Amino acid dipepetide frequency for Leptothrix ochracea L12

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.385AlaAla: 14.385 ± 0.429
1.48AlaCys: 1.48 ± 0.136
5.955AlaAsp: 5.955 ± 0.219
6.167AlaGlu: 6.167 ± 0.247
3.459AlaPhe: 3.459 ± 0.155
8.57AlaGly: 8.57 ± 0.305
2.921AlaHis: 2.921 ± 0.168
4.786AlaIle: 4.786 ± 0.222
3.784AlaLys: 3.784 ± 0.225
13.476AlaLeu: 13.476 ± 0.392
3.12AlaMet: 3.12 ± 0.163
2.888AlaAsn: 2.888 ± 0.164
5.477AlaPro: 5.477 ± 0.258
5.636AlaGln: 5.636 ± 0.227
7.156AlaArg: 7.156 ± 0.251
6.685AlaSer: 6.685 ± 0.23
6.213AlaThr: 6.213 ± 0.322
8.384AlaVal: 8.384 ± 0.259
1.918AlaTrp: 1.918 ± 0.139
2.27AlaTyr: 2.27 ± 0.124
0.0AlaXaa: 0.0 ± 0.0
Cys
1.122CysAla: 1.122 ± 0.09
0.159CysCys: 0.159 ± 0.032
0.591CysAsp: 0.591 ± 0.068
0.505CysGlu: 0.505 ± 0.059
0.372CysPhe: 0.372 ± 0.047
1.062CysGly: 1.062 ± 0.097
0.631CysHis: 0.631 ± 0.177
0.451CysIle: 0.451 ± 0.059
0.372CysLys: 0.372 ± 0.049
0.976CysLeu: 0.976 ± 0.09
0.252CysMet: 0.252 ± 0.039
0.312CysAsn: 0.312 ± 0.048
0.425CysPro: 0.425 ± 0.055
0.339CysGln: 0.339 ± 0.041
0.624CysArg: 0.624 ± 0.065
0.657CysSer: 0.657 ± 0.071
0.717CysThr: 0.717 ± 0.073
0.75CysVal: 0.75 ± 0.086
0.186CysTrp: 0.186 ± 0.036
0.193CysTyr: 0.193 ± 0.036
0.0CysXaa: 0.0 ± 0.0
Asp
6.545AspAla: 6.545 ± 0.219
0.564AspCys: 0.564 ± 0.072
2.483AspAsp: 2.483 ± 0.154
2.762AspGlu: 2.762 ± 0.166
2.031AspPhe: 2.031 ± 0.126
4.494AspGly: 4.494 ± 0.246
1.275AspHis: 1.275 ± 0.09
2.197AspIle: 2.197 ± 0.147
1.739AspLys: 1.739 ± 0.116
5.802AspLeu: 5.802 ± 0.219
1.221AspMet: 1.221 ± 0.098
1.215AspAsn: 1.215 ± 0.095
3.332AspPro: 3.332 ± 0.162
2.005AspGln: 2.005 ± 0.143
3.452AspArg: 3.452 ± 0.201
2.363AspSer: 2.363 ± 0.149
2.775AspThr: 2.775 ± 0.16
4.262AspVal: 4.262 ± 0.165
1.016AspTrp: 1.016 ± 0.084
1.188AspTyr: 1.188 ± 0.092
0.0AspXaa: 0.0 ± 0.0
Glu
6.134GluAla: 6.134 ± 0.231
0.385GluCys: 0.385 ± 0.059
2.337GluAsp: 2.337 ± 0.127
2.509GluGlu: 2.509 ± 0.163
1.547GluPhe: 1.547 ± 0.114
3.658GluGly: 3.658 ± 0.184
1.467GluHis: 1.467 ± 0.093
2.509GluIle: 2.509 ± 0.147
1.899GluLys: 1.899 ± 0.147
5.198GluLeu: 5.198 ± 0.229
1.215GluMet: 1.215 ± 0.101
1.089GluAsn: 1.089 ± 0.088
2.609GluPro: 2.609 ± 0.137
2.775GluGln: 2.775 ± 0.164
4.295GluArg: 4.295 ± 0.224
2.762GluSer: 2.762 ± 0.154
2.569GluThr: 2.569 ± 0.144
3.485GluVal: 3.485 ± 0.162
0.637GluTrp: 0.637 ± 0.065
0.982GluTyr: 0.982 ± 0.093
0.0GluXaa: 0.0 ± 0.0
Phe
3.439PheAla: 3.439 ± 0.167
0.478PheCys: 0.478 ± 0.059
2.503PheAsp: 2.503 ± 0.124
2.091PheGlu: 2.091 ± 0.143
1.162PhePhe: 1.162 ± 0.122
3.153PheGly: 3.153 ± 0.159
0.81PheHis: 0.81 ± 0.093
1.699PheIle: 1.699 ± 0.121
1.175PheLys: 1.175 ± 0.091
2.954PheLeu: 2.954 ± 0.172
0.797PheMet: 0.797 ± 0.076
1.115PheAsn: 1.115 ± 0.077
1.5PhePro: 1.5 ± 0.105
1.075PheGln: 1.075 ± 0.084
1.872PheArg: 1.872 ± 0.114
2.224PheSer: 2.224 ± 0.129
1.826PheThr: 1.826 ± 0.131
2.722PheVal: 2.722 ± 0.15
0.471PheTrp: 0.471 ± 0.061
0.903PheTyr: 0.903 ± 0.067
0.0PheXaa: 0.0 ± 0.0
Gly
7.853GlyAla: 7.853 ± 0.339
1.115GlyCys: 1.115 ± 0.094
3.79GlyAsp: 3.79 ± 0.169
3.684GlyGlu: 3.684 ± 0.158
2.934GlyPhe: 2.934 ± 0.152
6.638GlyGly: 6.638 ± 0.325
2.27GlyHis: 2.27 ± 0.144
3.824GlyIle: 3.824 ± 0.178
2.848GlyLys: 2.848 ± 0.16
9.021GlyLeu: 9.021 ± 0.25
2.038GlyMet: 2.038 ± 0.122
2.416GlyAsn: 2.416 ± 0.256
2.987GlyPro: 2.987 ± 0.13
3.286GlyGln: 3.286 ± 0.143
4.959GlyArg: 4.959 ± 0.202
5.032GlySer: 5.032 ± 0.255
4.786GlyThr: 4.786 ± 0.315
6.413GlyVal: 6.413 ± 0.237
1.593GlyTrp: 1.593 ± 0.108
2.071GlyTyr: 2.071 ± 0.121
0.0GlyXaa: 0.0 ± 0.0
His
3.18HisAla: 3.18 ± 0.188
0.285HisCys: 0.285 ± 0.044
1.188HisAsp: 1.188 ± 0.087
1.414HisGlu: 1.414 ± 0.112
1.082HisPhe: 1.082 ± 0.099
2.303HisGly: 2.303 ± 0.123
0.797HisHis: 0.797 ± 0.096
1.135HisIle: 1.135 ± 0.091
0.757HisLys: 0.757 ± 0.098
2.542HisLeu: 2.542 ± 0.152
0.524HisMet: 0.524 ± 0.066
0.624HisAsn: 0.624 ± 0.057
1.872HisPro: 1.872 ± 0.131
1.182HisGln: 1.182 ± 0.099
2.045HisArg: 2.045 ± 0.13
0.982HisSer: 0.982 ± 0.083
1.374HisThr: 1.374 ± 0.109
1.839HisVal: 1.839 ± 0.127
0.531HisTrp: 0.531 ± 0.074
0.524HisTyr: 0.524 ± 0.059
0.0HisXaa: 0.0 ± 0.0
Ile
5.423IleAla: 5.423 ± 0.181
0.358IleCys: 0.358 ± 0.045
3.339IleAsp: 3.339 ± 0.157
3.246IleGlu: 3.246 ± 0.172
1.633IlePhe: 1.633 ± 0.114
4.162IleGly: 4.162 ± 0.199
1.394IleHis: 1.394 ± 0.093
1.786IleIle: 1.786 ± 0.118
1.686IleLys: 1.686 ± 0.12
3.824IleLeu: 3.824 ± 0.188
0.863IleMet: 0.863 ± 0.094
1.56IleAsn: 1.56 ± 0.128
2.038IlePro: 2.038 ± 0.133
1.786IleGln: 1.786 ± 0.095
2.781IleArg: 2.781 ± 0.158
3.093IleSer: 3.093 ± 0.15
3.107IleThr: 3.107 ± 0.154
3.233IleVal: 3.233 ± 0.184
0.511IleTrp: 0.511 ± 0.059
1.202IleTyr: 1.202 ± 0.087
0.0IleXaa: 0.0 ± 0.0
Lys
4.043LysAla: 4.043 ± 0.227
0.279LysCys: 0.279 ± 0.047
1.799LysAsp: 1.799 ± 0.128
1.56LysGlu: 1.56 ± 0.12
0.876LysPhe: 0.876 ± 0.092
2.337LysGly: 2.337 ± 0.135
0.737LysHis: 0.737 ± 0.084
1.739LysIle: 1.739 ± 0.128
1.407LysLys: 1.407 ± 0.127
3.306LysLeu: 3.306 ± 0.171
0.85LysMet: 0.85 ± 0.083
1.122LysAsn: 1.122 ± 0.094
2.065LysPro: 2.065 ± 0.116
1.215LysGln: 1.215 ± 0.097
2.157LysArg: 2.157 ± 0.153
1.865LysSer: 1.865 ± 0.12
2.151LysThr: 2.151 ± 0.13
2.755LysVal: 2.755 ± 0.142
0.292LysTrp: 0.292 ± 0.048
0.604LysTyr: 0.604 ± 0.067
0.0LysXaa: 0.0 ± 0.0
Leu
12.453LeuAla: 12.453 ± 0.402
0.982LeuCys: 0.982 ± 0.076
5.994LeuAsp: 5.994 ± 0.191
5.37LeuGlu: 5.37 ± 0.251
3.319LeuPhe: 3.319 ± 0.184
8.51LeuGly: 8.51 ± 0.25
2.888LeuHis: 2.888 ± 0.176
5.589LeuIle: 5.589 ± 0.203
3.631LeuLys: 3.631 ± 0.18
10.9LeuLeu: 10.9 ± 0.397
2.981LeuMet: 2.981 ± 0.144
3.087LeuAsn: 3.087 ± 0.168
5.795LeuPro: 5.795 ± 0.219
4.182LeuGln: 4.182 ± 0.174
7.621LeuArg: 7.621 ± 0.297
7.309LeuSer: 7.309 ± 0.231
5.477LeuThr: 5.477 ± 0.257
7.302LeuVal: 7.302 ± 0.247
1.454LeuTrp: 1.454 ± 0.116
2.151LeuTyr: 2.151 ± 0.131
0.0LeuXaa: 0.0 ± 0.0
Met
2.775MetAla: 2.775 ± 0.151
0.219MetCys: 0.219 ± 0.037
1.294MetAsp: 1.294 ± 0.077
0.982MetGlu: 0.982 ± 0.084
0.677MetPhe: 0.677 ± 0.079
1.905MetGly: 1.905 ± 0.125
0.591MetHis: 0.591 ± 0.069
1.228MetIle: 1.228 ± 0.092
1.115MetLys: 1.115 ± 0.093
2.722MetLeu: 2.722 ± 0.14
0.538MetMet: 0.538 ± 0.073
0.996MetAsn: 0.996 ± 0.075
1.5MetPro: 1.5 ± 0.101
1.129MetGln: 1.129 ± 0.08
1.699MetArg: 1.699 ± 0.114
1.872MetSer: 1.872 ± 0.115
1.54MetThr: 1.54 ± 0.112
1.865MetVal: 1.865 ± 0.115
0.246MetTrp: 0.246 ± 0.043
0.358MetTyr: 0.358 ± 0.047
0.0MetXaa: 0.0 ± 0.0
Asn
3.239AsnAla: 3.239 ± 0.174
0.312AsnCys: 0.312 ± 0.046
1.374AsnAsp: 1.374 ± 0.111
1.175AsnGlu: 1.175 ± 0.097
1.016AsnPhe: 1.016 ± 0.087
2.702AsnGly: 2.702 ± 0.298
0.724AsnHis: 0.724 ± 0.072
1.215AsnIle: 1.215 ± 0.097
0.929AsnLys: 0.929 ± 0.088
3.02AsnLeu: 3.02 ± 0.16
0.617AsnMet: 0.617 ± 0.061
0.976AsnAsn: 0.976 ± 0.121
1.899AsnPro: 1.899 ± 0.109
1.089AsnGln: 1.089 ± 0.104
1.54AsnArg: 1.54 ± 0.118
1.414AsnSer: 1.414 ± 0.129
1.918AsnThr: 1.918 ± 0.141
2.157AsnVal: 2.157 ± 0.154
0.445AsnTrp: 0.445 ± 0.062
0.85AsnTyr: 0.85 ± 0.124
0.0AsnXaa: 0.0 ± 0.0
Pro
5.835ProAla: 5.835 ± 0.227
0.425ProCys: 0.425 ± 0.059
3.06ProAsp: 3.06 ± 0.151
3.12ProGlu: 3.12 ± 0.137
1.547ProPhe: 1.547 ± 0.096
3.764ProGly: 3.764 ± 0.189
1.182ProHis: 1.182 ± 0.097
2.556ProIle: 2.556 ± 0.155
1.845ProLys: 1.845 ± 0.12
5.324ProLeu: 5.324 ± 0.222
1.6ProMet: 1.6 ± 0.096
1.699ProAsn: 1.699 ± 0.134
2.602ProPro: 2.602 ± 0.163
1.958ProGln: 1.958 ± 0.123
2.576ProArg: 2.576 ± 0.147
3.306ProSer: 3.306 ± 0.154
3.127ProThr: 3.127 ± 0.214
4.361ProVal: 4.361 ± 0.181
0.876ProTrp: 0.876 ± 0.091
1.155ProTyr: 1.155 ± 0.092
0.0ProXaa: 0.0 ± 0.0
Gln
5.968GlnAla: 5.968 ± 0.21
0.378GlnCys: 0.378 ± 0.049
2.045GlnAsp: 2.045 ± 0.131
1.792GlnGlu: 1.792 ± 0.127
1.268GlnPhe: 1.268 ± 0.087
3.346GlnGly: 3.346 ± 0.155
1.062GlnHis: 1.062 ± 0.085
2.191GlnIle: 2.191 ± 0.118
1.248GlnLys: 1.248 ± 0.086
4.069GlnLeu: 4.069 ± 0.167
0.909GlnMet: 0.909 ± 0.081
0.956GlnAsn: 0.956 ± 0.08
2.377GlnPro: 2.377 ± 0.14
2.184GlnGln: 2.184 ± 0.15
3.226GlnArg: 3.226 ± 0.162
2.31GlnSer: 2.31 ± 0.162
2.483GlnThr: 2.483 ± 0.156
3.346GlnVal: 3.346 ± 0.17
0.664GlnTrp: 0.664 ± 0.068
0.75GlnTyr: 0.75 ± 0.08
0.0GlnXaa: 0.0 ± 0.0
Arg
5.974ArgAla: 5.974 ± 0.211
0.704ArgCys: 0.704 ± 0.07
3.279ArgAsp: 3.279 ± 0.143
3.644ArgGlu: 3.644 ± 0.241
2.722ArgPhe: 2.722 ± 0.127
3.963ArgGly: 3.963 ± 0.175
1.958ArgHis: 1.958 ± 0.136
3.498ArgIle: 3.498 ± 0.178
2.025ArgLys: 2.025 ± 0.125
7.581ArgLeu: 7.581 ± 0.291
1.872ArgMet: 1.872 ± 0.132
1.719ArgAsn: 1.719 ± 0.121
3.074ArgPro: 3.074 ± 0.149
3.266ArgGln: 3.266 ± 0.17
4.574ArgArg: 4.574 ± 0.259
3.89ArgSer: 3.89 ± 0.156
3.22ArgThr: 3.22 ± 0.181
4.906ArgVal: 4.906 ± 0.187
1.268ArgTrp: 1.268 ± 0.11
1.699ArgTyr: 1.699 ± 0.111
0.0ArgXaa: 0.0 ± 0.0
Ser
7.276SerAla: 7.276 ± 0.268
0.697SerCys: 0.697 ± 0.091
2.708SerAsp: 2.708 ± 0.146
2.788SerGlu: 2.788 ± 0.154
2.416SerPhe: 2.416 ± 0.153
5.423SerGly: 5.423 ± 0.242
1.401SerHis: 1.401 ± 0.105
2.788SerIle: 2.788 ± 0.152
1.64SerLys: 1.64 ± 0.12
6.386SerLeu: 6.386 ± 0.213
1.673SerMet: 1.673 ± 0.108
1.819SerAsn: 1.819 ± 0.141
3.034SerPro: 3.034 ± 0.154
2.005SerGln: 2.005 ± 0.113
3.352SerArg: 3.352 ± 0.158
4.222SerSer: 4.222 ± 0.255
3.863SerThr: 3.863 ± 0.282
4.561SerVal: 4.561 ± 0.199
0.883SerTrp: 0.883 ± 0.087
1.52SerTyr: 1.52 ± 0.121
0.0SerXaa: 0.0 ± 0.0
Thr
6.14ThrAla: 6.14 ± 0.274
0.651ThrCys: 0.651 ± 0.077
3.054ThrAsp: 3.054 ± 0.173
2.41ThrGlu: 2.41 ± 0.127
1.819ThrPhe: 1.819 ± 0.129
4.813ThrGly: 4.813 ± 0.239
1.421ThrHis: 1.421 ± 0.111
2.284ThrIle: 2.284 ± 0.129
1.62ThrLys: 1.62 ± 0.117
7.342ThrLeu: 7.342 ± 0.383
1.334ThrMet: 1.334 ± 0.1
1.54ThrAsn: 1.54 ± 0.19
4.043ThrPro: 4.043 ± 0.279
2.416ThrGln: 2.416 ± 0.124
3.246ThrArg: 3.246 ± 0.164
3.293ThrSer: 3.293 ± 0.234
3.684ThrThr: 3.684 ± 0.226
4.335ThrVal: 4.335 ± 0.244
0.896ThrTrp: 0.896 ± 0.095
1.082ThrTyr: 1.082 ± 0.09
0.0ThrXaa: 0.0 ± 0.0
Val
8.829ValAla: 8.829 ± 0.27
0.77ValCys: 0.77 ± 0.075
4.175ValAsp: 4.175 ± 0.158
3.478ValGlu: 3.478 ± 0.147
2.483ValPhe: 2.483 ± 0.127
5.822ValGly: 5.822 ± 0.249
1.812ValHis: 1.812 ± 0.1
3.731ValIle: 3.731 ± 0.167
2.237ValLys: 2.237 ± 0.136
8.172ValLeu: 8.172 ± 0.263
2.005ValMet: 2.005 ± 0.122
2.323ValAsn: 2.323 ± 0.168
3.558ValPro: 3.558 ± 0.18
3.074ValGln: 3.074 ± 0.142
4.979ValArg: 4.979 ± 0.194
4.833ValSer: 4.833 ± 0.218
4.381ValThr: 4.381 ± 0.208
6.34ValVal: 6.34 ± 0.245
1.168ValTrp: 1.168 ± 0.104
1.686ValTyr: 1.686 ± 0.121
0.0ValXaa: 0.0 ± 0.0
Trp
1.48TrpAla: 1.48 ± 0.103
0.232TrpCys: 0.232 ± 0.037
0.724TrpAsp: 0.724 ± 0.077
0.451TrpGlu: 0.451 ± 0.055
0.551TrpPhe: 0.551 ± 0.059
1.022TrpGly: 1.022 ± 0.115
0.418TrpHis: 0.418 ± 0.05
0.81TrpIle: 0.81 ± 0.079
0.511TrpLys: 0.511 ± 0.062
2.184TrpLeu: 2.184 ± 0.163
0.458TrpMet: 0.458 ± 0.059
0.511TrpAsn: 0.511 ± 0.067
0.697TrpPro: 0.697 ± 0.084
0.949TrpGln: 0.949 ± 0.086
1.202TrpArg: 1.202 ± 0.1
1.042TrpSer: 1.042 ± 0.091
0.75TrpThr: 0.75 ± 0.082
1.175TrpVal: 1.175 ± 0.087
0.378TrpTrp: 0.378 ± 0.057
0.319TrpTyr: 0.319 ± 0.048
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.635TyrAla: 2.635 ± 0.141
0.219TyrCys: 0.219 ± 0.041
1.029TyrAsp: 1.029 ± 0.08
0.909TyrGlu: 0.909 ± 0.085
1.055TyrPhe: 1.055 ± 0.084
1.912TyrGly: 1.912 ± 0.116
0.425TyrHis: 0.425 ± 0.057
1.009TyrIle: 1.009 ± 0.086
0.69TyrLys: 0.69 ± 0.073
2.197TyrLeu: 2.197 ± 0.116
0.378TyrMet: 0.378 ± 0.052
0.644TyrAsn: 0.644 ± 0.07
1.036TyrPro: 1.036 ± 0.092
1.022TyrGln: 1.022 ± 0.075
1.487TyrArg: 1.487 ± 0.106
1.301TyrSer: 1.301 ± 0.104
1.46TyrThr: 1.46 ± 0.121
1.666TyrVal: 1.666 ± 0.103
0.431TyrTrp: 0.431 ± 0.056
0.611TyrTyr: 0.611 ± 0.063
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 531 proteins (150642 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski