Amino acid dipepetide frequency for Frederiksenia canicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.889AlaAla: 6.889 ± 0.157
1.1AlaCys: 1.1 ± 0.041
4.637AlaAsp: 4.637 ± 0.094
6.762AlaGlu: 6.762 ± 0.124
3.68AlaPhe: 3.68 ± 0.091
5.725AlaGly: 5.725 ± 0.139
1.493AlaHis: 1.493 ± 0.052
6.346AlaIle: 6.346 ± 0.114
6.325AlaLys: 6.325 ± 0.125
9.368AlaLeu: 9.368 ± 0.137
2.446AlaMet: 2.446 ± 0.076
3.956AlaAsn: 3.956 ± 0.124
2.443AlaPro: 2.443 ± 0.067
3.898AlaGln: 3.898 ± 0.092
3.45AlaArg: 3.45 ± 0.088
4.176AlaSer: 4.176 ± 0.086
4.486AlaThr: 4.486 ± 0.124
6.434AlaVal: 6.434 ± 0.121
0.833AlaTrp: 0.833 ± 0.037
2.427AlaTyr: 2.427 ± 0.068
0.0AlaXaa: 0.0 ± 0.0
Cys
0.718CysAla: 0.718 ± 0.033
0.162CysCys: 0.162 ± 0.017
0.525CysAsp: 0.525 ± 0.032
0.682CysGlu: 0.682 ± 0.038
0.459CysPhe: 0.459 ± 0.028
0.883CysGly: 0.883 ± 0.039
0.264CysHis: 0.264 ± 0.023
0.589CysIle: 0.589 ± 0.03
0.498CysLys: 0.498 ± 0.031
1.004CysLeu: 1.004 ± 0.045
0.143CysMet: 0.143 ± 0.014
0.358CysAsn: 0.358 ± 0.028
0.434CysPro: 0.434 ± 0.032
0.472CysGln: 0.472 ± 0.028
0.475CysArg: 0.475 ± 0.031
0.626CysSer: 0.626 ± 0.033
0.44CysThr: 0.44 ± 0.026
0.676CysVal: 0.676 ± 0.037
0.112CysTrp: 0.112 ± 0.014
0.382CysTyr: 0.382 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
3.644AspAla: 3.644 ± 0.09
0.451AspCys: 0.451 ± 0.025
2.476AspAsp: 2.476 ± 0.08
3.812AspGlu: 3.812 ± 0.089
2.603AspPhe: 2.603 ± 0.071
3.389AspGly: 3.389 ± 0.097
0.993AspHis: 0.993 ± 0.042
3.524AspIle: 3.524 ± 0.087
3.188AspLys: 3.188 ± 0.083
5.162AspLeu: 5.162 ± 0.095
1.022AspMet: 1.022 ± 0.041
2.279AspAsn: 2.279 ± 0.063
2.196AspPro: 2.196 ± 0.058
1.817AspGln: 1.817 ± 0.056
2.281AspArg: 2.281 ± 0.063
2.661AspSer: 2.661 ± 0.061
2.124AspThr: 2.124 ± 0.064
3.699AspVal: 3.699 ± 0.092
0.753AspTrp: 0.753 ± 0.036
2.067AspTyr: 2.067 ± 0.066
0.0AspXaa: 0.0 ± 0.0
Glu
4.893GluAla: 4.893 ± 0.111
0.486GluCys: 0.486 ± 0.027
2.38GluAsp: 2.38 ± 0.073
3.527GluGlu: 3.527 ± 0.104
2.476GluPhe: 2.476 ± 0.062
3.373GluGly: 3.373 ± 0.083
1.33GluHis: 1.33 ± 0.051
4.749GluIle: 4.749 ± 0.097
5.27GluLys: 5.27 ± 0.106
6.723GluLeu: 6.723 ± 0.127
1.908GluMet: 1.908 ± 0.056
3.648GluAsn: 3.648 ± 0.087
2.16GluPro: 2.16 ± 0.084
4.411GluGln: 4.411 ± 0.107
3.45GluArg: 3.45 ± 0.091
3.005GluSer: 3.005 ± 0.071
3.247GluThr: 3.247 ± 0.065
3.911GluVal: 3.911 ± 0.1
0.814GluTrp: 0.814 ± 0.033
1.71GluTyr: 1.71 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
4.035PheAla: 4.035 ± 0.096
0.591PheCys: 0.591 ± 0.032
2.803PheAsp: 2.803 ± 0.07
2.649PheGlu: 2.649 ± 0.062
2.109PhePhe: 2.109 ± 0.064
3.534PheGly: 3.534 ± 0.093
0.877PheHis: 0.877 ± 0.037
3.067PheIle: 3.067 ± 0.085
2.149PheLys: 2.149 ± 0.058
4.121PheLeu: 4.121 ± 0.099
1.03PheMet: 1.03 ± 0.047
2.153PheAsn: 2.153 ± 0.065
1.581PhePro: 1.581 ± 0.051
1.476PheGln: 1.476 ± 0.047
1.577PheArg: 1.577 ± 0.05
3.375PheSer: 3.375 ± 0.083
2.38PheThr: 2.38 ± 0.068
3.048PheVal: 3.048 ± 0.082
0.555PheTrp: 0.555 ± 0.032
1.575PheTyr: 1.575 ± 0.045
0.0PheXaa: 0.0 ± 0.0
Gly
4.931GlyAla: 4.931 ± 0.126
0.781GlyCys: 0.781 ± 0.044
3.174GlyAsp: 3.174 ± 0.085
4.535GlyGlu: 4.535 ± 0.094
3.23GlyPhe: 3.23 ± 0.082
4.747GlyGly: 4.747 ± 0.131
1.306GlyHis: 1.306 ± 0.047
5.124GlyIle: 5.124 ± 0.11
5.143GlyLys: 5.143 ± 0.11
6.99GlyLeu: 6.99 ± 0.121
1.809GlyMet: 1.809 ± 0.062
2.818GlyAsn: 2.818 ± 0.095
1.124GlyPro: 1.124 ± 0.045
2.43GlyGln: 2.43 ± 0.066
2.91GlyArg: 2.91 ± 0.073
3.865GlySer: 3.865 ± 0.083
3.422GlyThr: 3.422 ± 0.102
5.307GlyVal: 5.307 ± 0.094
0.91GlyTrp: 0.91 ± 0.036
2.54GlyTyr: 2.54 ± 0.064
0.0GlyXaa: 0.0 ± 0.0
His
1.341HisAla: 1.341 ± 0.049
0.343HisCys: 0.343 ± 0.024
0.942HisAsp: 0.942 ± 0.04
0.832HisGlu: 0.832 ± 0.035
1.196HisPhe: 1.196 ± 0.051
1.306HisGly: 1.306 ± 0.05
0.685HisHis: 0.685 ± 0.04
1.583HisIle: 1.583 ± 0.059
1.144HisLys: 1.144 ± 0.047
2.295HisLeu: 2.295 ± 0.067
0.333HisMet: 0.333 ± 0.022
1.019HisAsn: 1.019 ± 0.038
1.059HisPro: 1.059 ± 0.046
1.248HisGln: 1.248 ± 0.051
1.1HisArg: 1.1 ± 0.04
1.423HisSer: 1.423 ± 0.047
1.105HisThr: 1.105 ± 0.04
0.932HisVal: 0.932 ± 0.043
0.289HisTrp: 0.289 ± 0.023
0.923HisTyr: 0.923 ± 0.037
0.002HisXaa: 0.002 ± 0.002
Ile
6.885IleAla: 6.885 ± 0.119
0.802IleCys: 0.802 ± 0.037
4.084IleAsp: 4.084 ± 0.08
4.45IleGlu: 4.45 ± 0.104
2.779IlePhe: 2.779 ± 0.088
5.153IleGly: 5.153 ± 0.111
1.355IleHis: 1.355 ± 0.047
4.081IleIle: 4.081 ± 0.103
3.51IleLys: 3.51 ± 0.086
6.155IleLeu: 6.155 ± 0.124
1.202IleMet: 1.202 ± 0.043
2.979IleAsn: 2.979 ± 0.073
2.627IlePro: 2.627 ± 0.073
2.837IleGln: 2.837 ± 0.07
2.932IleArg: 2.932 ± 0.073
4.447IleSer: 4.447 ± 0.09
3.653IleThr: 3.653 ± 0.074
4.442IleVal: 4.442 ± 0.086
0.673IleTrp: 0.673 ± 0.034
1.995IleTyr: 1.995 ± 0.062
0.0IleXaa: 0.0 ± 0.0
Lys
5.855LysAla: 5.855 ± 0.151
0.373LysCys: 0.373 ± 0.026
2.875LysAsp: 2.875 ± 0.091
3.846LysGlu: 3.846 ± 0.098
2.08LysPhe: 2.08 ± 0.059
3.936LysGly: 3.936 ± 0.083
1.196LysHis: 1.196 ± 0.048
3.853LysIle: 3.853 ± 0.079
3.782LysLys: 3.782 ± 0.092
6.058LysLeu: 6.058 ± 0.099
1.948LysMet: 1.948 ± 0.067
3.049LysAsn: 3.049 ± 0.075
2.57LysPro: 2.57 ± 0.073
3.359LysGln: 3.359 ± 0.091
3.01LysArg: 3.01 ± 0.075
3.375LysSer: 3.375 ± 0.096
3.339LysThr: 3.339 ± 0.08
4.335LysVal: 4.335 ± 0.095
0.726LysTrp: 0.726 ± 0.034
1.605LysTyr: 1.605 ± 0.059
0.0LysXaa: 0.0 ± 0.0
Leu
10.436LeuAla: 10.436 ± 0.149
1.031LeuCys: 1.031 ± 0.049
5.563LeuAsp: 5.563 ± 0.115
5.772LeuGlu: 5.772 ± 0.12
4.901LeuPhe: 4.901 ± 0.118
6.982LeuGly: 6.982 ± 0.124
2.108LeuHis: 2.108 ± 0.068
6.423LeuIle: 6.423 ± 0.121
5.726LeuLys: 5.726 ± 0.114
11.069LeuLeu: 11.069 ± 0.21
2.413LeuMet: 2.413 ± 0.075
5.079LeuAsn: 5.079 ± 0.107
4.937LeuPro: 4.937 ± 0.107
4.422LeuGln: 4.422 ± 0.098
4.613LeuArg: 4.613 ± 0.089
7.336LeuSer: 7.336 ± 0.145
5.802LeuThr: 5.802 ± 0.099
6.709LeuVal: 6.709 ± 0.11
1.136LeuTrp: 1.136 ± 0.054
2.7LeuTyr: 2.7 ± 0.076
0.0LeuXaa: 0.0 ± 0.0
Met
2.399MetAla: 2.399 ± 0.073
0.16MetCys: 0.16 ± 0.014
0.943MetAsp: 0.943 ± 0.041
1.168MetGlu: 1.168 ± 0.043
0.89MetPhe: 0.89 ± 0.036
1.562MetGly: 1.562 ± 0.056
0.434MetHis: 0.434 ± 0.024
1.525MetIle: 1.525 ± 0.059
1.731MetLys: 1.731 ± 0.054
2.567MetLeu: 2.567 ± 0.068
0.765MetMet: 0.765 ± 0.032
1.149MetAsn: 1.149 ± 0.051
1.064MetPro: 1.064 ± 0.044
1.319MetGln: 1.319 ± 0.048
1.025MetArg: 1.025 ± 0.046
1.5MetSer: 1.5 ± 0.056
1.374MetThr: 1.374 ± 0.052
1.561MetVal: 1.561 ± 0.051
0.233MetTrp: 0.233 ± 0.022
0.456MetTyr: 0.456 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
4.107AsnAla: 4.107 ± 0.097
0.391AsnCys: 0.391 ± 0.027
2.169AsnAsp: 2.169 ± 0.063
2.702AsnGlu: 2.702 ± 0.066
1.83AsnPhe: 1.83 ± 0.058
3.494AsnGly: 3.494 ± 0.102
1.036AsnHis: 1.036 ± 0.038
3.093AsnIle: 3.093 ± 0.077
2.54AsnLys: 2.54 ± 0.077
4.727AsnLeu: 4.727 ± 0.094
0.907AsnMet: 0.907 ± 0.044
2.086AsnAsn: 2.086 ± 0.089
2.531AsnPro: 2.531 ± 0.067
2.435AsnGln: 2.435 ± 0.064
2.109AsnArg: 2.109 ± 0.06
2.528AsnSer: 2.528 ± 0.075
2.16AsnThr: 2.16 ± 0.078
3.328AsnVal: 3.328 ± 0.09
0.626AsnTrp: 0.626 ± 0.03
1.575AsnTyr: 1.575 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
2.988ProAla: 2.988 ± 0.073
0.302ProCys: 0.302 ± 0.022
2.001ProAsp: 2.001 ± 0.055
3.222ProGlu: 3.222 ± 0.079
1.987ProPhe: 1.987 ± 0.058
1.335ProGly: 1.335 ± 0.052
0.907ProHis: 0.907 ± 0.038
2.697ProIle: 2.697 ± 0.062
2.419ProLys: 2.419 ± 0.067
4.071ProLeu: 4.071 ± 0.088
0.967ProMet: 0.967 ± 0.039
2.352ProAsn: 2.352 ± 0.063
1.182ProPro: 1.182 ± 0.055
1.839ProGln: 1.839 ± 0.061
1.283ProArg: 1.283 ± 0.048
2.051ProSer: 2.051 ± 0.065
2.617ProThr: 2.617 ± 0.072
2.674ProVal: 2.674 ± 0.073
0.399ProTrp: 0.399 ± 0.028
1.443ProTyr: 1.443 ± 0.057
0.002ProXaa: 0.002 ± 0.001
Gln
4.802GlnAla: 4.802 ± 0.097
0.346GlnCys: 0.346 ± 0.024
1.918GlnAsp: 1.918 ± 0.058
2.333GlnGlu: 2.333 ± 0.069
2.292GlnPhe: 2.292 ± 0.062
3.089GlnGly: 3.089 ± 0.082
1.27GlnHis: 1.27 ± 0.043
3.252GlnIle: 3.252 ± 0.082
2.946GlnLys: 2.946 ± 0.077
5.319GlnLeu: 5.319 ± 0.13
1.02GlnMet: 1.02 ± 0.041
2.223GlnAsn: 2.223 ± 0.064
2.014GlnPro: 2.014 ± 0.071
3.623GlnGln: 3.623 ± 0.102
2.389GlnArg: 2.389 ± 0.069
2.551GlnSer: 2.551 ± 0.073
2.49GlnThr: 2.49 ± 0.068
2.983GlnVal: 2.983 ± 0.063
0.64GlnTrp: 0.64 ± 0.034
1.38GlnTyr: 1.38 ± 0.059
0.0GlnXaa: 0.0 ± 0.0
Arg
3.18ArgAla: 3.18 ± 0.075
0.453ArgCys: 0.453 ± 0.033
2.246ArgAsp: 2.246 ± 0.056
3.023ArgGlu: 3.023 ± 0.088
2.41ArgPhe: 2.41 ± 0.066
2.474ArgGly: 2.474 ± 0.063
1.121ArgHis: 1.121 ± 0.043
3.042ArgIle: 3.042 ± 0.078
2.608ArgLys: 2.608 ± 0.068
4.972ArgLeu: 4.972 ± 0.107
1.026ArgMet: 1.026 ± 0.035
2.108ArgAsn: 2.108 ± 0.054
1.627ArgPro: 1.627 ± 0.052
2.347ArgGln: 2.347 ± 0.055
2.161ArgArg: 2.161 ± 0.069
2.454ArgSer: 2.454 ± 0.062
2.067ArgThr: 2.067 ± 0.065
2.844ArgVal: 2.844 ± 0.073
0.547ArgTrp: 0.547 ± 0.032
1.803ArgTyr: 1.803 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
4.863SerAla: 4.863 ± 0.101
0.528SerCys: 0.528 ± 0.032
2.955SerAsp: 2.955 ± 0.075
3.739SerGlu: 3.739 ± 0.08
2.567SerPhe: 2.567 ± 0.066
4.489SerGly: 4.489 ± 0.089
1.391SerHis: 1.391 ± 0.046
3.543SerIle: 3.543 ± 0.081
3.126SerLys: 3.126 ± 0.089
6.32SerLeu: 6.32 ± 0.108
1.273SerMet: 1.273 ± 0.048
2.391SerAsn: 2.391 ± 0.062
2.46SerPro: 2.46 ± 0.058
2.982SerGln: 2.982 ± 0.075
2.502SerArg: 2.502 ± 0.069
3.452SerSer: 3.452 ± 0.095
2.859SerThr: 2.859 ± 0.075
4.033SerVal: 4.033 ± 0.078
0.693SerTrp: 0.693 ± 0.034
1.922SerTyr: 1.922 ± 0.068
0.0SerXaa: 0.0 ± 0.0
Thr
4.942ThrAla: 4.942 ± 0.108
0.429ThrCys: 0.429 ± 0.026
2.623ThrAsp: 2.623 ± 0.063
3.35ThrGlu: 3.35 ± 0.071
2.308ThrPhe: 2.308 ± 0.066
3.851ThrGly: 3.851 ± 0.102
1.122ThrHis: 1.122 ± 0.041
3.348ThrIle: 3.348 ± 0.071
2.699ThrLys: 2.699 ± 0.069
6.058ThrLeu: 6.058 ± 0.11
1.133ThrMet: 1.133 ± 0.048
2.069ThrAsn: 2.069 ± 0.078
2.496ThrPro: 2.496 ± 0.072
2.381ThrGln: 2.381 ± 0.067
2.001ThrArg: 2.001 ± 0.054
2.645ThrSer: 2.645 ± 0.065
2.851ThrThr: 2.851 ± 0.093
3.557ThrVal: 3.557 ± 0.098
0.531ThrTrp: 0.531 ± 0.032
1.419ThrTyr: 1.419 ± 0.052
0.0ThrXaa: 0.0 ± 0.0
Val
6.435ValAla: 6.435 ± 0.13
0.67ValCys: 0.67 ± 0.036
3.653ValAsp: 3.653 ± 0.094
4.964ValGlu: 4.964 ± 0.102
2.669ValPhe: 2.669 ± 0.067
4.878ValGly: 4.878 ± 0.111
1.094ValHis: 1.094 ± 0.046
4.785ValIle: 4.785 ± 0.093
4.181ValLys: 4.181 ± 0.085
6.943ValLeu: 6.943 ± 0.115
1.723ValMet: 1.723 ± 0.057
2.9ValAsn: 2.9 ± 0.102
2.63ValPro: 2.63 ± 0.057
2.535ValGln: 2.535 ± 0.069
2.914ValArg: 2.914 ± 0.069
4.258ValSer: 4.258 ± 0.081
3.405ValThr: 3.405 ± 0.08
5.143ValVal: 5.143 ± 0.114
0.679ValTrp: 0.679 ± 0.035
1.735ValTyr: 1.735 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
0.946TrpAla: 0.946 ± 0.04
0.132TrpCys: 0.132 ± 0.014
0.563TrpAsp: 0.563 ± 0.032
0.571TrpGlu: 0.571 ± 0.033
0.582TrpPhe: 0.582 ± 0.031
0.725TrpGly: 0.725 ± 0.037
0.296TrpHis: 0.296 ± 0.025
0.764TrpIle: 0.764 ± 0.037
0.671TrpLys: 0.671 ± 0.033
1.735TrpLeu: 1.735 ± 0.065
0.22TrpMet: 0.22 ± 0.019
0.525TrpAsn: 0.525 ± 0.037
0.157TrpPro: 0.157 ± 0.015
1.031TrpGln: 1.031 ± 0.044
0.605TrpArg: 0.605 ± 0.035
0.539TrpSer: 0.539 ± 0.027
0.473TrpThr: 0.473 ± 0.028
0.745TrpVal: 0.745 ± 0.038
0.185TrpTrp: 0.185 ± 0.018
0.336TrpTyr: 0.336 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.586TyrAla: 2.586 ± 0.062
0.373TyrCys: 0.373 ± 0.026
1.611TyrAsp: 1.611 ± 0.048
1.534TyrGlu: 1.534 ± 0.053
1.638TyrPhe: 1.638 ± 0.05
2.172TyrGly: 2.172 ± 0.056
0.821TyrHis: 0.821 ± 0.039
1.652TyrIle: 1.652 ± 0.062
1.512TyrLys: 1.512 ± 0.057
3.499TyrLeu: 3.499 ± 0.103
0.533TyrMet: 0.533 ± 0.029
1.232TyrAsn: 1.232 ± 0.042
1.446TyrPro: 1.446 ± 0.048
2.017TyrGln: 2.017 ± 0.064
1.721TyrArg: 1.721 ± 0.048
1.825TyrSer: 1.825 ± 0.05
1.522TyrThr: 1.522 ± 0.049
1.834TyrVal: 1.834 ± 0.052
0.467TyrTrp: 0.467 ± 0.029
1.136TyrTyr: 1.136 ± 0.045
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.002XaaGln: 0.002 ± 0.002
0.002XaaArg: 0.002 ± 0.001
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.006XaaXaa: 0.006 ± 0.004
Statistics based on 1971 proteins (636187 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski