Amino acid dipepetide frequency for Streptococcus satellite phage Javan354

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.625AlaAla: 1.625 ± 0.665
1.219AlaCys: 1.219 ± 0.561
2.438AlaAsp: 2.438 ± 0.793
5.689AlaGlu: 5.689 ± 1.793
1.625AlaPhe: 1.625 ± 0.914
2.844AlaGly: 2.844 ± 0.97
0.0AlaHis: 0.0 ± 0.0
4.063AlaIle: 4.063 ± 1.038
3.657AlaLys: 3.657 ± 1.004
10.158AlaLeu: 10.158 ± 2.7
1.219AlaMet: 1.219 ± 0.603
2.844AlaAsn: 2.844 ± 1.26
1.219AlaPro: 1.219 ± 0.675
1.625AlaGln: 1.625 ± 0.936
4.063AlaArg: 4.063 ± 1.105
4.063AlaSer: 4.063 ± 1.125
2.844AlaThr: 2.844 ± 1.291
7.314AlaVal: 7.314 ± 1.248
1.219AlaTrp: 1.219 ± 0.65
3.251AlaTyr: 3.251 ± 0.838
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.813CysAsp: 0.813 ± 0.631
0.406CysGlu: 0.406 ± 0.305
0.406CysPhe: 0.406 ± 0.397
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.406CysLeu: 0.406 ± 0.354
0.0CysMet: 0.0 ± 0.0
0.406CysAsn: 0.406 ± 0.364
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.406CysArg: 0.406 ± 0.354
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.406CysVal: 0.406 ± 0.305
0.0CysTrp: 0.0 ± 0.0
0.813CysTyr: 0.813 ± 0.894
0.0CysXaa: 0.0 ± 0.0
Asp
0.813AspAla: 0.813 ± 0.652
0.0AspCys: 0.0 ± 0.0
4.47AspAsp: 4.47 ± 1.376
4.063AspGlu: 4.063 ± 1.156
1.625AspPhe: 1.625 ± 0.667
4.063AspGly: 4.063 ± 1.585
2.032AspHis: 2.032 ± 0.829
4.47AspIle: 4.47 ± 0.921
5.282AspLys: 5.282 ± 1.192
10.565AspLeu: 10.565 ± 1.428
2.032AspMet: 2.032 ± 0.798
2.844AspAsn: 2.844 ± 1.544
1.219AspPro: 1.219 ± 0.65
0.406AspGln: 0.406 ± 0.354
2.844AspArg: 2.844 ± 1.145
1.625AspSer: 1.625 ± 1.072
2.032AspThr: 2.032 ± 0.836
1.625AspVal: 1.625 ± 0.638
0.406AspTrp: 0.406 ± 0.411
4.876AspTyr: 4.876 ± 1.561
0.0AspXaa: 0.0 ± 0.0
Glu
6.501GluAla: 6.501 ± 1.533
0.0GluCys: 0.0 ± 0.0
3.251GluAsp: 3.251 ± 1.055
5.689GluGlu: 5.689 ± 1.827
1.625GluPhe: 1.625 ± 0.86
5.282GluGly: 5.282 ± 1.184
2.032GluHis: 2.032 ± 0.925
7.314GluIle: 7.314 ± 2.091
5.282GluLys: 5.282 ± 1.869
11.377GluLeu: 11.377 ± 2.301
2.438GluMet: 2.438 ± 0.766
6.501GluAsn: 6.501 ± 1.934
0.406GluPro: 0.406 ± 0.364
3.251GluGln: 3.251 ± 0.965
5.282GluArg: 5.282 ± 2.149
2.844GluSer: 2.844 ± 1.086
3.657GluThr: 3.657 ± 0.929
5.689GluVal: 5.689 ± 1.53
0.406GluTrp: 0.406 ± 0.354
1.219GluTyr: 1.219 ± 0.548
0.0GluXaa: 0.0 ± 0.0
Phe
2.844PheAla: 2.844 ± 1.251
0.0PheCys: 0.0 ± 0.0
3.657PheAsp: 3.657 ± 1.007
3.251PheGlu: 3.251 ± 0.758
2.844PhePhe: 2.844 ± 0.902
2.032PheGly: 2.032 ± 0.784
1.219PheHis: 1.219 ± 0.61
2.438PheIle: 2.438 ± 0.975
1.625PheLys: 1.625 ± 0.771
5.689PheLeu: 5.689 ± 1.521
0.406PheMet: 0.406 ± 0.447
1.625PheAsn: 1.625 ± 1.032
0.813PhePro: 0.813 ± 0.794
0.406PheGln: 0.406 ± 0.416
2.032PheArg: 2.032 ± 0.719
4.063PheSer: 4.063 ± 1.336
4.063PheThr: 4.063 ± 1.542
3.251PheVal: 3.251 ± 0.992
0.813PheTrp: 0.813 ± 0.526
1.219PheTyr: 1.219 ± 0.697
0.0PheXaa: 0.0 ± 0.0
Gly
3.657GlyAla: 3.657 ± 1.487
0.813GlyCys: 0.813 ± 0.509
1.625GlyAsp: 1.625 ± 0.632
4.063GlyGlu: 4.063 ± 0.998
2.844GlyPhe: 2.844 ± 0.958
0.813GlyGly: 0.813 ± 0.52
1.219GlyHis: 1.219 ± 0.497
5.282GlyIle: 5.282 ± 1.242
5.689GlyLys: 5.689 ± 1.211
7.314GlyLeu: 7.314 ± 2.281
0.813GlyMet: 0.813 ± 0.5
1.625GlyAsn: 1.625 ± 0.898
0.0GlyPro: 0.0 ± 0.0
1.219GlyGln: 1.219 ± 0.723
2.844GlyArg: 2.844 ± 0.834
1.219GlySer: 1.219 ± 0.755
2.844GlyThr: 2.844 ± 0.798
3.657GlyVal: 3.657 ± 1.273
1.625GlyTrp: 1.625 ± 0.772
4.063GlyTyr: 4.063 ± 1.319
0.0GlyXaa: 0.0 ± 0.0
His
1.219HisAla: 1.219 ± 0.751
0.0HisCys: 0.0 ± 0.0
1.625HisAsp: 1.625 ± 0.696
0.0HisGlu: 0.0 ± 0.0
1.625HisPhe: 1.625 ± 0.684
1.625HisGly: 1.625 ± 0.515
0.0HisHis: 0.0 ± 0.0
0.813HisIle: 0.813 ± 0.546
1.625HisLys: 1.625 ± 0.6
2.438HisLeu: 2.438 ± 1.427
0.406HisMet: 0.406 ± 0.397
1.219HisAsn: 1.219 ± 0.495
0.0HisPro: 0.0 ± 0.0
0.406HisGln: 0.406 ± 0.305
0.406HisArg: 0.406 ± 0.45
1.219HisSer: 1.219 ± 0.562
0.813HisThr: 0.813 ± 0.552
0.406HisVal: 0.406 ± 0.45
0.0HisTrp: 0.0 ± 0.0
1.219HisTyr: 1.219 ± 0.804
0.0HisXaa: 0.0 ± 0.0
Ile
3.657IleAla: 3.657 ± 1.307
0.813IleCys: 0.813 ± 0.581
5.689IleAsp: 5.689 ± 1.339
5.689IleGlu: 5.689 ± 1.243
3.657IlePhe: 3.657 ± 0.972
2.844IleGly: 2.844 ± 0.938
0.813IleHis: 0.813 ± 0.423
6.095IleIle: 6.095 ± 1.363
4.876IleLys: 4.876 ± 1.204
6.501IleLeu: 6.501 ± 1.27
1.625IleMet: 1.625 ± 0.74
2.032IleAsn: 2.032 ± 0.62
2.032IlePro: 2.032 ± 0.613
2.032IleGln: 2.032 ± 0.69
2.032IleArg: 2.032 ± 0.778
7.314IleSer: 7.314 ± 2.077
3.251IleThr: 3.251 ± 1.287
4.876IleVal: 4.876 ± 1.52
0.0IleTrp: 0.0 ± 0.0
2.438IleTyr: 2.438 ± 1.238
0.0IleXaa: 0.0 ± 0.0
Lys
6.501LysAla: 6.501 ± 2.435
0.0LysCys: 0.0 ± 0.0
4.876LysAsp: 4.876 ± 1.377
5.282LysGlu: 5.282 ± 1.688
2.844LysPhe: 2.844 ± 1.067
5.689LysGly: 5.689 ± 1.418
1.625LysHis: 1.625 ± 0.881
4.063LysIle: 4.063 ± 1.121
12.19LysLys: 12.19 ± 1.505
8.127LysLeu: 8.127 ± 1.215
2.032LysMet: 2.032 ± 0.825
4.47LysAsn: 4.47 ± 1.101
3.251LysPro: 3.251 ± 0.949
4.47LysGln: 4.47 ± 1.429
5.282LysArg: 5.282 ± 1.679
3.657LysSer: 3.657 ± 1.375
2.844LysThr: 2.844 ± 0.717
4.063LysVal: 4.063 ± 1.472
1.219LysTrp: 1.219 ± 0.449
3.657LysTyr: 3.657 ± 0.858
0.0LysXaa: 0.0 ± 0.0
Leu
8.127LeuAla: 8.127 ± 1.583
0.406LeuCys: 0.406 ± 0.397
8.127LeuAsp: 8.127 ± 1.262
13.409LeuGlu: 13.409 ± 3.062
6.501LeuPhe: 6.501 ± 1.848
4.47LeuGly: 4.47 ± 1.24
2.032LeuHis: 2.032 ± 1.253
7.314LeuIle: 7.314 ± 2.292
9.752LeuLys: 9.752 ± 1.515
7.72LeuLeu: 7.72 ± 2.535
3.251LeuMet: 3.251 ± 1.336
8.127LeuAsn: 8.127 ± 1.148
2.438LeuPro: 2.438 ± 0.86
2.844LeuGln: 2.844 ± 1.121
3.251LeuArg: 3.251 ± 0.828
6.501LeuSer: 6.501 ± 1.668
7.72LeuThr: 7.72 ± 1.476
6.501LeuVal: 6.501 ± 2.041
2.438LeuTrp: 2.438 ± 1.299
3.657LeuTyr: 3.657 ± 0.971
0.0LeuXaa: 0.0 ± 0.0
Met
1.219MetAla: 1.219 ± 0.721
0.0MetCys: 0.0 ± 0.0
1.625MetAsp: 1.625 ± 0.731
1.625MetGlu: 1.625 ± 0.752
1.219MetPhe: 1.219 ± 1.015
1.219MetGly: 1.219 ± 0.541
0.0MetHis: 0.0 ± 0.0
0.813MetIle: 0.813 ± 0.407
1.625MetLys: 1.625 ± 0.81
2.032MetLeu: 2.032 ± 0.918
0.406MetMet: 0.406 ± 0.485
2.844MetAsn: 2.844 ± 0.818
0.406MetPro: 0.406 ± 0.364
2.032MetGln: 2.032 ± 0.516
0.406MetArg: 0.406 ± 0.364
0.813MetSer: 0.813 ± 0.47
0.813MetThr: 0.813 ± 0.458
2.844MetVal: 2.844 ± 1.271
0.0MetTrp: 0.0 ± 0.0
0.406MetTyr: 0.406 ± 0.305
0.0MetXaa: 0.0 ± 0.0
Asn
2.032AsnAla: 2.032 ± 0.974
0.0AsnCys: 0.0 ± 0.0
2.438AsnAsp: 2.438 ± 1.001
3.251AsnGlu: 3.251 ± 0.932
2.032AsnPhe: 2.032 ± 1.162
4.876AsnGly: 4.876 ± 1.435
1.219AsnHis: 1.219 ± 0.632
3.657AsnIle: 3.657 ± 1.622
4.876AsnLys: 4.876 ± 1.28
5.282AsnLeu: 5.282 ± 1.061
0.813AsnMet: 0.813 ± 0.573
2.844AsnAsn: 2.844 ± 0.713
3.657AsnPro: 3.657 ± 1.075
2.032AsnGln: 2.032 ± 0.62
2.844AsnArg: 2.844 ± 0.733
4.063AsnSer: 4.063 ± 0.837
4.063AsnThr: 4.063 ± 1.289
0.406AsnVal: 0.406 ± 0.411
1.219AsnTrp: 1.219 ± 0.649
1.625AsnTyr: 1.625 ± 0.615
0.0AsnXaa: 0.0 ± 0.0
Pro
2.438ProAla: 2.438 ± 0.805
0.406ProCys: 0.406 ± 0.447
1.625ProAsp: 1.625 ± 0.515
1.625ProGlu: 1.625 ± 0.799
1.625ProPhe: 1.625 ± 0.531
0.813ProGly: 0.813 ± 0.529
0.0ProHis: 0.0 ± 0.0
1.625ProIle: 1.625 ± 0.524
2.032ProLys: 2.032 ± 0.993
2.844ProLeu: 2.844 ± 0.889
0.0ProMet: 0.0 ± 0.0
1.219ProAsn: 1.219 ± 0.466
0.813ProPro: 0.813 ± 0.482
0.0ProGln: 0.0 ± 0.0
2.438ProArg: 2.438 ± 0.863
0.813ProSer: 0.813 ± 0.526
1.219ProThr: 1.219 ± 0.576
1.219ProVal: 1.219 ± 0.675
0.406ProTrp: 0.406 ± 0.397
2.032ProTyr: 2.032 ± 0.814
0.0ProXaa: 0.0 ± 0.0
Gln
1.219GlnAla: 1.219 ± 0.751
0.0GlnCys: 0.0 ± 0.0
0.406GlnAsp: 0.406 ± 0.416
2.032GlnGlu: 2.032 ± 0.728
1.219GlnPhe: 1.219 ± 0.466
2.438GlnGly: 2.438 ± 0.91
0.406GlnHis: 0.406 ± 0.402
0.813GlnIle: 0.813 ± 0.607
2.844GlnLys: 2.844 ± 1.616
4.063GlnLeu: 4.063 ± 1.499
0.406GlnMet: 0.406 ± 0.447
2.032GlnAsn: 2.032 ± 0.717
0.0GlnPro: 0.0 ± 0.0
2.844GlnGln: 2.844 ± 1.712
2.438GlnArg: 2.438 ± 0.803
3.657GlnSer: 3.657 ± 1.611
1.219GlnThr: 1.219 ± 0.8
2.844GlnVal: 2.844 ± 1.118
0.406GlnTrp: 0.406 ± 0.44
3.251GlnTyr: 3.251 ± 0.937
0.0GlnXaa: 0.0 ± 0.0
Arg
4.47ArgAla: 4.47 ± 1.339
0.0ArgCys: 0.0 ± 0.0
2.438ArgAsp: 2.438 ± 0.741
4.063ArgGlu: 4.063 ± 1.37
2.032ArgPhe: 2.032 ± 0.906
1.625ArgGly: 1.625 ± 0.781
1.219ArgHis: 1.219 ± 0.691
2.844ArgIle: 2.844 ± 0.719
4.063ArgLys: 4.063 ± 0.974
6.908ArgLeu: 6.908 ± 1.569
2.438ArgMet: 2.438 ± 1.041
2.438ArgAsn: 2.438 ± 0.896
1.219ArgPro: 1.219 ± 0.633
2.032ArgGln: 2.032 ± 0.598
2.844ArgArg: 2.844 ± 1.466
3.251ArgSer: 3.251 ± 1.003
2.438ArgThr: 2.438 ± 0.862
3.657ArgVal: 3.657 ± 1.574
0.0ArgTrp: 0.0 ± 0.0
3.251ArgTyr: 3.251 ± 1.387
0.0ArgXaa: 0.0 ± 0.0
Ser
3.251SerAla: 3.251 ± 1.054
0.0SerCys: 0.0 ± 0.0
4.063SerAsp: 4.063 ± 0.873
4.063SerGlu: 4.063 ± 0.856
3.251SerPhe: 3.251 ± 0.876
3.657SerGly: 3.657 ± 0.87
0.406SerHis: 0.406 ± 0.354
4.47SerIle: 4.47 ± 1.5
3.251SerLys: 3.251 ± 0.849
4.47SerLeu: 4.47 ± 1.647
0.813SerMet: 0.813 ± 0.708
2.032SerAsn: 2.032 ± 1.212
2.438SerPro: 2.438 ± 1.098
3.251SerGln: 3.251 ± 1.608
4.063SerArg: 4.063 ± 1.416
2.438SerSer: 2.438 ± 0.888
1.625SerThr: 1.625 ± 1.043
4.063SerVal: 4.063 ± 1.386
0.406SerTrp: 0.406 ± 0.354
3.251SerTyr: 3.251 ± 1.097
0.0SerXaa: 0.0 ± 0.0
Thr
2.844ThrAla: 2.844 ± 1.328
0.0ThrCys: 0.0 ± 0.0
3.251ThrAsp: 3.251 ± 1.083
5.282ThrGlu: 5.282 ± 1.436
1.625ThrPhe: 1.625 ± 0.676
2.438ThrGly: 2.438 ± 0.771
1.219ThrHis: 1.219 ± 0.562
4.063ThrIle: 4.063 ± 1.752
4.063ThrLys: 4.063 ± 1.068
6.095ThrLeu: 6.095 ± 1.098
0.406ThrMet: 0.406 ± 0.354
1.625ThrAsn: 1.625 ± 0.673
2.844ThrPro: 2.844 ± 0.999
1.625ThrGln: 1.625 ± 0.683
1.625ThrArg: 1.625 ± 0.661
2.032ThrSer: 2.032 ± 1.126
4.47ThrThr: 4.47 ± 1.543
2.438ThrVal: 2.438 ± 1.241
0.0ThrTrp: 0.0 ± 0.0
2.032ThrTyr: 2.032 ± 1.036
0.0ThrXaa: 0.0 ± 0.0
Val
6.908ValAla: 6.908 ± 1.625
0.0ValCys: 0.0 ± 0.0
2.438ValAsp: 2.438 ± 0.704
4.063ValGlu: 4.063 ± 1.788
4.063ValPhe: 4.063 ± 0.963
3.251ValGly: 3.251 ± 1.455
1.625ValHis: 1.625 ± 0.568
4.063ValIle: 4.063 ± 1.389
4.876ValLys: 4.876 ± 1.011
4.47ValLeu: 4.47 ± 1.37
1.625ValMet: 1.625 ± 0.768
4.47ValAsn: 4.47 ± 1.529
1.625ValPro: 1.625 ± 0.763
1.625ValGln: 1.625 ± 0.707
3.657ValArg: 3.657 ± 1.058
2.844ValSer: 2.844 ± 0.872
2.438ValThr: 2.438 ± 0.796
0.813ValVal: 0.813 ± 0.512
1.219ValTrp: 1.219 ± 0.754
2.032ValTyr: 2.032 ± 0.715
0.0ValXaa: 0.0 ± 0.0
Trp
0.406TrpAla: 0.406 ± 0.354
0.406TrpCys: 0.406 ± 0.305
1.219TrpAsp: 1.219 ± 1.115
2.032TrpGlu: 2.032 ± 0.782
0.406TrpPhe: 0.406 ± 0.411
0.406TrpGly: 0.406 ± 0.305
0.0TrpHis: 0.0 ± 0.0
1.219TrpIle: 1.219 ± 0.697
0.813TrpLys: 0.813 ± 0.619
1.219TrpLeu: 1.219 ± 0.874
0.406TrpMet: 0.406 ± 0.397
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.406TrpGln: 0.406 ± 0.354
1.625TrpArg: 1.625 ± 0.696
0.406TrpSer: 0.406 ± 0.354
0.406TrpThr: 0.406 ± 0.305
0.0TrpVal: 0.0 ± 0.0
0.406TrpTrp: 0.406 ± 0.354
0.406TrpTyr: 0.406 ± 0.367
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.251TyrAla: 3.251 ± 1.362
0.0TyrCys: 0.0 ± 0.0
1.219TyrAsp: 1.219 ± 0.904
4.47TyrGlu: 4.47 ± 1.024
1.219TyrPhe: 1.219 ± 0.528
2.844TyrGly: 2.844 ± 0.967
0.0TyrHis: 0.0 ± 0.0
2.844TyrIle: 2.844 ± 0.919
8.127TyrLys: 8.127 ± 1.88
6.908TyrLeu: 6.908 ± 1.19
0.406TyrMet: 0.406 ± 0.305
2.032TyrAsn: 2.032 ± 1.043
0.813TyrPro: 0.813 ± 0.611
2.032TyrGln: 2.032 ± 0.667
2.844TyrArg: 2.844 ± 1.289
2.438TyrSer: 2.438 ± 1.125
1.219TyrThr: 1.219 ± 0.573
2.032TyrVal: 2.032 ± 0.92
0.0TyrTrp: 0.0 ± 0.0
3.251TyrTyr: 3.251 ± 0.912
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 17 proteins (2462 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski