SerVal: 4.313 ± 0.096	0.598SerTrp: 0.598 ± 0.033	1.941SerTyr: 1.941 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	5.515ThrAla: 5.515 ± 0.184	0.626ThrCys: 0.626 ± 0.03	3.348ThrAsp: 3.348 ± 0.086	3.767ThrGlu: 3.767 ± 0.079	1.998ThrPhe: 1.998 ± 0.052	5.506ThrGly: 5.506 ± 0.119	0.911ThrHis: 0.911 ± 0.036	3.301ThrIle: 3.301 ± 0.086	2.976ThrLys: 2.976 ± 0.076	5.113ThrLeu: 5.113 ± 0.084	1.338ThrMet: 1.338 ± 0.044	1.933ThrAsn: 1.933 ± 0.059	2.414ThrPro: 2.414 ± 0.059	1.36ThrGln: 1.36 ± 0.047	2.244ThrArg: 2.244 ± 0.052	2.48ThrSer: 2.48 ± 0.071	2.835ThrThr: 2.835 ± 0.103	5.148ThrVal: 5.148 ± 0.111	0.499ThrTrp: 0.499 ± 0.029	1.754ThrTyr: 1.754 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	6.221ValAla: 6.221 ± 0.127	1.069ValCys: 1.069 ± 0.04	3.682ValAsp: 3.682 ± 0.091	4.337ValGlu: 4.337 ± 0.09	3.015ValPhe: 3.015 ± 0.069	4.686ValGly: 4.686 ± 0.108	1.191ValHis: 1.191 ± 0.04	4.856ValIle: 4.856 ± 0.082	4.957ValLys: 4.957 ± 0.088	7.211ValLeu: 7.211 ± 0.123	2.171ValMet: 2.171 ± 0.058	3.111ValAsn: 3.111 ± 0.098	3.085ValPro: 3.085 ± 0.072	2.093ValGln: 2.093 ± 0.061	3.309ValArg: 3.309 ± 0.072	4.418ValSer: 4.418 ± 0.073	4.78ValThr: 4.78 ± 0.114	5.149ValVal: 5.149 ± 0.097	0.647ValTrp: 0.647 ± 0.029	2.462ValTyr: 2.462 ± 0.062	0.0ValXaa: 0.0 ± 0.0
Trp	0.688TrpAla: 0.688 ± 0.028	0.135TrpCys: 0.135 ± 0.014	0.572TrpAsp: 0.572 ± 0.031	0.673TrpGlu: 0.673 ± 0.027	0.456TrpPhe: 0.456 ± 0.03	0.74TrpGly: 0.74 ± 0.045	0.229TrpHis: 0.229 ± 0.017	0.573TrpIle: 0.573 ± 0.029	0.723TrpLys: 0.723 ± 0.033	1.054TrpLeu: 1.054 ± 0.045	0.328TrpMet: 0.328 ± 0.019	0.544TrpAsn: 0.544 ± 0.031	0.32TrpPro: 0.32 ± 0.023	0.52TrpGln: 0.52 ± 0.026	0.483TrpArg: 0.483 ± 0.023	0.447TrpSer: 0.447 ± 0.022	0.498TrpThr: 0.498 ± 0.03	0.548TrpVal: 0.548 ± 0.03	0.147TrpTrp: 0.147 ± 0.014	0.401TrpTyr: 0.401 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.622TyrAla: 2.622 ± 0.073	0.572TyrCys: 0.572 ± 0.031	2.128TyrAsp: 2.128 ± 0.058	2.189TyrGlu: 2.189 ± 0.059	1.591TyrPhe: 1.591 ± 0.051	2.867TyrGly: 2.867 ± 0.086	0.748TyrHis: 0.748 ± 0.035	2.002TyrIle: 2.002 ± 0.052	2.039TyrLys: 2.039 ± 0.054	3.138TyrLeu: 3.138 ± 0.075	0.919TyrMet: 0.919 ± 0.038	1.712TyrAsn: 1.712 ± 0.049	1.431TyrPro: 1.431 ± 0.054	1.05TyrGln: 1.05 ± 0.044	2.011TyrArg: 2.011 ± 0.062	1.953TyrSer: 1.953 ± 0.06	1.969TyrThr: 1.969 ± 0.065	2.463TyrVal: 2.463 ± 0.056	0.407TyrTrp: 0.407 ± 0.026	1.562TyrTyr: 1.562 ± 0.059	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2273 proteins (742859 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---