Amino acid dipepetide frequency for Frischella perrara

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.864AlaAla: 4.864 ± 0.116
0.835AlaCys: 0.835 ± 0.033
3.658AlaAsp: 3.658 ± 0.081
4.028AlaGlu: 4.028 ± 0.096
2.822AlaPhe: 2.822 ± 0.066
4.332AlaGly: 4.332 ± 0.102
1.29AlaHis: 1.29 ± 0.044
6.498AlaIle: 6.498 ± 0.113
5.111AlaLys: 5.111 ± 0.094
7.727AlaLeu: 7.727 ± 0.112
1.876AlaMet: 1.876 ± 0.059
3.833AlaAsn: 3.833 ± 0.081
2.054AlaPro: 2.054 ± 0.066
3.356AlaGln: 3.356 ± 0.084
2.774AlaArg: 2.774 ± 0.07
4.077AlaSer: 4.077 ± 0.081
3.647AlaThr: 3.647 ± 0.084
4.198AlaVal: 4.198 ± 0.076
0.723AlaTrp: 0.723 ± 0.033
2.37AlaTyr: 2.37 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
0.754CysAla: 0.754 ± 0.029
0.207CysCys: 0.207 ± 0.02
0.627CysAsp: 0.627 ± 0.025
0.568CysGlu: 0.568 ± 0.028
0.535CysPhe: 0.535 ± 0.027
0.823CysGly: 0.823 ± 0.033
0.361CysHis: 0.361 ± 0.022
0.851CysIle: 0.851 ± 0.037
0.453CysLys: 0.453 ± 0.021
1.09CysLeu: 1.09 ± 0.039
0.217CysMet: 0.217 ± 0.018
0.465CysAsn: 0.465 ± 0.024
0.435CysPro: 0.435 ± 0.025
0.581CysGln: 0.581 ± 0.03
0.469CysArg: 0.469 ± 0.023
0.753CysSer: 0.753 ± 0.031
0.423CysThr: 0.423 ± 0.026
0.594CysVal: 0.594 ± 0.027
0.158CysTrp: 0.158 ± 0.013
0.507CysTyr: 0.507 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
3.385AspAla: 3.385 ± 0.074
0.561AspCys: 0.561 ± 0.029
2.934AspAsp: 2.934 ± 0.066
3.72AspGlu: 3.72 ± 0.082
2.562AspPhe: 2.562 ± 0.06
3.275AspGly: 3.275 ± 0.077
1.142AspHis: 1.142 ± 0.041
4.953AspIle: 4.953 ± 0.096
3.846AspLys: 3.846 ± 0.078
5.162AspLeu: 5.162 ± 0.083
1.238AspMet: 1.238 ± 0.037
3.55AspAsn: 3.55 ± 0.072
1.99AspPro: 1.99 ± 0.058
1.98AspGln: 1.98 ± 0.054
2.005AspArg: 2.005 ± 0.052
3.255AspSer: 3.255 ± 0.073
2.295AspThr: 2.295 ± 0.058
3.225AspVal: 3.225 ± 0.066
0.735AspTrp: 0.735 ± 0.029
2.518AspTyr: 2.518 ± 0.06
0.0AspXaa: 0.0 ± 0.0
Glu
3.853GluAla: 3.853 ± 0.091
0.465GluCys: 0.465 ± 0.025
2.507GluAsp: 2.507 ± 0.061
3.025GluGlu: 3.025 ± 0.08
2.171GluPhe: 2.171 ± 0.055
2.901GluGly: 2.901 ± 0.076
1.333GluHis: 1.333 ± 0.042
4.793GluIle: 4.793 ± 0.089
4.285GluLys: 4.285 ± 0.085
6.181GluLeu: 6.181 ± 0.103
1.464GluMet: 1.464 ± 0.05
3.397GluAsn: 3.397 ± 0.068
1.7GluPro: 1.7 ± 0.051
3.809GluGln: 3.809 ± 0.082
2.583GluArg: 2.583 ± 0.062
3.177GluSer: 3.177 ± 0.067
2.691GluThr: 2.691 ± 0.067
3.412GluVal: 3.412 ± 0.081
0.598GluTrp: 0.598 ± 0.03
1.928GluTyr: 1.928 ± 0.055
0.0GluXaa: 0.0 ± 0.0
Phe
3.007PheAla: 3.007 ± 0.068
0.582PheCys: 0.582 ± 0.028
2.774PheAsp: 2.774 ± 0.063
2.256PheGlu: 2.256 ± 0.054
2.007PhePhe: 2.007 ± 0.058
2.665PheGly: 2.665 ± 0.07
0.787PheHis: 0.787 ± 0.028
3.98PheIle: 3.98 ± 0.09
2.483PheLys: 2.483 ± 0.063
3.605PheLeu: 3.605 ± 0.07
0.981PheMet: 0.981 ± 0.036
2.827PheAsn: 2.827 ± 0.058
1.446PhePro: 1.446 ± 0.046
1.214PheGln: 1.214 ± 0.037
1.413PheArg: 1.413 ± 0.049
3.408PheSer: 3.408 ± 0.076
2.512PheThr: 2.512 ± 0.068
2.403PheVal: 2.403 ± 0.068
0.544PheTrp: 0.544 ± 0.026
1.891PheTyr: 1.891 ± 0.062
0.0PheXaa: 0.0 ± 0.0
Gly
3.895GlyAla: 3.895 ± 0.095
0.894GlyCys: 0.894 ± 0.041
3.186GlyAsp: 3.186 ± 0.077
3.622GlyGlu: 3.622 ± 0.092
2.923GlyPhe: 2.923 ± 0.077
3.961GlyGly: 3.961 ± 0.091
1.434GlyHis: 1.434 ± 0.047
5.437GlyIle: 5.437 ± 0.097
4.157GlyLys: 4.157 ± 0.088
5.925GlyLeu: 5.925 ± 0.096
1.589GlyMet: 1.589 ± 0.041
2.882GlyAsn: 2.882 ± 0.071
1.239GlyPro: 1.239 ± 0.046
2.548GlyGln: 2.548 ± 0.063
2.569GlyArg: 2.569 ± 0.058
3.56GlySer: 3.56 ± 0.071
2.847GlyThr: 2.847 ± 0.063
4.042GlyVal: 4.042 ± 0.092
0.772GlyTrp: 0.772 ± 0.031
2.673GlyTyr: 2.673 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
1.296HisAla: 1.296 ± 0.039
0.348HisCys: 0.348 ± 0.021
1.168HisAsp: 1.168 ± 0.047
0.989HisGlu: 0.989 ± 0.037
1.236HisPhe: 1.236 ± 0.046
1.29HisGly: 1.29 ± 0.046
0.751HisHis: 0.751 ± 0.035
1.741HisIle: 1.741 ± 0.051
1.073HisLys: 1.073 ± 0.043
2.258HisLeu: 2.258 ± 0.053
0.391HisMet: 0.391 ± 0.022
1.142HisAsn: 1.142 ± 0.038
1.001HisPro: 1.001 ± 0.042
1.189HisGln: 1.189 ± 0.037
0.949HisArg: 0.949 ± 0.041
1.275HisSer: 1.275 ± 0.041
1.001HisThr: 1.001 ± 0.034
1.115HisVal: 1.115 ± 0.039
0.305HisTrp: 0.305 ± 0.022
1.159HisTyr: 1.159 ± 0.042
0.0HisXaa: 0.0 ± 0.0
Ile
7.08IleAla: 7.08 ± 0.117
0.985IleCys: 0.985 ± 0.028
5.542IleAsp: 5.542 ± 0.086
5.528IleGlu: 5.528 ± 0.102
3.356IlePhe: 3.356 ± 0.082
5.244IleGly: 5.244 ± 0.102
1.506IleHis: 1.506 ± 0.045
7.312IleIle: 7.312 ± 0.122
5.728IleLys: 5.728 ± 0.097
7.528IleLeu: 7.528 ± 0.119
1.849IleMet: 1.849 ± 0.05
5.266IleAsn: 5.266 ± 0.094
3.341IlePro: 3.341 ± 0.059
2.899IleGln: 2.899 ± 0.056
3.314IleArg: 3.314 ± 0.072
5.732IleSer: 5.732 ± 0.092
5.117IleThr: 5.117 ± 0.083
5.09IleVal: 5.09 ± 0.085
0.801IleTrp: 0.801 ± 0.039
2.832IleTyr: 2.832 ± 0.059
0.0IleXaa: 0.0 ± 0.0
Lys
4.478LysAla: 4.478 ± 0.11
0.457LysCys: 0.457 ± 0.026
3.193LysAsp: 3.193 ± 0.078
3.697LysGlu: 3.697 ± 0.082
1.93LysPhe: 1.93 ± 0.057
3.404LysGly: 3.404 ± 0.072
1.371LysHis: 1.371 ± 0.042
5.239LysIle: 5.239 ± 0.085
4.357LysLys: 4.357 ± 0.102
6.549LysLeu: 6.549 ± 0.108
1.668LysMet: 1.668 ± 0.046
3.851LysAsn: 3.851 ± 0.091
2.523LysPro: 2.523 ± 0.06
4.088LysGln: 4.088 ± 0.112
2.87LysArg: 2.87 ± 0.068
3.841LysSer: 3.841 ± 0.079
3.766LysThr: 3.766 ± 0.08
3.764LysVal: 3.764 ± 0.083
0.683LysTrp: 0.683 ± 0.033
2.149LysTyr: 2.149 ± 0.057
0.0LysXaa: 0.0 ± 0.0
Leu
8.339LeuAla: 8.339 ± 0.116
1.16LeuCys: 1.16 ± 0.041
5.388LeuAsp: 5.388 ± 0.098
5.126LeuGlu: 5.126 ± 0.086
4.81LeuPhe: 4.81 ± 0.099
6.007LeuGly: 6.007 ± 0.101
1.887LeuHis: 1.887 ± 0.052
8.581LeuIle: 8.581 ± 0.12
6.3LeuLys: 6.3 ± 0.101
10.663LeuLeu: 10.663 ± 0.149
2.291LeuMet: 2.291 ± 0.057
5.884LeuAsn: 5.884 ± 0.103
4.774LeuPro: 4.774 ± 0.088
3.872LeuGln: 3.872 ± 0.078
3.908LeuArg: 3.908 ± 0.083
7.684LeuSer: 7.684 ± 0.118
6.391LeuThr: 6.391 ± 0.103
6.132LeuVal: 6.132 ± 0.093
1.042LeuTrp: 1.042 ± 0.044
3.175LeuTyr: 3.175 ± 0.054
0.0LeuXaa: 0.0 ± 0.0
Met
1.796MetAla: 1.796 ± 0.055
0.157MetCys: 0.157 ± 0.017
1.022MetAsp: 1.022 ± 0.04
1.003MetGlu: 1.003 ± 0.036
0.758MetPhe: 0.758 ± 0.033
1.473MetGly: 1.473 ± 0.047
0.475MetHis: 0.475 ± 0.024
1.988MetIle: 1.988 ± 0.051
1.516MetLys: 1.516 ± 0.04
2.536MetLeu: 2.536 ± 0.058
0.693MetMet: 0.693 ± 0.038
1.286MetAsn: 1.286 ± 0.041
1.09MetPro: 1.09 ± 0.038
1.139MetGln: 1.139 ± 0.036
0.934MetArg: 0.934 ± 0.035
1.581MetSer: 1.581 ± 0.042
1.414MetThr: 1.414 ± 0.042
1.493MetVal: 1.493 ± 0.04
0.194MetTrp: 0.194 ± 0.017
0.541MetTyr: 0.541 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
3.421AsnAla: 3.421 ± 0.07
0.561AsnCys: 0.561 ± 0.026
3.279AsnAsp: 3.279 ± 0.078
3.263AsnGlu: 3.263 ± 0.076
2.03AsnPhe: 2.03 ± 0.05
3.464AsnGly: 3.464 ± 0.08
1.334AsnHis: 1.334 ± 0.044
4.761AsnIle: 4.761 ± 0.085
3.97AsnLys: 3.97 ± 0.088
5.206AsnLeu: 5.206 ± 0.086
1.207AsnMet: 1.207 ± 0.042
3.887AsnAsn: 3.887 ± 0.089
2.327AsnPro: 2.327 ± 0.056
3.366AsnGln: 3.366 ± 0.082
2.366AsnArg: 2.366 ± 0.057
3.553AsnSer: 3.553 ± 0.086
2.759AsnThr: 2.759 ± 0.066
2.863AsnVal: 2.863 ± 0.07
0.762AsnTrp: 0.762 ± 0.038
2.335AsnTyr: 2.335 ± 0.062
0.0AsnXaa: 0.0 ± 0.0
Pro
2.432ProAla: 2.432 ± 0.054
0.323ProCys: 0.323 ± 0.02
2.195ProAsp: 2.195 ± 0.056
2.565ProGlu: 2.565 ± 0.065
1.813ProPhe: 1.813 ± 0.054
1.641ProGly: 1.641 ± 0.048
0.83ProHis: 0.83 ± 0.036
3.312ProIle: 3.312 ± 0.067
2.298ProLys: 2.298 ± 0.059
3.867ProLeu: 3.867 ± 0.08
0.758ProMet: 0.758 ± 0.033
2.279ProAsn: 2.279 ± 0.064
1.034ProPro: 1.034 ± 0.039
1.563ProGln: 1.563 ± 0.047
1.149ProArg: 1.149 ± 0.04
2.209ProSer: 2.209 ± 0.049
2.228ProThr: 2.228 ± 0.056
2.328ProVal: 2.328 ± 0.062
0.403ProTrp: 0.403 ± 0.024
1.533ProTyr: 1.533 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
3.542GlnAla: 3.542 ± 0.072
0.417GlnCys: 0.417 ± 0.024
2.18GlnAsp: 2.18 ± 0.064
2.464GlnGlu: 2.464 ± 0.059
1.999GlnPhe: 1.999 ± 0.053
2.633GlnGly: 2.633 ± 0.067
1.164GlnHis: 1.164 ± 0.045
3.779GlnIle: 3.779 ± 0.082
2.785GlnLys: 2.785 ± 0.076
5.817GlnLeu: 5.817 ± 0.11
1.009GlnMet: 1.009 ± 0.038
2.489GlnAsn: 2.489 ± 0.063
1.656GlnPro: 1.656 ± 0.057
3.342GlnGln: 3.342 ± 0.098
2.112GlnArg: 2.112 ± 0.06
2.897GlnSer: 2.897 ± 0.073
2.371GlnThr: 2.371 ± 0.063
2.651GlnVal: 2.651 ± 0.062
0.627GlnTrp: 0.627 ± 0.033
1.963GlnTyr: 1.963 ± 0.059
0.0GlnXaa: 0.0 ± 0.0
Arg
2.536ArgAla: 2.536 ± 0.063
0.412ArgCys: 0.412 ± 0.025
2.133ArgAsp: 2.133 ± 0.058
2.399ArgGlu: 2.399 ± 0.059
2.017ArgPhe: 2.017 ± 0.052
2.167ArgGly: 2.167 ± 0.059
0.99ArgHis: 0.99 ± 0.035
3.416ArgIle: 3.416 ± 0.067
2.439ArgLys: 2.439 ± 0.057
4.535ArgLeu: 4.535 ± 0.086
0.924ArgMet: 0.924 ± 0.036
2.046ArgAsn: 2.046 ± 0.05
1.309ArgPro: 1.309 ± 0.046
2.074ArgGln: 2.074 ± 0.063
2.004ArgArg: 2.004 ± 0.059
2.262ArgSer: 2.262 ± 0.048
1.859ArgThr: 1.859 ± 0.05
2.433ArgVal: 2.433 ± 0.063
0.502ArgTrp: 0.502 ± 0.023
2.003ArgTyr: 2.003 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
4.129SerAla: 4.129 ± 0.085
0.675SerCys: 0.675 ± 0.034
3.533SerAsp: 3.533 ± 0.074
3.479SerGlu: 3.479 ± 0.069
2.824SerPhe: 2.824 ± 0.072
4.354SerGly: 4.354 ± 0.09
1.443SerHis: 1.443 ± 0.043
5.42SerIle: 5.42 ± 0.093
3.7SerLys: 3.7 ± 0.072
7.285SerLeu: 7.285 ± 0.13
1.438SerMet: 1.438 ± 0.044
3.234SerAsn: 3.234 ± 0.077
2.283SerPro: 2.283 ± 0.061
2.982SerGln: 2.982 ± 0.068
2.457SerArg: 2.457 ± 0.059
4.22SerSer: 4.22 ± 0.1
3.205SerThr: 3.205 ± 0.062
3.892SerVal: 3.892 ± 0.073
0.729SerTrp: 0.729 ± 0.031
2.436SerTyr: 2.436 ± 0.064
0.0SerXaa: 0.0 ± 0.0
Thr
3.72ThrAla: 3.72 ± 0.074
0.465ThrCys: 0.465 ± 0.026
2.868ThrAsp: 2.868 ± 0.074
2.889ThrGlu: 2.889 ± 0.064
2.128ThrPhe: 2.128 ± 0.059
3.65ThrGly: 3.65 ± 0.083
1.131ThrHis: 1.131 ± 0.043
4.823ThrIle: 4.823 ± 0.081
3.08ThrLys: 3.08 ± 0.071
6.202ThrLeu: 6.202 ± 0.094
1.096ThrMet: 1.096 ± 0.039
2.685ThrAsn: 2.685 ± 0.063
2.525ThrPro: 2.525 ± 0.064
2.354ThrGln: 2.354 ± 0.063
1.87ThrArg: 1.87 ± 0.059
3.234ThrSer: 3.234 ± 0.074
3.04ThrThr: 3.04 ± 0.068
3.468ThrVal: 3.468 ± 0.081
0.506ThrTrp: 0.506 ± 0.028
1.646ThrTyr: 1.646 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
4.495ValAla: 4.495 ± 0.092
0.715ValCys: 0.715 ± 0.034
3.421ValAsp: 3.421 ± 0.076
3.549ValGlu: 3.549 ± 0.068
2.335ValPhe: 2.335 ± 0.046
3.934ValGly: 3.934 ± 0.091
0.961ValHis: 0.961 ± 0.039
5.64ValIle: 5.64 ± 0.083
3.978ValLys: 3.978 ± 0.076
5.634ValLeu: 5.634 ± 0.097
1.523ValMet: 1.523 ± 0.048
3.279ValAsn: 3.279 ± 0.069
2.042ValPro: 2.042 ± 0.053
1.796ValGln: 1.796 ± 0.043
2.248ValArg: 2.248 ± 0.065
3.982ValSer: 3.982 ± 0.076
3.679ValThr: 3.679 ± 0.088
3.811ValVal: 3.811 ± 0.085
0.542ValTrp: 0.542 ± 0.033
1.87ValTyr: 1.87 ± 0.047
0.0ValXaa: 0.0 ± 0.0
Trp
0.631TrpAla: 0.631 ± 0.028
0.147TrpCys: 0.147 ± 0.014
0.506TrpAsp: 0.506 ± 0.027
0.395TrpGlu: 0.395 ± 0.022
0.654TrpPhe: 0.654 ± 0.032
0.687TrpGly: 0.687 ± 0.038
0.352TrpHis: 0.352 ± 0.028
0.802TrpIle: 0.802 ± 0.033
0.494TrpLys: 0.494 ± 0.027
1.563TrpLeu: 1.563 ± 0.052
0.248TrpMet: 0.248 ± 0.018
0.498TrpAsn: 0.498 ± 0.03
0.365TrpPro: 0.365 ± 0.021
1.065TrpGln: 1.065 ± 0.044
0.582TrpArg: 0.582 ± 0.029
0.673TrpSer: 0.673 ± 0.032
0.408TrpThr: 0.408 ± 0.024
0.656TrpVal: 0.656 ± 0.03
0.122TrpTrp: 0.122 ± 0.011
0.495TrpTyr: 0.495 ± 0.038
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.42TyrAla: 2.42 ± 0.054
0.503TyrCys: 0.503 ± 0.024
2.216TyrAsp: 2.216 ± 0.069
1.709TyrGlu: 1.709 ± 0.052
1.874TyrPhe: 1.874 ± 0.053
2.25TyrGly: 2.25 ± 0.06
1.135TyrHis: 1.135 ± 0.048
2.724TyrIle: 2.724 ± 0.067
1.829TyrLys: 1.829 ± 0.047
4.082TyrLeu: 4.082 ± 0.082
0.628TyrMet: 0.628 ± 0.03
1.933TyrAsn: 1.933 ± 0.07
1.626TyrPro: 1.626 ± 0.056
2.678TyrGln: 2.678 ± 0.064
1.883TyrArg: 1.883 ± 0.053
2.348TyrSer: 2.348 ± 0.062
1.725TyrThr: 1.725 ± 0.055
1.863TyrVal: 1.863 ± 0.051
0.595TyrTrp: 0.595 ± 0.039
1.684TyrTyr: 1.684 ± 0.061
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2270 proteins (759465 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski