Amino acid dipepetide frequency for Apis mellifera associated microvirus 53

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.348AlaAla: 4.348 ± 1.676
0.0AlaCys: 0.0 ± 0.0
5.072AlaAsp: 5.072 ± 2.133
1.449AlaGlu: 1.449 ± 0.568
3.623AlaPhe: 3.623 ± 1.805
5.797AlaGly: 5.797 ± 2.167
0.725AlaHis: 0.725 ± 0.632
5.072AlaIle: 5.072 ± 3.288
2.899AlaLys: 2.899 ± 1.152
7.246AlaLeu: 7.246 ± 2.623
2.899AlaMet: 2.899 ± 1.937
2.899AlaAsn: 2.899 ± 1.152
5.797AlaPro: 5.797 ± 1.67
2.174AlaGln: 2.174 ± 1.08
8.696AlaArg: 8.696 ± 3.362
5.072AlaSer: 5.072 ± 1.775
3.623AlaThr: 3.623 ± 1.55
3.623AlaVal: 3.623 ± 1.794
0.725AlaTrp: 0.725 ± 0.511
2.174AlaTyr: 2.174 ± 0.875
0.0AlaXaa: 0.0 ± 0.0
Cys
0.725CysAla: 0.725 ± 0.511
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
0.725CysPhe: 0.725 ± 0.668
1.449CysGly: 1.449 ± 0.666
0.0CysHis: 0.0 ± 0.0
0.725CysIle: 0.725 ± 0.668
0.0CysLys: 0.0 ± 0.0
1.449CysLeu: 1.449 ± 0.923
0.725CysMet: 0.725 ± 0.753
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.725CysArg: 0.725 ± 0.668
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.725CysTrp: 0.725 ± 0.668
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.899AspAla: 2.899 ± 1.135
0.0AspCys: 0.0 ± 0.0
5.072AspAsp: 5.072 ± 0.724
4.348AspGlu: 4.348 ± 1.701
6.522AspPhe: 6.522 ± 3.32
5.072AspGly: 5.072 ± 2.744
0.725AspHis: 0.725 ± 0.511
2.899AspIle: 2.899 ± 1.135
1.449AspLys: 1.449 ± 1.058
5.797AspLeu: 5.797 ± 1.997
0.0AspMet: 0.0 ± 0.0
2.174AspAsn: 2.174 ± 0.875
5.797AspPro: 5.797 ± 3.719
5.072AspGln: 5.072 ± 2.116
2.899AspArg: 2.899 ± 0.651
2.174AspSer: 2.174 ± 1.087
4.348AspThr: 4.348 ± 1.894
2.899AspVal: 2.899 ± 1.142
0.725AspTrp: 0.725 ± 0.511
1.449AspTyr: 1.449 ± 0.568
0.0AspXaa: 0.0 ± 0.0
Glu
6.522GluAla: 6.522 ± 1.743
0.0GluCys: 0.0 ± 0.0
1.449GluAsp: 1.449 ± 1.021
2.899GluGlu: 2.899 ± 1.047
2.899GluPhe: 2.899 ± 1.142
0.725GluGly: 0.725 ± 0.963
2.174GluHis: 2.174 ± 0.64
1.449GluIle: 1.449 ± 0.568
1.449GluLys: 1.449 ± 0.666
3.623GluLeu: 3.623 ± 1.916
0.725GluMet: 0.725 ± 0.668
0.725GluAsn: 0.725 ± 0.668
1.449GluPro: 1.449 ± 1.927
1.449GluGln: 1.449 ± 1.927
5.072GluArg: 5.072 ± 1.662
2.899GluSer: 2.899 ± 0.651
4.348GluThr: 4.348 ± 2.107
5.072GluVal: 5.072 ± 2.23
0.0GluTrp: 0.0 ± 0.0
3.623GluTyr: 3.623 ± 1.888
0.0GluXaa: 0.0 ± 0.0
Phe
5.797PheAla: 5.797 ± 3.113
0.0PheCys: 0.0 ± 0.0
1.449PheAsp: 1.449 ± 1.035
5.797PheGlu: 5.797 ± 4.493
2.174PhePhe: 2.174 ± 1.232
5.797PheGly: 5.797 ± 1.574
0.0PheHis: 0.0 ± 0.0
5.797PheIle: 5.797 ± 2.178
2.899PheLys: 2.899 ± 2.043
0.725PheLeu: 0.725 ± 0.668
0.0PheMet: 0.0 ± 0.476
2.899PheAsn: 2.899 ± 1.149
1.449PhePro: 1.449 ± 0.901
0.725PheGln: 0.725 ± 0.511
3.623PheArg: 3.623 ± 1.15
3.623PheSer: 3.623 ± 1.303
0.725PheThr: 0.725 ± 0.511
0.725PheVal: 0.725 ± 0.963
0.725PheTrp: 0.725 ± 0.511
0.725PheTyr: 0.725 ± 0.511
0.0PheXaa: 0.0 ± 0.0
Gly
6.522GlyAla: 6.522 ± 2.401
0.725GlyCys: 0.725 ± 0.668
7.246GlyAsp: 7.246 ± 1.817
4.348GlyGlu: 4.348 ± 1.849
4.348GlyPhe: 4.348 ± 1.676
12.319GlyGly: 12.319 ± 4.38
0.725GlyHis: 0.725 ± 0.511
3.623GlyIle: 3.623 ± 1.137
2.899GlyLys: 2.899 ± 1.084
8.696GlyLeu: 8.696 ± 2.186
0.725GlyMet: 0.725 ± 0.511
4.348GlyAsn: 4.348 ± 1.498
5.072GlyPro: 5.072 ± 1.499
4.348GlyGln: 4.348 ± 0.798
4.348GlyArg: 4.348 ± 3.286
6.522GlySer: 6.522 ± 2.276
1.449GlyThr: 1.449 ± 0.866
7.246GlyVal: 7.246 ± 3.04
0.0GlyTrp: 0.0 ± 0.0
2.899GlyTyr: 2.899 ± 1.084
0.0GlyXaa: 0.0 ± 0.0
His
2.174HisAla: 2.174 ± 1.344
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
1.449HisGlu: 1.449 ± 1.058
3.623HisPhe: 3.623 ± 1.367
3.623HisGly: 3.623 ± 1.009
0.725HisHis: 0.725 ± 0.511
0.725HisIle: 0.725 ± 0.511
1.449HisLys: 1.449 ± 0.866
1.449HisLeu: 1.449 ± 0.568
0.725HisMet: 0.725 ± 0.632
0.0HisAsn: 0.0 ± 0.0
1.449HisPro: 1.449 ± 0.568
0.0HisGln: 0.0 ± 0.0
0.725HisArg: 0.725 ± 0.668
2.899HisSer: 2.899 ± 1.556
0.0HisThr: 0.0 ± 0.0
3.623HisVal: 3.623 ± 1.121
0.0HisTrp: 0.0 ± 0.0
0.725HisTyr: 0.725 ± 0.668
0.0HisXaa: 0.0 ± 0.0
Ile
1.449IleAla: 1.449 ± 0.923
0.725IleCys: 0.725 ± 0.668
2.174IleAsp: 2.174 ± 1.896
1.449IleGlu: 1.449 ± 0.666
0.725IlePhe: 0.725 ± 0.511
3.623IleGly: 3.623 ± 0.684
2.899IleHis: 2.899 ± 1.084
1.449IleIle: 1.449 ± 0.666
5.797IleLys: 5.797 ± 2.664
1.449IleLeu: 1.449 ± 0.666
0.0IleMet: 0.0 ± 0.0
0.725IleAsn: 0.725 ± 0.511
4.348IlePro: 4.348 ± 0.667
5.072IleGln: 5.072 ± 1.349
3.623IleArg: 3.623 ± 1.121
5.797IleSer: 5.797 ± 1.226
2.899IleThr: 2.899 ± 1.084
0.725IleVal: 0.725 ± 0.668
0.725IleTrp: 0.725 ± 0.511
2.899IleTyr: 2.899 ± 1.556
0.0IleXaa: 0.0 ± 0.0
Lys
1.449LysAla: 1.449 ± 1.021
0.0LysCys: 0.0 ± 0.0
1.449LysAsp: 1.449 ± 0.666
4.348LysGlu: 4.348 ± 0.913
2.174LysPhe: 2.174 ± 1.196
3.623LysGly: 3.623 ± 0.684
2.174LysHis: 2.174 ± 1.08
0.0LysIle: 0.0 ± 0.0
2.174LysLys: 2.174 ± 2.003
2.174LysLeu: 2.174 ± 2.003
2.174LysMet: 2.174 ± 1.307
2.174LysAsn: 2.174 ± 1.38
4.348LysPro: 4.348 ± 1.727
2.174LysGln: 2.174 ± 1.715
6.522LysArg: 6.522 ± 1.878
5.072LysSer: 5.072 ± 2.549
4.348LysThr: 4.348 ± 1.483
0.725LysVal: 0.725 ± 0.668
1.449LysTrp: 1.449 ± 0.666
0.0LysTyr: 0.0 ± 0.0
0.0LysXaa: 0.0 ± 0.0
Leu
2.899LeuAla: 2.899 ± 1.332
0.0LeuCys: 0.0 ± 0.0
5.797LeuAsp: 5.797 ± 1.37
2.174LeuGlu: 2.174 ± 1.08
2.899LeuPhe: 2.899 ± 1.142
8.696LeuGly: 8.696 ± 1.715
0.725LeuHis: 0.725 ± 0.632
3.623LeuIle: 3.623 ± 1.303
2.899LeuLys: 2.899 ± 1.332
5.072LeuLeu: 5.072 ± 1.267
1.449LeuMet: 1.449 ± 1.2
1.449LeuAsn: 1.449 ± 0.568
8.696LeuPro: 8.696 ± 2.363
5.072LeuGln: 5.072 ± 2.065
5.797LeuArg: 5.797 ± 1.222
5.797LeuSer: 5.797 ± 2.033
5.797LeuThr: 5.797 ± 1.366
1.449LeuVal: 1.449 ± 0.568
0.0LeuTrp: 0.0 ± 0.0
0.725LeuTyr: 0.725 ± 0.511
0.0LeuXaa: 0.0 ± 0.0
Met
2.899MetAla: 2.899 ± 1.98
0.0MetCys: 0.0 ± 0.0
0.725MetAsp: 0.725 ± 0.963
0.725MetGlu: 0.725 ± 0.632
0.725MetPhe: 0.725 ± 0.511
4.348MetGly: 4.348 ± 2.258
1.449MetHis: 1.449 ± 0.666
0.725MetIle: 0.725 ± 0.668
2.174MetLys: 2.174 ± 0.85
0.0MetLeu: 0.0 ± 0.0
0.725MetMet: 0.725 ± 0.511
0.725MetAsn: 0.725 ± 0.632
0.0MetPro: 0.0 ± 0.0
1.449MetGln: 1.449 ± 1.264
0.0MetArg: 0.0 ± 0.0
2.899MetSer: 2.899 ± 1.178
1.449MetThr: 1.449 ± 0.866
2.174MetVal: 2.174 ± 1.532
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.623AsnAla: 3.623 ± 1.138
0.0AsnCys: 0.0 ± 0.0
2.899AsnAsp: 2.899 ± 1.152
1.449AsnGlu: 1.449 ± 0.901
2.174AsnPhe: 2.174 ± 1.684
0.725AsnGly: 0.725 ± 0.668
0.725AsnHis: 0.725 ± 0.511
0.725AsnIle: 0.725 ± 0.963
1.449AsnLys: 1.449 ± 0.959
5.072AsnLeu: 5.072 ± 1.267
2.174AsnMet: 2.174 ± 1.087
2.174AsnAsn: 2.174 ± 1.087
1.449AsnPro: 1.449 ± 1.058
0.725AsnGln: 0.725 ± 0.963
4.348AsnArg: 4.348 ± 1.776
2.174AsnSer: 2.174 ± 0.875
2.899AsnThr: 2.899 ± 1.316
2.899AsnVal: 2.899 ± 1.683
0.725AsnTrp: 0.725 ± 0.632
2.174AsnTyr: 2.174 ± 0.848
0.0AsnXaa: 0.0 ± 0.0
Pro
5.797ProAla: 5.797 ± 2.509
1.449ProCys: 1.449 ± 0.666
6.522ProAsp: 6.522 ± 3.589
3.623ProGlu: 3.623 ± 1.865
2.174ProPhe: 2.174 ± 0.981
5.797ProGly: 5.797 ± 1.37
0.725ProHis: 0.725 ± 0.668
0.0ProIle: 0.0 ± 0.0
4.348ProLys: 4.348 ± 1.06
3.623ProLeu: 3.623 ± 1.01
2.899ProMet: 2.899 ± 1.135
5.072ProAsn: 5.072 ± 2.308
5.072ProPro: 5.072 ± 1.509
1.449ProGln: 1.449 ± 1.035
4.348ProArg: 4.348 ± 1.573
4.348ProSer: 4.348 ± 2.76
2.899ProThr: 2.899 ± 1.641
3.623ProVal: 3.623 ± 2.002
0.725ProTrp: 0.725 ± 0.511
1.449ProTyr: 1.449 ± 1.058
0.0ProXaa: 0.0 ± 0.0
Gln
5.072GlnAla: 5.072 ± 2.022
0.725GlnCys: 0.725 ± 0.668
5.797GlnAsp: 5.797 ± 2.721
2.899GlnGlu: 2.899 ± 1.103
0.725GlnPhe: 0.725 ± 0.511
1.449GlnGly: 1.449 ± 1.058
2.174GlnHis: 2.174 ± 1.196
1.449GlnIle: 1.449 ± 1.035
4.348GlnLys: 4.348 ± 1.28
0.725GlnLeu: 0.725 ± 0.511
0.725GlnMet: 0.725 ± 0.963
2.174GlnAsn: 2.174 ± 1.442
0.725GlnPro: 0.725 ± 0.963
3.623GlnGln: 3.623 ± 1.616
3.623GlnArg: 3.623 ± 1.009
2.174GlnSer: 2.174 ± 1.442
3.623GlnThr: 3.623 ± 1.286
2.174GlnVal: 2.174 ± 1.418
0.0GlnTrp: 0.0 ± 0.0
1.449GlnTyr: 1.449 ± 0.866
0.0GlnXaa: 0.0 ± 0.0
Arg
5.797ArgAla: 5.797 ± 3.499
1.449ArgCys: 1.449 ± 0.901
5.072ArgAsp: 5.072 ± 2.343
3.623ArgGlu: 3.623 ± 1.017
3.623ArgPhe: 3.623 ± 1.917
1.449ArgGly: 1.449 ± 0.959
2.899ArgHis: 2.899 ± 1.536
6.522ArgIle: 6.522 ± 1.928
4.348ArgLys: 4.348 ± 4.272
5.072ArgLeu: 5.072 ± 1.775
2.899ArgMet: 2.899 ± 0.769
2.174ArgAsn: 2.174 ± 1.313
4.348ArgPro: 4.348 ± 1.963
2.174ArgGln: 2.174 ± 1.38
9.42ArgArg: 9.42 ± 3.459
7.246ArgSer: 7.246 ± 1.316
2.899ArgThr: 2.899 ± 1.683
0.725ArgVal: 0.725 ± 0.888
0.725ArgTrp: 0.725 ± 0.632
9.42ArgTyr: 9.42 ± 1.844
0.0ArgXaa: 0.0 ± 0.0
Ser
7.246SerAla: 7.246 ± 2.213
1.449SerCys: 1.449 ± 1.335
3.623SerAsp: 3.623 ± 1.838
2.174SerGlu: 2.174 ± 0.64
2.174SerPhe: 2.174 ± 1.165
5.797SerGly: 5.797 ± 1.19
1.449SerHis: 1.449 ± 0.568
5.797SerIle: 5.797 ± 1.276
2.899SerLys: 2.899 ± 1.395
5.797SerLeu: 5.797 ± 2.01
0.725SerMet: 0.725 ± 0.632
3.623SerAsn: 3.623 ± 1.286
2.899SerPro: 2.899 ± 2.034
5.072SerGln: 5.072 ± 2.936
6.522SerArg: 6.522 ± 3.321
5.797SerSer: 5.797 ± 1.824
2.174SerThr: 2.174 ± 0.981
3.623SerVal: 3.623 ± 1.009
1.449SerTrp: 1.449 ± 1.264
2.899SerTyr: 2.899 ± 2.0
0.0SerXaa: 0.0 ± 0.0
Thr
2.899ThrAla: 2.899 ± 1.178
0.725ThrCys: 0.725 ± 0.888
0.725ThrAsp: 0.725 ± 0.632
2.174ThrGlu: 2.174 ± 0.981
2.174ThrPhe: 2.174 ± 1.853
7.246ThrGly: 7.246 ± 1.437
1.449ThrHis: 1.449 ± 1.058
2.899ThrIle: 2.899 ± 0.962
2.899ThrLys: 2.899 ± 2.03
4.348ThrLeu: 4.348 ± 1.583
1.449ThrMet: 1.449 ± 0.967
1.449ThrAsn: 1.449 ± 1.021
5.797ThrPro: 5.797 ± 1.46
2.174ThrGln: 2.174 ± 0.85
1.449ThrArg: 1.449 ± 1.776
3.623ThrSer: 3.623 ± 1.286
3.623ThrThr: 3.623 ± 1.616
2.899ThrVal: 2.899 ± 1.084
0.0ThrTrp: 0.0 ± 0.0
4.348ThrTyr: 4.348 ± 1.493
0.0ThrXaa: 0.0 ± 0.0
Val
3.623ValAla: 3.623 ± 1.137
0.0ValCys: 0.0 ± 0.0
2.899ValAsp: 2.899 ± 0.746
1.449ValGlu: 1.449 ± 1.058
0.725ValPhe: 0.725 ± 0.511
7.246ValGly: 7.246 ± 1.427
1.449ValHis: 1.449 ± 1.021
1.449ValIle: 1.449 ± 1.021
1.449ValLys: 1.449 ± 0.959
5.797ValLeu: 5.797 ± 2.007
0.725ValMet: 0.725 ± 0.632
1.449ValAsn: 1.449 ± 0.568
5.797ValPro: 5.797 ± 2.096
0.0ValGln: 0.0 ± 0.0
3.623ValArg: 3.623 ± 1.633
1.449ValSer: 1.449 ± 0.901
4.348ValThr: 4.348 ± 1.28
0.725ValVal: 0.725 ± 0.632
0.0ValTrp: 0.0 ± 0.0
2.174ValTyr: 2.174 ± 0.782
0.0ValXaa: 0.0 ± 0.0
Trp
0.725TrpAla: 0.725 ± 0.668
0.0TrpCys: 0.0 ± 0.0
1.449TrpAsp: 1.449 ± 1.021
0.725TrpGlu: 0.725 ± 0.511
0.0TrpPhe: 0.0 ± 0.0
0.725TrpGly: 0.725 ± 0.632
0.725TrpHis: 0.725 ± 0.511
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
0.0TrpLeu: 0.0 ± 0.0
0.0TrpMet: 0.0 ± 0.0
0.725TrpAsn: 0.725 ± 0.632
0.0TrpPro: 0.0 ± 0.0
1.449TrpGln: 1.449 ± 0.666
0.725TrpArg: 0.725 ± 0.632
0.725TrpSer: 0.725 ± 0.632
0.725TrpThr: 0.725 ± 0.511
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.449TyrAla: 1.449 ± 1.021
0.0TyrCys: 0.0 ± 0.0
2.899TyrAsp: 2.899 ± 1.194
1.449TyrGlu: 1.449 ± 0.568
2.174TyrPhe: 2.174 ± 0.92
2.899TyrGly: 2.899 ± 0.946
1.449TyrHis: 1.449 ± 0.923
3.623TyrIle: 3.623 ± 1.42
0.725TyrLys: 0.725 ± 0.632
2.899TyrLeu: 2.899 ± 1.415
0.725TyrMet: 0.725 ± 0.511
3.623TyrAsn: 3.623 ± 1.55
1.449TyrPro: 1.449 ± 0.923
1.449TyrGln: 1.449 ± 0.666
5.797TyrArg: 5.797 ± 1.679
2.899TyrSer: 2.899 ± 1.103
2.174TyrThr: 2.174 ± 0.848
1.449TyrVal: 1.449 ± 0.666
0.0TyrTrp: 0.0 ± 0.0
1.449TyrTyr: 1.449 ± 0.901
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1381 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski