Amino acid dipepetide frequency for Halovibrio salipaludis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.876AlaAla: 9.876 ± 0.139	0.984AlaCys: 0.984 ± 0.029	5.753AlaAsp: 5.753 ± 0.085	6.884AlaGlu: 6.884 ± 0.094	3.553AlaPhe: 3.553 ± 0.061	8.975AlaGly: 8.975 ± 0.115	2.029AlaHis: 2.029 ± 0.048	4.929AlaIle: 4.929 ± 0.073	2.065AlaLys: 2.065 ± 0.049	11.778AlaLeu: 11.778 ± 0.146	3.105AlaMet: 3.105 ± 0.052	2.557AlaAsn: 2.557 ± 0.051	4.12AlaPro: 4.12 ± 0.068	3.581AlaGln: 3.581 ± 0.061	7.601AlaArg: 7.601 ± 0.1	5.707AlaSer: 5.707 ± 0.071	4.945AlaThr: 4.945 ± 0.071	7.114AlaVal: 7.114 ± 0.099	1.439AlaTrp: 1.439 ± 0.04	2.112AlaTyr: 2.112 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.724CysAla: 0.724 ± 0.025	0.119CysCys: 0.119 ± 0.01	0.509CysAsp: 0.509 ± 0.022	0.564CysGlu: 0.564 ± 0.023	0.344CysPhe: 0.344 ± 0.02	0.859CysGly: 0.859 ± 0.029	0.314CysHis: 0.314 ± 0.018	0.393CysIle: 0.393 ± 0.018	0.164CysLys: 0.164 ± 0.011	0.899CysLeu: 0.899 ± 0.032	0.181CysMet: 0.181 ± 0.012	0.231CysAsn: 0.231 ± 0.016	0.498CysPro: 0.498 ± 0.023	0.338CysGln: 0.338 ± 0.018	0.727CysArg: 0.727 ± 0.026	0.543CysSer: 0.543 ± 0.025	0.405CysThr: 0.405 ± 0.022	0.593CysVal: 0.593 ± 0.022	0.129CysTrp: 0.129 ± 0.011	0.225CysTyr: 0.225 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	5.736AspAla: 5.736 ± 0.09	0.495AspCys: 0.495 ± 0.021	3.738AspAsp: 3.738 ± 0.079	4.708AspGlu: 4.708 ± 0.071	2.178AspPhe: 2.178 ± 0.047	4.927AspGly: 4.927 ± 0.104	1.428AspHis: 1.428 ± 0.035	2.711AspIle: 2.711 ± 0.057	1.289AspLys: 1.289 ± 0.038	5.742AspLeu: 5.742 ± 0.078	1.427AspMet: 1.427 ± 0.04	1.736AspAsn: 1.736 ± 0.043	3.496AspPro: 3.496 ± 0.06	2.641AspGln: 2.641 ± 0.052	4.333AspArg: 4.333 ± 0.06	3.259AspSer: 3.259 ± 0.062	2.988AspThr: 2.988 ± 0.078	3.959AspVal: 3.959 ± 0.075	1.149AspTrp: 1.149 ± 0.035	1.926AspTyr: 1.926 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	8.219GluAla: 8.219 ± 0.115	0.513GluCys: 0.513 ± 0.022	3.871GluAsp: 3.871 ± 0.07	4.848GluGlu: 4.848 ± 0.084	1.947GluPhe: 1.947 ± 0.046	5.577GluGly: 5.577 ± 0.079	1.836GluHis: 1.836 ± 0.041	3.0GluIle: 3.0 ± 0.056	2.531GluLys: 2.531 ± 0.057	7.211GluLeu: 7.211 ± 0.094	1.659GluMet: 1.659 ± 0.038	2.126GluAsn: 2.126 ± 0.039	3.699GluPro: 3.699 ± 0.082	3.999GluGln: 3.999 ± 0.065	6.261GluArg: 6.261 ± 0.09	4.048GluSer: 4.048 ± 0.06	4.278GluThr: 4.278 ± 0.07	4.563GluVal: 4.563 ± 0.079	1.001GluTrp: 1.001 ± 0.028	1.574GluTyr: 1.574 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	2.977PheAla: 2.977 ± 0.055	0.378PheCys: 0.378 ± 0.017	2.174PheAsp: 2.174 ± 0.047	2.403PheGlu: 2.403 ± 0.054	1.39PhePhe: 1.39 ± 0.042	3.01PheGly: 3.01 ± 0.061	0.876PheHis: 0.876 ± 0.028	1.68PheIle: 1.68 ± 0.047	0.742PheLys: 0.742 ± 0.031	3.299PheLeu: 3.299 ± 0.071	0.908PheMet: 0.908 ± 0.029	1.283PheAsn: 1.283 ± 0.035	1.569PhePro: 1.569 ± 0.036	1.334PheGln: 1.334 ± 0.036	2.591PheArg: 2.591 ± 0.051	2.377PheSer: 2.377 ± 0.053	1.888PheThr: 1.888 ± 0.048	2.275PheVal: 2.275 ± 0.057	0.545PheTrp: 0.545 ± 0.025	1.031PheTyr: 1.031 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	7.269GlyAla: 7.269 ± 0.098	0.914GlyCys: 0.914 ± 0.034	4.961GlyAsp: 4.961 ± 0.098	6.092GlyGlu: 6.092 ± 0.085	3.322GlyPhe: 3.322 ± 0.061	6.772GlyGly: 6.772 ± 0.094	2.069GlyHis: 2.069 ± 0.05	4.57GlyIle: 4.57 ± 0.076	2.448GlyLys: 2.448 ± 0.056	8.459GlyLeu: 8.459 ± 0.121	2.548GlyMet: 2.548 ± 0.045	2.589GlyAsn: 2.589 ± 0.074	2.844GlyPro: 2.844 ± 0.053	3.39GlyGln: 3.39 ± 0.062	5.581GlyArg: 5.581 ± 0.078	4.748GlySer: 4.748 ± 0.085	4.385GlyThr: 4.385 ± 0.081	6.052GlyVal: 6.052 ± 0.076	1.347GlyTrp: 1.347 ± 0.04	2.542GlyTyr: 2.542 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.962HisAla: 1.962 ± 0.044	0.334HisCys: 0.334 ± 0.019	1.304HisAsp: 1.304 ± 0.037	1.617HisGlu: 1.617 ± 0.04	0.963HisPhe: 0.963 ± 0.032	2.076HisGly: 2.076 ± 0.047	0.76HisHis: 0.76 ± 0.031	0.982HisIle: 0.982 ± 0.032	0.518HisLys: 0.518 ± 0.022	2.512HisLeu: 2.512 ± 0.053	0.555HisMet: 0.555 ± 0.023	0.647HisAsn: 0.647 ± 0.029	1.499HisPro: 1.499 ± 0.043	1.078HisGln: 1.078 ± 0.029	1.837HisArg: 1.837 ± 0.044	1.295HisSer: 1.295 ± 0.035	1.054HisThr: 1.054 ± 0.033	1.34HisVal: 1.34 ± 0.032	0.461HisTrp: 0.461 ± 0.021	0.843HisTyr: 0.843 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	4.959IleAla: 4.959 ± 0.072	0.392IleCys: 0.392 ± 0.019	2.88IleAsp: 2.88 ± 0.06	3.669IleGlu: 3.669 ± 0.065	1.361IlePhe: 1.361 ± 0.045	4.016IleGly: 4.016 ± 0.074	1.218IleHis: 1.218 ± 0.038	2.024IleIle: 2.024 ± 0.053	1.279IleLys: 1.279 ± 0.042	4.24IleLeu: 4.24 ± 0.072	1.027IleMet: 1.027 ± 0.034	1.805IleAsn: 1.805 ± 0.048	2.474IlePro: 2.474 ± 0.054	1.897IleGln: 1.897 ± 0.043	3.808IleArg: 3.808 ± 0.058	2.667IleSer: 2.667 ± 0.052	2.805IleThr: 2.805 ± 0.055	3.026IleVal: 3.026 ± 0.059	0.515IleTrp: 0.515 ± 0.024	1.039IleTyr: 1.039 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	2.942LysAla: 2.942 ± 0.062	0.14LysCys: 0.14 ± 0.013	1.473LysAsp: 1.473 ± 0.042	1.828LysGlu: 1.828 ± 0.053	0.56LysPhe: 0.56 ± 0.023	2.22LysGly: 2.22 ± 0.052	0.622LysHis: 0.622 ± 0.024	1.011LysIle: 1.011 ± 0.033	1.14LysLys: 1.14 ± 0.04	2.522LysLeu: 2.522 ± 0.054	0.556LysMet: 0.556 ± 0.025	0.753LysAsn: 0.753 ± 0.029	1.549LysPro: 1.549 ± 0.04	1.373LysGln: 1.373 ± 0.038	2.053LysArg: 2.053 ± 0.055	1.363LysSer: 1.363 ± 0.036	1.482LysThr: 1.482 ± 0.038	1.935LysVal: 1.935 ± 0.043	0.281LysTrp: 0.281 ± 0.016	0.55LysTyr: 0.55 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	11.743LeuAla: 11.743 ± 0.145	0.96LeuCys: 0.96 ± 0.033	6.513LeuAsp: 6.513 ± 0.09	7.774LeuGlu: 7.774 ± 0.108	3.581LeuPhe: 3.581 ± 0.084	8.331LeuGly: 8.331 ± 0.099	2.201LeuHis: 2.201 ± 0.052	4.877LeuIle: 4.877 ± 0.09	3.129LeuLys: 3.129 ± 0.067	10.194LeuLeu: 10.194 ± 0.135	2.865LeuMet: 2.865 ± 0.046	3.363LeuAsn: 3.363 ± 0.05	5.213LeuPro: 5.213 ± 0.081	3.696LeuGln: 3.696 ± 0.059	7.199LeuArg: 7.199 ± 0.097	6.558LeuSer: 6.558 ± 0.088	5.554LeuThr: 5.554 ± 0.079	7.558LeuVal: 7.558 ± 0.113	1.286LeuTrp: 1.286 ± 0.041	2.399LeuTyr: 2.399 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	3.182MetAla: 3.182 ± 0.062	0.146MetCys: 0.146 ± 0.011	1.581MetAsp: 1.581 ± 0.036	1.778MetGlu: 1.778 ± 0.039	0.583MetPhe: 0.583 ± 0.025	2.097MetGly: 2.097 ± 0.054	0.492MetHis: 0.492 ± 0.021	1.16MetIle: 1.16 ± 0.036	0.923MetLys: 0.923 ± 0.03	2.607MetLeu: 2.607 ± 0.053	0.657MetMet: 0.657 ± 0.029	0.904MetAsn: 0.904 ± 0.027	1.456MetPro: 1.456 ± 0.041	0.981MetGln: 0.981 ± 0.028	1.641MetArg: 1.641 ± 0.042	1.543MetSer: 1.543 ± 0.034	1.766MetThr: 1.766 ± 0.039	1.86MetVal: 1.86 ± 0.046	0.16MetTrp: 0.16 ± 0.013	0.379MetTyr: 0.379 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.024AsnAla: 3.024 ± 0.058	0.253AsnCys: 0.253 ± 0.016	1.635AsnAsp: 1.635 ± 0.041	1.947AsnGlu: 1.947 ± 0.05	0.877AsnPhe: 0.877 ± 0.032	2.628AsnGly: 2.628 ± 0.061	0.775AsnHis: 0.775 ± 0.025	1.355AsnIle: 1.355 ± 0.038	0.705AsnLys: 0.705 ± 0.027	3.203AsnLeu: 3.203 ± 0.055	0.637AsnMet: 0.637 ± 0.025	0.991AsnAsn: 0.991 ± 0.033	1.983AsnPro: 1.983 ± 0.042	1.353AsnGln: 1.353 ± 0.038	2.553AsnArg: 2.553 ± 0.052	1.525AsnSer: 1.525 ± 0.042	1.626AsnThr: 1.626 ± 0.046	1.923AsnVal: 1.923 ± 0.045	0.477AsnTrp: 0.477 ± 0.024	0.741AsnTyr: 0.741 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	4.662ProAla: 4.662 ± 0.084	0.333ProCys: 0.333 ± 0.019	3.812ProAsp: 3.812 ± 0.065	5.547ProGlu: 5.547 ± 0.093	1.683ProPhe: 1.683 ± 0.036	4.524ProGly: 4.524 ± 0.08	0.964ProHis: 0.964 ± 0.028	1.966ProIle: 1.966 ± 0.049	1.118ProLys: 1.118 ± 0.035	4.823ProLeu: 4.823 ± 0.073	1.216ProMet: 1.216 ± 0.033	1.213ProAsn: 1.213 ± 0.036	1.98ProPro: 1.98 ± 0.053	1.603ProGln: 1.603 ± 0.038	2.682ProArg: 2.682 ± 0.049	2.497ProSer: 2.497 ± 0.046	2.02ProThr: 2.02 ± 0.047	4.247ProVal: 4.247 ± 0.074	0.807ProTrp: 0.807 ± 0.028	1.112ProTyr: 1.112 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.646GlnAla: 4.646 ± 0.064	0.347GlnCys: 0.347 ± 0.019	2.031GlnAsp: 2.031 ± 0.053	2.579GlnGlu: 2.579 ± 0.058	1.284GlnPhe: 1.284 ± 0.035	3.353GlnGly: 3.353 ± 0.064	0.947GlnHis: 0.947 ± 0.036	1.545GlnIle: 1.545 ± 0.039	1.337GlnLys: 1.337 ± 0.038	4.324GlnLeu: 4.324 ± 0.069	1.025GlnMet: 1.025 ± 0.032	1.044GlnAsn: 1.044 ± 0.033	2.111GlnPro: 2.111 ± 0.048	2.371GlnGln: 2.371 ± 0.06	3.388GlnArg: 3.388 ± 0.061	2.314GlnSer: 2.314 ± 0.051	1.954GlnThr: 1.954 ± 0.049	2.957GlnVal: 2.957 ± 0.054	0.766GlnTrp: 0.766 ± 0.024	1.032GlnTyr: 1.032 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	6.184ArgAla: 6.184 ± 0.086	0.608ArgCys: 0.608 ± 0.026	4.406ArgAsp: 4.406 ± 0.061	6.025ArgGlu: 6.025 ± 0.091	3.156ArgPhe: 3.156 ± 0.052	4.342ArgGly: 4.342 ± 0.067	2.042ArgHis: 2.042 ± 0.048	4.38ArgIle: 4.38 ± 0.071	2.063ArgLys: 2.063 ± 0.052	8.422ArgLeu: 8.422 ± 0.107	2.002ArgMet: 2.002 ± 0.043	2.401ArgAsn: 2.401 ± 0.05	2.985ArgPro: 2.985 ± 0.054	3.46ArgGln: 3.46 ± 0.065	5.714ArgArg: 5.714 ± 0.087	3.802ArgSer: 3.802 ± 0.059	3.349ArgThr: 3.349 ± 0.06	5.406ArgVal: 5.406 ± 0.066	1.14ArgTrp: 1.14 ± 0.039	2.327ArgTyr: 2.327 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	5.362SerAla: 5.362 ± 0.073	0.401SerCys: 0.401 ± 0.016	3.541SerAsp: 3.541 ± 0.073	4.108SerGlu: 4.108 ± 0.066	1.977SerPhe: 1.977 ± 0.048	5.851SerGly: 5.851 ± 0.099	1.335SerHis: 1.335 ± 0.039	2.667SerIle: 2.667 ± 0.046	1.322SerLys: 1.322 ± 0.038	6.019SerLeu: 6.019 ± 0.08	1.559SerMet: 1.559 ± 0.039	1.721SerAsn: 1.721 ± 0.051	2.696SerPro: 2.696 ± 0.045	2.129SerGln: 2.129 ± 0.05	4.147SerArg: 4.147 ± 0.065	3.28SerSer: 3.28 ± 0.062	2.695SerThr: 2.695 ± 0.06	4.066SerVal: 4.066 ± 0.063	0.756SerTrp: 0.756 ± 0.032	1.21SerTyr: 1.21 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.056ThrAla: 5.056 ± 0.082	0.405ThrCys: 0.405 ± 0.021	3.133ThrAsp: 3.133 ± 0.066	3.295ThrGlu: 3.295 ± 0.056	1.857ThrPhe: 1.857 ± 0.046	5.263ThrGly: 5.263 ± 0.08	1.132ThrHis: 1.132 ± 0.033	2.441ThrIle: 2.441 ± 0.053	0.94ThrLys: 0.94 ± 0.03	6.608ThrLeu: 6.608 ± 0.097	1.125ThrMet: 1.125 ± 0.032	1.357ThrAsn: 1.357 ± 0.043	3.16ThrPro: 3.16 ± 0.061	1.764ThrGln: 1.764 ± 0.043	3.637ThrArg: 3.637 ± 0.061	2.649ThrSer: 2.649 ± 0.07	2.8ThrThr: 2.8 ± 0.063	3.949ThrVal: 3.949 ± 0.066	0.653ThrTrp: 0.653 ± 0.029	1.149ThrTyr: 1.149 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	7.322ValAla: 7.322 ± 0.101	0.599ValCys: 0.599 ± 0.024	4.45ValAsp: 4.45 ± 0.074	4.726ValGlu: 4.726 ± 0.072	2.564ValPhe: 2.564 ± 0.056	5.03ValGly: 5.03 ± 0.078	1.532ValHis: 1.532 ± 0.039	3.723ValIle: 3.723 ± 0.069	1.724ValLys: 1.724 ± 0.051	7.389ValLeu: 7.389 ± 0.099	1.971ValMet: 1.971 ± 0.047	2.273ValAsn: 2.273 ± 0.054	3.443ValPro: 3.443 ± 0.062	2.274ValGln: 2.274 ± 0.051	4.862ValArg: 4.862 ± 0.08	4.42ValSer: 4.42 ± 0.075	4.464ValThr: 4.464 ± 0.07	5.484ValVal: 5.484 ± 0.087	0.857ValTrp: 0.857 ± 0.032	1.618ValTyr: 1.618 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.087TrpAla: 1.087 ± 0.037	0.166TrpCys: 0.166 ± 0.012	0.631TrpAsp: 0.631 ± 0.026	0.78TrpGlu: 0.78 ± 0.032	0.626TrpPhe: 0.626 ± 0.027	0.95TrpGly: 0.95 ± 0.033	0.421TrpHis: 0.421 ± 0.022	0.668TrpIle: 0.668 ± 0.03	0.38TrpLys: 0.38 ± 0.02	2.107TrpLeu: 2.107 ± 0.047	0.371TrpMet: 0.371 ± 0.017	0.431TrpAsn: 0.431 ± 0.022	0.728TrpPro: 0.728 ± 0.026	0.881TrpGln: 0.881 ± 0.03	1.177TrpArg: 1.177 ± 0.033	0.794TrpSer: 0.794 ± 0.033	0.616TrpThr: 0.616 ± 0.026	0.984TrpVal: 0.984 ± 0.033	0.264TrpTrp: 0.264 ± 0.019	0.401TrpTyr: 0.401 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.174TyrAla: 2.174 ± 0.043	0.272TyrCys: 0.272 ± 0.017	1.471TyrAsp: 1.471 ± 0.048	1.589TyrGlu: 1.589 ± 0.038	0.925TyrPhe: 0.925 ± 0.025	2.104TyrGly: 2.104 ± 0.04	0.645TyrHis: 0.645 ± 0.025	1.018TyrIle: 1.018 ± 0.032	0.535TyrLys: 0.535 ± 0.026	2.636TyrLeu: 2.636 ± 0.053	0.501TyrMet: 0.501 ± 0.022	0.785TyrAsn: 0.785 ± 0.03	1.308TyrPro: 1.308 ± 0.035	1.213TyrGln: 1.213 ± 0.033	2.419TyrArg: 2.419 ± 0.051	1.453TyrSer: 1.453 ± 0.04	1.298TyrThr: 1.298 ± 0.036	1.433TyrVal: 1.433 ± 0.036	0.431TyrTrp: 0.431 ± 0.021	0.694TyrTyr: 0.694 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3225 proteins (1065101 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---