Amino acid dipepetide frequency for Gordonia phage YorkOnyx

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.094AlaAla: 17.094 ± 1.351
0.708AlaCys: 0.708 ± 0.248
9.2AlaAsp: 9.2 ± 0.996
9.255AlaGlu: 9.255 ± 0.881
3.049AlaPhe: 3.049 ± 0.497
12.521AlaGly: 12.521 ± 1.082
1.96AlaHis: 1.96 ± 0.332
6.805AlaIle: 6.805 ± 0.954
3.811AlaLys: 3.811 ± 0.437
9.636AlaLeu: 9.636 ± 1.127
2.395AlaMet: 2.395 ± 0.346
2.994AlaAsn: 2.994 ± 0.484
6.424AlaPro: 6.424 ± 0.572
5.117AlaGln: 5.117 ± 0.505
8.656AlaArg: 8.656 ± 0.665
5.934AlaSer: 5.934 ± 0.717
6.587AlaThr: 6.587 ± 0.491
8.003AlaVal: 8.003 ± 0.636
2.286AlaTrp: 2.286 ± 0.313
2.286AlaTyr: 2.286 ± 0.41
0.0AlaXaa: 0.0 ± 0.0
Cys
1.361CysAla: 1.361 ± 0.286
0.0CysCys: 0.0 ± 0.0
0.599CysAsp: 0.599 ± 0.183
0.436CysGlu: 0.436 ± 0.134
0.109CysPhe: 0.109 ± 0.086
1.198CysGly: 1.198 ± 0.391
0.109CysHis: 0.109 ± 0.072
0.109CysIle: 0.109 ± 0.127
0.163CysLys: 0.163 ± 0.098
0.218CysLeu: 0.218 ± 0.093
0.054CysMet: 0.054 ± 0.051
0.109CysAsn: 0.109 ± 0.077
0.544CysPro: 0.544 ± 0.162
0.327CysGln: 0.327 ± 0.159
0.544CysArg: 0.544 ± 0.211
0.544CysSer: 0.544 ± 0.19
0.49CysThr: 0.49 ± 0.206
0.49CysVal: 0.49 ± 0.181
0.109CysTrp: 0.109 ± 0.074
0.109CysTyr: 0.109 ± 0.077
0.0CysXaa: 0.0 ± 0.0
Asp
8.765AspAla: 8.765 ± 0.932
0.272AspCys: 0.272 ± 0.125
8.547AspAsp: 8.547 ± 1.088
5.879AspGlu: 5.879 ± 0.934
0.817AspPhe: 0.817 ± 0.268
7.622AspGly: 7.622 ± 0.732
1.851AspHis: 1.851 ± 0.34
1.851AspIle: 1.851 ± 0.254
1.089AspLys: 1.089 ± 0.288
5.172AspLeu: 5.172 ± 0.53
1.851AspMet: 1.851 ± 0.266
2.123AspAsn: 2.123 ± 0.37
7.349AspPro: 7.349 ± 0.8
2.559AspGln: 2.559 ± 0.484
5.117AspArg: 5.117 ± 0.566
2.613AspSer: 2.613 ± 0.34
3.321AspThr: 3.321 ± 0.445
6.261AspVal: 6.261 ± 0.583
1.579AspTrp: 1.579 ± 0.261
1.797AspTyr: 1.797 ± 0.368
0.0AspXaa: 0.0 ± 0.0
Glu
6.424GluAla: 6.424 ± 0.603
0.436GluCys: 0.436 ± 0.168
2.831GluAsp: 2.831 ± 0.433
1.307GluGlu: 1.307 ± 0.322
2.014GluPhe: 2.014 ± 0.315
3.702GluGly: 3.702 ± 0.49
1.688GluHis: 1.688 ± 0.337
2.395GluIle: 2.395 ± 0.286
1.361GluLys: 1.361 ± 0.286
5.117GluLeu: 5.117 ± 0.728
1.034GluMet: 1.034 ± 0.276
1.47GluAsn: 1.47 ± 0.235
3.43GluPro: 3.43 ± 0.481
3.049GluGln: 3.049 ± 0.472
4.355GluArg: 4.355 ± 0.582
2.178GluSer: 2.178 ± 0.475
3.212GluThr: 3.212 ± 0.535
5.008GluVal: 5.008 ± 0.51
1.688GluTrp: 1.688 ± 0.406
2.014GluTyr: 2.014 ± 0.302
0.0GluXaa: 0.0 ± 0.0
Phe
3.375PheAla: 3.375 ± 0.421
0.436PheCys: 0.436 ± 0.178
2.395PheAsp: 2.395 ± 0.365
1.579PheGlu: 1.579 ± 0.288
0.436PhePhe: 0.436 ± 0.198
2.831PheGly: 2.831 ± 0.452
0.653PheHis: 0.653 ± 0.203
1.415PheIle: 1.415 ± 0.261
0.599PheLys: 0.599 ± 0.181
1.633PheLeu: 1.633 ± 0.318
0.49PheMet: 0.49 ± 0.152
0.327PheAsn: 0.327 ± 0.151
0.98PhePro: 0.98 ± 0.214
0.381PheGln: 0.381 ± 0.133
1.198PheArg: 1.198 ± 0.247
1.034PheSer: 1.034 ± 0.263
1.579PheThr: 1.579 ± 0.277
1.851PheVal: 1.851 ± 0.308
0.327PheTrp: 0.327 ± 0.117
0.218PheTyr: 0.218 ± 0.108
0.0PheXaa: 0.0 ± 0.0
Gly
9.745GlyAla: 9.745 ± 1.333
0.762GlyCys: 0.762 ± 0.279
5.879GlyAsp: 5.879 ± 0.616
4.301GlyGlu: 4.301 ± 0.577
2.069GlyPhe: 2.069 ± 0.401
8.003GlyGly: 8.003 ± 1.061
2.559GlyHis: 2.559 ± 0.426
3.539GlyIle: 3.539 ± 0.465
2.613GlyLys: 2.613 ± 0.413
6.043GlyLeu: 6.043 ± 0.807
2.286GlyMet: 2.286 ± 0.294
1.851GlyAsn: 1.851 ± 0.369
4.029GlyPro: 4.029 ± 0.607
2.994GlyGln: 2.994 ± 0.461
8.057GlyArg: 8.057 ± 0.67
5.117GlySer: 5.117 ± 0.557
6.369GlyThr: 6.369 ± 0.764
7.349GlyVal: 7.349 ± 0.603
1.47GlyTrp: 1.47 ± 0.298
2.341GlyTyr: 2.341 ± 0.407
0.0GlyXaa: 0.0 ± 0.0
His
2.286HisAla: 2.286 ± 0.335
0.0HisCys: 0.0 ± 0.0
2.123HisAsp: 2.123 ± 0.383
1.633HisGlu: 1.633 ± 0.307
0.272HisPhe: 0.272 ± 0.116
1.198HisGly: 1.198 ± 0.239
0.327HisHis: 0.327 ± 0.154
0.817HisIle: 0.817 ± 0.2
0.381HisLys: 0.381 ± 0.123
1.797HisLeu: 1.797 ± 0.333
0.599HisMet: 0.599 ± 0.197
0.327HisAsn: 0.327 ± 0.127
1.089HisPro: 1.089 ± 0.232
0.871HisGln: 0.871 ± 0.199
2.014HisArg: 2.014 ± 0.352
0.762HisSer: 0.762 ± 0.221
1.797HisThr: 1.797 ± 0.389
1.797HisVal: 1.797 ± 0.336
0.327HisTrp: 0.327 ± 0.128
0.49HisTyr: 0.49 ± 0.167
0.0HisXaa: 0.0 ± 0.0
Ile
5.825IleAla: 5.825 ± 0.614
0.163IleCys: 0.163 ± 0.101
3.811IleAsp: 3.811 ± 0.369
3.865IleGlu: 3.865 ± 0.497
0.436IlePhe: 0.436 ± 0.241
4.192IleGly: 4.192 ± 0.928
0.708IleHis: 0.708 ± 0.191
2.178IleIle: 2.178 ± 0.356
0.98IleLys: 0.98 ± 0.428
2.232IleLeu: 2.232 ± 0.285
0.544IleMet: 0.544 ± 0.186
0.925IleAsn: 0.925 ± 0.237
2.94IlePro: 2.94 ± 0.413
0.925IleGln: 0.925 ± 0.258
2.885IleArg: 2.885 ± 0.379
1.851IleSer: 1.851 ± 0.345
3.756IleThr: 3.756 ± 0.465
4.029IleVal: 4.029 ± 0.422
0.762IleTrp: 0.762 ± 0.181
0.762IleTyr: 0.762 ± 0.206
0.0IleXaa: 0.0 ± 0.0
Lys
2.94LysAla: 2.94 ± 0.398
0.109LysCys: 0.109 ± 0.107
1.089LysAsp: 1.089 ± 0.256
0.599LysGlu: 0.599 ± 0.158
1.034LysPhe: 1.034 ± 0.266
1.524LysGly: 1.524 ± 0.359
0.436LysHis: 0.436 ± 0.126
1.688LysIle: 1.688 ± 0.361
0.49LysLys: 0.49 ± 0.151
1.579LysLeu: 1.579 ± 0.254
0.49LysMet: 0.49 ± 0.167
0.762LysAsn: 0.762 ± 0.248
1.198LysPro: 1.198 ± 0.236
1.089LysGln: 1.089 ± 0.243
2.069LysArg: 2.069 ± 0.352
1.742LysSer: 1.742 ± 0.384
1.579LysThr: 1.579 ± 0.284
2.014LysVal: 2.014 ± 0.305
0.544LysTrp: 0.544 ± 0.156
0.817LysTyr: 0.817 ± 0.192
0.0LysXaa: 0.0 ± 0.0
Leu
9.309LeuAla: 9.309 ± 0.898
0.653LeuCys: 0.653 ± 0.2
5.553LeuAsp: 5.553 ± 0.818
2.504LeuGlu: 2.504 ± 0.404
2.286LeuPhe: 2.286 ± 0.37
7.349LeuGly: 7.349 ± 1.078
1.688LeuHis: 1.688 ± 0.311
2.94LeuIle: 2.94 ± 0.458
0.98LeuLys: 0.98 ± 0.264
5.226LeuLeu: 5.226 ± 0.587
0.925LeuMet: 0.925 ± 0.201
2.123LeuAsn: 2.123 ± 0.353
4.791LeuPro: 4.791 ± 0.514
3.266LeuGln: 3.266 ± 0.438
6.478LeuArg: 6.478 ± 0.52
3.321LeuSer: 3.321 ± 0.412
5.662LeuThr: 5.662 ± 0.53
6.261LeuVal: 6.261 ± 0.628
1.633LeuTrp: 1.633 ± 0.272
1.252LeuTyr: 1.252 ± 0.29
0.0LeuXaa: 0.0 ± 0.0
Met
1.797MetAla: 1.797 ± 0.321
0.163MetCys: 0.163 ± 0.11
1.089MetAsp: 1.089 ± 0.196
0.544MetGlu: 0.544 ± 0.218
0.599MetPhe: 0.599 ± 0.183
1.198MetGly: 1.198 ± 0.29
0.708MetHis: 0.708 ± 0.247
0.817MetIle: 0.817 ± 0.173
0.599MetLys: 0.599 ± 0.191
1.96MetLeu: 1.96 ± 0.351
0.218MetMet: 0.218 ± 0.111
0.708MetAsn: 0.708 ± 0.163
1.633MetPro: 1.633 ± 0.309
1.034MetGln: 1.034 ± 0.3
1.579MetArg: 1.579 ± 0.277
1.361MetSer: 1.361 ± 0.251
3.157MetThr: 3.157 ± 0.444
1.633MetVal: 1.633 ± 0.287
0.381MetTrp: 0.381 ± 0.131
0.109MetTyr: 0.109 ± 0.085
0.0MetXaa: 0.0 ± 0.0
Asn
3.375AsnAla: 3.375 ± 0.457
0.381AsnCys: 0.381 ± 0.143
2.286AsnAsp: 2.286 ± 0.308
1.252AsnGlu: 1.252 ± 0.266
0.49AsnPhe: 0.49 ± 0.16
2.831AsnGly: 2.831 ± 0.43
0.436AsnHis: 0.436 ± 0.151
0.98AsnIle: 0.98 ± 0.311
0.49AsnLys: 0.49 ± 0.184
1.851AsnLeu: 1.851 ± 0.333
0.817AsnMet: 0.817 ± 0.201
0.762AsnAsn: 0.762 ± 0.158
2.286AsnPro: 2.286 ± 0.404
0.599AsnGln: 0.599 ± 0.192
1.633AsnArg: 1.633 ± 0.381
1.252AsnSer: 1.252 ± 0.293
1.415AsnThr: 1.415 ± 0.269
1.797AsnVal: 1.797 ± 0.272
0.653AsnTrp: 0.653 ± 0.233
0.381AsnTyr: 0.381 ± 0.15
0.0AsnXaa: 0.0 ± 0.0
Pro
8.057ProAla: 8.057 ± 0.683
0.327ProCys: 0.327 ± 0.172
5.662ProAsp: 5.662 ± 0.837
4.083ProGlu: 4.083 ± 0.631
1.633ProPhe: 1.633 ± 0.392
5.281ProGly: 5.281 ± 0.471
1.252ProHis: 1.252 ± 0.295
3.484ProIle: 3.484 ± 0.464
1.307ProLys: 1.307 ± 0.37
4.355ProLeu: 4.355 ± 0.442
1.252ProMet: 1.252 ± 0.23
2.341ProAsn: 2.341 ± 0.339
4.301ProPro: 4.301 ± 0.596
1.579ProGln: 1.579 ± 0.305
2.994ProArg: 2.994 ± 0.418
2.722ProSer: 2.722 ± 0.413
4.083ProThr: 4.083 ± 0.516
4.954ProVal: 4.954 ± 0.649
0.925ProTrp: 0.925 ± 0.217
1.47ProTyr: 1.47 ± 0.256
0.0ProXaa: 0.0 ± 0.0
Gln
5.444GlnAla: 5.444 ± 0.553
0.381GlnCys: 0.381 ± 0.121
1.034GlnAsp: 1.034 ± 0.256
1.198GlnGlu: 1.198 ± 0.247
1.089GlnPhe: 1.089 ± 0.217
1.905GlnGly: 1.905 ± 0.304
0.925GlnHis: 0.925 ± 0.237
1.524GlnIle: 1.524 ± 0.319
0.817GlnLys: 0.817 ± 0.209
3.157GlnLeu: 3.157 ± 0.462
0.817GlnMet: 0.817 ± 0.236
0.762GlnAsn: 0.762 ± 0.225
2.831GlnPro: 2.831 ± 0.397
2.776GlnGln: 2.776 ± 0.374
3.756GlnArg: 3.756 ± 0.535
1.579GlnSer: 1.579 ± 0.318
2.45GlnThr: 2.45 ± 0.379
3.375GlnVal: 3.375 ± 0.402
0.871GlnTrp: 0.871 ± 0.232
0.762GlnTyr: 0.762 ± 0.204
0.0GlnXaa: 0.0 ± 0.0
Arg
9.799ArgAla: 9.799 ± 0.824
0.599ArgCys: 0.599 ± 0.158
5.226ArgAsp: 5.226 ± 0.542
3.43ArgGlu: 3.43 ± 0.454
1.797ArgPhe: 1.797 ± 0.269
5.063ArgGly: 5.063 ± 0.764
0.871ArgHis: 0.871 ± 0.237
4.083ArgIle: 4.083 ± 0.549
2.341ArgLys: 2.341 ± 0.399
5.553ArgLeu: 5.553 ± 0.566
2.232ArgMet: 2.232 ± 0.324
2.123ArgAsn: 2.123 ± 0.352
3.593ArgPro: 3.593 ± 0.595
2.994ArgGln: 2.994 ± 0.413
10.126ArgArg: 10.126 ± 1.268
3.484ArgSer: 3.484 ± 0.535
3.92ArgThr: 3.92 ± 0.546
6.261ArgVal: 6.261 ± 0.663
2.014ArgTrp: 2.014 ± 0.417
2.341ArgTyr: 2.341 ± 0.415
0.0ArgXaa: 0.0 ± 0.0
Ser
5.771SerAla: 5.771 ± 0.628
0.436SerCys: 0.436 ± 0.182
3.157SerAsp: 3.157 ± 0.48
2.395SerGlu: 2.395 ± 0.368
1.143SerPhe: 1.143 ± 0.26
5.226SerGly: 5.226 ± 0.677
1.089SerHis: 1.089 ± 0.213
1.905SerIle: 1.905 ± 0.295
1.307SerLys: 1.307 ± 0.334
3.321SerLeu: 3.321 ± 0.466
1.034SerMet: 1.034 ± 0.225
1.089SerAsn: 1.089 ± 0.273
2.668SerPro: 2.668 ± 0.45
1.688SerGln: 1.688 ± 0.423
3.43SerArg: 3.43 ± 0.445
3.484SerSer: 3.484 ± 0.637
3.865SerThr: 3.865 ± 0.58
3.756SerVal: 3.756 ± 0.369
1.198SerTrp: 1.198 ± 0.29
0.817SerTyr: 0.817 ± 0.179
0.0SerXaa: 0.0 ± 0.0
Thr
8.71ThrAla: 8.71 ± 0.743
0.708ThrCys: 0.708 ± 0.244
5.281ThrAsp: 5.281 ± 0.478
3.484ThrGlu: 3.484 ± 0.381
1.633ThrPhe: 1.633 ± 0.356
5.553ThrGly: 5.553 ± 0.617
1.143ThrHis: 1.143 ± 0.283
2.885ThrIle: 2.885 ± 0.432
1.96ThrLys: 1.96 ± 0.343
5.117ThrLeu: 5.117 ± 0.442
1.47ThrMet: 1.47 ± 0.229
1.905ThrAsn: 1.905 ± 0.314
5.063ThrPro: 5.063 ± 0.538
1.524ThrGln: 1.524 ± 0.251
3.974ThrArg: 3.974 ± 0.505
3.593ThrSer: 3.593 ± 0.475
4.573ThrThr: 4.573 ± 0.644
5.39ThrVal: 5.39 ± 0.651
1.252ThrTrp: 1.252 ± 0.226
1.361ThrTyr: 1.361 ± 0.269
0.0ThrXaa: 0.0 ± 0.0
Val
9.799ValAla: 9.799 ± 0.832
0.599ValCys: 0.599 ± 0.196
7.839ValAsp: 7.839 ± 0.691
4.464ValGlu: 4.464 ± 0.454
1.524ValPhe: 1.524 ± 0.231
6.914ValGly: 6.914 ± 0.69
1.415ValHis: 1.415 ± 0.275
3.049ValIle: 3.049 ± 0.461
1.633ValLys: 1.633 ± 0.219
5.662ValLeu: 5.662 ± 0.574
1.47ValMet: 1.47 ± 0.262
2.286ValAsn: 2.286 ± 0.369
4.301ValPro: 4.301 ± 0.483
3.049ValGln: 3.049 ± 0.347
5.607ValArg: 5.607 ± 0.628
3.92ValSer: 3.92 ± 0.408
6.206ValThr: 6.206 ± 0.597
6.097ValVal: 6.097 ± 0.526
2.069ValTrp: 2.069 ± 0.278
1.905ValTyr: 1.905 ± 0.372
0.0ValXaa: 0.0 ± 0.0
Trp
2.395TrpAla: 2.395 ± 0.309
0.327TrpCys: 0.327 ± 0.16
1.198TrpAsp: 1.198 ± 0.253
1.034TrpGlu: 1.034 ± 0.235
0.653TrpPhe: 0.653 ± 0.19
0.817TrpGly: 0.817 ± 0.207
0.544TrpHis: 0.544 ± 0.185
0.925TrpIle: 0.925 ± 0.248
0.599TrpLys: 0.599 ± 0.198
2.668TrpLeu: 2.668 ± 0.371
0.708TrpMet: 0.708 ± 0.179
0.436TrpAsn: 0.436 ± 0.191
1.252TrpPro: 1.252 ± 0.285
0.98TrpGln: 0.98 ± 0.21
1.579TrpArg: 1.579 ± 0.317
1.252TrpSer: 1.252 ± 0.325
1.034TrpThr: 1.034 ± 0.242
1.579TrpVal: 1.579 ± 0.33
0.327TrpTrp: 0.327 ± 0.162
0.49TrpTyr: 0.49 ± 0.135
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.45TyrAla: 2.45 ± 0.494
0.163TyrCys: 0.163 ± 0.086
1.633TyrAsp: 1.633 ± 0.361
1.47TyrGlu: 1.47 ± 0.277
0.653TyrPhe: 0.653 ± 0.18
2.45TyrGly: 2.45 ± 0.32
0.544TyrHis: 0.544 ± 0.174
0.381TyrIle: 0.381 ± 0.157
0.272TyrLys: 0.272 ± 0.123
1.96TyrLeu: 1.96 ± 0.324
0.544TyrMet: 0.544 ± 0.163
0.544TyrAsn: 0.544 ± 0.184
1.361TyrPro: 1.361 ± 0.283
0.653TyrGln: 0.653 ± 0.236
1.797TyrArg: 1.797 ± 0.33
1.034TyrSer: 1.034 ± 0.202
1.524TyrThr: 1.524 ± 0.342
1.905TyrVal: 1.905 ± 0.395
0.381TyrTrp: 0.381 ± 0.142
0.436TyrTyr: 0.436 ± 0.134
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 84 proteins (18370 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski