Amino acid dipepetide frequency for Streptomyces luteoverticillatus (Streptoverticillium luteoverticillatus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.3AlaAla: 22.3 ± 0.209	1.149AlaCys: 1.149 ± 0.023	8.295AlaAsp: 8.295 ± 0.084	9.108AlaGlu: 9.108 ± 0.12	3.601AlaPhe: 3.601 ± 0.043	13.871AlaGly: 13.871 ± 0.117	3.072AlaHis: 3.072 ± 0.043	3.319AlaIle: 3.319 ± 0.045	3.036AlaLys: 3.036 ± 0.056	15.08AlaLeu: 15.08 ± 0.104	2.57AlaMet: 2.57 ± 0.041	1.923AlaAsn: 1.923 ± 0.034	7.698AlaPro: 7.698 ± 0.106	3.397AlaGln: 3.397 ± 0.048	11.055AlaArg: 11.055 ± 0.1	5.794AlaSer: 5.794 ± 0.058	7.178AlaThr: 7.178 ± 0.069	12.448AlaVal: 12.448 ± 0.095	1.813AlaTrp: 1.813 ± 0.033	2.651AlaTyr: 2.651 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.23CysAla: 1.23 ± 0.028	0.097CysCys: 0.097 ± 0.008	0.518CysAsp: 0.518 ± 0.018	0.416CysGlu: 0.416 ± 0.015	0.229CysPhe: 0.229 ± 0.011	1.025CysGly: 1.025 ± 0.025	0.192CysHis: 0.192 ± 0.01	0.128CysIle: 0.128 ± 0.008	0.111CysLys: 0.111 ± 0.008	0.784CysLeu: 0.784 ± 0.022	0.125CysMet: 0.125 ± 0.009	0.13CysAsn: 0.13 ± 0.009	0.535CysPro: 0.535 ± 0.019	0.166CysGln: 0.166 ± 0.009	0.697CysArg: 0.697 ± 0.019	0.456CysSer: 0.456 ± 0.016	0.46CysThr: 0.46 ± 0.017	0.73CysVal: 0.73 ± 0.02	0.133CysTrp: 0.133 ± 0.008	0.159CysTyr: 0.159 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.931AspAla: 7.931 ± 0.078	0.455AspCys: 0.455 ± 0.018	3.454AspAsp: 3.454 ± 0.043	3.825AspGlu: 3.825 ± 0.042	1.621AspPhe: 1.621 ± 0.03	6.554AspGly: 6.554 ± 0.068	1.444AspHis: 1.444 ± 0.025	1.816AspIle: 1.816 ± 0.035	1.28AspLys: 1.28 ± 0.031	5.778AspLeu: 5.778 ± 0.056	0.798AspMet: 0.798 ± 0.021	0.894AspAsn: 0.894 ± 0.021	4.387AspPro: 4.387 ± 0.051	1.371AspGln: 1.371 ± 0.026	5.104AspArg: 5.104 ± 0.058	2.325AspSer: 2.325 ± 0.038	3.039AspThr: 3.039 ± 0.04	4.661AspVal: 4.661 ± 0.054	0.984AspTrp: 0.984 ± 0.024	1.103AspTyr: 1.103 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	7.676GluAla: 7.676 ± 0.109	0.405GluCys: 0.405 ± 0.015	2.847GluAsp: 2.847 ± 0.043	3.597GluGlu: 3.597 ± 0.055	1.434GluPhe: 1.434 ± 0.028	4.455GluGly: 4.455 ± 0.053	1.508GluHis: 1.508 ± 0.032	2.175GluIle: 2.175 ± 0.038	1.521GluLys: 1.521 ± 0.035	7.019GluLeu: 7.019 ± 0.074	0.859GluMet: 0.859 ± 0.017	1.008GluAsn: 1.008 ± 0.021	3.373GluPro: 3.373 ± 0.051	1.942GluGln: 1.942 ± 0.035	5.894GluArg: 5.894 ± 0.065	2.382GluSer: 2.382 ± 0.032	2.817GluThr: 2.817 ± 0.04	4.16GluVal: 4.16 ± 0.049	0.781GluTrp: 0.781 ± 0.019	1.036GluTyr: 1.036 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.734PheAla: 3.734 ± 0.048	0.276PheCys: 0.276 ± 0.01	1.881PheAsp: 1.881 ± 0.031	1.427PheGlu: 1.427 ± 0.03	0.853PhePhe: 0.853 ± 0.025	3.001PheGly: 3.001 ± 0.042	0.666PheHis: 0.666 ± 0.017	0.681PheIle: 0.681 ± 0.021	0.508PheLys: 0.508 ± 0.018	2.579PheLeu: 2.579 ± 0.041	0.386PheMet: 0.386 ± 0.015	0.521PheAsn: 0.521 ± 0.016	1.473PhePro: 1.473 ± 0.03	0.654PheGln: 0.654 ± 0.019	1.897PheArg: 1.897 ± 0.031	1.47PheSer: 1.47 ± 0.031	2.076PheThr: 2.076 ± 0.035	2.206PheVal: 2.206 ± 0.035	0.396PheTrp: 0.396 ± 0.014	0.554PheTyr: 0.554 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	11.455GlyAla: 11.455 ± 0.1	0.907GlyCys: 0.907 ± 0.022	5.342GlyAsp: 5.342 ± 0.048	5.191GlyGlu: 5.191 ± 0.053	2.888GlyPhe: 2.888 ± 0.041	9.442GlyGly: 9.442 ± 0.093	2.551GlyHis: 2.551 ± 0.035	3.307GlyIle: 3.307 ± 0.043	2.572GlyLys: 2.572 ± 0.051	9.631GlyLeu: 9.631 ± 0.076	2.086GlyMet: 2.086 ± 0.033	1.77GlyAsn: 1.77 ± 0.037	5.65GlyPro: 5.65 ± 0.065	2.542GlyGln: 2.542 ± 0.041	8.426GlyArg: 8.426 ± 0.071	5.205GlySer: 5.205 ± 0.059	6.56GlyThr: 6.56 ± 0.058	7.752GlyVal: 7.752 ± 0.071	1.736GlyTrp: 1.736 ± 0.032	2.257GlyTyr: 2.257 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.82HisAla: 2.82 ± 0.04	0.227HisCys: 0.227 ± 0.012	1.407HisAsp: 1.407 ± 0.028	1.29HisGlu: 1.29 ± 0.026	0.614HisPhe: 0.614 ± 0.017	2.542HisGly: 2.542 ± 0.038	0.719HisHis: 0.719 ± 0.02	0.67HisIle: 0.67 ± 0.022	0.364HisLys: 0.364 ± 0.014	2.427HisLeu: 2.427 ± 0.035	0.334HisMet: 0.334 ± 0.013	0.35HisAsn: 0.35 ± 0.014	1.898HisPro: 1.898 ± 0.031	0.638HisGln: 0.638 ± 0.018	2.184HisArg: 2.184 ± 0.037	1.059HisSer: 1.059 ± 0.023	1.344HisThr: 1.344 ± 0.028	1.741HisVal: 1.741 ± 0.032	0.385HisTrp: 0.385 ± 0.013	0.502HisTyr: 0.502 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.693IleAla: 4.693 ± 0.052	0.292IleCys: 0.292 ± 0.012	2.0IleAsp: 2.0 ± 0.034	1.82IleGlu: 1.82 ± 0.033	0.632IlePhe: 0.632 ± 0.021	3.323IleGly: 3.323 ± 0.05	0.639IleHis: 0.639 ± 0.017	0.8IleIle: 0.8 ± 0.023	0.742IleLys: 0.742 ± 0.026	2.174IleLeu: 2.174 ± 0.042	0.412IleMet: 0.412 ± 0.015	0.642IleAsn: 0.642 ± 0.018	1.761IlePro: 1.761 ± 0.031	0.635IleGln: 0.635 ± 0.018	2.197IleArg: 2.197 ± 0.036	1.587IleSer: 1.587 ± 0.029	2.091IleThr: 2.091 ± 0.031	2.598IleVal: 2.598 ± 0.048	0.339IleTrp: 0.339 ± 0.013	0.449IleTyr: 0.449 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	3.083LysAla: 3.083 ± 0.05	0.125LysCys: 0.125 ± 0.008	1.459LysAsp: 1.459 ± 0.035	1.2LysGlu: 1.2 ± 0.029	0.451LysPhe: 0.451 ± 0.018	2.008LysGly: 2.008 ± 0.038	0.435LysHis: 0.435 ± 0.016	0.815LysIle: 0.815 ± 0.023	0.891LysLys: 0.891 ± 0.034	1.986LysLeu: 1.986 ± 0.036	0.402LysMet: 0.402 ± 0.015	0.557LysAsn: 0.557 ± 0.019	1.377LysPro: 1.377 ± 0.031	0.68LysGln: 0.68 ± 0.02	1.486LysArg: 1.486 ± 0.029	1.222LysSer: 1.222 ± 0.029	1.292LysThr: 1.292 ± 0.032	1.909LysVal: 1.909 ± 0.041	0.287LysTrp: 0.287 ± 0.011	0.415LysTyr: 0.415 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	15.532LeuAla: 15.532 ± 0.12	0.853LeuCys: 0.853 ± 0.02	6.512LeuAsp: 6.512 ± 0.054	4.795LeuGlu: 4.795 ± 0.054	2.567LeuPhe: 2.567 ± 0.046	9.224LeuGly: 9.224 ± 0.071	2.251LeuHis: 2.251 ± 0.036	3.123LeuIle: 3.123 ± 0.048	1.991LeuLys: 1.991 ± 0.035	11.286LeuLeu: 11.286 ± 0.097	1.612LeuMet: 1.612 ± 0.033	1.597LeuAsn: 1.597 ± 0.03	6.633LeuPro: 6.633 ± 0.064	1.911LeuGln: 1.911 ± 0.032	9.096LeuArg: 9.096 ± 0.084	5.155LeuSer: 5.155 ± 0.05	6.94LeuThr: 6.94 ± 0.072	8.476LeuVal: 8.476 ± 0.065	1.352LeuTrp: 1.352 ± 0.028	1.855LeuTyr: 1.855 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	2.354MetAla: 2.354 ± 0.037	0.156MetCys: 0.156 ± 0.009	0.898MetAsp: 0.898 ± 0.02	0.78MetGlu: 0.78 ± 0.019	0.448MetPhe: 0.448 ± 0.016	1.411MetGly: 1.411 ± 0.028	0.327MetHis: 0.327 ± 0.012	0.605MetIle: 0.605 ± 0.019	0.378MetLys: 0.378 ± 0.014	1.642MetLeu: 1.642 ± 0.029	0.305MetMet: 0.305 ± 0.013	0.421MetAsn: 0.421 ± 0.015	1.147MetPro: 1.147 ± 0.028	0.38MetGln: 0.38 ± 0.014	1.45MetArg: 1.45 ± 0.03	1.273MetSer: 1.273 ± 0.024	1.5MetThr: 1.5 ± 0.03	1.223MetVal: 1.223 ± 0.026	0.193MetTrp: 0.193 ± 0.011	0.32MetTyr: 0.32 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.21AsnAla: 2.21 ± 0.036	0.151AsnCys: 0.151 ± 0.008	0.974AsnAsp: 0.974 ± 0.023	0.777AsnGlu: 0.777 ± 0.019	0.441AsnPhe: 0.441 ± 0.015	1.935AsnGly: 1.935 ± 0.04	0.385AsnHis: 0.385 ± 0.014	0.619AsnIle: 0.619 ± 0.018	0.439AsnLys: 0.439 ± 0.017	1.54AsnLeu: 1.54 ± 0.031	0.283AsnMet: 0.283 ± 0.013	0.409AsnAsn: 0.409 ± 0.015	1.286AsnPro: 1.286 ± 0.027	0.474AsnGln: 0.474 ± 0.016	1.25AsnArg: 1.25 ± 0.025	0.844AsnSer: 0.844 ± 0.019	1.036AsnThr: 1.036 ± 0.03	1.364AsnVal: 1.364 ± 0.027	0.267AsnTrp: 0.267 ± 0.012	0.392AsnTyr: 0.392 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	9.155ProAla: 9.155 ± 0.095	0.392ProCys: 0.392 ± 0.015	4.507ProAsp: 4.507 ± 0.054	4.37ProGlu: 4.37 ± 0.05	1.611ProPhe: 1.611 ± 0.035	7.4ProGly: 7.4 ± 0.084	1.471ProHis: 1.471 ± 0.03	1.195ProIle: 1.195 ± 0.027	1.262ProLys: 1.262 ± 0.031	5.511ProLeu: 5.511 ± 0.056	0.981ProMet: 0.981 ± 0.025	0.882ProAsn: 0.882 ± 0.021	3.781ProPro: 3.781 ± 0.073	1.622ProGln: 1.622 ± 0.032	4.324ProArg: 4.324 ± 0.054	3.107ProSer: 3.107 ± 0.047	3.117ProThr: 3.117 ± 0.04	5.656ProVal: 5.656 ± 0.055	0.963ProTrp: 0.963 ± 0.022	1.388ProTyr: 1.388 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.443GlnAla: 3.443 ± 0.051	0.167GlnCys: 0.167 ± 0.009	1.289GlnAsp: 1.289 ± 0.031	1.359GlnGlu: 1.359 ± 0.028	0.607GlnPhe: 0.607 ± 0.019	2.27GlnGly: 2.27 ± 0.036	0.632GlnHis: 0.632 ± 0.018	0.933GlnIle: 0.933 ± 0.023	0.571GlnLys: 0.571 ± 0.019	2.653GlnLeu: 2.653 ± 0.042	0.434GlnMet: 0.434 ± 0.014	0.454GlnAsn: 0.454 ± 0.018	1.524GlnPro: 1.524 ± 0.032	1.107GlnGln: 1.107 ± 0.026	2.331GlnArg: 2.331 ± 0.035	1.086GlnSer: 1.086 ± 0.024	1.151GlnThr: 1.151 ± 0.026	2.037GlnVal: 2.037 ± 0.033	0.459GlnTrp: 0.459 ± 0.015	0.546GlnTyr: 0.546 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	10.717ArgAla: 10.717 ± 0.112	0.675ArgCys: 0.675 ± 0.02	4.449ArgAsp: 4.449 ± 0.056	5.063ArgGlu: 5.063 ± 0.065	2.486ArgPhe: 2.486 ± 0.037	6.097ArgGly: 6.097 ± 0.059	2.254ArgHis: 2.254 ± 0.035	2.956ArgIle: 2.956 ± 0.041	1.76ArgLys: 1.76 ± 0.034	9.164ArgLeu: 9.164 ± 0.08	1.795ArgMet: 1.795 ± 0.031	1.384ArgAsn: 1.384 ± 0.03	5.552ArgPro: 5.552 ± 0.074	2.226ArgGln: 2.226 ± 0.037	8.251ArgArg: 8.251 ± 0.093	3.884ArgSer: 3.884 ± 0.041	5.422ArgThr: 5.422 ± 0.056	6.317ArgVal: 6.317 ± 0.06	1.449ArgTrp: 1.449 ± 0.029	1.834ArgTyr: 1.834 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.569SerAla: 6.569 ± 0.06	0.433SerCys: 0.433 ± 0.017	2.407SerAsp: 2.407 ± 0.033	2.129SerGlu: 2.129 ± 0.036	1.571SerPhe: 1.571 ± 0.03	5.919SerGly: 5.919 ± 0.067	1.011SerHis: 1.011 ± 0.023	1.301SerIle: 1.301 ± 0.03	1.006SerLys: 1.006 ± 0.025	4.727SerLeu: 4.727 ± 0.048	0.98SerMet: 0.98 ± 0.023	0.794SerAsn: 0.794 ± 0.022	3.223SerPro: 3.223 ± 0.048	1.1SerGln: 1.1 ± 0.027	3.631SerArg: 3.631 ± 0.044	2.741SerSer: 2.741 ± 0.045	2.775SerThr: 2.775 ± 0.046	4.137SerVal: 4.137 ± 0.047	0.866SerTrp: 0.866 ± 0.023	1.133SerTyr: 1.133 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	9.11ThrAla: 9.11 ± 0.073	0.423ThrCys: 0.423 ± 0.015	3.575ThrAsp: 3.575 ± 0.043	3.107ThrGlu: 3.107 ± 0.04	1.593ThrPhe: 1.593 ± 0.034	7.069ThrGly: 7.069 ± 0.071	1.248ThrHis: 1.248 ± 0.027	1.676ThrIle: 1.676 ± 0.035	1.101ThrLys: 1.101 ± 0.023	5.561ThrLeu: 5.561 ± 0.054	0.887ThrMet: 0.887 ± 0.021	0.939ThrAsn: 0.939 ± 0.023	4.107ThrPro: 4.107 ± 0.048	1.201ThrGln: 1.201 ± 0.031	3.932ThrArg: 3.932 ± 0.044	2.94ThrSer: 2.94 ± 0.041	3.873ThrThr: 3.873 ± 0.059	5.976ThrVal: 5.976 ± 0.064	0.858ThrTrp: 0.858 ± 0.022	1.274ThrTyr: 1.274 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	10.835ValAla: 10.835 ± 0.085	0.767ValCys: 0.767 ± 0.021	4.828ValAsp: 4.828 ± 0.054	4.67ValGlu: 4.67 ± 0.05	2.467ValPhe: 2.467 ± 0.035	6.388ValGly: 6.388 ± 0.072	1.904ValHis: 1.904 ± 0.03	2.751ValIle: 2.751 ± 0.039	1.775ValLys: 1.775 ± 0.036	9.415ValLeu: 9.415 ± 0.089	1.448ValMet: 1.448 ± 0.027	1.626ValAsn: 1.626 ± 0.034	5.443ValPro: 5.443 ± 0.053	1.906ValGln: 1.906 ± 0.033	7.332ValArg: 7.332 ± 0.071	4.172ValSer: 4.172 ± 0.055	5.607ValThr: 5.607 ± 0.059	7.999ValVal: 7.999 ± 0.091	1.129ValTrp: 1.129 ± 0.024	1.515ValTyr: 1.515 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.719TrpAla: 1.719 ± 0.033	0.171TrpCys: 0.171 ± 0.008	0.829TrpAsp: 0.829 ± 0.025	0.752TrpGlu: 0.752 ± 0.024	0.497TrpPhe: 0.497 ± 0.017	1.064TrpGly: 1.064 ± 0.024	0.403TrpHis: 0.403 ± 0.014	0.507TrpIle: 0.507 ± 0.016	0.376TrpLys: 0.376 ± 0.013	1.794TrpLeu: 1.794 ± 0.032	0.28TrpMet: 0.28 ± 0.011	0.378TrpAsn: 0.378 ± 0.015	0.793TrpPro: 0.793 ± 0.021	0.578TrpGln: 0.578 ± 0.019	1.358TrpArg: 1.358 ± 0.028	0.857TrpSer: 0.857 ± 0.021	1.051TrpThr: 1.051 ± 0.024	0.99TrpVal: 0.99 ± 0.021	0.333TrpTrp: 0.333 ± 0.013	0.352TrpTyr: 0.352 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.792TyrAla: 2.792 ± 0.04	0.2TyrCys: 0.2 ± 0.011	1.352TyrAsp: 1.352 ± 0.03	1.213TyrGlu: 1.213 ± 0.025	0.629TyrPhe: 0.629 ± 0.018	2.271TyrGly: 2.271 ± 0.033	0.404TyrHis: 0.404 ± 0.014	0.446TyrIle: 0.446 ± 0.015	0.397TyrLys: 0.397 ± 0.014	2.01TyrLeu: 2.01 ± 0.036	0.234TyrMet: 0.234 ± 0.011	0.4TyrAsn: 0.4 ± 0.014	1.053TyrPro: 1.053 ± 0.022	0.524TyrGln: 0.524 ± 0.018	1.84TyrArg: 1.84 ± 0.033	0.895TyrSer: 0.895 ± 0.021	1.121TyrThr: 1.121 ± 0.027	1.597TyrVal: 1.597 ± 0.027	0.356TyrTrp: 0.356 ± 0.016	0.44TyrTyr: 0.44 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6118 proteins (2059982 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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