Amino acid dipepetide frequency for Bat betaherpesvirus B7D8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.903AlaAla: 6.903 ± 0.529
1.632AlaCys: 1.632 ± 0.154
4.236AlaAsp: 4.236 ± 0.295
4.126AlaGlu: 4.126 ± 0.312
2.965AlaPhe: 2.965 ± 0.217
4.032AlaGly: 4.032 ± 0.352
1.334AlaHis: 1.334 ± 0.138
3.31AlaIle: 3.31 ± 0.246
2.902AlaLys: 2.902 ± 0.19
5.805AlaLeu: 5.805 ± 0.399
1.977AlaMet: 1.977 ± 0.156
2.667AlaAsn: 2.667 ± 0.185
3.546AlaPro: 3.546 ± 0.269
1.757AlaGln: 1.757 ± 0.215
4.832AlaArg: 4.832 ± 0.338
5.899AlaSer: 5.899 ± 0.346
4.628AlaThr: 4.628 ± 0.298
5.648AlaVal: 5.648 ± 0.334
1.114AlaTrp: 1.114 ± 0.164
2.51AlaTyr: 2.51 ± 0.206
0.0AlaXaa: 0.0 ± 0.0
Cys
1.992CysAla: 1.992 ± 0.17
0.91CysCys: 0.91 ± 0.164
1.961CysAsp: 1.961 ± 0.211
1.443CysGlu: 1.443 ± 0.151
1.051CysPhe: 1.051 ± 0.123
1.961CysGly: 1.961 ± 0.216
0.659CysHis: 0.659 ± 0.095
1.522CysIle: 1.522 ± 0.167
1.035CysLys: 1.035 ± 0.136
2.29CysLeu: 2.29 ± 0.191
0.784CysMet: 0.784 ± 0.119
0.973CysAsn: 0.973 ± 0.126
1.239CysPro: 1.239 ± 0.189
0.518CysGln: 0.518 ± 0.084
2.243CysArg: 2.243 ± 0.22
1.726CysSer: 1.726 ± 0.168
1.647CysThr: 1.647 ± 0.168
3.044CysVal: 3.044 ± 0.302
0.251CysTrp: 0.251 ± 0.059
1.067CysTyr: 1.067 ± 0.117
0.0CysXaa: 0.0 ± 0.0
Asp
5.24AspAla: 5.24 ± 0.339
1.02AspCys: 1.02 ± 0.131
5.114AspAsp: 5.114 ± 0.388
3.938AspGlu: 3.938 ± 0.278
2.275AspPhe: 2.275 ± 0.199
4.424AspGly: 4.424 ± 0.444
1.396AspHis: 1.396 ± 0.118
3.138AspIle: 3.138 ± 0.223
2.055AspLys: 2.055 ± 0.194
4.754AspLeu: 4.754 ± 0.317
1.537AspMet: 1.537 ± 0.136
2.243AspAsn: 2.243 ± 0.185
2.981AspPro: 2.981 ± 0.228
0.988AspGln: 0.988 ± 0.125
4.628AspArg: 4.628 ± 0.248
3.859AspSer: 3.859 ± 0.236
3.702AspThr: 3.702 ± 0.24
5.632AspVal: 5.632 ± 0.341
0.533AspTrp: 0.533 ± 0.088
1.977AspTyr: 1.977 ± 0.165
0.0AspXaa: 0.0 ± 0.0
Glu
3.828GluAla: 3.828 ± 0.402
1.428GluCys: 1.428 ± 0.143
3.922GluAsp: 3.922 ± 0.294
3.044GluGlu: 3.044 ± 0.257
1.773GluPhe: 1.773 ± 0.186
2.369GluGly: 2.369 ± 0.235
1.13GluHis: 1.13 ± 0.097
2.824GluIle: 2.824 ± 0.227
2.039GluLys: 2.039 ± 0.191
4.095GluLeu: 4.095 ± 0.305
1.506GluMet: 1.506 ± 0.162
2.651GluAsn: 2.651 ± 0.189
2.51GluPro: 2.51 ± 0.216
1.318GluGln: 1.318 ± 0.154
4.534GluArg: 4.534 ± 0.326
3.922GluSer: 3.922 ± 0.297
4.079GluThr: 4.079 ± 0.259
2.824GluVal: 2.824 ± 0.214
0.596GluTrp: 0.596 ± 0.093
1.569GluTyr: 1.569 ± 0.146
0.0GluXaa: 0.0 ± 0.0
Phe
2.84PheAla: 2.84 ± 0.221
1.318PheCys: 1.318 ± 0.159
2.479PheAsp: 2.479 ± 0.199
1.851PheGlu: 1.851 ± 0.175
2.463PhePhe: 2.463 ± 0.248
2.698PheGly: 2.698 ± 0.198
0.941PheHis: 0.941 ± 0.119
2.745PheIle: 2.745 ± 0.255
1.82PheLys: 1.82 ± 0.163
4.173PheLeu: 4.173 ± 0.265
0.973PheMet: 0.973 ± 0.119
1.616PheAsn: 1.616 ± 0.175
1.757PhePro: 1.757 ± 0.148
1.051PheGln: 1.051 ± 0.11
2.62PheArg: 2.62 ± 0.2
3.342PheSer: 3.342 ± 0.254
2.4PheThr: 2.4 ± 0.226
3.514PheVal: 3.514 ± 0.214
0.377PheTrp: 0.377 ± 0.066
1.663PheTyr: 1.663 ± 0.17
0.0PheXaa: 0.0 ± 0.0
Gly
4.252GlyAla: 4.252 ± 0.299
1.757GlyCys: 1.757 ± 0.18
3.938GlyAsp: 3.938 ± 0.309
3.608GlyGlu: 3.608 ± 0.391
2.557GlyPhe: 2.557 ± 0.199
4.597GlyGly: 4.597 ± 0.424
1.177GlyHis: 1.177 ± 0.142
2.385GlyIle: 2.385 ± 0.173
2.149GlyLys: 2.149 ± 0.204
5.475GlyLeu: 5.475 ± 0.435
1.428GlyMet: 1.428 ± 0.116
2.447GlyAsn: 2.447 ± 0.218
2.557GlyPro: 2.557 ± 0.245
1.726GlyGln: 1.726 ± 0.194
5.554GlyArg: 5.554 ± 0.493
5.35GlySer: 5.35 ± 0.454
3.938GlyThr: 3.938 ± 0.256
4.346GlyVal: 4.346 ± 0.312
0.941GlyTrp: 0.941 ± 0.124
2.479GlyTyr: 2.479 ± 0.208
0.0GlyXaa: 0.0 ± 0.0
His
1.663HisAla: 1.663 ± 0.168
0.392HisCys: 0.392 ± 0.087
1.553HisAsp: 1.553 ± 0.165
1.067HisGlu: 1.067 ± 0.131
0.722HisPhe: 0.722 ± 0.102
1.318HisGly: 1.318 ± 0.132
0.69HisHis: 0.69 ± 0.116
1.381HisIle: 1.381 ± 0.153
0.863HisLys: 0.863 ± 0.139
2.055HisLeu: 2.055 ± 0.2
0.643HisMet: 0.643 ± 0.089
0.879HisAsn: 0.879 ± 0.122
1.271HisPro: 1.271 ± 0.146
0.628HisGln: 0.628 ± 0.1
2.118HisArg: 2.118 ± 0.171
1.224HisSer: 1.224 ± 0.164
1.302HisThr: 1.302 ± 0.17
2.212HisVal: 2.212 ± 0.2
0.204HisTrp: 0.204 ± 0.05
0.612HisTyr: 0.612 ± 0.097
0.0HisXaa: 0.0 ± 0.0
Ile
3.295IleAla: 3.295 ± 0.232
1.459IleCys: 1.459 ± 0.151
2.73IleAsp: 2.73 ± 0.307
1.694IleGlu: 1.694 ± 0.175
2.714IlePhe: 2.714 ± 0.237
2.934IleGly: 2.934 ± 0.24
1.428IleHis: 1.428 ± 0.161
2.118IleIle: 2.118 ± 0.237
2.039IleLys: 2.039 ± 0.202
4.675IleLeu: 4.675 ± 0.324
1.318IleMet: 1.318 ± 0.176
2.855IleAsn: 2.855 ± 0.269
2.353IlePro: 2.353 ± 0.204
1.271IleGln: 1.271 ± 0.183
3.608IleArg: 3.608 ± 0.233
4.299IleSer: 4.299 ± 0.319
3.31IleThr: 3.31 ± 0.28
3.938IleVal: 3.938 ± 0.229
0.58IleTrp: 0.58 ± 0.092
2.102IleTyr: 2.102 ± 0.183
0.0IleXaa: 0.0 ± 0.0
Lys
2.118LysAla: 2.118 ± 0.153
0.831LysCys: 0.831 ± 0.111
2.447LysAsp: 2.447 ± 0.207
1.741LysGlu: 1.741 ± 0.206
1.318LysPhe: 1.318 ± 0.129
1.569LysGly: 1.569 ± 0.156
1.177LysHis: 1.177 ± 0.119
2.541LysIle: 2.541 ± 0.214
2.51LysLys: 2.51 ± 0.25
3.389LysLeu: 3.389 ± 0.245
1.067LysMet: 1.067 ± 0.129
2.463LysAsn: 2.463 ± 0.241
1.647LysPro: 1.647 ± 0.186
1.255LysGln: 1.255 ± 0.145
3.373LysArg: 3.373 ± 0.249
2.761LysSer: 2.761 ± 0.246
3.138LysThr: 3.138 ± 0.275
2.149LysVal: 2.149 ± 0.222
0.345LysTrp: 0.345 ± 0.072
1.381LysTyr: 1.381 ± 0.132
0.0LysXaa: 0.0 ± 0.0
Leu
5.538LeuAla: 5.538 ± 0.316
3.106LeuCys: 3.106 ± 0.259
4.267LeuAsp: 4.267 ± 0.277
4.408LeuGlu: 4.408 ± 0.293
3.483LeuPhe: 3.483 ± 0.249
5.711LeuGly: 5.711 ± 0.592
2.259LeuHis: 2.259 ± 0.283
4.346LeuIle: 4.346 ± 0.262
3.687LeuLys: 3.687 ± 0.284
7.577LeuLeu: 7.577 ± 0.424
2.385LeuMet: 2.385 ± 0.215
3.31LeuAsn: 3.31 ± 0.263
3.749LeuPro: 3.749 ± 0.226
2.29LeuGln: 2.29 ± 0.238
6.668LeuArg: 6.668 ± 0.29
8.252LeuSer: 8.252 ± 0.401
5.711LeuThr: 5.711 ± 0.304
4.408LeuVal: 4.408 ± 0.271
0.973LeuTrp: 0.973 ± 0.142
3.436LeuTyr: 3.436 ± 0.239
0.0LeuXaa: 0.0 ± 0.0
Met
1.569MetAla: 1.569 ± 0.175
0.831MetCys: 0.831 ± 0.126
1.255MetAsp: 1.255 ± 0.162
1.13MetGlu: 1.13 ± 0.131
1.569MetPhe: 1.569 ± 0.18
0.988MetGly: 0.988 ± 0.143
0.486MetHis: 0.486 ± 0.09
1.192MetIle: 1.192 ± 0.147
0.847MetLys: 0.847 ± 0.106
2.541MetLeu: 2.541 ± 0.193
0.8MetMet: 0.8 ± 0.099
1.035MetAsn: 1.035 ± 0.138
1.035MetPro: 1.035 ± 0.129
0.455MetGln: 0.455 ± 0.099
2.008MetArg: 2.008 ± 0.184
2.385MetSer: 2.385 ± 0.231
1.255MetThr: 1.255 ± 0.161
1.679MetVal: 1.679 ± 0.185
0.329MetTrp: 0.329 ± 0.072
1.286MetTyr: 1.286 ± 0.135
0.0MetXaa: 0.0 ± 0.0
Asn
3.373AsnAla: 3.373 ± 0.248
0.973AsnCys: 0.973 ± 0.116
2.541AsnAsp: 2.541 ± 0.181
2.212AsnGlu: 2.212 ± 0.198
1.537AsnPhe: 1.537 ± 0.154
3.232AsnGly: 3.232 ± 0.249
0.643AsnHis: 0.643 ± 0.089
2.4AsnIle: 2.4 ± 0.234
1.569AsnLys: 1.569 ± 0.189
3.31AsnLeu: 3.31 ± 0.233
0.737AsnMet: 0.737 ± 0.108
1.459AsnAsn: 1.459 ± 0.176
1.851AsnPro: 1.851 ± 0.155
0.863AsnGln: 0.863 ± 0.134
3.232AsnArg: 3.232 ± 0.228
2.259AsnSer: 2.259 ± 0.229
2.432AsnThr: 2.432 ± 0.217
4.33AsnVal: 4.33 ± 0.33
0.408AsnTrp: 0.408 ± 0.076
1.114AsnTyr: 1.114 ± 0.139
0.0AsnXaa: 0.0 ± 0.0
Pro
3.169ProAla: 3.169 ± 0.248
1.365ProCys: 1.365 ± 0.137
2.73ProAsp: 2.73 ± 0.196
2.918ProGlu: 2.918 ± 0.222
1.992ProPhe: 1.992 ± 0.158
3.31ProGly: 3.31 ± 0.266
0.941ProHis: 0.941 ± 0.128
2.071ProIle: 2.071 ± 0.219
1.788ProLys: 1.788 ± 0.186
3.451ProLeu: 3.451 ± 0.208
1.067ProMet: 1.067 ± 0.122
1.302ProAsn: 1.302 ± 0.147
3.467ProPro: 3.467 ± 0.3
1.192ProGln: 1.192 ± 0.163
3.702ProArg: 3.702 ± 0.295
3.749ProSer: 3.749 ± 0.318
2.683ProThr: 2.683 ± 0.228
3.734ProVal: 3.734 ± 0.282
0.784ProTrp: 0.784 ± 0.137
1.396ProTyr: 1.396 ± 0.134
0.0ProXaa: 0.0 ± 0.0
Gln
1.49GlnAla: 1.49 ± 0.167
0.816GlnCys: 0.816 ± 0.108
1.334GlnAsp: 1.334 ± 0.146
1.051GlnGlu: 1.051 ± 0.105
0.973GlnPhe: 0.973 ± 0.152
1.114GlnGly: 1.114 ± 0.142
0.643GlnHis: 0.643 ± 0.097
1.286GlnIle: 1.286 ± 0.148
1.349GlnLys: 1.349 ± 0.179
2.338GlnLeu: 2.338 ± 0.203
0.753GlnMet: 0.753 ± 0.109
1.145GlnAsn: 1.145 ± 0.142
1.349GlnPro: 1.349 ± 0.162
0.879GlnGln: 0.879 ± 0.138
2.416GlnArg: 2.416 ± 0.176
1.679GlnSer: 1.679 ± 0.168
1.992GlnThr: 1.992 ± 0.19
1.161GlnVal: 1.161 ± 0.131
0.361GlnTrp: 0.361 ± 0.11
0.926GlnTyr: 0.926 ± 0.115
0.0GlnXaa: 0.0 ± 0.0
Arg
4.738ArgAla: 4.738 ± 0.308
2.432ArgCys: 2.432 ± 0.25
4.926ArgAsp: 4.926 ± 0.245
3.671ArgGlu: 3.671 ± 0.245
3.467ArgPhe: 3.467 ± 0.219
5.13ArgGly: 5.13 ± 0.408
2.228ArgHis: 2.228 ± 0.192
3.514ArgIle: 3.514 ± 0.214
2.667ArgLys: 2.667 ± 0.202
7.279ArgLeu: 7.279 ± 0.418
1.585ArgMet: 1.585 ± 0.178
3.044ArgAsn: 3.044 ± 0.195
3.546ArgPro: 3.546 ± 0.337
2.134ArgGln: 2.134 ± 0.191
8.158ArgArg: 8.158 ± 0.686
6.244ArgSer: 6.244 ± 0.362
4.173ArgThr: 4.173 ± 0.275
5.601ArgVal: 5.601 ± 0.422
0.894ArgTrp: 0.894 ± 0.12
3.404ArgTyr: 3.404 ± 0.218
0.0ArgXaa: 0.0 ± 0.0
Ser
5.742SerAla: 5.742 ± 0.368
2.228SerCys: 2.228 ± 0.222
5.475SerAsp: 5.475 ± 0.343
4.722SerGlu: 4.722 ± 0.272
3.185SerPhe: 3.185 ± 0.227
5.491SerGly: 5.491 ± 0.363
1.647SerHis: 1.647 ± 0.185
3.498SerIle: 3.498 ± 0.222
2.636SerLys: 2.636 ± 0.244
6.73SerLeu: 6.73 ± 0.336
1.914SerMet: 1.914 ± 0.179
2.526SerAsn: 2.526 ± 0.2
3.483SerPro: 3.483 ± 0.279
2.134SerGln: 2.134 ± 0.173
5.412SerArg: 5.412 ± 0.344
6.087SerSer: 6.087 ± 0.441
4.706SerThr: 4.706 ± 0.272
7.154SerVal: 7.154 ± 0.457
0.784SerTrp: 0.784 ± 0.119
2.432SerTyr: 2.432 ± 0.2
0.0SerXaa: 0.0 ± 0.0
Thr
5.224ThrAla: 5.224 ± 0.32
1.804ThrCys: 1.804 ± 0.176
3.797ThrAsp: 3.797 ± 0.277
3.342ThrGlu: 3.342 ± 0.21
2.949ThrPhe: 2.949 ± 0.234
3.624ThrGly: 3.624 ± 0.198
1.506ThrHis: 1.506 ± 0.169
3.451ThrIle: 3.451 ± 0.288
2.29ThrLys: 2.29 ± 0.208
5.052ThrLeu: 5.052 ± 0.317
1.239ThrMet: 1.239 ± 0.164
2.338ThrAsn: 2.338 ± 0.205
3.012ThrPro: 3.012 ± 0.279
1.6ThrGln: 1.6 ± 0.199
4.408ThrArg: 4.408 ± 0.302
4.55ThrSer: 4.55 ± 0.343
3.906ThrThr: 3.906 ± 0.293
6.385ThrVal: 6.385 ± 0.321
0.659ThrTrp: 0.659 ± 0.095
2.353ThrTyr: 2.353 ± 0.234
0.0ThrXaa: 0.0 ± 0.0
Val
5.663ValAla: 5.663 ± 0.338
2.573ValCys: 2.573 ± 0.236
4.173ValAsp: 4.173 ± 0.28
3.279ValGlu: 3.279 ± 0.224
3.671ValPhe: 3.671 ± 0.249
4.597ValGly: 4.597 ± 0.347
1.459ValHis: 1.459 ± 0.147
4.142ValIle: 4.142 ± 0.228
2.934ValLys: 2.934 ± 0.234
6.464ValLeu: 6.464 ± 0.33
1.836ValMet: 1.836 ± 0.173
3.561ValAsn: 3.561 ± 0.243
3.561ValPro: 3.561 ± 0.22
1.977ValGln: 1.977 ± 0.18
5.601ValArg: 5.601 ± 0.303
6.934ValSer: 6.934 ± 0.395
5.711ValThr: 5.711 ± 0.319
4.926ValVal: 4.926 ± 0.373
0.91ValTrp: 0.91 ± 0.113
3.2ValTyr: 3.2 ± 0.212
0.0ValXaa: 0.0 ± 0.0
Trp
0.706TrpAla: 0.706 ± 0.112
0.612TrpCys: 0.612 ± 0.113
0.549TrpAsp: 0.549 ± 0.101
0.565TrpGlu: 0.565 ± 0.116
0.628TrpPhe: 0.628 ± 0.096
0.737TrpGly: 0.737 ± 0.148
0.251TrpHis: 0.251 ± 0.071
0.659TrpIle: 0.659 ± 0.085
0.565TrpLys: 0.565 ± 0.108
1.067TrpLeu: 1.067 ± 0.142
0.298TrpMet: 0.298 ± 0.076
0.345TrpAsn: 0.345 ± 0.065
0.675TrpPro: 0.675 ± 0.094
0.361TrpGln: 0.361 ± 0.071
0.565TrpArg: 0.565 ± 0.099
0.894TrpSer: 0.894 ± 0.152
0.628TrpThr: 0.628 ± 0.099
0.659TrpVal: 0.659 ± 0.127
0.267TrpTrp: 0.267 ± 0.079
0.596TrpTyr: 0.596 ± 0.103
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.479TyrAla: 2.479 ± 0.199
0.831TyrCys: 0.831 ± 0.144
2.008TyrAsp: 2.008 ± 0.159
2.149TyrGlu: 2.149 ± 0.205
1.349TyrPhe: 1.349 ± 0.152
2.824TyrGly: 2.824 ± 0.203
0.8TyrHis: 0.8 ± 0.112
2.196TyrIle: 2.196 ± 0.199
1.475TyrLys: 1.475 ± 0.139
3.044TyrLeu: 3.044 ± 0.2
0.816TyrMet: 0.816 ± 0.11
1.616TyrAsn: 1.616 ± 0.172
1.224TyrPro: 1.224 ± 0.158
0.659TyrGln: 0.659 ± 0.083
3.153TyrArg: 3.153 ± 0.271
2.589TyrSer: 2.589 ± 0.204
2.149TyrThr: 2.149 ± 0.197
3.828TyrVal: 3.828 ± 0.283
0.314TyrTrp: 0.314 ± 0.068
1.239TyrTyr: 1.239 ± 0.137
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 189 proteins (63743 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski