Amino acid dipepetide frequency for Methylovirgula ligni

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.131AlaAla: 20.131 ± 0.215	1.036AlaCys: 1.036 ± 0.046	7.004AlaAsp: 7.004 ± 0.079	8.074AlaGlu: 8.074 ± 0.11	4.661AlaPhe: 4.661 ± 0.059	10.312AlaGly: 10.312 ± 0.123	2.75AlaHis: 2.75 ± 0.054	6.892AlaIle: 6.892 ± 0.084	4.864AlaLys: 4.864 ± 0.093	14.55AlaLeu: 14.55 ± 0.139	2.694AlaMet: 2.694 ± 0.053	3.151AlaAsn: 3.151 ± 0.055	6.614AlaPro: 6.614 ± 0.099	4.603AlaGln: 4.603 ± 0.075	9.323AlaArg: 9.323 ± 0.112	6.431AlaSer: 6.431 ± 0.078	6.381AlaThr: 6.381 ± 0.092	8.436AlaVal: 8.436 ± 0.111	1.43AlaTrp: 1.43 ± 0.042	2.828AlaTyr: 2.828 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	1.07CysAla: 1.07 ± 0.04	0.105CysCys: 0.105 ± 0.012	0.477CysAsp: 0.477 ± 0.022	0.424CysGlu: 0.424 ± 0.022	0.302CysPhe: 0.302 ± 0.021	0.881CysGly: 0.881 ± 0.033	0.21CysHis: 0.21 ± 0.019	0.383CysIle: 0.383 ± 0.023	0.187CysLys: 0.187 ± 0.014	0.802CysLeu: 0.802 ± 0.034	0.12CysMet: 0.12 ± 0.01	0.214CysAsn: 0.214 ± 0.016	0.418CysPro: 0.418 ± 0.022	0.192CysGln: 0.192 ± 0.014	0.559CysArg: 0.559 ± 0.025	0.454CysSer: 0.454 ± 0.022	0.376CysThr: 0.376 ± 0.026	0.597CysVal: 0.597 ± 0.027	0.093CysTrp: 0.093 ± 0.009	0.203CysTyr: 0.203 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.932AspAla: 6.932 ± 0.087	0.467AspCys: 0.467 ± 0.024	2.953AspAsp: 2.953 ± 0.058	3.303AspGlu: 3.303 ± 0.069	2.405AspPhe: 2.405 ± 0.047	4.575AspGly: 4.575 ± 0.073	1.206AspHis: 1.206 ± 0.035	3.183AspIle: 3.183 ± 0.064	1.898AspLys: 1.898 ± 0.047	6.102AspLeu: 6.102 ± 0.085	1.034AspMet: 1.034 ± 0.034	1.271AspAsn: 1.271 ± 0.036	3.435AspPro: 3.435 ± 0.059	1.621AspGln: 1.621 ± 0.04	3.649AspArg: 3.649 ± 0.061	2.371AspSer: 2.371 ± 0.051	2.462AspThr: 2.462 ± 0.054	4.262AspVal: 4.262 ± 0.064	0.901AspTrp: 0.901 ± 0.033	1.605AspTyr: 1.605 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	7.899GluAla: 7.899 ± 0.099	0.31GluCys: 0.31 ± 0.017	2.73GluAsp: 2.73 ± 0.055	2.843GluGlu: 2.843 ± 0.077	1.794GluPhe: 1.794 ± 0.041	3.699GluGly: 3.699 ± 0.076	1.233GluHis: 1.233 ± 0.038	3.922GluIle: 3.922 ± 0.065	2.543GluLys: 2.543 ± 0.054	5.113GluLeu: 5.113 ± 0.081	1.211GluMet: 1.211 ± 0.037	1.577GluAsn: 1.577 ± 0.044	2.635GluPro: 2.635 ± 0.059	1.751GluGln: 1.751 ± 0.045	4.371GluArg: 4.371 ± 0.076	2.694GluSer: 2.694 ± 0.053	3.504GluThr: 3.504 ± 0.059	3.532GluVal: 3.532 ± 0.063	0.595GluTrp: 0.595 ± 0.025	0.951GluTyr: 0.951 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	5.386PheAla: 5.386 ± 0.074	0.439PheCys: 0.439 ± 0.021	2.743PheAsp: 2.743 ± 0.06	2.087PheGlu: 2.087 ± 0.05	1.633PhePhe: 1.633 ± 0.043	3.856PheGly: 3.856 ± 0.058	0.839PheHis: 0.839 ± 0.03	1.856PheIle: 1.856 ± 0.045	1.074PheLys: 1.074 ± 0.036	3.633PheLeu: 3.633 ± 0.069	0.689PheMet: 0.689 ± 0.025	1.1PheAsn: 1.1 ± 0.037	1.66PhePro: 1.66 ± 0.042	1.023PheGln: 1.023 ± 0.035	2.271PheArg: 2.271 ± 0.054	2.413PheSer: 2.413 ± 0.051	1.981PheThr: 1.981 ± 0.042	3.132PheVal: 3.132 ± 0.062	0.554PheTrp: 0.554 ± 0.024	0.977PheTyr: 0.977 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	9.68GlyAla: 9.68 ± 0.124	0.741GlyCys: 0.741 ± 0.025	4.215GlyAsp: 4.215 ± 0.072	4.255GlyGlu: 4.255 ± 0.069	3.809GlyPhe: 3.809 ± 0.072	7.019GlyGly: 7.019 ± 0.138	2.017GlyHis: 2.017 ± 0.056	4.438GlyIle: 4.438 ± 0.061	3.264GlyLys: 3.264 ± 0.07	8.838GlyLeu: 8.838 ± 0.107	1.713GlyMet: 1.713 ± 0.048	2.081GlyAsn: 2.081 ± 0.052	3.376GlyPro: 3.376 ± 0.064	2.566GlyGln: 2.566 ± 0.052	5.692GlyArg: 5.692 ± 0.065	4.171GlySer: 4.171 ± 0.076	4.491GlyThr: 4.491 ± 0.082	5.882GlyVal: 5.882 ± 0.088	1.225GlyTrp: 1.225 ± 0.039	2.221GlyTyr: 2.221 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	2.486HisAla: 2.486 ± 0.057	0.225HisCys: 0.225 ± 0.015	1.262HisAsp: 1.262 ± 0.033	1.101HisGlu: 1.101 ± 0.034	0.993HisPhe: 0.993 ± 0.026	1.937HisGly: 1.937 ± 0.054	0.711HisHis: 0.711 ± 0.037	1.137HisIle: 1.137 ± 0.033	0.627HisLys: 0.627 ± 0.027	2.237HisLeu: 2.237 ± 0.052	0.482HisMet: 0.482 ± 0.024	0.506HisAsn: 0.506 ± 0.023	1.431HisPro: 1.431 ± 0.04	0.588HisGln: 0.588 ± 0.022	1.486HisArg: 1.486 ± 0.036	1.027HisSer: 1.027 ± 0.032	0.867HisThr: 0.867 ± 0.031	1.637HisVal: 1.637 ± 0.038	0.346HisTrp: 0.346 ± 0.019	0.667HisTyr: 0.667 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	8.004IleAla: 8.004 ± 0.105	0.515IleCys: 0.515 ± 0.022	3.774IleAsp: 3.774 ± 0.063	3.68IleGlu: 3.68 ± 0.073	2.135IlePhe: 2.135 ± 0.051	5.181IleGly: 5.181 ± 0.08	0.972IleHis: 0.972 ± 0.036	2.608IleIle: 2.608 ± 0.058	1.643IleLys: 1.643 ± 0.048	4.947IleLeu: 4.947 ± 0.083	0.823IleMet: 0.823 ± 0.033	1.474IleAsn: 1.474 ± 0.048	2.32IlePro: 2.32 ± 0.05	1.15IleGln: 1.15 ± 0.037	2.899IleArg: 2.899 ± 0.048	3.124IleSer: 3.124 ± 0.055	2.624IleThr: 2.624 ± 0.051	4.722IleVal: 4.722 ± 0.082	0.635IleTrp: 0.635 ± 0.028	1.272IleTyr: 1.272 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	4.564LysAla: 4.564 ± 0.076	0.175LysCys: 0.175 ± 0.012	1.78LysAsp: 1.78 ± 0.049	1.609LysGlu: 1.609 ± 0.053	1.17LysPhe: 1.17 ± 0.037	2.499LysGly: 2.499 ± 0.057	0.691LysHis: 0.691 ± 0.029	2.268LysIle: 2.268 ± 0.057	1.499LysLys: 1.499 ± 0.054	3.906LysLeu: 3.906 ± 0.074	0.753LysMet: 0.753 ± 0.029	0.987LysAsn: 0.987 ± 0.031	2.263LysPro: 2.263 ± 0.051	1.091LysGln: 1.091 ± 0.038	2.426LysArg: 2.426 ± 0.058	2.033LysSer: 2.033 ± 0.052	2.15LysThr: 2.15 ± 0.048	2.446LysVal: 2.446 ± 0.054	0.38LysTrp: 0.38 ± 0.021	0.673LysTyr: 0.673 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	15.111LeuAla: 15.111 ± 0.153	0.891LeuCys: 0.891 ± 0.028	6.1LeuAsp: 6.1 ± 0.091	5.118LeuGlu: 5.118 ± 0.078	3.759LeuPhe: 3.759 ± 0.072	8.288LeuGly: 8.288 ± 0.106	2.054LeuHis: 2.054 ± 0.044	5.465LeuIle: 5.465 ± 0.075	3.783LeuLys: 3.783 ± 0.071	9.84LeuLeu: 9.84 ± 0.138	1.856LeuMet: 1.856 ± 0.042	2.771LeuAsn: 2.771 ± 0.058	5.81LeuPro: 5.81 ± 0.084	2.814LeuGln: 2.814 ± 0.06	7.222LeuArg: 7.222 ± 0.097	6.302LeuSer: 6.302 ± 0.083	5.719LeuThr: 5.719 ± 0.084	7.505LeuVal: 7.505 ± 0.089	1.127LeuTrp: 1.127 ± 0.033	2.301LeuTyr: 2.301 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	2.352MetAla: 2.352 ± 0.054	0.102MetCys: 0.102 ± 0.01	0.888MetAsp: 0.888 ± 0.031	0.797MetGlu: 0.797 ± 0.029	0.608MetPhe: 0.608 ± 0.026	1.24MetGly: 1.24 ± 0.037	0.376MetHis: 0.376 ± 0.021	1.149MetIle: 1.149 ± 0.035	0.794MetLys: 0.794 ± 0.027	1.962MetLeu: 1.962 ± 0.045	0.433MetMet: 0.433 ± 0.023	0.656MetAsn: 0.656 ± 0.029	1.285MetPro: 1.285 ± 0.035	0.693MetGln: 0.693 ± 0.029	1.546MetArg: 1.546 ± 0.04	1.441MetSer: 1.441 ± 0.042	1.528MetThr: 1.528 ± 0.042	1.144MetVal: 1.144 ± 0.037	0.18MetTrp: 0.18 ± 0.015	0.275MetTyr: 0.275 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.228AsnAla: 3.228 ± 0.061	0.247AsnCys: 0.247 ± 0.017	1.365AsnAsp: 1.365 ± 0.037	1.271AsnGlu: 1.271 ± 0.037	1.208AsnPhe: 1.208 ± 0.038	2.252AsnGly: 2.252 ± 0.054	0.525AsnHis: 0.525 ± 0.025	1.61AsnIle: 1.61 ± 0.041	0.752AsnLys: 0.752 ± 0.03	2.751AsnLeu: 2.751 ± 0.045	0.54AsnMet: 0.54 ± 0.025	0.749AsnAsn: 0.749 ± 0.028	1.732AsnPro: 1.732 ± 0.044	0.763AsnGln: 0.763 ± 0.03	1.652AsnArg: 1.652 ± 0.042	1.396AsnSer: 1.396 ± 0.044	1.2AsnThr: 1.2 ± 0.041	2.076AsnVal: 2.076 ± 0.045	0.475AsnTrp: 0.475 ± 0.025	0.777AsnTyr: 0.777 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	6.737ProAla: 6.737 ± 0.086	0.311ProCys: 0.311 ± 0.018	3.416ProAsp: 3.416 ± 0.065	3.549ProGlu: 3.549 ± 0.068	2.002ProPhe: 2.002 ± 0.047	4.645ProGly: 4.645 ± 0.08	1.257ProHis: 1.257 ± 0.04	2.458ProIle: 2.458 ± 0.053	1.876ProLys: 1.876 ± 0.049	5.192ProLeu: 5.192 ± 0.082	0.948ProMet: 0.948 ± 0.031	1.431ProAsn: 1.431 ± 0.044	3.452ProPro: 3.452 ± 0.095	2.047ProGln: 2.047 ± 0.051	3.24ProArg: 3.24 ± 0.064	2.806ProSer: 2.806 ± 0.056	2.436ProThr: 2.436 ± 0.049	4.058ProVal: 4.058 ± 0.073	0.615ProTrp: 0.615 ± 0.027	1.262ProTyr: 1.262 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	4.048GlnAla: 4.048 ± 0.072	0.194GlnCys: 0.194 ± 0.017	1.468GlnAsp: 1.468 ± 0.04	1.464GlnGlu: 1.464 ± 0.043	1.122GlnPhe: 1.122 ± 0.035	2.287GlnGly: 2.287 ± 0.052	0.639GlnHis: 0.639 ± 0.025	2.029GlnIle: 2.029 ± 0.048	1.31GlnLys: 1.31 ± 0.042	2.825GlnLeu: 2.825 ± 0.063	0.728GlnMet: 0.728 ± 0.027	0.925GlnAsn: 0.925 ± 0.033	1.799GlnPro: 1.799 ± 0.046	1.219GlnGln: 1.219 ± 0.044	2.32GlnArg: 2.32 ± 0.049	1.856GlnSer: 1.856 ± 0.043	1.907GlnThr: 1.907 ± 0.047	2.145GlnVal: 2.145 ± 0.046	0.352GlnTrp: 0.352 ± 0.02	0.654GlnTyr: 0.654 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	8.398ArgAla: 8.398 ± 0.106	0.481ArgCys: 0.481 ± 0.024	3.908ArgAsp: 3.908 ± 0.075	4.011ArgGlu: 4.011 ± 0.078	2.91ArgPhe: 2.91 ± 0.056	4.887ArgGly: 4.887 ± 0.068	1.693ArgHis: 1.693 ± 0.048	3.756ArgIle: 3.756 ± 0.067	2.362ArgLys: 2.362 ± 0.058	7.826ArgLeu: 7.826 ± 0.112	1.421ArgMet: 1.421 ± 0.04	1.799ArgAsn: 1.799 ± 0.044	3.5ArgPro: 3.5 ± 0.065	2.49ArgGln: 2.49 ± 0.052	5.563ArgArg: 5.563 ± 0.082	3.253ArgSer: 3.253 ± 0.059	3.223ArgThr: 3.223 ± 0.064	4.526ArgVal: 4.526 ± 0.069	0.832ArgTrp: 0.832 ± 0.029	1.606ArgTyr: 1.606 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.468SerAla: 6.468 ± 0.085	0.447SerCys: 0.447 ± 0.022	2.986SerAsp: 2.986 ± 0.068	2.898SerGlu: 2.898 ± 0.056	2.382SerPhe: 2.382 ± 0.055	5.242SerGly: 5.242 ± 0.098	1.132SerHis: 1.132 ± 0.034	2.819SerIle: 2.819 ± 0.05	1.659SerLys: 1.659 ± 0.045	5.831SerLeu: 5.831 ± 0.093	1.031SerMet: 1.031 ± 0.036	1.39SerAsn: 1.39 ± 0.039	2.819SerPro: 2.819 ± 0.059	1.707SerGln: 1.707 ± 0.047	3.42SerArg: 3.42 ± 0.064	3.004SerSer: 3.004 ± 0.069	2.665SerThr: 2.665 ± 0.059	3.866SerVal: 3.866 ± 0.062	0.659SerTrp: 0.659 ± 0.026	1.312SerTyr: 1.312 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	6.24ThrAla: 6.24 ± 0.084	0.435ThrCys: 0.435 ± 0.023	2.627ThrAsp: 2.627 ± 0.058	2.453ThrGlu: 2.453 ± 0.044	2.105ThrPhe: 2.105 ± 0.05	4.725ThrGly: 4.725 ± 0.078	1.132ThrHis: 1.132 ± 0.036	2.992ThrIle: 2.992 ± 0.066	1.647ThrLys: 1.647 ± 0.046	6.017ThrLeu: 6.017 ± 0.098	0.911ThrMet: 0.911 ± 0.033	1.425ThrAsn: 1.425 ± 0.043	3.516ThrPro: 3.516 ± 0.064	1.672ThrGln: 1.672 ± 0.044	3.214ThrArg: 3.214 ± 0.056	2.89ThrSer: 2.89 ± 0.063	2.75ThrThr: 2.75 ± 0.062	3.588ThrVal: 3.588 ± 0.062	0.673ThrTrp: 0.673 ± 0.022	1.347ThrTyr: 1.347 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	9.503ValAla: 9.503 ± 0.115	0.56ValCys: 0.56 ± 0.027	3.938ValAsp: 3.938 ± 0.065	4.269ValGlu: 4.269 ± 0.066	2.783ValPhe: 2.783 ± 0.058	5.29ValGly: 5.29 ± 0.084	1.401ValHis: 1.401 ± 0.036	3.868ValIle: 3.868 ± 0.072	2.467ValLys: 2.467 ± 0.06	7.434ValLeu: 7.434 ± 0.095	1.407ValMet: 1.407 ± 0.039	1.949ValAsn: 1.949 ± 0.049	3.854ValPro: 3.854 ± 0.06	1.9ValGln: 1.9 ± 0.042	4.668ValArg: 4.668 ± 0.074	4.08ValSer: 4.08 ± 0.071	4.262ValThr: 4.262 ± 0.074	5.407ValVal: 5.407 ± 0.086	0.774ValTrp: 0.774 ± 0.03	1.535ValTyr: 1.535 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.153TrpAla: 1.153 ± 0.035	0.123TrpCys: 0.123 ± 0.012	0.54TrpAsp: 0.54 ± 0.024	0.462TrpGlu: 0.462 ± 0.023	0.527TrpPhe: 0.527 ± 0.025	0.783TrpGly: 0.783 ± 0.03	0.375TrpHis: 0.375 ± 0.019	0.634TrpIle: 0.634 ± 0.025	0.428TrpLys: 0.428 ± 0.021	1.61TrpLeu: 1.61 ± 0.046	0.243TrpMet: 0.243 ± 0.017	0.421TrpAsn: 0.421 ± 0.025	0.689TrpPro: 0.689 ± 0.028	0.591TrpGln: 0.591 ± 0.023	1.156TrpArg: 1.156 ± 0.037	0.74TrpSer: 0.74 ± 0.026	0.737TrpThr: 0.737 ± 0.029	0.689TrpVal: 0.689 ± 0.028	0.183TrpTrp: 0.183 ± 0.014	0.304TrpTyr: 0.304 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.774TyrAla: 2.774 ± 0.06	0.263TyrCys: 0.263 ± 0.016	1.463TyrAsp: 1.463 ± 0.041	1.238TyrGlu: 1.238 ± 0.038	1.038TyrPhe: 1.038 ± 0.038	2.095TyrGly: 2.095 ± 0.058	0.541TyrHis: 0.541 ± 0.023	1.036TyrIle: 1.036 ± 0.036	0.685TyrLys: 0.685 ± 0.03	2.425TyrLeu: 2.425 ± 0.052	0.406TyrMet: 0.406 ± 0.021	0.691TyrAsn: 0.691 ± 0.027	1.13TyrPro: 1.13 ± 0.047	0.811TyrGln: 0.811 ± 0.027	1.768TyrArg: 1.768 ± 0.048	1.251TyrSer: 1.251 ± 0.039	1.098TyrThr: 1.098 ± 0.037	1.697TyrVal: 1.697 ± 0.042	0.36TyrTrp: 0.36 ± 0.019	0.642TyrTyr: 0.642 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3170 proteins (974626 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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