Amino acid dipepetide frequency for Roseisalinus antarcticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.127AlaAla: 18.127 ± 0.175	1.083AlaCys: 1.083 ± 0.029	7.559AlaAsp: 7.559 ± 0.095	8.92AlaGlu: 8.92 ± 0.103	4.4AlaPhe: 4.4 ± 0.057	11.827AlaGly: 11.827 ± 0.133	2.352AlaHis: 2.352 ± 0.048	5.787AlaIle: 5.787 ± 0.061	2.762AlaLys: 2.762 ± 0.067	13.991AlaLeu: 13.991 ± 0.156	3.779AlaMet: 3.779 ± 0.068	2.502AlaAsn: 2.502 ± 0.043	6.612AlaPro: 6.612 ± 0.1	4.02AlaGln: 4.02 ± 0.064	9.81AlaArg: 9.81 ± 0.128	5.681AlaSer: 5.681 ± 0.068	6.388AlaThr: 6.388 ± 0.086	8.738AlaVal: 8.738 ± 0.102	1.59AlaTrp: 1.59 ± 0.039	2.452AlaTyr: 2.452 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.089CysAla: 1.089 ± 0.034	0.116CysCys: 0.116 ± 0.009	0.574CysAsp: 0.574 ± 0.025	0.456CysGlu: 0.456 ± 0.022	0.292CysPhe: 0.292 ± 0.015	0.919CysGly: 0.919 ± 0.029	0.254CysHis: 0.254 ± 0.012	0.37CysIle: 0.37 ± 0.018	0.174CysLys: 0.174 ± 0.013	0.811CysLeu: 0.811 ± 0.029	0.157CysMet: 0.157 ± 0.011	0.191CysAsn: 0.191 ± 0.012	0.503CysPro: 0.503 ± 0.021	0.195CysGln: 0.195 ± 0.012	0.618CysArg: 0.618 ± 0.024	0.384CysSer: 0.384 ± 0.016	0.417CysThr: 0.417 ± 0.019	0.56CysVal: 0.56 ± 0.022	0.128CysTrp: 0.128 ± 0.008	0.178CysTyr: 0.178 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.794AspAla: 7.794 ± 0.104	0.48AspCys: 0.48 ± 0.019	3.78AspAsp: 3.78 ± 0.108	3.417AspGlu: 3.417 ± 0.057	2.274AspPhe: 2.274 ± 0.041	6.337AspGly: 6.337 ± 0.147	1.334AspHis: 1.334 ± 0.035	3.116AspIle: 3.116 ± 0.057	1.381AspLys: 1.381 ± 0.04	6.852AspLeu: 6.852 ± 0.098	1.615AspMet: 1.615 ± 0.034	1.237AspAsn: 1.237 ± 0.035	4.164AspPro: 4.164 ± 0.073	1.685AspGln: 1.685 ± 0.035	5.108AspArg: 5.108 ± 0.069	2.435AspSer: 2.435 ± 0.06	3.22AspThr: 3.22 ± 0.084	4.342AspVal: 4.342 ± 0.067	1.304AspTrp: 1.304 ± 0.034	1.446AspTyr: 1.446 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	8.626GluAla: 8.626 ± 0.098	0.356GluCys: 0.356 ± 0.017	3.438GluAsp: 3.438 ± 0.055	3.259GluGlu: 3.259 ± 0.065	1.694GluPhe: 1.694 ± 0.033	5.052GluGly: 5.052 ± 0.07	1.059GluHis: 1.059 ± 0.029	3.716GluIle: 3.716 ± 0.058	1.497GluLys: 1.497 ± 0.046	4.732GluLeu: 4.732 ± 0.066	1.798GluMet: 1.798 ± 0.034	1.438GluAsn: 1.438 ± 0.037	2.56GluPro: 2.56 ± 0.048	1.746GluGln: 1.746 ± 0.039	4.301GluArg: 4.301 ± 0.069	2.291GluSer: 2.291 ± 0.037	4.121GluThr: 4.121 ± 0.063	4.612GluVal: 4.612 ± 0.063	0.704GluTrp: 0.704 ± 0.023	0.931GluTyr: 0.931 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.425PheAla: 4.425 ± 0.073	0.372PheCys: 0.372 ± 0.017	2.928PheAsp: 2.928 ± 0.06	2.194PheGlu: 2.194 ± 0.042	1.306PhePhe: 1.306 ± 0.037	3.699PheGly: 3.699 ± 0.055	0.738PheHis: 0.738 ± 0.022	1.458PheIle: 1.458 ± 0.036	0.704PheLys: 0.704 ± 0.022	3.333PheLeu: 3.333 ± 0.062	0.755PheMet: 0.755 ± 0.027	0.942PheAsn: 0.942 ± 0.026	1.527PhePro: 1.527 ± 0.035	0.969PheGln: 0.969 ± 0.025	2.347PheArg: 2.347 ± 0.042	2.032PheSer: 2.032 ± 0.044	1.957PheThr: 1.957 ± 0.037	2.692PheVal: 2.692 ± 0.045	0.538PheTrp: 0.538 ± 0.02	0.87PheTyr: 0.87 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	11.019GlyAla: 11.019 ± 0.128	0.868GlyCys: 0.868 ± 0.027	5.402GlyAsp: 5.402 ± 0.146	4.758GlyGlu: 4.758 ± 0.074	3.674GlyPhe: 3.674 ± 0.053	8.407GlyGly: 8.407 ± 0.173	1.906GlyHis: 1.906 ± 0.04	4.523GlyIle: 4.523 ± 0.065	2.536GlyLys: 2.536 ± 0.047	9.809GlyLeu: 9.809 ± 0.11	2.423GlyMet: 2.423 ± 0.048	2.172GlyAsn: 2.172 ± 0.066	4.377GlyPro: 4.377 ± 0.069	3.109GlyGln: 3.109 ± 0.053	6.849GlyArg: 6.849 ± 0.085	4.497GlySer: 4.497 ± 0.089	5.326GlyThr: 5.326 ± 0.101	6.424GlyVal: 6.424 ± 0.073	1.603GlyTrp: 1.603 ± 0.037	2.206GlyTyr: 2.206 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.358HisAla: 2.358 ± 0.05	0.198HisCys: 0.198 ± 0.01	1.354HisAsp: 1.354 ± 0.03	1.05HisGlu: 1.05 ± 0.033	0.765HisPhe: 0.765 ± 0.023	1.9HisGly: 1.9 ± 0.043	0.555HisHis: 0.555 ± 0.022	0.843HisIle: 0.843 ± 0.026	0.396HisLys: 0.396 ± 0.016	2.029HisLeu: 2.029 ± 0.042	0.524HisMet: 0.524 ± 0.024	0.381HisAsn: 0.381 ± 0.017	1.297HisPro: 1.297 ± 0.038	0.502HisGln: 0.502 ± 0.021	1.427HisArg: 1.427 ± 0.039	0.827HisSer: 0.827 ± 0.026	0.764HisThr: 0.764 ± 0.023	1.531HisVal: 1.531 ± 0.035	0.372HisTrp: 0.372 ± 0.018	0.519HisTyr: 0.519 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.906IleAla: 6.906 ± 0.081	0.542IleCys: 0.542 ± 0.019	3.573IleAsp: 3.573 ± 0.06	3.364IleGlu: 3.364 ± 0.052	1.654IlePhe: 1.654 ± 0.036	4.808IleGly: 4.808 ± 0.066	0.849IleHis: 0.849 ± 0.026	1.809IleIle: 1.809 ± 0.044	1.051IleLys: 1.051 ± 0.034	4.653IleLeu: 4.653 ± 0.066	0.951IleMet: 0.951 ± 0.031	1.149IleAsn: 1.149 ± 0.031	2.255IlePro: 2.255 ± 0.039	1.029IleGln: 1.029 ± 0.022	3.375IleArg: 3.375 ± 0.05	2.72IleSer: 2.72 ± 0.046	2.676IleThr: 2.676 ± 0.05	3.915IleVal: 3.915 ± 0.053	0.735IleTrp: 0.735 ± 0.025	1.143IleTyr: 1.143 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.054LysAla: 3.054 ± 0.074	0.141LysCys: 0.141 ± 0.009	1.354LysAsp: 1.354 ± 0.036	1.066LysGlu: 1.066 ± 0.037	0.645LysPhe: 0.645 ± 0.02	2.116LysGly: 2.116 ± 0.051	0.457LysHis: 0.457 ± 0.019	1.235LysIle: 1.235 ± 0.033	0.816LysLys: 0.816 ± 0.031	2.298LysLeu: 2.298 ± 0.054	0.62LysMet: 0.62 ± 0.023	0.525LysAsn: 0.525 ± 0.021	1.388LysPro: 1.388 ± 0.038	0.657LysGln: 0.657 ± 0.025	1.792LysArg: 1.792 ± 0.045	1.48LysSer: 1.48 ± 0.036	1.56LysThr: 1.56 ± 0.042	1.817LysVal: 1.817 ± 0.046	0.309LysTrp: 0.309 ± 0.013	0.429LysTyr: 0.429 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	13.563LeuAla: 13.563 ± 0.152	0.943LeuCys: 0.943 ± 0.03	6.38LeuAsp: 6.38 ± 0.084	5.188LeuGlu: 5.188 ± 0.063	3.471LeuPhe: 3.471 ± 0.058	8.833LeuGly: 8.833 ± 0.094	1.805LeuHis: 1.805 ± 0.04	4.749LeuIle: 4.749 ± 0.06	2.499LeuLys: 2.499 ± 0.055	8.852LeuLeu: 8.852 ± 0.117	2.464LeuMet: 2.464 ± 0.053	2.348LeuAsn: 2.348 ± 0.044	5.664LeuPro: 5.664 ± 0.076	2.539LeuGln: 2.539 ± 0.051	7.561LeuArg: 7.561 ± 0.088	6.661LeuSer: 6.661 ± 0.078	6.127LeuThr: 6.127 ± 0.083	7.267LeuVal: 7.267 ± 0.072	1.359LeuTrp: 1.359 ± 0.036	1.889LeuTyr: 1.889 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.44MetAla: 3.44 ± 0.059	0.147MetCys: 0.147 ± 0.01	1.345MetAsp: 1.345 ± 0.037	1.22MetGlu: 1.22 ± 0.032	0.716MetPhe: 0.716 ± 0.023	2.133MetGly: 2.133 ± 0.047	0.392MetHis: 0.392 ± 0.016	1.45MetIle: 1.45 ± 0.038	0.841MetLys: 0.841 ± 0.027	2.443MetLeu: 2.443 ± 0.05	0.68MetMet: 0.68 ± 0.025	0.687MetAsn: 0.687 ± 0.022	1.469MetPro: 1.469 ± 0.04	0.83MetGln: 0.83 ± 0.024	1.879MetArg: 1.879 ± 0.039	1.664MetSer: 1.664 ± 0.037	2.211MetThr: 2.211 ± 0.045	1.815MetVal: 1.815 ± 0.036	0.231MetTrp: 0.231 ± 0.014	0.282MetTyr: 0.282 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.833AsnAla: 2.833 ± 0.05	0.197AsnCys: 0.197 ± 0.012	1.49AsnAsp: 1.49 ± 0.063	1.015AsnGlu: 1.015 ± 0.029	0.847AsnPhe: 0.847 ± 0.026	2.229AsnGly: 2.229 ± 0.044	0.433AsnHis: 0.433 ± 0.017	1.161AsnIle: 1.161 ± 0.034	0.472AsnLys: 0.472 ± 0.021	2.189AsnLeu: 2.189 ± 0.042	0.583AsnMet: 0.583 ± 0.023	0.573AsnAsn: 0.573 ± 0.022	1.647AsnPro: 1.647 ± 0.035	0.611AsnGln: 0.611 ± 0.02	1.627AsnArg: 1.627 ± 0.03	1.037AsnSer: 1.037 ± 0.033	1.248AsnThr: 1.248 ± 0.041	1.762AsnVal: 1.762 ± 0.035	0.414AsnTrp: 0.414 ± 0.017	0.584AsnTyr: 0.584 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.581ProAla: 6.581 ± 0.088	0.364ProCys: 0.364 ± 0.017	4.304ProAsp: 4.304 ± 0.073	4.298ProGlu: 4.298 ± 0.062	1.938ProPhe: 1.938 ± 0.036	5.183ProGly: 5.183 ± 0.075	1.054ProHis: 1.054 ± 0.028	2.155ProIle: 2.155 ± 0.038	1.229ProLys: 1.229 ± 0.037	4.843ProLeu: 4.843 ± 0.06	1.269ProMet: 1.269 ± 0.03	1.117ProAsn: 1.117 ± 0.024	2.858ProPro: 2.858 ± 0.065	1.518ProGln: 1.518 ± 0.032	3.265ProArg: 3.265 ± 0.059	2.554ProSer: 2.554 ± 0.049	2.562ProThr: 2.562 ± 0.044	4.452ProVal: 4.452 ± 0.061	0.716ProTrp: 0.716 ± 0.024	1.136ProTyr: 1.136 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.776GlnAla: 3.776 ± 0.059	0.183GlnCys: 0.183 ± 0.012	1.597GlnAsp: 1.597 ± 0.035	1.433GlnGlu: 1.433 ± 0.031	0.918GlnPhe: 0.918 ± 0.025	2.488GlnGly: 2.488 ± 0.051	0.486GlnHis: 0.486 ± 0.021	1.778GlnIle: 1.778 ± 0.032	0.801GlnLys: 0.801 ± 0.025	2.501GlnLeu: 2.501 ± 0.036	0.903GlnMet: 0.903 ± 0.024	0.716GlnAsn: 0.716 ± 0.021	1.47GlnPro: 1.47 ± 0.035	0.869GlnGln: 0.869 ± 0.029	2.205GlnArg: 2.205 ± 0.044	1.691GlnSer: 1.691 ± 0.036	1.804GlnThr: 1.804 ± 0.038	2.325GlnVal: 2.325 ± 0.039	0.371GlnTrp: 0.371 ± 0.019	0.518GlnTyr: 0.518 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	8.714ArgAla: 8.714 ± 0.119	0.535ArgCys: 0.535 ± 0.023	4.695ArgAsp: 4.695 ± 0.058	4.054ArgGlu: 4.054 ± 0.057	2.767ArgPhe: 2.767 ± 0.049	5.379ArgGly: 5.379 ± 0.059	1.696ArgHis: 1.696 ± 0.037	4.291ArgIle: 4.291 ± 0.051	1.943ArgLys: 1.943 ± 0.046	8.171ArgLeu: 8.171 ± 0.103	2.08ArgMet: 2.08 ± 0.038	1.752ArgAsn: 1.752 ± 0.037	3.94ArgPro: 3.94 ± 0.065	2.437ArgGln: 2.437 ± 0.047	5.959ArgArg: 5.959 ± 0.108	3.7ArgSer: 3.7 ± 0.056	3.675ArgThr: 3.675 ± 0.054	4.959ArgVal: 4.959 ± 0.068	1.058ArgTrp: 1.058 ± 0.027	1.584ArgTyr: 1.584 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.964SerAla: 5.964 ± 0.074	0.392SerCys: 0.392 ± 0.018	3.419SerAsp: 3.419 ± 0.082	2.767SerGlu: 2.767 ± 0.046	2.105SerPhe: 2.105 ± 0.046	5.706SerGly: 5.706 ± 0.098	1.021SerHis: 1.021 ± 0.03	2.385SerIle: 2.385 ± 0.044	1.136SerLys: 1.136 ± 0.034	5.004SerLeu: 5.004 ± 0.06	1.252SerMet: 1.252 ± 0.033	1.261SerAsn: 1.261 ± 0.034	2.624SerPro: 2.624 ± 0.048	1.482SerGln: 1.482 ± 0.026	3.619SerArg: 3.619 ± 0.053	2.53SerSer: 2.53 ± 0.06	2.584SerThr: 2.584 ± 0.048	3.939SerVal: 3.939 ± 0.063	0.791SerTrp: 0.791 ± 0.026	1.202SerTyr: 1.202 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.728ThrAla: 6.728 ± 0.09	0.471ThrCys: 0.471 ± 0.019	3.491ThrAsp: 3.491 ± 0.077	3.162ThrGlu: 3.162 ± 0.049	2.13ThrPhe: 2.13 ± 0.051	6.08ThrGly: 6.08 ± 0.113	1.026ThrHis: 1.026 ± 0.028	2.811ThrIle: 2.811 ± 0.056	1.124ThrLys: 1.124 ± 0.035	6.375ThrLeu: 6.375 ± 0.104	1.267ThrMet: 1.267 ± 0.026	1.185ThrAsn: 1.185 ± 0.03	3.511ThrPro: 3.511 ± 0.059	1.369ThrGln: 1.369 ± 0.033	3.807ThrArg: 3.807 ± 0.052	2.693ThrSer: 2.693 ± 0.047	2.968ThrThr: 2.968 ± 0.055	4.475ThrVal: 4.475 ± 0.088	0.767ThrTrp: 0.767 ± 0.023	1.275ThrTyr: 1.275 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	9.452ValAla: 9.452 ± 0.091	0.62ValCys: 0.62 ± 0.024	4.3ValAsp: 4.3 ± 0.067	4.481ValGlu: 4.481 ± 0.059	2.809ValPhe: 2.809 ± 0.046	5.592ValGly: 5.592 ± 0.062	1.337ValHis: 1.337 ± 0.029	3.924ValIle: 3.924 ± 0.058	1.583ValLys: 1.583 ± 0.038	7.517ValLeu: 7.517 ± 0.071	1.925ValMet: 1.925 ± 0.043	1.876ValAsn: 1.876 ± 0.039	3.797ValPro: 3.797 ± 0.053	2.018ValGln: 2.018 ± 0.039	4.96ValArg: 4.96 ± 0.062	4.383ValSer: 4.383 ± 0.072	5.122ValThr: 5.122 ± 0.092	5.681ValVal: 5.681 ± 0.083	0.986ValTrp: 0.986 ± 0.025	1.455ValTyr: 1.455 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.5TrpAla: 1.5 ± 0.039	0.134TrpCys: 0.134 ± 0.009	0.818TrpAsp: 0.818 ± 0.025	0.65TrpGlu: 0.65 ± 0.022	0.533TrpPhe: 0.533 ± 0.019	1.048TrpGly: 1.048 ± 0.029	0.343TrpHis: 0.343 ± 0.016	0.764TrpIle: 0.764 ± 0.021	0.368TrpLys: 0.368 ± 0.016	1.662TrpLeu: 1.662 ± 0.043	0.382TrpMet: 0.382 ± 0.016	0.393TrpAsn: 0.393 ± 0.018	0.745TrpPro: 0.745 ± 0.024	0.641TrpGln: 0.641 ± 0.025	1.269TrpArg: 1.269 ± 0.033	0.867TrpSer: 0.867 ± 0.024	0.958TrpThr: 0.958 ± 0.029	0.938TrpVal: 0.938 ± 0.027	0.248TrpTrp: 0.248 ± 0.014	0.281TrpTyr: 0.281 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.432TyrAla: 2.432 ± 0.045	0.242TyrCys: 0.242 ± 0.014	1.521TyrAsp: 1.521 ± 0.03	1.181TyrGlu: 1.181 ± 0.033	0.846TyrPhe: 0.846 ± 0.026	2.153TyrGly: 2.153 ± 0.05	0.493TyrHis: 0.493 ± 0.017	0.832TyrIle: 0.832 ± 0.022	0.445TyrLys: 0.445 ± 0.018	2.098TyrLeu: 2.098 ± 0.041	0.448TyrMet: 0.448 ± 0.018	0.507TyrAsn: 0.507 ± 0.018	0.99TyrPro: 0.99 ± 0.025	0.608TyrGln: 0.608 ± 0.023	1.61TyrArg: 1.61 ± 0.038	1.054TyrSer: 1.054 ± 0.026	1.031TyrThr: 1.031 ± 0.035	1.573TyrVal: 1.573 ± 0.032	0.319TyrTrp: 0.319 ± 0.013	0.545TyrTyr: 0.545 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4698 proteins (1473940 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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