Amino acid dipepetide frequency for Diadromus pulchellus ascovirus 4a

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.688AlaAla: 4.688 ± 0.433
0.909AlaCys: 0.909 ± 0.162
4.489AlaAsp: 4.489 ± 0.436
3.466AlaGlu: 3.466 ± 0.315
3.267AlaPhe: 3.267 ± 0.345
3.182AlaGly: 3.182 ± 0.33
1.023AlaHis: 1.023 ± 0.181
3.551AlaIle: 3.551 ± 0.341
4.347AlaLys: 4.347 ± 0.389
5.199AlaLeu: 5.199 ± 0.421
1.79AlaMet: 1.79 ± 0.177
2.642AlaAsn: 2.642 ± 0.314
2.671AlaPro: 2.671 ± 0.329
1.932AlaGln: 1.932 ± 0.297
3.523AlaArg: 3.523 ± 0.402
4.404AlaSer: 4.404 ± 0.396
3.353AlaThr: 3.353 ± 0.321
5.341AlaVal: 5.341 ± 0.283
0.71AlaTrp: 0.71 ± 0.172
1.989AlaTyr: 1.989 ± 0.238
0.0AlaXaa: 0.0 ± 0.0
Cys
0.852CysAla: 0.852 ± 0.169
0.483CysCys: 0.483 ± 0.117
1.477CysAsp: 1.477 ± 0.203
0.938CysGlu: 0.938 ± 0.205
0.767CysPhe: 0.767 ± 0.181
1.25CysGly: 1.25 ± 0.193
0.455CysHis: 0.455 ± 0.114
1.165CysIle: 1.165 ± 0.183
1.534CysLys: 1.534 ± 0.255
1.392CysLeu: 1.392 ± 0.195
0.483CysMet: 0.483 ± 0.108
0.994CysAsn: 0.994 ± 0.162
0.767CysPro: 0.767 ± 0.136
0.625CysGln: 0.625 ± 0.117
1.222CysArg: 1.222 ± 0.223
1.563CysSer: 1.563 ± 0.246
0.824CysThr: 0.824 ± 0.145
1.762CysVal: 1.762 ± 0.291
0.17CysTrp: 0.17 ± 0.071
0.455CysTyr: 0.455 ± 0.125
0.0CysXaa: 0.0 ± 0.0
Asp
4.659AspAla: 4.659 ± 0.368
1.165AspCys: 1.165 ± 0.234
4.802AspAsp: 4.802 ± 0.496
5.711AspGlu: 5.711 ± 0.372
3.409AspPhe: 3.409 ± 0.295
3.381AspGly: 3.381 ± 0.384
1.563AspHis: 1.563 ± 0.227
3.693AspIle: 3.693 ± 0.303
3.608AspLys: 3.608 ± 0.296
4.688AspLeu: 4.688 ± 0.363
1.875AspMet: 1.875 ± 0.196
2.585AspAsn: 2.585 ± 0.241
2.443AspPro: 2.443 ± 0.293
1.762AspGln: 1.762 ± 0.206
3.949AspArg: 3.949 ± 0.298
4.006AspSer: 4.006 ± 0.326
3.125AspThr: 3.125 ± 0.301
5.995AspVal: 5.995 ± 0.461
0.739AspTrp: 0.739 ± 0.146
2.699AspTyr: 2.699 ± 0.245
0.0AspXaa: 0.0 ± 0.0
Glu
4.12GluAla: 4.12 ± 0.442
0.994GluCys: 0.994 ± 0.176
4.432GluAsp: 4.432 ± 0.325
4.006GluGlu: 4.006 ± 0.416
3.864GluPhe: 3.864 ± 0.321
2.614GluGly: 2.614 ± 0.275
1.08GluHis: 1.08 ± 0.215
3.637GluIle: 3.637 ± 0.32
4.802GluLys: 4.802 ± 0.367
4.915GluLeu: 4.915 ± 0.476
2.131GluMet: 2.131 ± 0.274
3.438GluAsn: 3.438 ± 0.306
2.046GluPro: 2.046 ± 0.21
2.5GluGln: 2.5 ± 0.319
4.546GluArg: 4.546 ± 0.533
3.267GluSer: 3.267 ± 0.322
4.745GluThr: 4.745 ± 0.35
3.949GluVal: 3.949 ± 0.279
0.909GluTrp: 0.909 ± 0.167
2.245GluTyr: 2.245 ± 0.289
0.0GluXaa: 0.0 ± 0.0
Phe
3.239PheAla: 3.239 ± 0.355
1.364PheCys: 1.364 ± 0.19
3.722PheAsp: 3.722 ± 0.357
4.091PheGlu: 4.091 ± 0.282
1.904PhePhe: 1.904 ± 0.247
3.154PheGly: 3.154 ± 0.311
0.824PheHis: 0.824 ± 0.187
2.557PheIle: 2.557 ± 0.324
3.608PheLys: 3.608 ± 0.392
3.807PheLeu: 3.807 ± 0.33
1.733PheMet: 1.733 ± 0.206
2.443PheAsn: 2.443 ± 0.247
1.932PhePro: 1.932 ± 0.251
1.108PheGln: 1.108 ± 0.162
2.529PheArg: 2.529 ± 0.273
3.551PheSer: 3.551 ± 0.302
1.875PheThr: 1.875 ± 0.274
4.83PheVal: 4.83 ± 0.408
0.369PheTrp: 0.369 ± 0.097
1.762PheTyr: 1.762 ± 0.236
0.0PheXaa: 0.0 ± 0.0
Gly
3.154GlyAla: 3.154 ± 0.346
0.994GlyCys: 0.994 ± 0.155
2.926GlyAsp: 2.926 ± 0.274
2.756GlyGlu: 2.756 ± 0.285
2.358GlyPhe: 2.358 ± 0.251
3.466GlyGly: 3.466 ± 0.404
0.796GlyHis: 0.796 ± 0.165
2.955GlyIle: 2.955 ± 0.29
2.983GlyLys: 2.983 ± 0.244
4.034GlyLeu: 4.034 ± 0.288
1.335GlyMet: 1.335 ± 0.222
2.671GlyAsn: 2.671 ± 0.281
1.136GlyPro: 1.136 ± 0.201
1.279GlyGln: 1.279 ± 0.22
3.068GlyArg: 3.068 ± 0.283
3.608GlySer: 3.608 ± 0.309
3.438GlyThr: 3.438 ± 0.292
4.773GlyVal: 4.773 ± 0.394
0.682GlyTrp: 0.682 ± 0.156
1.96GlyTyr: 1.96 ± 0.26
0.0GlyXaa: 0.0 ± 0.0
His
0.881HisAla: 0.881 ± 0.163
0.369HisCys: 0.369 ± 0.094
1.051HisAsp: 1.051 ± 0.179
0.994HisGlu: 0.994 ± 0.147
0.852HisPhe: 0.852 ± 0.176
1.108HisGly: 1.108 ± 0.185
0.597HisHis: 0.597 ± 0.165
1.165HisIle: 1.165 ± 0.18
1.136HisLys: 1.136 ± 0.183
1.619HisLeu: 1.619 ± 0.223
0.313HisMet: 0.313 ± 0.101
1.307HisAsn: 1.307 ± 0.211
1.222HisPro: 1.222 ± 0.189
0.455HisGln: 0.455 ± 0.115
0.881HisArg: 0.881 ± 0.17
0.824HisSer: 0.824 ± 0.129
0.881HisThr: 0.881 ± 0.133
1.79HisVal: 1.79 ± 0.331
0.17HisTrp: 0.17 ± 0.065
0.653HisTyr: 0.653 ± 0.163
0.0HisXaa: 0.0 ± 0.0
Ile
3.267IleAla: 3.267 ± 0.295
1.108IleCys: 1.108 ± 0.176
4.319IleAsp: 4.319 ± 0.372
4.176IleGlu: 4.176 ± 0.4
2.301IlePhe: 2.301 ± 0.289
2.358IleGly: 2.358 ± 0.247
1.023IleHis: 1.023 ± 0.16
3.779IleIle: 3.779 ± 0.36
5.313IleLys: 5.313 ± 0.378
4.972IleLeu: 4.972 ± 0.316
1.818IleMet: 1.818 ± 0.211
3.807IleAsn: 3.807 ± 0.343
1.989IlePro: 1.989 ± 0.272
1.506IleGln: 1.506 ± 0.213
3.978IleArg: 3.978 ± 0.455
4.319IleSer: 4.319 ± 0.405
2.728IleThr: 2.728 ± 0.288
4.773IleVal: 4.773 ± 0.347
0.455IleTrp: 0.455 ± 0.112
1.818IleTyr: 1.818 ± 0.213
0.0IleXaa: 0.0 ± 0.0
Lys
3.409LysAla: 3.409 ± 0.326
1.477LysCys: 1.477 ± 0.238
3.182LysAsp: 3.182 ± 0.304
4.205LysGlu: 4.205 ± 0.324
3.267LysPhe: 3.267 ± 0.284
2.557LysGly: 2.557 ± 0.291
1.762LysHis: 1.762 ± 0.226
4.858LysIle: 4.858 ± 0.379
5.483LysLys: 5.483 ± 0.488
6.307LysLeu: 6.307 ± 0.459
2.5LysMet: 2.5 ± 0.254
4.546LysAsn: 4.546 ± 0.405
2.87LysPro: 2.87 ± 0.378
3.353LysGln: 3.353 ± 0.35
4.546LysArg: 4.546 ± 0.369
4.546LysSer: 4.546 ± 0.377
5.37LysThr: 5.37 ± 0.413
3.693LysVal: 3.693 ± 0.322
0.881LysTrp: 0.881 ± 0.158
2.756LysTyr: 2.756 ± 0.243
0.0LysXaa: 0.0 ± 0.0
Leu
5.228LeuAla: 5.228 ± 0.413
1.648LeuCys: 1.648 ± 0.25
5.597LeuAsp: 5.597 ± 0.446
5.37LeuGlu: 5.37 ± 0.356
4.347LeuPhe: 4.347 ± 0.429
4.262LeuGly: 4.262 ± 0.36
0.966LeuHis: 0.966 ± 0.184
3.864LeuIle: 3.864 ± 0.25
6.961LeuLys: 6.961 ± 0.491
7.188LeuLeu: 7.188 ± 0.491
1.676LeuMet: 1.676 ± 0.193
4.915LeuAsn: 4.915 ± 0.509
2.728LeuPro: 2.728 ± 0.271
1.875LeuGln: 1.875 ± 0.207
3.892LeuArg: 3.892 ± 0.304
6.08LeuSer: 6.08 ± 0.419
3.267LeuThr: 3.267 ± 0.294
6.194LeuVal: 6.194 ± 0.397
0.653LeuTrp: 0.653 ± 0.117
3.182LeuTyr: 3.182 ± 0.365
0.0LeuXaa: 0.0 ± 0.0
Met
1.449MetAla: 1.449 ± 0.205
0.796MetCys: 0.796 ± 0.177
1.421MetAsp: 1.421 ± 0.16
2.102MetGlu: 2.102 ± 0.244
1.335MetPhe: 1.335 ± 0.203
1.392MetGly: 1.392 ± 0.205
0.256MetHis: 0.256 ± 0.071
1.648MetIle: 1.648 ± 0.242
1.875MetLys: 1.875 ± 0.209
1.875MetLeu: 1.875 ± 0.252
0.767MetMet: 0.767 ± 0.142
1.506MetAsn: 1.506 ± 0.178
0.994MetPro: 0.994 ± 0.173
0.597MetGln: 0.597 ± 0.138
1.96MetArg: 1.96 ± 0.243
2.102MetSer: 2.102 ± 0.31
1.79MetThr: 1.79 ± 0.236
2.245MetVal: 2.245 ± 0.235
0.142MetTrp: 0.142 ± 0.06
0.966MetTyr: 0.966 ± 0.197
0.0MetXaa: 0.0 ± 0.0
Asn
3.097AsnAla: 3.097 ± 0.242
0.852AsnCys: 0.852 ± 0.168
3.523AsnAsp: 3.523 ± 0.33
4.034AsnGlu: 4.034 ± 0.465
2.5AsnPhe: 2.5 ± 0.32
3.381AsnGly: 3.381 ± 0.413
0.739AsnHis: 0.739 ± 0.131
4.205AsnIle: 4.205 ± 0.378
4.858AsnLys: 4.858 ± 0.395
3.466AsnLeu: 3.466 ± 0.311
1.676AsnMet: 1.676 ± 0.225
3.551AsnAsn: 3.551 ± 0.37
1.676AsnPro: 1.676 ± 0.211
1.534AsnGln: 1.534 ± 0.229
3.722AsnArg: 3.722 ± 0.397
2.813AsnSer: 2.813 ± 0.327
3.466AsnThr: 3.466 ± 0.374
3.779AsnVal: 3.779 ± 0.35
0.398AsnTrp: 0.398 ± 0.109
1.563AsnTyr: 1.563 ± 0.198
0.0AsnXaa: 0.0 ± 0.0
Pro
2.529ProAla: 2.529 ± 0.35
0.398ProCys: 0.398 ± 0.107
2.983ProAsp: 2.983 ± 0.291
2.983ProGlu: 2.983 ± 0.24
1.96ProPhe: 1.96 ± 0.191
2.074ProGly: 2.074 ± 0.236
0.824ProHis: 0.824 ± 0.146
2.358ProIle: 2.358 ± 0.287
2.159ProLys: 2.159 ± 0.295
2.472ProLeu: 2.472 ± 0.221
0.653ProMet: 0.653 ± 0.143
2.671ProAsn: 2.671 ± 0.418
1.676ProPro: 1.676 ± 0.244
0.824ProGln: 0.824 ± 0.142
2.358ProArg: 2.358 ± 0.329
2.813ProSer: 2.813 ± 0.317
1.648ProThr: 1.648 ± 0.212
3.296ProVal: 3.296 ± 0.354
0.653ProTrp: 0.653 ± 0.139
1.392ProTyr: 1.392 ± 0.191
0.0ProXaa: 0.0 ± 0.0
Gln
1.762GlnAla: 1.762 ± 0.245
0.54GlnCys: 0.54 ± 0.133
1.506GlnAsp: 1.506 ± 0.234
1.534GlnGlu: 1.534 ± 0.214
1.335GlnPhe: 1.335 ± 0.208
1.051GlnGly: 1.051 ± 0.186
0.483GlnHis: 0.483 ± 0.145
2.443GlnIle: 2.443 ± 0.283
1.875GlnLys: 1.875 ± 0.194
2.926GlnLeu: 2.926 ± 0.296
0.739GlnMet: 0.739 ± 0.13
1.648GlnAsn: 1.648 ± 0.272
1.449GlnPro: 1.449 ± 0.241
0.966GlnGln: 0.966 ± 0.174
2.102GlnArg: 2.102 ± 0.27
1.477GlnSer: 1.477 ± 0.209
1.563GlnThr: 1.563 ± 0.183
1.222GlnVal: 1.222 ± 0.179
0.227GlnTrp: 0.227 ± 0.077
1.335GlnTyr: 1.335 ± 0.157
0.0GlnXaa: 0.0 ± 0.0
Arg
4.091ArgAla: 4.091 ± 0.486
0.994ArgCys: 0.994 ± 0.162
3.75ArgAsp: 3.75 ± 0.282
3.097ArgGlu: 3.097 ± 0.383
2.813ArgPhe: 2.813 ± 0.341
2.728ArgGly: 2.728 ± 0.31
1.08ArgHis: 1.08 ± 0.196
3.637ArgIle: 3.637 ± 0.262
3.495ArgLys: 3.495 ± 0.314
5.256ArgLeu: 5.256 ± 0.355
1.335ArgMet: 1.335 ± 0.172
3.211ArgAsn: 3.211 ± 0.341
2.216ArgPro: 2.216 ± 0.236
2.472ArgGln: 2.472 ± 0.261
5.853ArgArg: 5.853 ± 0.979
4.461ArgSer: 4.461 ± 0.58
3.04ArgThr: 3.04 ± 0.244
4.915ArgVal: 4.915 ± 0.357
0.369ArgTrp: 0.369 ± 0.093
2.387ArgTyr: 2.387 ± 0.298
0.0ArgXaa: 0.0 ± 0.0
Ser
4.233SerAla: 4.233 ± 0.41
1.08SerCys: 1.08 ± 0.216
4.915SerAsp: 4.915 ± 0.313
4.489SerGlu: 4.489 ± 0.38
3.409SerPhe: 3.409 ± 0.271
3.722SerGly: 3.722 ± 0.337
1.506SerHis: 1.506 ± 0.242
4.063SerIle: 4.063 ± 0.394
4.205SerLys: 4.205 ± 0.352
4.972SerLeu: 4.972 ± 0.343
1.847SerMet: 1.847 ± 0.227
2.926SerAsn: 2.926 ± 0.355
3.665SerPro: 3.665 ± 0.68
1.335SerGln: 1.335 ± 0.173
3.75SerArg: 3.75 ± 0.39
5.427SerSer: 5.427 ± 0.466
3.551SerThr: 3.551 ± 0.369
5.995SerVal: 5.995 ± 0.445
0.597SerTrp: 0.597 ± 0.124
2.301SerTyr: 2.301 ± 0.339
0.0SerXaa: 0.0 ± 0.0
Thr
3.324ThrAla: 3.324 ± 0.309
1.165ThrCys: 1.165 ± 0.181
3.097ThrAsp: 3.097 ± 0.298
2.642ThrGlu: 2.642 ± 0.24
2.87ThrPhe: 2.87 ± 0.305
3.296ThrGly: 3.296 ± 0.303
0.938ThrHis: 0.938 ± 0.151
3.324ThrIle: 3.324 ± 0.286
4.319ThrLys: 4.319 ± 0.339
4.716ThrLeu: 4.716 ± 0.321
1.08ThrMet: 1.08 ± 0.183
3.097ThrAsn: 3.097 ± 0.299
2.415ThrPro: 2.415 ± 0.254
1.307ThrGln: 1.307 ± 0.194
3.012ThrArg: 3.012 ± 0.326
3.068ThrSer: 3.068 ± 0.309
3.381ThrThr: 3.381 ± 0.352
4.29ThrVal: 4.29 ± 0.309
0.398ThrTrp: 0.398 ± 0.1
1.875ThrTyr: 1.875 ± 0.211
0.0ThrXaa: 0.0 ± 0.0
Val
5.54ValAla: 5.54 ± 0.41
1.733ValCys: 1.733 ± 0.259
5.569ValAsp: 5.569 ± 0.484
5.114ValGlu: 5.114 ± 0.405
5.256ValPhe: 5.256 ± 0.429
3.154ValGly: 3.154 ± 0.237
1.392ValHis: 1.392 ± 0.178
4.176ValIle: 4.176 ± 0.347
5.597ValLys: 5.597 ± 0.36
6.08ValLeu: 6.08 ± 0.47
2.216ValMet: 2.216 ± 0.287
3.949ValAsn: 3.949 ± 0.319
3.58ValPro: 3.58 ± 0.377
1.904ValGln: 1.904 ± 0.24
3.551ValArg: 3.551 ± 0.28
6.194ValSer: 6.194 ± 0.483
3.239ValThr: 3.239 ± 0.33
7.813ValVal: 7.813 ± 0.642
0.625ValTrp: 0.625 ± 0.147
3.239ValTyr: 3.239 ± 0.266
0.0ValXaa: 0.0 ± 0.0
Trp
0.54TrpAla: 0.54 ± 0.107
0.284TrpCys: 0.284 ± 0.089
0.682TrpAsp: 0.682 ± 0.14
0.398TrpGlu: 0.398 ± 0.111
0.824TrpPhe: 0.824 ± 0.134
0.597TrpGly: 0.597 ± 0.151
0.17TrpHis: 0.17 ± 0.077
0.341TrpIle: 0.341 ± 0.095
0.852TrpLys: 0.852 ± 0.132
1.108TrpLeu: 1.108 ± 0.199
0.313TrpMet: 0.313 ± 0.085
0.739TrpAsn: 0.739 ± 0.164
0.114TrpPro: 0.114 ± 0.049
0.057TrpGln: 0.057 ± 0.041
0.455TrpArg: 0.455 ± 0.102
0.568TrpSer: 0.568 ± 0.14
0.511TrpThr: 0.511 ± 0.121
0.511TrpVal: 0.511 ± 0.132
0.057TrpTrp: 0.057 ± 0.042
0.313TrpTyr: 0.313 ± 0.104
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.415TyrAla: 2.415 ± 0.242
0.824TyrCys: 0.824 ± 0.139
2.415TyrAsp: 2.415 ± 0.278
2.131TyrGlu: 2.131 ± 0.263
1.762TyrPhe: 1.762 ± 0.222
1.648TyrGly: 1.648 ± 0.254
0.796TyrHis: 0.796 ± 0.142
2.415TyrIle: 2.415 ± 0.234
2.557TyrLys: 2.557 ± 0.262
2.898TyrLeu: 2.898 ± 0.363
0.909TyrMet: 0.909 ± 0.142
2.188TyrAsn: 2.188 ± 0.24
1.136TyrPro: 1.136 ± 0.164
0.796TyrGln: 0.796 ± 0.162
2.301TyrArg: 2.301 ± 0.293
2.898TyrSer: 2.898 ± 0.307
1.818TyrThr: 1.818 ± 0.199
2.756TyrVal: 2.756 ± 0.32
0.227TyrTrp: 0.227 ± 0.071
1.932TyrTyr: 1.932 ± 0.228
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 119 proteins (35198 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski