Amino acid dipepetide frequency for Sandaracinobacter sp. PAMC 28131

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.747AlaAla: 20.747 ± 0.25	0.912AlaCys: 0.912 ± 0.032	8.604AlaAsp: 8.604 ± 0.101	8.579AlaGlu: 8.579 ± 0.122	4.363AlaPhe: 4.363 ± 0.067	12.042AlaGly: 12.042 ± 0.133	2.473AlaHis: 2.473 ± 0.046	6.364AlaIle: 6.364 ± 0.082	3.971AlaLys: 3.971 ± 0.07	14.821AlaLeu: 14.821 ± 0.191	3.736AlaMet: 3.736 ± 0.066	3.15AlaAsn: 3.15 ± 0.062	6.694AlaPro: 6.694 ± 0.097	4.548AlaGln: 4.548 ± 0.068	10.131AlaArg: 10.131 ± 0.124	6.376AlaSer: 6.376 ± 0.081	6.643AlaThr: 6.643 ± 0.087	8.825AlaVal: 8.825 ± 0.117	1.58AlaTrp: 1.58 ± 0.037	2.378AlaTyr: 2.378 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.828CysAla: 0.828 ± 0.025	0.098CysCys: 0.098 ± 0.011	0.393CysAsp: 0.393 ± 0.018	0.334CysGlu: 0.334 ± 0.019	0.234CysPhe: 0.234 ± 0.015	0.717CysGly: 0.717 ± 0.031	0.169CysHis: 0.169 ± 0.012	0.295CysIle: 0.295 ± 0.017	0.12CysLys: 0.12 ± 0.011	0.624CysLeu: 0.624 ± 0.027	0.104CysMet: 0.104 ± 0.01	0.165CysAsn: 0.165 ± 0.012	0.422CysPro: 0.422 ± 0.021	0.218CysGln: 0.218 ± 0.014	0.524CysArg: 0.524 ± 0.024	0.4CysSer: 0.4 ± 0.021	0.368CysThr: 0.368 ± 0.018	0.45CysVal: 0.45 ± 0.023	0.116CysTrp: 0.116 ± 0.011	0.158CysTyr: 0.158 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.937AspAla: 6.937 ± 0.083	0.391AspCys: 0.391 ± 0.02	2.794AspAsp: 2.794 ± 0.061	3.185AspGlu: 3.185 ± 0.059	1.991AspPhe: 1.991 ± 0.041	5.617AspGly: 5.617 ± 0.087	1.084AspHis: 1.084 ± 0.031	2.793AspIle: 2.793 ± 0.055	1.528AspLys: 1.528 ± 0.039	5.624AspLeu: 5.624 ± 0.081	1.317AspMet: 1.317 ± 0.036	1.213AspAsn: 1.213 ± 0.038	3.577AspPro: 3.577 ± 0.059	1.545AspGln: 1.545 ± 0.038	4.37AspArg: 4.37 ± 0.068	2.75AspSer: 2.75 ± 0.062	2.408AspThr: 2.408 ± 0.054	4.024AspVal: 4.024 ± 0.065	1.152AspTrp: 1.152 ± 0.032	1.436AspTyr: 1.436 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	8.412GluAla: 8.412 ± 0.122	0.237GluCys: 0.237 ± 0.014	2.404GluAsp: 2.404 ± 0.051	2.368GluGlu: 2.368 ± 0.054	1.507GluPhe: 1.507 ± 0.042	4.597GluGly: 4.597 ± 0.07	0.973GluHis: 0.973 ± 0.031	2.797GluIle: 2.797 ± 0.059	1.785GluLys: 1.785 ± 0.052	5.56GluLeu: 5.56 ± 0.076	1.267GluMet: 1.267 ± 0.034	1.255GluAsn: 1.255 ± 0.038	2.86GluPro: 2.86 ± 0.055	2.091GluGln: 2.091 ± 0.053	4.697GluArg: 4.697 ± 0.074	2.332GluSer: 2.332 ± 0.052	3.359GluThr: 3.359 ± 0.063	3.583GluVal: 3.583 ± 0.07	0.742GluTrp: 0.742 ± 0.025	0.866GluTyr: 0.866 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.835PheAla: 4.835 ± 0.073	0.275PheCys: 0.275 ± 0.015	2.372PheAsp: 2.372 ± 0.05	2.093PheGlu: 2.093 ± 0.045	1.164PhePhe: 1.164 ± 0.04	3.631PheGly: 3.631 ± 0.063	0.758PheHis: 0.758 ± 0.027	1.471PheIle: 1.471 ± 0.049	0.776PheLys: 0.776 ± 0.028	3.242PheLeu: 3.242 ± 0.067	0.746PheMet: 0.746 ± 0.032	0.98PheAsn: 0.98 ± 0.036	1.55PhePro: 1.55 ± 0.046	0.989PheGln: 0.989 ± 0.033	2.342PheArg: 2.342 ± 0.044	1.943PheSer: 1.943 ± 0.048	2.026PheThr: 2.026 ± 0.04	2.516PheVal: 2.516 ± 0.049	0.531PheTrp: 0.531 ± 0.026	0.806PheTyr: 0.806 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	10.237GlyAla: 10.237 ± 0.126	0.713GlyCys: 0.713 ± 0.029	4.51GlyAsp: 4.51 ± 0.083	4.919GlyGlu: 4.919 ± 0.069	3.818GlyPhe: 3.818 ± 0.069	8.897GlyGly: 8.897 ± 0.309	1.999GlyHis: 1.999 ± 0.046	4.146GlyIle: 4.146 ± 0.075	3.198GlyLys: 3.198 ± 0.064	9.465GlyLeu: 9.465 ± 0.111	2.201GlyMet: 2.201 ± 0.049	2.327GlyAsn: 2.327 ± 0.069	4.176GlyPro: 4.176 ± 0.069	3.22GlyGln: 3.22 ± 0.063	6.772GlyArg: 6.772 ± 0.078	5.035GlySer: 5.035 ± 0.103	4.676GlyThr: 4.676 ± 0.08	6.408GlyVal: 6.408 ± 0.089	1.813GlyTrp: 1.813 ± 0.045	2.056GlyTyr: 2.056 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.406HisAla: 2.406 ± 0.049	0.213HisCys: 0.213 ± 0.016	1.05HisAsp: 1.05 ± 0.031	0.93HisGlu: 0.93 ± 0.027	0.757HisPhe: 0.757 ± 0.025	1.919HisGly: 1.919 ± 0.046	0.521HisHis: 0.521 ± 0.023	0.907HisIle: 0.907 ± 0.029	0.46HisLys: 0.46 ± 0.022	1.995HisLeu: 1.995 ± 0.049	0.45HisMet: 0.45 ± 0.023	0.437HisAsn: 0.437 ± 0.022	1.326HisPro: 1.326 ± 0.038	0.547HisGln: 0.547 ± 0.021	1.435HisArg: 1.435 ± 0.04	0.988HisSer: 0.988 ± 0.03	0.644HisThr: 0.644 ± 0.023	1.508HisVal: 1.508 ± 0.039	0.392HisTrp: 0.392 ± 0.018	0.496HisTyr: 0.496 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.234IleAla: 7.234 ± 0.088	0.359IleCys: 0.359 ± 0.02	3.177IleAsp: 3.177 ± 0.06	3.134IleGlu: 3.134 ± 0.054	1.547IlePhe: 1.547 ± 0.041	4.681IleGly: 4.681 ± 0.087	0.807IleHis: 0.807 ± 0.028	1.915IleIle: 1.915 ± 0.047	0.943IleLys: 0.943 ± 0.035	4.301IleLeu: 4.301 ± 0.075	0.751IleMet: 0.751 ± 0.027	1.155IleAsn: 1.155 ± 0.036	2.385IlePro: 2.385 ± 0.048	1.086IleGln: 1.086 ± 0.034	3.29IleArg: 3.29 ± 0.059	2.841IleSer: 2.841 ± 0.05	2.476IleThr: 2.476 ± 0.057	3.643IleVal: 3.643 ± 0.065	0.606IleTrp: 0.606 ± 0.024	0.957IleTyr: 0.957 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.46LysAla: 4.46 ± 0.08	0.122LysCys: 0.122 ± 0.01	1.43LysAsp: 1.43 ± 0.047	1.158LysGlu: 1.158 ± 0.038	0.746LysPhe: 0.746 ± 0.029	2.587LysGly: 2.587 ± 0.053	0.458LysHis: 0.458 ± 0.022	1.34LysIle: 1.34 ± 0.038	0.95LysLys: 0.95 ± 0.037	3.38LysLeu: 3.38 ± 0.073	0.697LysMet: 0.697 ± 0.027	0.614LysAsn: 0.614 ± 0.025	2.174LysPro: 2.174 ± 0.054	0.945LysGln: 0.945 ± 0.03	2.237LysArg: 2.237 ± 0.042	1.59LysSer: 1.59 ± 0.045	1.557LysThr: 1.557 ± 0.038	2.116LysVal: 2.116 ± 0.049	0.357LysTrp: 0.357 ± 0.019	0.469LysTyr: 0.469 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	15.474LeuAla: 15.474 ± 0.181	0.696LeuCys: 0.696 ± 0.026	5.735LeuAsp: 5.735 ± 0.078	5.136LeuGlu: 5.136 ± 0.078	3.884LeuPhe: 3.884 ± 0.074	8.742LeuGly: 8.742 ± 0.096	1.871LeuHis: 1.871 ± 0.045	5.024LeuIle: 5.024 ± 0.084	3.723LeuLys: 3.723 ± 0.072	11.321LeuLeu: 11.321 ± 0.166	2.343LeuMet: 2.343 ± 0.053	2.672LeuAsn: 2.672 ± 0.058	6.27LeuPro: 6.27 ± 0.083	2.929LeuGln: 2.929 ± 0.056	6.699LeuArg: 6.699 ± 0.095	6.489LeuSer: 6.489 ± 0.085	5.657LeuThr: 5.657 ± 0.081	7.289LeuVal: 7.289 ± 0.102	1.441LeuTrp: 1.441 ± 0.043	1.89LeuTyr: 1.89 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	3.354MetAla: 3.354 ± 0.069	0.137MetCys: 0.137 ± 0.012	1.074MetAsp: 1.074 ± 0.032	1.042MetGlu: 1.042 ± 0.035	0.649MetPhe: 0.649 ± 0.028	1.966MetGly: 1.966 ± 0.046	0.402MetHis: 0.402 ± 0.02	1.105MetIle: 1.105 ± 0.032	0.874MetLys: 0.874 ± 0.029	2.568MetLeu: 2.568 ± 0.056	0.606MetMet: 0.606 ± 0.024	0.636MetAsn: 0.636 ± 0.024	1.434MetPro: 1.434 ± 0.037	0.825MetGln: 0.825 ± 0.027	1.696MetArg: 1.696 ± 0.04	1.377MetSer: 1.377 ± 0.033	1.519MetThr: 1.519 ± 0.036	1.553MetVal: 1.553 ± 0.045	0.23MetTrp: 0.23 ± 0.015	0.237MetTyr: 0.237 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.06AsnAla: 3.06 ± 0.063	0.225AsnCys: 0.225 ± 0.015	1.23AsnAsp: 1.23 ± 0.038	1.042AsnGlu: 1.042 ± 0.03	0.897AsnPhe: 0.897 ± 0.034	2.421AsnGly: 2.421 ± 0.073	0.455AsnHis: 0.455 ± 0.018	1.318AsnIle: 1.318 ± 0.037	0.592AsnLys: 0.592 ± 0.026	2.515AsnLeu: 2.515 ± 0.054	0.569AsnMet: 0.569 ± 0.024	0.703AsnAsn: 0.703 ± 0.036	1.931AsnPro: 1.931 ± 0.045	0.775AsnGln: 0.775 ± 0.03	1.887AsnArg: 1.887 ± 0.049	1.429AsnSer: 1.429 ± 0.049	0.96AsnThr: 0.96 ± 0.036	1.668AsnVal: 1.668 ± 0.044	0.461AsnTrp: 0.461 ± 0.021	0.636AsnTyr: 0.636 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	8.037ProAla: 8.037 ± 0.103	0.306ProCys: 0.306 ± 0.016	3.997ProAsp: 3.997 ± 0.061	3.846ProGlu: 3.846 ± 0.067	2.051ProPhe: 2.051 ± 0.048	5.532ProGly: 5.532 ± 0.083	1.073ProHis: 1.073 ± 0.034	2.241ProIle: 2.241 ± 0.045	1.59ProLys: 1.59 ± 0.046	5.406ProLeu: 5.406 ± 0.083	1.289ProMet: 1.289 ± 0.035	1.347ProAsn: 1.347 ± 0.035	3.467ProPro: 3.467 ± 0.086	1.791ProGln: 1.791 ± 0.041	3.165ProArg: 3.165 ± 0.056	2.686ProSer: 2.686 ± 0.048	2.734ProThr: 2.734 ± 0.05	4.566ProVal: 4.566 ± 0.079	0.795ProTrp: 0.795 ± 0.028	1.061ProTyr: 1.061 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.499GlnAla: 4.499 ± 0.073	0.18GlnCys: 0.18 ± 0.013	1.284GlnAsp: 1.284 ± 0.034	1.212GlnGlu: 1.212 ± 0.037	1.108GlnPhe: 1.108 ± 0.037	2.578GlnGly: 2.578 ± 0.051	0.575GlnHis: 0.575 ± 0.02	1.626GlnIle: 1.626 ± 0.04	0.956GlnLys: 0.956 ± 0.029	3.592GlnLeu: 3.592 ± 0.066	0.844GlnMet: 0.844 ± 0.03	0.705GlnAsn: 0.705 ± 0.027	2.161GlnPro: 2.161 ± 0.051	1.411GlnGln: 1.411 ± 0.043	2.474GlnArg: 2.474 ± 0.052	1.87GlnSer: 1.87 ± 0.053	1.705GlnThr: 1.705 ± 0.043	2.359GlnVal: 2.359 ± 0.047	0.494GlnTrp: 0.494 ± 0.022	0.548GlnTyr: 0.548 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	9.084ArgAla: 9.084 ± 0.106	0.439ArgCys: 0.439 ± 0.021	3.886ArgAsp: 3.886 ± 0.067	3.8ArgGlu: 3.8 ± 0.066	3.165ArgPhe: 3.165 ± 0.065	5.015ArgGly: 5.015 ± 0.073	1.734ArgHis: 1.734 ± 0.041	3.939ArgIle: 3.939 ± 0.065	1.98ArgLys: 1.98 ± 0.043	8.89ArgLeu: 8.89 ± 0.104	1.913ArgMet: 1.913 ± 0.044	1.846ArgAsn: 1.846 ± 0.042	4.005ArgPro: 4.005 ± 0.063	2.73ArgGln: 2.73 ± 0.054	5.901ArgArg: 5.901 ± 0.102	3.555ArgSer: 3.555 ± 0.06	3.466ArgThr: 3.466 ± 0.062	4.686ArgVal: 4.686 ± 0.072	1.203ArgTrp: 1.203 ± 0.038	1.747ArgTyr: 1.747 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	6.967SerAla: 6.967 ± 0.091	0.406SerCys: 0.406 ± 0.021	2.847SerAsp: 2.847 ± 0.054	2.467SerGlu: 2.467 ± 0.048	2.273SerPhe: 2.273 ± 0.05	5.774SerGly: 5.774 ± 0.101	1.029SerHis: 1.029 ± 0.033	2.693SerIle: 2.693 ± 0.06	1.329SerLys: 1.329 ± 0.037	5.427SerLeu: 5.427 ± 0.074	1.133SerMet: 1.133 ± 0.032	1.394SerAsn: 1.394 ± 0.036	2.96SerPro: 2.96 ± 0.053	1.5SerGln: 1.5 ± 0.037	3.84SerArg: 3.84 ± 0.065	2.852SerSer: 2.852 ± 0.063	2.609SerThr: 2.609 ± 0.066	3.706SerVal: 3.706 ± 0.065	0.823SerTrp: 0.823 ± 0.034	1.318SerTyr: 1.318 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	6.655ThrAla: 6.655 ± 0.1	0.292ThrCys: 0.292 ± 0.018	3.058ThrAsp: 3.058 ± 0.059	2.43ThrGlu: 2.43 ± 0.045	1.564ThrPhe: 1.564 ± 0.049	5.311ThrGly: 5.311 ± 0.074	0.955ThrHis: 0.955 ± 0.029	2.545ThrIle: 2.545 ± 0.053	1.279ThrLys: 1.279 ± 0.039	5.893ThrLeu: 5.893 ± 0.088	1.014ThrMet: 1.014 ± 0.03	1.23ThrAsn: 1.23 ± 0.037	3.664ThrPro: 3.664 ± 0.058	1.42ThrGln: 1.42 ± 0.038	3.375ThrArg: 3.375 ± 0.057	2.607ThrSer: 2.607 ± 0.054	2.626ThrThr: 2.626 ± 0.059	3.912ThrVal: 3.912 ± 0.065	0.588ThrTrp: 0.588 ± 0.025	0.996ThrTyr: 0.996 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	9.568ValAla: 9.568 ± 0.109	0.436ValCys: 0.436 ± 0.021	3.949ValAsp: 3.949 ± 0.068	4.394ValGlu: 4.394 ± 0.078	1.962ValPhe: 1.962 ± 0.049	5.561ValGly: 5.561 ± 0.093	1.269ValHis: 1.269 ± 0.037	3.386ValIle: 3.386 ± 0.061	2.308ValLys: 2.308 ± 0.059	6.671ValLeu: 6.671 ± 0.087	1.571ValMet: 1.571 ± 0.041	1.906ValAsn: 1.906 ± 0.047	4.142ValPro: 4.142 ± 0.071	2.316ValGln: 2.316 ± 0.048	5.107ValArg: 5.107 ± 0.072	4.206ValSer: 4.206 ± 0.077	4.262ValThr: 4.262 ± 0.071	4.982ValVal: 4.982 ± 0.084	0.942ValTrp: 0.942 ± 0.031	1.188ValTyr: 1.188 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.655TrpAla: 1.655 ± 0.042	0.13TrpCys: 0.13 ± 0.01	0.633TrpAsp: 0.633 ± 0.024	0.607TrpGlu: 0.607 ± 0.026	0.551TrpPhe: 0.551 ± 0.022	1.065TrpGly: 1.065 ± 0.038	0.347TrpHis: 0.347 ± 0.018	0.665TrpIle: 0.665 ± 0.023	0.531TrpLys: 0.531 ± 0.025	1.981TrpLeu: 1.981 ± 0.047	0.36TrpMet: 0.36 ± 0.019	0.473TrpAsn: 0.473 ± 0.021	0.818TrpPro: 0.818 ± 0.025	0.611TrpGln: 0.611 ± 0.025	1.355TrpArg: 1.355 ± 0.037	0.875TrpSer: 0.875 ± 0.03	0.79TrpThr: 0.79 ± 0.026	0.873TrpVal: 0.873 ± 0.032	0.279TrpTrp: 0.279 ± 0.017	0.244TrpTyr: 0.244 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.484TyrAla: 2.484 ± 0.046	0.17TyrCys: 0.17 ± 0.014	1.31TyrAsp: 1.31 ± 0.04	1.016TyrGlu: 1.016 ± 0.032	0.817TyrPhe: 0.817 ± 0.026	1.932TyrGly: 1.932 ± 0.047	0.431TyrHis: 0.431 ± 0.02	0.719TyrIle: 0.719 ± 0.028	0.494TyrLys: 0.494 ± 0.024	2.009TyrLeu: 2.009 ± 0.049	0.373TyrMet: 0.373 ± 0.017	0.563TyrAsn: 0.563 ± 0.024	0.962TyrPro: 0.962 ± 0.031	0.685TyrGln: 0.685 ± 0.026	1.688TyrArg: 1.688 ± 0.043	1.149TyrSer: 1.149 ± 0.035	0.933TyrThr: 0.933 ± 0.038	1.457TyrVal: 1.457 ± 0.04	0.296TyrTrp: 0.296 ± 0.016	0.505TyrTyr: 0.505 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3327 proteins (1063820 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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