Amino acid dipepetide frequency for Amnimonas aquatica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.358AlaAla: 16.358 ± 0.246	1.242AlaCys: 1.242 ± 0.049	7.307AlaAsp: 7.307 ± 0.112	7.816AlaGlu: 7.816 ± 0.121	3.753AlaPhe: 3.753 ± 0.089	12.125AlaGly: 12.125 ± 0.19	2.413AlaHis: 2.413 ± 0.074	4.946AlaIle: 4.946 ± 0.102	3.104AlaLys: 3.104 ± 0.11	14.495AlaLeu: 14.495 ± 0.192	3.073AlaMet: 3.073 ± 0.079	2.361AlaAsn: 2.361 ± 0.067	5.3AlaPro: 5.3 ± 0.101	4.606AlaGln: 4.606 ± 0.108	9.233AlaArg: 9.233 ± 0.15	5.939AlaSer: 5.939 ± 0.106	5.419AlaThr: 5.419 ± 0.107	8.859AlaVal: 8.859 ± 0.143	1.811AlaTrp: 1.811 ± 0.069	2.314AlaTyr: 2.314 ± 0.065	0.013AlaXaa: 0.013 ± 0.005
Cys	0.881CysAla: 0.881 ± 0.046	0.108CysCys: 0.108 ± 0.013	0.582CysAsp: 0.582 ± 0.036	0.494CysGlu: 0.494 ± 0.036	0.327CysPhe: 0.327 ± 0.025	0.892CysGly: 0.892 ± 0.052	0.318CysHis: 0.318 ± 0.025	0.398CysIle: 0.398 ± 0.031	0.18CysLys: 0.18 ± 0.018	0.929CysLeu: 0.929 ± 0.042	0.186CysMet: 0.186 ± 0.019	0.212CysAsn: 0.212 ± 0.02	0.522CysPro: 0.522 ± 0.033	0.338CysGln: 0.338 ± 0.023	0.771CysArg: 0.771 ± 0.038	0.481CysSer: 0.481 ± 0.035	0.415CysThr: 0.415 ± 0.03	0.691CysVal: 0.691 ± 0.033	0.151CysTrp: 0.151 ± 0.018	0.214CysTyr: 0.214 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	6.999AspAla: 6.999 ± 0.13	0.506AspCys: 0.506 ± 0.033	3.385AspAsp: 3.385 ± 0.087	3.396AspGlu: 3.396 ± 0.081	2.101AspPhe: 2.101 ± 0.075	4.919AspGly: 4.919 ± 0.113	1.27AspHis: 1.27 ± 0.058	3.307AspIle: 3.307 ± 0.082	1.764AspLys: 1.764 ± 0.057	5.924AspLeu: 5.924 ± 0.118	1.482AspMet: 1.482 ± 0.051	1.45AspAsn: 1.45 ± 0.054	2.879AspPro: 2.879 ± 0.075	1.794AspGln: 1.794 ± 0.058	3.757AspArg: 3.757 ± 0.085	2.779AspSer: 2.779 ± 0.062	2.543AspThr: 2.543 ± 0.072	3.894AspVal: 3.894 ± 0.094	1.047AspTrp: 1.047 ± 0.056	1.623AspTyr: 1.623 ± 0.055	0.002AspXaa: 0.002 ± 0.002
Glu	7.532GluAla: 7.532 ± 0.127	0.368GluCys: 0.368 ± 0.023	2.667GluAsp: 2.667 ± 0.069	2.814GluGlu: 2.814 ± 0.088	1.779GluPhe: 1.779 ± 0.07	3.989GluGly: 3.989 ± 0.085	1.539GluHis: 1.539 ± 0.058	2.809GluIle: 2.809 ± 0.082	2.047GluLys: 2.047 ± 0.07	6.368GluLeu: 6.368 ± 0.116	1.173GluMet: 1.173 ± 0.046	1.331GluAsn: 1.331 ± 0.048	2.476GluPro: 2.476 ± 0.074	3.134GluGln: 3.134 ± 0.081	4.974GluArg: 4.974 ± 0.107	2.537GluSer: 2.537 ± 0.077	2.688GluThr: 2.688 ± 0.063	4.381GluVal: 4.381 ± 0.092	0.665GluTrp: 0.665 ± 0.036	1.084GluTyr: 1.084 ± 0.042	0.002GluXaa: 0.002 ± 0.002
Phe	3.656PheAla: 3.656 ± 0.083	0.377PheCys: 0.377 ± 0.025	2.309PheAsp: 2.309 ± 0.067	1.809PheGlu: 1.809 ± 0.055	1.348PhePhe: 1.348 ± 0.067	3.231PheGly: 3.231 ± 0.078	0.723PheHis: 0.723 ± 0.035	1.701PheIle: 1.701 ± 0.061	0.972PheLys: 0.972 ± 0.041	3.303PheLeu: 3.303 ± 0.082	0.905PheMet: 0.905 ± 0.041	1.008PheAsn: 1.008 ± 0.041	1.532PhePro: 1.532 ± 0.055	1.067PheGln: 1.067 ± 0.045	2.275PheArg: 2.275 ± 0.069	2.05PheSer: 2.05 ± 0.066	1.779PheThr: 1.779 ± 0.048	2.413PheVal: 2.413 ± 0.073	0.485PheTrp: 0.485 ± 0.031	0.915PheTyr: 0.915 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	8.073GlyAla: 8.073 ± 0.144	0.944GlyCys: 0.944 ± 0.045	4.604GlyAsp: 4.604 ± 0.095	5.116GlyGlu: 5.116 ± 0.115	3.275GlyPhe: 3.275 ± 0.086	7.171GlyGly: 7.171 ± 0.134	2.138GlyHis: 2.138 ± 0.061	4.433GlyIle: 4.433 ± 0.099	3.216GlyLys: 3.216 ± 0.088	9.858GlyLeu: 9.858 ± 0.162	2.377GlyMet: 2.377 ± 0.075	2.061GlyAsn: 2.061 ± 0.057	2.837GlyPro: 2.837 ± 0.076	3.417GlyGln: 3.417 ± 0.086	6.289GlyArg: 6.289 ± 0.104	4.577GlySer: 4.577 ± 0.105	3.993GlyThr: 3.993 ± 0.086	6.398GlyVal: 6.398 ± 0.111	1.357GlyTrp: 1.357 ± 0.051	2.275GlyTyr: 2.275 ± 0.066	0.009GlyXaa: 0.009 ± 0.004
His	2.807HisAla: 2.807 ± 0.072	0.27HisCys: 0.27 ± 0.021	1.422HisAsp: 1.422 ± 0.058	1.292HisGlu: 1.292 ± 0.056	0.9HisPhe: 0.9 ± 0.05	2.294HisGly: 2.294 ± 0.071	0.712HisHis: 0.712 ± 0.046	1.043HisIle: 1.043 ± 0.043	0.526HisLys: 0.526 ± 0.035	2.346HisLeu: 2.346 ± 0.064	0.52HisMet: 0.52 ± 0.033	0.515HisAsn: 0.515 ± 0.028	1.504HisPro: 1.504 ± 0.059	0.874HisGln: 0.874 ± 0.039	1.636HisArg: 1.636 ± 0.051	0.924HisSer: 0.924 ± 0.046	0.883HisThr: 0.883 ± 0.04	1.55HisVal: 1.55 ± 0.058	0.428HisTrp: 0.428 ± 0.031	0.682HisTyr: 0.682 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	5.766IleAla: 5.766 ± 0.113	0.483IleCys: 0.483 ± 0.03	3.034IleAsp: 3.034 ± 0.079	2.972IleGlu: 2.972 ± 0.079	1.327IlePhe: 1.327 ± 0.049	4.424IleGly: 4.424 ± 0.106	0.935IleHis: 0.935 ± 0.039	2.047IleIle: 2.047 ± 0.071	1.556IleLys: 1.556 ± 0.048	3.813IleLeu: 3.813 ± 0.084	1.0IleMet: 1.0 ± 0.048	1.47IleAsn: 1.47 ± 0.057	2.11IlePro: 2.11 ± 0.066	1.305IleGln: 1.305 ± 0.047	3.411IleArg: 3.411 ± 0.091	2.641IleSer: 2.641 ± 0.076	2.558IleThr: 2.558 ± 0.074	3.288IleVal: 3.288 ± 0.084	0.435IleTrp: 0.435 ± 0.025	1.054IleTyr: 1.054 ± 0.041	0.006IleXaa: 0.006 ± 0.003
Lys	3.816LysAla: 3.816 ± 0.097	0.184LysCys: 0.184 ± 0.023	1.567LysAsp: 1.567 ± 0.054	1.415LysGlu: 1.415 ± 0.056	0.812LysPhe: 0.812 ± 0.044	2.348LysGly: 2.348 ± 0.081	0.678LysHis: 0.678 ± 0.036	1.322LysIle: 1.322 ± 0.055	1.151LysLys: 1.151 ± 0.06	3.233LysLeu: 3.233 ± 0.087	0.781LysMet: 0.781 ± 0.039	0.749LysAsn: 0.749 ± 0.041	1.89LysPro: 1.89 ± 0.064	1.327LysGln: 1.327 ± 0.048	2.221LysArg: 2.221 ± 0.072	1.61LysSer: 1.61 ± 0.056	1.63LysThr: 1.63 ± 0.059	2.335LysVal: 2.335 ± 0.071	0.281LysTrp: 0.281 ± 0.023	0.66LysTyr: 0.66 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	15.765LeuAla: 15.765 ± 0.219	0.998LeuCys: 0.998 ± 0.046	6.432LeuAsp: 6.432 ± 0.116	5.508LeuGlu: 5.508 ± 0.106	3.69LeuPhe: 3.69 ± 0.09	9.004LeuGly: 9.004 ± 0.133	2.469LeuHis: 2.469 ± 0.071	4.865LeuIle: 4.865 ± 0.094	3.61LeuLys: 3.61 ± 0.096	12.861LeuLeu: 12.861 ± 0.247	2.554LeuMet: 2.554 ± 0.068	2.76LeuAsn: 2.76 ± 0.077	7.099LeuPro: 7.099 ± 0.142	4.441LeuGln: 4.441 ± 0.102	8.817LeuArg: 8.817 ± 0.148	6.287LeuSer: 6.287 ± 0.118	5.523LeuThr: 5.523 ± 0.115	8.092LeuVal: 8.092 ± 0.125	1.281LeuTrp: 1.281 ± 0.056	1.937LeuTyr: 1.937 ± 0.065	0.007LeuXaa: 0.007 ± 0.003
Met	3.136MetAla: 3.136 ± 0.073	0.162MetCys: 0.162 ± 0.016	1.11MetAsp: 1.11 ± 0.044	0.981MetGlu: 0.981 ± 0.04	0.574MetPhe: 0.574 ± 0.032	1.626MetGly: 1.626 ± 0.06	0.498MetHis: 0.498 ± 0.028	1.063MetIle: 1.063 ± 0.045	0.924MetLys: 0.924 ± 0.038	2.597MetLeu: 2.597 ± 0.077	0.597MetMet: 0.597 ± 0.038	0.809MetAsn: 0.809 ± 0.039	1.47MetPro: 1.47 ± 0.051	0.996MetGln: 0.996 ± 0.048	1.621MetArg: 1.621 ± 0.058	1.699MetSer: 1.699 ± 0.053	1.835MetThr: 1.835 ± 0.056	1.537MetVal: 1.537 ± 0.058	0.139MetTrp: 0.139 ± 0.015	0.353MetTyr: 0.353 ± 0.027	0.002MetXaa: 0.002 ± 0.002
Asn	2.759AsnAla: 2.759 ± 0.078	0.221AsnCys: 0.221 ± 0.025	1.361AsnAsp: 1.361 ± 0.057	1.145AsnGlu: 1.145 ± 0.05	0.844AsnPhe: 0.844 ± 0.037	2.153AsnGly: 2.153 ± 0.071	0.506AsnHis: 0.506 ± 0.031	1.32AsnIle: 1.32 ± 0.059	0.781AsnLys: 0.781 ± 0.035	2.712AsnLeu: 2.712 ± 0.07	0.561AsnMet: 0.561 ± 0.029	0.693AsnAsn: 0.693 ± 0.039	1.818AsnPro: 1.818 ± 0.061	0.952AsnGln: 0.952 ± 0.048	1.64AsnArg: 1.64 ± 0.062	1.08AsnSer: 1.08 ± 0.048	1.205AsnThr: 1.205 ± 0.047	1.654AsnVal: 1.654 ± 0.057	0.323AsnTrp: 0.323 ± 0.024	0.652AsnTyr: 0.652 ± 0.035	0.002AsnXaa: 0.002 ± 0.002
Pro	7.672ProAla: 7.672 ± 0.138	0.359ProCys: 0.359 ± 0.026	3.487ProAsp: 3.487 ± 0.083	3.734ProGlu: 3.734 ± 0.077	1.666ProPhe: 1.666 ± 0.068	4.814ProGly: 4.814 ± 0.092	1.041ProHis: 1.041 ± 0.044	1.561ProIle: 1.561 ± 0.058	1.234ProLys: 1.234 ± 0.05	5.539ProLeu: 5.539 ± 0.097	1.074ProMet: 1.074 ± 0.043	1.097ProAsn: 1.097 ± 0.051	2.221ProPro: 2.221 ± 0.084	1.758ProGln: 1.758 ± 0.058	2.956ProArg: 2.956 ± 0.08	2.288ProSer: 2.288 ± 0.064	1.905ProThr: 1.905 ± 0.064	4.913ProVal: 4.913 ± 0.098	0.818ProTrp: 0.818 ± 0.046	1.078ProTyr: 1.078 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	5.835GlnAla: 5.835 ± 0.11	0.305GlnCys: 0.305 ± 0.026	1.892GlnAsp: 1.892 ± 0.061	1.801GlnGlu: 1.801 ± 0.067	1.177GlnPhe: 1.177 ± 0.04	3.145GlnGly: 3.145 ± 0.075	0.933GlnHis: 0.933 ± 0.042	1.725GlnIle: 1.725 ± 0.061	1.106GlnLys: 1.106 ± 0.05	4.556GlnLeu: 4.556 ± 0.103	0.855GlnMet: 0.855 ± 0.04	0.799GlnAsn: 0.799 ± 0.038	2.277GlnPro: 2.277 ± 0.07	2.061GlnGln: 2.061 ± 0.074	3.361GlnArg: 3.361 ± 0.077	1.647GlnSer: 1.647 ± 0.066	1.736GlnThr: 1.736 ± 0.057	3.383GlnVal: 3.383 ± 0.076	0.532GlnTrp: 0.532 ± 0.031	0.831GlnTyr: 0.831 ± 0.04	0.002GlnXaa: 0.002 ± 0.002
Arg	7.789ArgAla: 7.789 ± 0.123	0.619ArgCys: 0.619 ± 0.031	4.498ArgAsp: 4.498 ± 0.101	5.123ArgGlu: 5.123 ± 0.128	2.963ArgPhe: 2.963 ± 0.077	4.714ArgGly: 4.714 ± 0.081	2.225ArgHis: 2.225 ± 0.07	3.647ArgIle: 3.647 ± 0.08	2.192ArgLys: 2.192 ± 0.068	9.025ArgLeu: 9.025 ± 0.147	1.835ArgMet: 1.835 ± 0.061	1.892ArgAsn: 1.892 ± 0.068	3.595ArgPro: 3.595 ± 0.082	3.818ArgGln: 3.818 ± 0.101	5.846ArgArg: 5.846 ± 0.129	3.216ArgSer: 3.216 ± 0.081	2.991ArgThr: 2.991 ± 0.073	5.446ArgVal: 5.446 ± 0.103	1.266ArgTrp: 1.266 ± 0.06	2.106ArgTyr: 2.106 ± 0.063	0.02ArgXaa: 0.02 ± 0.006
Ser	5.857SerAla: 5.857 ± 0.108	0.416SerCys: 0.416 ± 0.025	2.746SerAsp: 2.746 ± 0.067	2.718SerGlu: 2.718 ± 0.076	1.831SerPhe: 1.831 ± 0.06	4.997SerGly: 4.997 ± 0.102	1.169SerHis: 1.169 ± 0.046	2.114SerIle: 2.114 ± 0.059	1.416SerLys: 1.416 ± 0.049	6.149SerLeu: 6.149 ± 0.116	1.158SerMet: 1.158 ± 0.048	1.205SerAsn: 1.205 ± 0.052	2.773SerPro: 2.773 ± 0.073	1.848SerGln: 1.848 ± 0.064	3.844SerArg: 3.844 ± 0.097	2.669SerSer: 2.669 ± 0.084	2.357SerThr: 2.357 ± 0.068	3.813SerVal: 3.813 ± 0.096	0.753SerTrp: 0.753 ± 0.039	1.206SerTyr: 1.206 ± 0.048	0.007SerXaa: 0.007 ± 0.004
Thr	5.439ThrAla: 5.439 ± 0.104	0.442ThrCys: 0.442 ± 0.034	2.402ThrAsp: 2.402 ± 0.08	2.262ThrGlu: 2.262 ± 0.066	1.454ThrPhe: 1.454 ± 0.056	4.777ThrGly: 4.777 ± 0.106	1.022ThrHis: 1.022 ± 0.046	1.824ThrIle: 1.824 ± 0.062	0.978ThrLys: 0.978 ± 0.044	6.495ThrLeu: 6.495 ± 0.122	0.942ThrMet: 0.942 ± 0.044	0.965ThrAsn: 0.965 ± 0.046	3.199ThrPro: 3.199 ± 0.079	1.682ThrGln: 1.682 ± 0.056	3.556ThrArg: 3.556 ± 0.091	2.346ThrSer: 2.346 ± 0.069	2.495ThrThr: 2.495 ± 0.082	3.764ThrVal: 3.764 ± 0.079	0.593ThrTrp: 0.593 ± 0.04	0.98ThrTyr: 0.98 ± 0.049	0.002ThrXaa: 0.002 ± 0.002
Val	8.811ValAla: 8.811 ± 0.139	0.691ValCys: 0.691 ± 0.032	4.069ValAsp: 4.069 ± 0.09	4.147ValGlu: 4.147 ± 0.089	2.593ValPhe: 2.593 ± 0.068	5.011ValGly: 5.011 ± 0.104	1.593ValHis: 1.593 ± 0.051	4.117ValIle: 4.117 ± 0.097	2.361ValLys: 2.361 ± 0.082	8.867ValLeu: 8.867 ± 0.157	1.922ValMet: 1.922 ± 0.056	2.08ValAsn: 2.08 ± 0.062	3.874ValPro: 3.874 ± 0.074	2.526ValGln: 2.526 ± 0.076	5.489ValArg: 5.489 ± 0.109	4.428ValSer: 4.428 ± 0.104	4.017ValThr: 4.017 ± 0.091	6.289ValVal: 6.289 ± 0.135	0.907ValTrp: 0.907 ± 0.041	1.442ValTyr: 1.442 ± 0.051	0.004ValXaa: 0.004 ± 0.002
Trp	1.167TrpAla: 1.167 ± 0.05	0.156TrpCys: 0.156 ± 0.016	0.619TrpAsp: 0.619 ± 0.033	0.539TrpGlu: 0.539 ± 0.032	0.541TrpPhe: 0.541 ± 0.031	0.835TrpGly: 0.835 ± 0.044	0.392TrpHis: 0.392 ± 0.027	0.507TrpIle: 0.507 ± 0.03	0.288TrpLys: 0.288 ± 0.024	2.34TrpLeu: 2.34 ± 0.08	0.335TrpMet: 0.335 ± 0.025	0.342TrpAsn: 0.342 ± 0.024	0.751TrpPro: 0.751 ± 0.042	1.05TrpGln: 1.05 ± 0.048	1.303TrpArg: 1.303 ± 0.055	0.723TrpSer: 0.723 ± 0.038	0.56TrpThr: 0.56 ± 0.033	0.892TrpVal: 0.892 ± 0.044	0.244TrpTrp: 0.244 ± 0.022	0.258TrpTyr: 0.258 ± 0.021	0.004TrpXaa: 0.004 ± 0.002
Tyr	2.353TyrAla: 2.353 ± 0.059	0.234TyrCys: 0.234 ± 0.022	1.322TyrAsp: 1.322 ± 0.05	1.273TyrGlu: 1.273 ± 0.047	0.903TyrPhe: 0.903 ± 0.044	1.941TyrGly: 1.941 ± 0.055	0.548TyrHis: 0.548 ± 0.034	0.887TyrIle: 0.887 ± 0.047	0.604TyrLys: 0.604 ± 0.033	2.586TyrLeu: 2.586 ± 0.073	0.396TyrMet: 0.396 ± 0.032	0.578TyrAsn: 0.578 ± 0.036	1.082TyrPro: 1.082 ± 0.048	0.965TyrGln: 0.965 ± 0.042	1.82TyrArg: 1.82 ± 0.068	1.119TyrSer: 1.119 ± 0.046	1.084TyrThr: 1.084 ± 0.053	1.64TyrVal: 1.64 ± 0.061	0.331TyrTrp: 0.331 ± 0.028	0.586TyrTyr: 0.586 ± 0.032	0.002TyrXaa: 0.002 ± 0.002
Xaa	0.019XaaAla: 0.019 ± 0.005	0.006XaaCys: 0.006 ± 0.003	0.004XaaAsp: 0.004 ± 0.002	0.002XaaGlu: 0.002 ± 0.002	0.0XaaPhe: 0.0 ± 0.0	0.007XaaGly: 0.007 ± 0.004	0.004XaaHis: 0.004 ± 0.003	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.002XaaLeu: 0.002 ± 0.002	0.002XaaMet: 0.002 ± 0.002	0.004XaaAsn: 0.004 ± 0.002	0.007XaaPro: 0.007 ± 0.003	0.0XaaGln: 0.0 ± 0.0	0.007XaaArg: 0.007 ± 0.003	0.006XaaSer: 0.006 ± 0.003	0.006XaaThr: 0.006 ± 0.003	0.006XaaVal: 0.006 ± 0.003	0.002XaaTrp: 0.002 ± 0.002	0.002XaaTyr: 0.002 ± 0.002	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1914 proteins (537966 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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