Amino acid dipepetide frequency for Thalassotalea euphylliae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.137AlaAla: 8.137 ± 0.103	0.893AlaCys: 0.893 ± 0.025	5.115AlaAsp: 5.115 ± 0.08	6.027AlaGlu: 6.027 ± 0.091	3.652AlaPhe: 3.652 ± 0.054	5.958AlaGly: 5.958 ± 0.085	1.762AlaHis: 1.762 ± 0.037	6.601AlaIle: 6.601 ± 0.086	5.884AlaLys: 5.884 ± 0.089	9.808AlaLeu: 9.808 ± 0.123	2.532AlaMet: 2.532 ± 0.056	4.651AlaAsn: 4.651 ± 0.055	3.007AlaPro: 3.007 ± 0.056	4.612AlaGln: 4.612 ± 0.072	3.43AlaArg: 3.43 ± 0.063	6.164AlaSer: 6.164 ± 0.081	4.731AlaThr: 4.731 ± 0.068	5.84AlaVal: 5.84 ± 0.065	0.897AlaTrp: 0.897 ± 0.027	2.488AlaTyr: 2.488 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.713CysAla: 0.713 ± 0.027	0.135CysCys: 0.135 ± 0.011	0.55CysAsp: 0.55 ± 0.023	0.503CysGlu: 0.503 ± 0.022	0.417CysPhe: 0.417 ± 0.019	0.718CysGly: 0.718 ± 0.028	0.333CysHis: 0.333 ± 0.019	0.541CysIle: 0.541 ± 0.023	0.353CysLys: 0.353 ± 0.017	0.932CysLeu: 0.932 ± 0.028	0.169CysMet: 0.169 ± 0.013	0.363CysAsn: 0.363 ± 0.017	0.417CysPro: 0.417 ± 0.018	0.689CysGln: 0.689 ± 0.026	0.399CysArg: 0.399 ± 0.02	0.631CysSer: 0.631 ± 0.026	0.427CysThr: 0.427 ± 0.021	0.515CysVal: 0.515 ± 0.019	0.122CysTrp: 0.122 ± 0.01	0.341CysTyr: 0.341 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.466AspAla: 4.466 ± 0.071	0.528AspCys: 0.528 ± 0.025	3.328AspAsp: 3.328 ± 0.069	3.922AspGlu: 3.922 ± 0.068	2.634AspPhe: 2.634 ± 0.052	3.831AspGly: 3.831 ± 0.121	1.08AspHis: 1.08 ± 0.034	4.465AspIle: 4.465 ± 0.058	3.458AspLys: 3.458 ± 0.064	4.963AspLeu: 4.963 ± 0.07	1.33AspMet: 1.33 ± 0.033	2.848AspAsn: 2.848 ± 0.055	1.785AspPro: 1.785 ± 0.047	2.081AspGln: 2.081 ± 0.036	1.999AspArg: 1.999 ± 0.037	3.396AspSer: 3.396 ± 0.06	2.808AspThr: 2.808 ± 0.066	3.83AspVal: 3.83 ± 0.053	0.805AspTrp: 0.805 ± 0.028	2.106AspTyr: 2.106 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	4.975GluAla: 4.975 ± 0.073	0.444GluCys: 0.444 ± 0.02	2.679GluAsp: 2.679 ± 0.051	3.397GluGlu: 3.397 ± 0.067	2.63GluPhe: 2.63 ± 0.05	3.052GluGly: 3.052 ± 0.059	1.803GluHis: 1.803 ± 0.039	3.733GluIle: 3.733 ± 0.07	3.626GluLys: 3.626 ± 0.059	7.296GluLeu: 7.296 ± 0.091	1.449GluMet: 1.449 ± 0.034	2.824GluAsn: 2.824 ± 0.053	1.928GluPro: 1.928 ± 0.046	5.449GluGln: 5.449 ± 0.079	3.157GluArg: 3.157 ± 0.055	3.577GluSer: 3.577 ± 0.056	2.957GluThr: 2.957 ± 0.048	4.217GluVal: 4.217 ± 0.06	0.552GluTrp: 0.552 ± 0.023	1.701GluTyr: 1.701 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.943PheAla: 3.943 ± 0.064	0.443PheCys: 0.443 ± 0.018	2.996PheAsp: 2.996 ± 0.053	2.698PheGlu: 2.698 ± 0.048	1.711PhePhe: 1.711 ± 0.042	3.137PheGly: 3.137 ± 0.054	0.819PheHis: 0.819 ± 0.027	2.85PheIle: 2.85 ± 0.059	2.036PheLys: 2.036 ± 0.045	3.205PheLeu: 3.205 ± 0.053	0.909PheMet: 0.909 ± 0.031	2.297PheAsn: 2.297 ± 0.047	1.319PhePro: 1.319 ± 0.036	1.293PheGln: 1.293 ± 0.032	1.462PheArg: 1.462 ± 0.033	3.351PheSer: 3.351 ± 0.06	2.632PheThr: 2.632 ± 0.047	2.911PheVal: 2.911 ± 0.049	0.532PheTrp: 0.532 ± 0.02	1.443PheTyr: 1.443 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	5.06GlyAla: 5.06 ± 0.075	0.775GlyCys: 0.775 ± 0.024	3.872GlyAsp: 3.872 ± 0.093	4.45GlyGlu: 4.45 ± 0.071	3.226GlyPhe: 3.226 ± 0.059	4.482GlyGly: 4.482 ± 0.106	1.46GlyHis: 1.46 ± 0.038	4.455GlyIle: 4.455 ± 0.063	3.881GlyLys: 3.881 ± 0.063	6.494GlyLeu: 6.494 ± 0.087	1.67GlyMet: 1.67 ± 0.042	2.757GlyAsn: 2.757 ± 0.079	1.382GlyPro: 1.382 ± 0.041	3.077GlyGln: 3.077 ± 0.053	2.782GlyArg: 2.782 ± 0.056	3.954GlySer: 3.954 ± 0.089	3.178GlyThr: 3.178 ± 0.08	4.774GlyVal: 4.774 ± 0.071	0.825GlyTrp: 0.825 ± 0.024	2.505GlyTyr: 2.505 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.616HisAla: 1.616 ± 0.037	0.316HisCys: 0.316 ± 0.016	1.079HisAsp: 1.079 ± 0.032	1.126HisGlu: 1.126 ± 0.033	1.084HisPhe: 1.084 ± 0.028	1.502HisGly: 1.502 ± 0.033	0.7HisHis: 0.7 ± 0.027	1.465HisIle: 1.465 ± 0.033	1.03HisLys: 1.03 ± 0.026	2.264HisLeu: 2.264 ± 0.046	0.475HisMet: 0.475 ± 0.02	0.986HisAsn: 0.986 ± 0.033	1.015HisPro: 1.015 ± 0.029	1.563HisGln: 1.563 ± 0.036	0.97HisArg: 0.97 ± 0.035	1.392HisSer: 1.392 ± 0.035	1.005HisThr: 1.005 ± 0.029	1.297HisVal: 1.297 ± 0.032	0.367HisTrp: 0.367 ± 0.019	0.862HisTyr: 0.862 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.056IleAla: 7.056 ± 0.089	0.632IleCys: 0.632 ± 0.021	4.518IleAsp: 4.518 ± 0.056	4.768IleGlu: 4.768 ± 0.061	2.234IlePhe: 2.234 ± 0.047	4.423IleGly: 4.423 ± 0.061	1.2IleHis: 1.2 ± 0.026	3.523IleIle: 3.523 ± 0.063	3.552IleLys: 3.552 ± 0.07	4.731IleLeu: 4.731 ± 0.065	1.174IleMet: 1.174 ± 0.036	3.522IleAsn: 3.522 ± 0.063	2.388IlePro: 2.388 ± 0.048	2.123IleGln: 2.123 ± 0.042	2.571IleArg: 2.571 ± 0.049	4.748IleSer: 4.748 ± 0.064	3.807IleThr: 3.807 ± 0.054	4.282IleVal: 4.282 ± 0.068	0.622IleTrp: 0.622 ± 0.025	1.767IleTyr: 1.767 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	5.506LysAla: 5.506 ± 0.084	0.345LysCys: 0.345 ± 0.022	2.524LysAsp: 2.524 ± 0.05	2.975LysGlu: 2.975 ± 0.061	1.742LysPhe: 1.742 ± 0.044	3.092LysGly: 3.092 ± 0.056	1.379LysHis: 1.379 ± 0.036	2.919LysIle: 2.919 ± 0.055	2.812LysLys: 2.812 ± 0.068	5.821LysLeu: 5.821 ± 0.083	1.242LysMet: 1.242 ± 0.03	2.19LysAsn: 2.19 ± 0.043	2.507LysPro: 2.507 ± 0.049	3.5LysGln: 3.5 ± 0.061	2.726LysArg: 2.726 ± 0.051	3.291LysSer: 3.291 ± 0.058	2.925LysThr: 2.925 ± 0.053	4.029LysVal: 4.029 ± 0.07	0.525LysTrp: 0.525 ± 0.022	1.42LysTyr: 1.42 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	11.783LeuAla: 11.783 ± 0.124	0.882LeuCys: 0.882 ± 0.023	5.449LeuAsp: 5.449 ± 0.063	5.342LeuGlu: 5.342 ± 0.07	4.095LeuPhe: 4.095 ± 0.065	6.55LeuGly: 6.55 ± 0.087	1.836LeuHis: 1.836 ± 0.041	6.161LeuIle: 6.161 ± 0.084	5.203LeuLys: 5.203 ± 0.077	10.23LeuLeu: 10.23 ± 0.138	2.427LeuMet: 2.427 ± 0.045	4.688LeuAsn: 4.688 ± 0.072	4.681LeuPro: 4.681 ± 0.068	3.439LeuGln: 3.439 ± 0.061	3.761LeuArg: 3.761 ± 0.058	8.072LeuSer: 8.072 ± 0.087	6.789LeuThr: 6.789 ± 0.077	7.293LeuVal: 7.293 ± 0.097	0.981LeuTrp: 0.981 ± 0.034	2.678LeuTyr: 2.678 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.535MetAla: 2.535 ± 0.045	0.19MetCys: 0.19 ± 0.014	0.994MetAsp: 0.994 ± 0.028	1.118MetGlu: 1.118 ± 0.035	0.844MetPhe: 0.844 ± 0.024	1.408MetGly: 1.408 ± 0.036	0.448MetHis: 0.448 ± 0.02	1.251MetIle: 1.251 ± 0.038	1.332MetLys: 1.332 ± 0.032	2.593MetLeu: 2.593 ± 0.056	0.662MetMet: 0.662 ± 0.024	1.011MetAsn: 1.011 ± 0.029	1.247MetPro: 1.247 ± 0.034	1.055MetGln: 1.055 ± 0.029	1.046MetArg: 1.046 ± 0.031	1.798MetSer: 1.798 ± 0.034	1.443MetThr: 1.443 ± 0.038	1.619MetVal: 1.619 ± 0.038	0.213MetTrp: 0.213 ± 0.012	0.507MetTyr: 0.507 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.943AsnAla: 3.943 ± 0.061	0.431AsnCys: 0.431 ± 0.022	2.568AsnAsp: 2.568 ± 0.074	2.735AsnGlu: 2.735 ± 0.052	1.821AsnPhe: 1.821 ± 0.046	3.128AsnGly: 3.128 ± 0.072	1.062AsnHis: 1.062 ± 0.032	3.081AsnIle: 3.081 ± 0.056	2.58AsnLys: 2.58 ± 0.054	4.251AsnLeu: 4.251 ± 0.062	1.056AsnMet: 1.056 ± 0.032	2.338AsnAsn: 2.338 ± 0.05	1.938AsnPro: 1.938 ± 0.044	2.671AsnGln: 2.671 ± 0.051	1.939AsnArg: 1.939 ± 0.044	3.032AsnSer: 3.032 ± 0.059	2.651AsnThr: 2.651 ± 0.053	2.925AsnVal: 2.925 ± 0.055	0.666AsnTrp: 0.666 ± 0.025	1.546AsnTyr: 1.546 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	3.306ProAla: 3.306 ± 0.059	0.288ProCys: 0.288 ± 0.014	2.204ProAsp: 2.204 ± 0.047	3.065ProGlu: 3.065 ± 0.062	1.67ProPhe: 1.67 ± 0.037	2.072ProGly: 2.072 ± 0.049	0.78ProHis: 0.78 ± 0.028	2.434ProIle: 2.434 ± 0.052	1.994ProLys: 1.994 ± 0.052	3.811ProLeu: 3.811 ± 0.058	0.921ProMet: 0.921 ± 0.029	1.813ProAsn: 1.813 ± 0.039	1.013ProPro: 1.013 ± 0.032	1.551ProGln: 1.551 ± 0.032	1.203ProArg: 1.203 ± 0.032	2.527ProSer: 2.527 ± 0.044	2.062ProThr: 2.062 ± 0.045	2.843ProVal: 2.843 ± 0.044	0.441ProTrp: 0.441 ± 0.02	1.189ProTyr: 1.189 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	5.486GlnAla: 5.486 ± 0.081	0.369GlnCys: 0.369 ± 0.018	2.277GlnAsp: 2.277 ± 0.049	2.738GlnGlu: 2.738 ± 0.054	1.931GlnPhe: 1.931 ± 0.042	3.339GlnGly: 3.339 ± 0.047	1.376GlnHis: 1.376 ± 0.035	2.737GlnIle: 2.737 ± 0.049	2.175GlnLys: 2.175 ± 0.044	6.308GlnLeu: 6.308 ± 0.087	1.111GlnMet: 1.111 ± 0.031	1.789GlnAsn: 1.789 ± 0.049	1.917GlnPro: 1.917 ± 0.043	4.135GlnGln: 4.135 ± 0.089	2.278GlnArg: 2.278 ± 0.041	3.154GlnSer: 3.154 ± 0.061	2.628GlnThr: 2.628 ± 0.05	3.831GlnVal: 3.831 ± 0.055	0.652GlnTrp: 0.652 ± 0.023	1.426GlnTyr: 1.426 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	3.355ArgAla: 3.355 ± 0.059	0.347ArgCys: 0.347 ± 0.017	2.265ArgAsp: 2.265 ± 0.051	2.636ArgGlu: 2.636 ± 0.047	2.122ArgPhe: 2.122 ± 0.046	2.37ArgGly: 2.37 ± 0.051	1.02ArgHis: 1.02 ± 0.031	2.826ArgIle: 2.826 ± 0.055	2.243ArgLys: 2.243 ± 0.044	4.508ArgLeu: 4.508 ± 0.065	1.033ArgMet: 1.033 ± 0.032	1.869ArgAsn: 1.869 ± 0.038	1.381ArgPro: 1.381 ± 0.04	2.144ArgGln: 2.144 ± 0.045	1.931ArgArg: 1.931 ± 0.041	2.341ArgSer: 2.341 ± 0.05	1.962ArgThr: 1.962 ± 0.041	2.867ArgVal: 2.867 ± 0.049	0.567ArgTrp: 0.567 ± 0.021	1.64ArgTyr: 1.64 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.06SerAla: 6.06 ± 0.078	0.636SerCys: 0.636 ± 0.021	3.773SerAsp: 3.773 ± 0.058	4.118SerGlu: 4.118 ± 0.058	3.098SerPhe: 3.098 ± 0.059	4.819SerGly: 4.819 ± 0.092	1.503SerHis: 1.503 ± 0.036	4.045SerIle: 4.045 ± 0.062	3.329SerLys: 3.329 ± 0.064	7.221SerLeu: 7.221 ± 0.094	1.554SerMet: 1.554 ± 0.034	2.863SerAsn: 2.863 ± 0.059	2.529SerPro: 2.529 ± 0.047	3.464SerGln: 3.464 ± 0.06	2.645SerArg: 2.645 ± 0.049	4.613SerSer: 4.613 ± 0.081	3.457SerThr: 3.457 ± 0.071	4.574SerVal: 4.574 ± 0.077	0.774SerTrp: 0.774 ± 0.027	2.189SerTyr: 2.189 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	4.737ThrAla: 4.737 ± 0.063	0.464ThrCys: 0.464 ± 0.02	3.098ThrAsp: 3.098 ± 0.05	3.393ThrGlu: 3.393 ± 0.049	2.151ThrPhe: 2.151 ± 0.052	4.022ThrGly: 4.022 ± 0.063	1.116ThrHis: 1.116 ± 0.037	3.629ThrIle: 3.629 ± 0.068	2.628ThrLys: 2.628 ± 0.051	6.072ThrLeu: 6.072 ± 0.079	1.076ThrMet: 1.076 ± 0.034	2.461ThrAsn: 2.461 ± 0.05	2.564ThrPro: 2.564 ± 0.051	2.504ThrGln: 2.504 ± 0.045	2.145ThrArg: 2.145 ± 0.041	3.723ThrSer: 3.723 ± 0.065	3.033ThrThr: 3.033 ± 0.057	3.731ThrVal: 3.731 ± 0.083	0.609ThrTrp: 0.609 ± 0.026	1.481ThrTyr: 1.481 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	6.491ValAla: 6.491 ± 0.088	0.659ValCys: 0.659 ± 0.025	4.252ValAsp: 4.252 ± 0.067	4.523ValGlu: 4.523 ± 0.064	2.834ValPhe: 2.834 ± 0.053	4.346ValGly: 4.346 ± 0.066	1.238ValHis: 1.238 ± 0.035	4.787ValIle: 4.787 ± 0.071	3.8ValLys: 3.8 ± 0.073	6.609ValLeu: 6.609 ± 0.097	1.697ValMet: 1.697 ± 0.042	3.583ValAsn: 3.583 ± 0.069	2.465ValPro: 2.465 ± 0.044	2.278ValGln: 2.278 ± 0.044	2.567ValArg: 2.567 ± 0.048	4.924ValSer: 4.924 ± 0.073	4.24ValThr: 4.24 ± 0.08	5.164ValVal: 5.164 ± 0.084	0.665ValTrp: 0.665 ± 0.023	1.88ValTyr: 1.88 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.714TrpAla: 0.714 ± 0.028	0.125TrpCys: 0.125 ± 0.01	0.506TrpAsp: 0.506 ± 0.022	0.409TrpGlu: 0.409 ± 0.021	0.544TrpPhe: 0.544 ± 0.021	0.717TrpGly: 0.717 ± 0.028	0.382TrpHis: 0.382 ± 0.017	0.501TrpIle: 0.501 ± 0.022	0.308TrpLys: 0.308 ± 0.014	1.795TrpLeu: 1.795 ± 0.051	0.246TrpMet: 0.246 ± 0.016	0.351TrpAsn: 0.351 ± 0.017	0.445TrpPro: 0.445 ± 0.02	1.405TrpGln: 1.405 ± 0.036	0.682TrpArg: 0.682 ± 0.024	0.636TrpSer: 0.636 ± 0.023	0.447TrpThr: 0.447 ± 0.022	0.692TrpVal: 0.692 ± 0.027	0.164TrpTrp: 0.164 ± 0.012	0.354TrpTyr: 0.354 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.307TyrAla: 2.307 ± 0.046	0.366TyrCys: 0.366 ± 0.017	1.618TyrAsp: 1.618 ± 0.032	1.503TyrGlu: 1.503 ± 0.036	1.546TyrPhe: 1.546 ± 0.036	2.094TyrGly: 2.094 ± 0.046	0.814TyrHis: 0.814 ± 0.03	1.637TyrIle: 1.637 ± 0.039	1.247TyrLys: 1.247 ± 0.032	3.43TyrLeu: 3.43 ± 0.054	0.582TyrMet: 0.582 ± 0.021	1.156TyrAsn: 1.156 ± 0.031	1.259TyrPro: 1.259 ± 0.031	2.624TyrGln: 2.624 ± 0.053	1.731TyrArg: 1.731 ± 0.036	1.943TyrSer: 1.943 ± 0.043	1.456TyrThr: 1.456 ± 0.033	1.768TyrVal: 1.768 ± 0.034	0.443TyrTrp: 0.443 ± 0.02	1.032TyrTyr: 1.032 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3642 proteins (1233835 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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