Amino acid dipepetide frequency for Ereboglobus luteus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.324AlaAla: 14.324 ± 0.159	1.101AlaCys: 1.101 ± 0.032	6.299AlaAsp: 6.299 ± 0.087	5.601AlaGlu: 5.601 ± 0.088	4.014AlaPhe: 4.014 ± 0.074	10.289AlaGly: 10.289 ± 0.191	2.295AlaHis: 2.295 ± 0.047	5.873AlaIle: 5.873 ± 0.087	4.449AlaLys: 4.449 ± 0.082	10.788AlaLeu: 10.788 ± 0.133	2.257AlaMet: 2.257 ± 0.052	4.205AlaAsn: 4.205 ± 0.121	5.499AlaPro: 5.499 ± 0.105	3.808AlaGln: 3.808 ± 0.068	7.51AlaArg: 7.51 ± 0.13	6.821AlaSer: 6.821 ± 0.101	7.173AlaThr: 7.173 ± 0.17	6.787AlaVal: 6.787 ± 0.084	1.544AlaTrp: 1.544 ± 0.042	2.525AlaTyr: 2.525 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.241CysAla: 1.241 ± 0.047	0.13CysCys: 0.13 ± 0.01	0.573CysAsp: 0.573 ± 0.022	0.582CysGlu: 0.582 ± 0.026	0.38CysPhe: 0.38 ± 0.018	0.905CysGly: 0.905 ± 0.033	0.214CysHis: 0.214 ± 0.014	0.488CysIle: 0.488 ± 0.021	0.278CysLys: 0.278 ± 0.016	0.767CysLeu: 0.767 ± 0.029	0.198CysMet: 0.198 ± 0.015	0.265CysAsn: 0.265 ± 0.017	0.463CysPro: 0.463 ± 0.023	0.228CysGln: 0.228 ± 0.014	0.617CysArg: 0.617 ± 0.023	0.51CysSer: 0.51 ± 0.021	0.435CysThr: 0.435 ± 0.019	0.777CysVal: 0.777 ± 0.03	0.136CysTrp: 0.136 ± 0.01	0.244CysTyr: 0.244 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.616AspAla: 6.616 ± 0.083	0.532AspCys: 0.532 ± 0.022	2.847AspAsp: 2.847 ± 0.057	3.1AspGlu: 3.1 ± 0.06	2.343AspPhe: 2.343 ± 0.042	5.322AspGly: 5.322 ± 0.109	0.969AspHis: 0.969 ± 0.032	3.309AspIle: 3.309 ± 0.072	2.087AspLys: 2.087 ± 0.046	4.446AspLeu: 4.446 ± 0.07	1.047AspMet: 1.047 ± 0.03	1.98AspAsn: 1.98 ± 0.048	2.579AspPro: 2.579 ± 0.06	1.241AspGln: 1.241 ± 0.034	2.795AspArg: 2.795 ± 0.06	3.018AspSer: 3.018 ± 0.059	3.282AspThr: 3.282 ± 0.063	3.165AspVal: 3.165 ± 0.052	0.886AspTrp: 0.886 ± 0.028	1.974AspTyr: 1.974 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	5.008GluAla: 5.008 ± 0.085	0.466GluCys: 0.466 ± 0.021	1.991GluAsp: 1.991 ± 0.05	2.208GluGlu: 2.208 ± 0.059	1.981GluPhe: 1.981 ± 0.046	3.375GluGly: 3.375 ± 0.057	1.141GluHis: 1.141 ± 0.035	3.636GluIle: 3.636 ± 0.066	3.355GluLys: 3.355 ± 0.074	4.909GluLeu: 4.909 ± 0.074	1.226GluMet: 1.226 ± 0.035	2.487GluAsn: 2.487 ± 0.052	2.237GluPro: 2.237 ± 0.05	1.878GluGln: 1.878 ± 0.048	3.349GluArg: 3.349 ± 0.076	2.781GluSer: 2.781 ± 0.058	3.444GluThr: 3.444 ± 0.061	2.99GluVal: 2.99 ± 0.063	0.799GluTrp: 0.799 ± 0.026	1.458GluTyr: 1.458 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	4.347PheAla: 4.347 ± 0.073	0.464PheCys: 0.464 ± 0.019	2.501PheAsp: 2.501 ± 0.044	2.128PheGlu: 2.128 ± 0.046	1.713PhePhe: 1.713 ± 0.045	3.126PheGly: 3.126 ± 0.055	0.719PheHis: 0.719 ± 0.026	1.985PheIle: 1.985 ± 0.045	1.434PheLys: 1.434 ± 0.04	3.253PheLeu: 3.253 ± 0.062	0.789PheMet: 0.789 ± 0.029	1.587PheAsn: 1.587 ± 0.037	1.68PhePro: 1.68 ± 0.045	1.037PheGln: 1.037 ± 0.034	2.081PheArg: 2.081 ± 0.055	2.835PheSer: 2.835 ± 0.055	2.813PheThr: 2.813 ± 0.062	2.607PheVal: 2.607 ± 0.059	0.589PheTrp: 0.589 ± 0.028	1.17PheTyr: 1.17 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	9.533GlyAla: 9.533 ± 0.227	0.809GlyCys: 0.809 ± 0.03	4.569GlyAsp: 4.569 ± 0.104	4.14GlyGlu: 4.14 ± 0.067	3.177GlyPhe: 3.177 ± 0.061	8.311GlyGly: 8.311 ± 0.261	1.631GlyHis: 1.631 ± 0.047	4.654GlyIle: 4.654 ± 0.074	4.207GlyLys: 4.207 ± 0.074	6.797GlyLeu: 6.797 ± 0.094	1.836GlyMet: 1.836 ± 0.043	3.648GlyAsn: 3.648 ± 0.128	2.438GlyPro: 2.438 ± 0.056	2.242GlyGln: 2.242 ± 0.053	4.908GlyArg: 4.908 ± 0.082	5.428GlySer: 5.428 ± 0.182	6.614GlyThr: 6.614 ± 0.338	6.194GlyVal: 6.194 ± 0.126	1.345GlyTrp: 1.345 ± 0.043	2.507GlyTyr: 2.507 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.403HisAla: 2.403 ± 0.05	0.247HisCys: 0.247 ± 0.015	1.081HisAsp: 1.081 ± 0.034	1.071HisGlu: 1.071 ± 0.031	0.904HisPhe: 0.904 ± 0.031	1.953HisGly: 1.953 ± 0.057	0.53HisHis: 0.53 ± 0.023	1.121HisIle: 1.121 ± 0.028	0.691HisLys: 0.691 ± 0.028	1.851HisLeu: 1.851 ± 0.042	0.413HisMet: 0.413 ± 0.019	0.783HisAsn: 0.783 ± 0.028	1.34HisPro: 1.34 ± 0.042	0.555HisGln: 0.555 ± 0.025	1.145HisArg: 1.145 ± 0.034	1.14HisSer: 1.14 ± 0.037	1.322HisThr: 1.322 ± 0.035	1.291HisVal: 1.291 ± 0.034	0.354HisTrp: 0.354 ± 0.019	0.759HisTyr: 0.759 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.582IleAla: 6.582 ± 0.086	0.594IleCys: 0.594 ± 0.025	3.673IleAsp: 3.673 ± 0.055	3.302IleGlu: 3.302 ± 0.064	2.06IlePhe: 2.06 ± 0.046	4.527IleGly: 4.527 ± 0.073	1.139IleHis: 1.139 ± 0.034	3.176IleIle: 3.176 ± 0.061	2.373IleLys: 2.373 ± 0.056	4.367IleLeu: 4.367 ± 0.064	0.968IleMet: 0.968 ± 0.034	2.533IleAsn: 2.533 ± 0.068	2.799IlePro: 2.799 ± 0.069	1.448IleGln: 1.448 ± 0.044	3.141IleArg: 3.141 ± 0.062	3.554IleSer: 3.554 ± 0.074	4.575IleThr: 4.575 ± 0.149	3.712IleVal: 3.712 ± 0.061	0.637IleTrp: 0.637 ± 0.025	1.545IleTyr: 1.545 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	3.827LysAla: 3.827 ± 0.074	0.281LysCys: 0.281 ± 0.016	1.979LysAsp: 1.979 ± 0.05	1.881LysGlu: 1.881 ± 0.051	1.434LysPhe: 1.434 ± 0.038	2.663LysGly: 2.663 ± 0.056	1.018LysHis: 1.018 ± 0.032	2.806LysIle: 2.806 ± 0.054	2.931LysLys: 2.931 ± 0.088	4.088LysLeu: 4.088 ± 0.083	1.143LysMet: 1.143 ± 0.034	2.433LysAsn: 2.433 ± 0.056	2.534LysPro: 2.534 ± 0.067	1.536LysGln: 1.536 ± 0.044	2.689LysArg: 2.689 ± 0.063	2.546LysSer: 2.546 ± 0.048	3.526LysThr: 3.526 ± 0.06	2.307LysVal: 2.307 ± 0.051	0.6LysTrp: 0.6 ± 0.026	1.225LysTyr: 1.225 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	11.507LeuAla: 11.507 ± 0.149	1.008LeuCys: 1.008 ± 0.04	5.179LeuAsp: 5.179 ± 0.072	4.462LeuGlu: 4.462 ± 0.079	3.461LeuPhe: 3.461 ± 0.068	7.172LeuGly: 7.172 ± 0.106	1.915LeuHis: 1.915 ± 0.041	4.532LeuIle: 4.532 ± 0.081	3.843LeuLys: 3.843 ± 0.077	8.149LeuLeu: 8.149 ± 0.129	1.784LeuMet: 1.784 ± 0.043	3.357LeuAsn: 3.357 ± 0.076	4.705LeuPro: 4.705 ± 0.087	2.487LeuGln: 2.487 ± 0.053	6.488LeuArg: 6.488 ± 0.103	5.634LeuSer: 5.634 ± 0.089	5.737LeuThr: 5.737 ± 0.113	6.365LeuVal: 6.365 ± 0.095	1.251LeuTrp: 1.251 ± 0.04	2.323LeuTyr: 2.323 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	1.891MetAla: 1.891 ± 0.045	0.204MetCys: 0.204 ± 0.013	0.946MetAsp: 0.946 ± 0.029	0.959MetGlu: 0.959 ± 0.029	0.649MetPhe: 0.649 ± 0.024	1.378MetGly: 1.378 ± 0.042	0.44MetHis: 0.44 ± 0.021	1.138MetIle: 1.138 ± 0.032	1.254MetLys: 1.254 ± 0.035	2.116MetLeu: 2.116 ± 0.048	0.465MetMet: 0.465 ± 0.021	0.87MetAsn: 0.87 ± 0.031	1.367MetPro: 1.367 ± 0.036	0.737MetGln: 0.737 ± 0.025	1.711MetArg: 1.711 ± 0.043	1.42MetSer: 1.42 ± 0.036	1.292MetThr: 1.292 ± 0.033	1.13MetVal: 1.13 ± 0.034	0.215MetTrp: 0.215 ± 0.014	0.339MetTyr: 0.339 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	4.629AsnAla: 4.629 ± 0.131	0.307AsnCys: 0.307 ± 0.017	1.98AsnAsp: 1.98 ± 0.046	1.787AsnGlu: 1.787 ± 0.04	1.42AsnPhe: 1.42 ± 0.038	3.597AsnGly: 3.597 ± 0.117	0.796AsnHis: 0.796 ± 0.027	2.513AsnIle: 2.513 ± 0.063	1.5AsnLys: 1.5 ± 0.036	3.592AsnLeu: 3.592 ± 0.089	0.733AsnMet: 0.733 ± 0.023	1.997AsnAsn: 1.997 ± 0.09	2.501AsnPro: 2.501 ± 0.055	1.03AsnGln: 1.03 ± 0.03	2.074AsnArg: 2.074 ± 0.045	2.395AsnSer: 2.395 ± 0.095	3.148AsnThr: 3.148 ± 0.127	2.382AsnVal: 2.382 ± 0.056	0.667AsnTrp: 0.667 ± 0.027	1.352AsnTyr: 1.352 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	6.391ProAla: 6.391 ± 0.129	0.398ProCys: 0.398 ± 0.021	3.262ProAsp: 3.262 ± 0.067	3.395ProGlu: 3.395 ± 0.076	1.769ProPhe: 1.769 ± 0.051	4.243ProGly: 4.243 ± 0.084	1.077ProHis: 1.077 ± 0.034	1.987ProIle: 1.987 ± 0.053	2.087ProLys: 2.087 ± 0.05	4.099ProLeu: 4.099 ± 0.08	0.915ProMet: 0.915 ± 0.034	1.613ProAsn: 1.613 ± 0.045	2.727ProPro: 2.727 ± 0.078	1.431ProGln: 1.431 ± 0.039	2.868ProArg: 2.868 ± 0.067	3.012ProSer: 3.012 ± 0.064	2.271ProThr: 2.271 ± 0.059	3.963ProVal: 3.963 ± 0.084	0.725ProTrp: 0.725 ± 0.029	1.118ProTyr: 1.118 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.765GlnAla: 2.765 ± 0.055	0.242GlnCys: 0.242 ± 0.015	1.109GlnAsp: 1.109 ± 0.034	1.118GlnGlu: 1.118 ± 0.034	1.158GlnPhe: 1.158 ± 0.033	1.937GlnGly: 1.937 ± 0.052	0.641GlnHis: 0.641 ± 0.027	1.946GlnIle: 1.946 ± 0.039	1.54GlnLys: 1.54 ± 0.04	3.035GlnLeu: 3.035 ± 0.053	0.701GlnMet: 0.701 ± 0.025	1.287GlnAsn: 1.287 ± 0.037	1.701GlnPro: 1.701 ± 0.042	1.16GlnGln: 1.16 ± 0.041	1.996GlnArg: 1.996 ± 0.052	1.893GlnSer: 1.893 ± 0.041	2.107GlnThr: 2.107 ± 0.047	1.815GlnVal: 1.815 ± 0.042	0.489GlnTrp: 0.489 ± 0.029	0.808GlnTyr: 0.808 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	7.157ArgAla: 7.157 ± 0.131	0.574ArgCys: 0.574 ± 0.023	3.533ArgAsp: 3.533 ± 0.075	3.962ArgGlu: 3.962 ± 0.085	2.593ArgPhe: 2.593 ± 0.054	4.319ArgGly: 4.319 ± 0.071	1.514ArgHis: 1.514 ± 0.047	3.776ArgIle: 3.776 ± 0.066	2.577ArgLys: 2.577 ± 0.06	5.967ArgLeu: 5.967 ± 0.09	1.55ArgMet: 1.55 ± 0.046	2.218ArgAsn: 2.218 ± 0.043	2.872ArgPro: 2.872 ± 0.08	1.881ArgGln: 1.881 ± 0.047	4.166ArgArg: 4.166 ± 0.103	2.776ArgSer: 2.776 ± 0.057	3.167ArgThr: 3.167 ± 0.054	4.5ArgVal: 4.5 ± 0.078	0.954ArgTrp: 0.954 ± 0.034	1.766ArgTyr: 1.766 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	6.752SerAla: 6.752 ± 0.112	0.432SerCys: 0.432 ± 0.021	2.988SerAsp: 2.988 ± 0.05	2.697SerGlu: 2.697 ± 0.054	2.292SerPhe: 2.292 ± 0.047	6.918SerGly: 6.918 ± 0.251	1.265SerHis: 1.265 ± 0.035	3.276SerIle: 3.276 ± 0.066	2.287SerLys: 2.287 ± 0.056	5.63SerLeu: 5.63 ± 0.079	1.18SerMet: 1.18 ± 0.034	2.333SerAsn: 2.333 ± 0.088	3.216SerPro: 3.216 ± 0.072	1.698SerGln: 1.698 ± 0.037	3.444SerArg: 3.444 ± 0.072	3.817SerSer: 3.817 ± 0.09	3.791SerThr: 3.791 ± 0.096	3.958SerVal: 3.958 ± 0.071	0.764SerTrp: 0.764 ± 0.025	1.647SerTyr: 1.647 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	7.12ThrAla: 7.12 ± 0.159	0.419ThrCys: 0.419 ± 0.017	3.24ThrAsp: 3.24 ± 0.068	2.58ThrGlu: 2.58 ± 0.053	2.486ThrPhe: 2.486 ± 0.067	7.315ThrGly: 7.315 ± 0.311	1.456ThrHis: 1.456 ± 0.038	4.232ThrIle: 4.232 ± 0.122	2.189ThrLys: 2.189 ± 0.052	7.535ThrLeu: 7.535 ± 0.199	1.065ThrMet: 1.065 ± 0.03	2.556ThrAsn: 2.556 ± 0.112	3.925ThrPro: 3.925 ± 0.081	1.745ThrGln: 1.745 ± 0.041	3.449ThrArg: 3.449 ± 0.066	3.751ThrSer: 3.751 ± 0.097	4.234ThrThr: 4.234 ± 0.147	4.753ThrVal: 4.753 ± 0.127	0.889ThrTrp: 0.889 ± 0.033	1.728ThrTyr: 1.728 ± 0.062	0.0ThrXaa: 0.0 ± 0.0
Val	7.121ValAla: 7.121 ± 0.078	0.77ValCys: 0.77 ± 0.032	3.383ValAsp: 3.383 ± 0.055	3.593ValGlu: 3.593 ± 0.059	3.115ValPhe: 3.115 ± 0.067	4.489ValGly: 4.489 ± 0.077	1.198ValHis: 1.198 ± 0.033	4.024ValIle: 4.024 ± 0.058	2.528ValLys: 2.528 ± 0.06	5.991ValLeu: 5.991 ± 0.101	1.336ValMet: 1.336 ± 0.033	2.438ValAsn: 2.438 ± 0.064	2.922ValPro: 2.922 ± 0.068	1.732ValGln: 1.732 ± 0.044	4.306ValArg: 4.306 ± 0.07	4.558ValSer: 4.558 ± 0.075	4.946ValThr: 4.946 ± 0.117	4.765ValVal: 4.765 ± 0.073	0.917ValTrp: 0.917 ± 0.032	1.816ValTyr: 1.816 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	1.127TrpAla: 1.127 ± 0.029	0.185TrpCys: 0.185 ± 0.013	0.74TrpAsp: 0.74 ± 0.028	0.685TrpGlu: 0.685 ± 0.025	0.681TrpPhe: 0.681 ± 0.026	0.902TrpGly: 0.902 ± 0.032	0.387TrpHis: 0.387 ± 0.016	0.765TrpIle: 0.765 ± 0.026	0.685TrpLys: 0.685 ± 0.025	1.621TrpLeu: 1.621 ± 0.047	0.414TrpMet: 0.414 ± 0.018	0.619TrpAsn: 0.619 ± 0.022	0.652TrpPro: 0.652 ± 0.026	0.602TrpGln: 0.602 ± 0.028	1.222TrpArg: 1.222 ± 0.038	0.837TrpSer: 0.837 ± 0.029	0.905TrpThr: 0.905 ± 0.035	0.799TrpVal: 0.799 ± 0.024	0.3TrpTrp: 0.3 ± 0.019	0.385TrpTyr: 0.385 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.82TyrAla: 2.82 ± 0.051	0.267TyrCys: 0.267 ± 0.017	1.667TyrAsp: 1.667 ± 0.048	1.471TyrGlu: 1.471 ± 0.044	1.228TyrPhe: 1.228 ± 0.032	2.245TyrGly: 2.245 ± 0.056	0.611TyrHis: 0.611 ± 0.022	1.463TyrIle: 1.463 ± 0.039	1.15TyrLys: 1.15 ± 0.036	2.358TyrLeu: 2.358 ± 0.053	0.496TyrMet: 0.496 ± 0.023	1.192TyrAsn: 1.192 ± 0.036	1.198TyrPro: 1.198 ± 0.04	0.973TyrGln: 0.973 ± 0.034	1.865TyrArg: 1.865 ± 0.044	1.658TyrSer: 1.658 ± 0.043	1.885TyrThr: 1.885 ± 0.054	1.688TyrVal: 1.688 ± 0.041	0.453TyrTrp: 0.453 ± 0.02	1.086TyrTyr: 1.086 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2881 proteins (1204893 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---