Amino acid dipepetide frequency for Betaproteobacteria bacterium SCN1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.186AlaAla: 18.186 ± 0.197	1.473AlaCys: 1.473 ± 0.05	7.281AlaAsp: 7.281 ± 0.099	7.092AlaGlu: 7.092 ± 0.089	4.164AlaPhe: 4.164 ± 0.071	11.349AlaGly: 11.349 ± 0.154	3.06AlaHis: 3.06 ± 0.075	5.448AlaIle: 5.448 ± 0.079	3.356AlaLys: 3.356 ± 0.078	15.304AlaLeu: 15.304 ± 0.176	3.39AlaMet: 3.39 ± 0.066	2.853AlaAsn: 2.853 ± 0.066	5.949AlaPro: 5.949 ± 0.098	5.043AlaGln: 5.043 ± 0.081	10.248AlaArg: 10.248 ± 0.142	5.944AlaSer: 5.944 ± 0.081	5.557AlaThr: 5.557 ± 0.081	8.902AlaVal: 8.902 ± 0.102	2.126AlaTrp: 2.126 ± 0.053	2.861AlaTyr: 2.861 ± 0.067	0.0AlaXaa: 0.0 ± 0.0
Cys	1.144CysAla: 1.144 ± 0.039	0.142CysCys: 0.142 ± 0.015	0.547CysAsp: 0.547 ± 0.025	0.487CysGlu: 0.487 ± 0.022	0.295CysPhe: 0.295 ± 0.017	0.996CysGly: 0.996 ± 0.036	0.302CysHis: 0.302 ± 0.023	0.381CysIle: 0.381 ± 0.022	0.252CysLys: 0.252 ± 0.017	0.898CysLeu: 0.898 ± 0.034	0.2CysMet: 0.2 ± 0.015	0.244CysAsn: 0.244 ± 0.016	0.601CysPro: 0.601 ± 0.026	0.255CysGln: 0.255 ± 0.016	0.674CysArg: 0.674 ± 0.025	0.418CysSer: 0.418 ± 0.022	0.46CysThr: 0.46 ± 0.021	0.672CysVal: 0.672 ± 0.03	0.091CysTrp: 0.091 ± 0.01	0.218CysTyr: 0.218 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	8.156AspAla: 8.156 ± 0.122	0.534AspCys: 0.534 ± 0.026	3.048AspAsp: 3.048 ± 0.055	3.268AspGlu: 3.268 ± 0.066	2.325AspPhe: 2.325 ± 0.054	4.668AspGly: 4.668 ± 0.087	1.061AspHis: 1.061 ± 0.033	2.758AspIle: 2.758 ± 0.061	1.853AspLys: 1.853 ± 0.053	5.59AspLeu: 5.59 ± 0.087	1.378AspMet: 1.378 ± 0.038	1.327AspAsn: 1.327 ± 0.04	3.338AspPro: 3.338 ± 0.064	1.494AspGln: 1.494 ± 0.044	3.857AspArg: 3.857 ± 0.059	2.435AspSer: 2.435 ± 0.053	3.282AspThr: 3.282 ± 0.057	4.065AspVal: 4.065 ± 0.067	1.179AspTrp: 1.179 ± 0.038	1.749AspTyr: 1.749 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	7.497GluAla: 7.497 ± 0.114	0.413GluCys: 0.413 ± 0.022	2.436GluAsp: 2.436 ± 0.05	2.305GluGlu: 2.305 ± 0.059	1.726GluPhe: 1.726 ± 0.044	3.526GluGly: 3.526 ± 0.061	1.254GluHis: 1.254 ± 0.034	3.11GluIle: 3.11 ± 0.06	2.151GluLys: 2.151 ± 0.057	5.588GluLeu: 5.588 ± 0.079	1.305GluMet: 1.305 ± 0.041	1.502GluAsn: 1.502 ± 0.043	2.475GluPro: 2.475 ± 0.057	2.115GluGln: 2.115 ± 0.05	4.543GluArg: 4.543 ± 0.074	2.787GluSer: 2.787 ± 0.056	3.581GluThr: 3.581 ± 0.063	3.439GluVal: 3.439 ± 0.071	0.726GluTrp: 0.726 ± 0.033	1.23GluTyr: 1.23 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	4.318PheAla: 4.318 ± 0.077	0.354PheCys: 0.354 ± 0.021	2.607PheAsp: 2.607 ± 0.05	2.14PheGlu: 2.14 ± 0.051	1.358PhePhe: 1.358 ± 0.042	3.243PheGly: 3.243 ± 0.072	0.785PheHis: 0.785 ± 0.027	1.534PheIle: 1.534 ± 0.038	1.069PheLys: 1.069 ± 0.038	3.184PheLeu: 3.184 ± 0.066	0.814PheMet: 0.814 ± 0.03	1.043PheAsn: 1.043 ± 0.037	1.507PhePro: 1.507 ± 0.048	0.971PheGln: 0.971 ± 0.032	2.207PheArg: 2.207 ± 0.047	2.047PheSer: 2.047 ± 0.05	1.752PheThr: 1.752 ± 0.046	2.868PheVal: 2.868 ± 0.059	0.534PheTrp: 0.534 ± 0.03	0.963PheTyr: 0.963 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	8.47GlyAla: 8.47 ± 0.125	0.924GlyCys: 0.924 ± 0.034	4.414GlyAsp: 4.414 ± 0.081	4.72GlyGlu: 4.72 ± 0.061	3.307GlyPhe: 3.307 ± 0.068	6.853GlyGly: 6.853 ± 0.13	2.007GlyHis: 2.007 ± 0.046	4.227GlyIle: 4.227 ± 0.065	3.137GlyLys: 3.137 ± 0.07	9.084GlyLeu: 9.084 ± 0.119	2.329GlyMet: 2.329 ± 0.057	2.332GlyAsn: 2.332 ± 0.091	2.634GlyPro: 2.634 ± 0.057	3.125GlyGln: 3.125 ± 0.063	6.029GlyArg: 6.029 ± 0.091	3.956GlySer: 3.956 ± 0.083	4.201GlyThr: 4.201 ± 0.076	6.286GlyVal: 6.286 ± 0.085	1.449GlyTrp: 1.449 ± 0.043	2.432GlyTyr: 2.432 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	3.249HisAla: 3.249 ± 0.064	0.252HisCys: 0.252 ± 0.018	1.291HisAsp: 1.291 ± 0.038	1.095HisGlu: 1.095 ± 0.033	0.944HisPhe: 0.944 ± 0.03	2.128HisGly: 2.128 ± 0.051	0.644HisHis: 0.644 ± 0.027	1.037HisIle: 1.037 ± 0.031	0.565HisLys: 0.565 ± 0.024	2.497HisLeu: 2.497 ± 0.053	0.5HisMet: 0.5 ± 0.023	0.505HisAsn: 0.505 ± 0.024	1.588HisPro: 1.588 ± 0.035	0.619HisGln: 0.619 ± 0.027	1.614HisArg: 1.614 ± 0.043	0.896HisSer: 0.896 ± 0.032	1.177HisThr: 1.177 ± 0.038	1.532HisVal: 1.532 ± 0.042	0.397HisTrp: 0.397 ± 0.02	0.718HisTyr: 0.718 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.202IleAla: 6.202 ± 0.084	0.384IleCys: 0.384 ± 0.02	3.134IleAsp: 3.134 ± 0.056	3.365IleGlu: 3.365 ± 0.072	1.318IlePhe: 1.318 ± 0.045	4.065IleGly: 4.065 ± 0.076	0.996IleHis: 0.996 ± 0.036	1.431IleIle: 1.431 ± 0.051	1.467IleLys: 1.467 ± 0.045	4.109IleLeu: 4.109 ± 0.067	0.752IleMet: 0.752 ± 0.029	1.276IleAsn: 1.276 ± 0.044	2.241IlePro: 2.241 ± 0.046	1.46IleGln: 1.46 ± 0.039	3.246IleArg: 3.246 ± 0.051	1.986IleSer: 1.986 ± 0.048	2.138IleThr: 2.138 ± 0.05	3.756IleVal: 3.756 ± 0.069	0.526IleTrp: 0.526 ± 0.026	1.039IleTyr: 1.039 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.533LysAla: 3.533 ± 0.087	0.208LysCys: 0.208 ± 0.017	1.628LysAsp: 1.628 ± 0.05	1.474LysGlu: 1.474 ± 0.049	0.818LysPhe: 0.818 ± 0.034	2.259LysGly: 2.259 ± 0.054	0.671LysHis: 0.671 ± 0.027	1.467LysIle: 1.467 ± 0.042	1.432LysLys: 1.432 ± 0.062	3.564LysLeu: 3.564 ± 0.075	0.837LysMet: 0.837 ± 0.034	0.955LysAsn: 0.955 ± 0.029	2.157LysPro: 2.157 ± 0.057	1.394LysGln: 1.394 ± 0.041	2.367LysArg: 2.367 ± 0.057	1.725LysSer: 1.725 ± 0.048	2.092LysThr: 2.092 ± 0.055	2.144LysVal: 2.144 ± 0.053	0.41LysTrp: 0.41 ± 0.023	0.72LysTyr: 0.72 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	16.175LeuAla: 16.175 ± 0.202	0.821LeuCys: 0.821 ± 0.031	7.31LeuAsp: 7.31 ± 0.092	5.397LeuGlu: 5.397 ± 0.084	3.832LeuPhe: 3.832 ± 0.071	8.606LeuGly: 8.606 ± 0.121	2.424LeuHis: 2.424 ± 0.055	4.787LeuIle: 4.787 ± 0.082	4.033LeuLys: 4.033 ± 0.078	11.368LeuLeu: 11.368 ± 0.169	2.431LeuMet: 2.431 ± 0.059	2.95LeuAsn: 2.95 ± 0.055	6.639LeuPro: 6.639 ± 0.105	3.233LeuGln: 3.233 ± 0.065	7.501LeuArg: 7.501 ± 0.101	5.704LeuSer: 5.704 ± 0.073	5.713LeuThr: 5.713 ± 0.076	7.569LeuVal: 7.569 ± 0.107	1.32LeuTrp: 1.32 ± 0.045	2.378LeuTyr: 2.378 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.909MetAla: 2.909 ± 0.066	0.163MetCys: 0.163 ± 0.012	1.187MetAsp: 1.187 ± 0.037	1.079MetGlu: 1.079 ± 0.034	0.639MetPhe: 0.639 ± 0.026	1.658MetGly: 1.658 ± 0.047	0.596MetHis: 0.596 ± 0.024	0.978MetIle: 0.978 ± 0.036	1.133MetLys: 1.133 ± 0.037	2.747MetLeu: 2.747 ± 0.061	0.592MetMet: 0.592 ± 0.041	0.901MetAsn: 0.901 ± 0.035	1.478MetPro: 1.478 ± 0.034	1.089MetGln: 1.089 ± 0.033	1.953MetArg: 1.953 ± 0.048	1.518MetSer: 1.518 ± 0.04	1.382MetThr: 1.382 ± 0.044	1.434MetVal: 1.434 ± 0.037	0.197MetTrp: 0.197 ± 0.015	0.347MetTyr: 0.347 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.219AsnAla: 3.219 ± 0.057	0.252AsnCys: 0.252 ± 0.017	1.397AsnAsp: 1.397 ± 0.066	1.246AsnGlu: 1.246 ± 0.044	0.879AsnPhe: 0.879 ± 0.035	2.311AsnGly: 2.311 ± 0.06	0.53AsnHis: 0.53 ± 0.023	1.192AsnIle: 1.192 ± 0.036	0.752AsnLys: 0.752 ± 0.029	3.041AsnLeu: 3.041 ± 0.065	0.567AsnMet: 0.567 ± 0.025	0.715AsnAsn: 0.715 ± 0.031	1.953AsnPro: 1.953 ± 0.055	0.901AsnGln: 0.901 ± 0.028	1.926AsnArg: 1.926 ± 0.043	1.057AsnSer: 1.057 ± 0.035	1.323AsnThr: 1.323 ± 0.039	1.885AsnVal: 1.885 ± 0.045	0.408AsnTrp: 0.408 ± 0.023	0.643AsnTyr: 0.643 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	7.458ProAla: 7.458 ± 0.116	0.395ProCys: 0.395 ± 0.02	3.816ProAsp: 3.816 ± 0.062	3.422ProGlu: 3.422 ± 0.07	1.827ProPhe: 1.827 ± 0.041	4.862ProGly: 4.862 ± 0.08	1.269ProHis: 1.269 ± 0.037	1.852ProIle: 1.852 ± 0.046	1.366ProLys: 1.366 ± 0.04	5.249ProLeu: 5.249 ± 0.088	1.183ProMet: 1.183 ± 0.038	1.277ProAsn: 1.277 ± 0.042	2.923ProPro: 2.923 ± 0.077	1.833ProGln: 1.833 ± 0.045	3.125ProArg: 3.125 ± 0.064	2.21ProSer: 2.21 ± 0.051	2.293ProThr: 2.293 ± 0.059	4.5ProVal: 4.5 ± 0.068	0.791ProTrp: 0.791 ± 0.029	1.264ProTyr: 1.264 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	5.334GlnAla: 5.334 ± 0.081	0.296GlnCys: 0.296 ± 0.018	1.572GlnAsp: 1.572 ± 0.043	1.487GlnGlu: 1.487 ± 0.045	1.195GlnPhe: 1.195 ± 0.035	2.644GlnGly: 2.644 ± 0.058	0.805GlnHis: 0.805 ± 0.031	1.68GlnIle: 1.68 ± 0.038	1.157GlnLys: 1.157 ± 0.04	3.575GlnLeu: 3.575 ± 0.06	0.867GlnMet: 0.867 ± 0.035	0.884GlnAsn: 0.884 ± 0.036	2.115GlnPro: 2.115 ± 0.051	1.504GlnGln: 1.504 ± 0.049	2.735GlnArg: 2.735 ± 0.056	1.766GlnSer: 1.766 ± 0.047	2.063GlnThr: 2.063 ± 0.052	2.477GlnVal: 2.477 ± 0.054	0.476GlnTrp: 0.476 ± 0.023	0.806GlnTyr: 0.806 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	8.771ArgAla: 8.771 ± 0.119	0.548ArgCys: 0.548 ± 0.026	4.272ArgAsp: 4.272 ± 0.078	4.362ArgGlu: 4.362 ± 0.071	2.925ArgPhe: 2.925 ± 0.064	4.749ArgGly: 4.749 ± 0.074	2.023ArgHis: 2.023 ± 0.053	4.088ArgIle: 4.088 ± 0.065	2.044ArgLys: 2.044 ± 0.05	8.982ArgLeu: 8.982 ± 0.11	2.003ArgMet: 2.003 ± 0.055	1.917ArgAsn: 1.917 ± 0.043	3.387ArgPro: 3.387 ± 0.07	2.932ArgGln: 2.932 ± 0.054	5.447ArgArg: 5.447 ± 0.082	2.865ArgSer: 2.865 ± 0.059	3.465ArgThr: 3.465 ± 0.061	5.197ArgVal: 5.197 ± 0.081	1.074ArgTrp: 1.074 ± 0.035	2.169ArgTyr: 2.169 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	5.46SerAla: 5.46 ± 0.083	0.454SerCys: 0.454 ± 0.023	2.58SerAsp: 2.58 ± 0.056	2.295SerGlu: 2.295 ± 0.053	1.766SerPhe: 1.766 ± 0.048	5.094SerGly: 5.094 ± 0.091	1.085SerHis: 1.085 ± 0.035	2.189SerIle: 2.189 ± 0.044	1.332SerLys: 1.332 ± 0.038	5.304SerLeu: 5.304 ± 0.084	1.154SerMet: 1.154 ± 0.038	1.298SerAsn: 1.298 ± 0.038	2.581SerPro: 2.581 ± 0.054	1.635SerGln: 1.635 ± 0.039	3.4SerArg: 3.4 ± 0.065	2.404SerSer: 2.404 ± 0.066	2.372SerThr: 2.372 ± 0.051	3.467SerVal: 3.467 ± 0.062	0.643SerTrp: 0.643 ± 0.029	1.121SerTyr: 1.121 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	5.923ThrAla: 5.923 ± 0.087	0.486ThrCys: 0.486 ± 0.023	2.675ThrAsp: 2.675 ± 0.051	2.38ThrGlu: 2.38 ± 0.053	1.616ThrPhe: 1.616 ± 0.041	4.719ThrGly: 4.719 ± 0.067	1.375ThrHis: 1.375 ± 0.041	1.883ThrIle: 1.883 ± 0.052	1.068ThrLys: 1.068 ± 0.036	7.222ThrLeu: 7.222 ± 0.101	0.968ThrMet: 0.968 ± 0.036	1.037ThrAsn: 1.037 ± 0.035	3.519ThrPro: 3.519 ± 0.063	1.835ThrGln: 1.835 ± 0.041	3.8ThrArg: 3.8 ± 0.07	2.122ThrSer: 2.122 ± 0.046	2.466ThrThr: 2.466 ± 0.061	4.156ThrVal: 4.156 ± 0.074	0.651ThrTrp: 0.651 ± 0.028	1.157ThrTyr: 1.157 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	9.108ValAla: 9.108 ± 0.11	0.771ValCys: 0.771 ± 0.033	4.081ValAsp: 4.081 ± 0.062	4.39ValGlu: 4.39 ± 0.078	2.785ValPhe: 2.785 ± 0.069	5.159ValGly: 5.159 ± 0.088	1.46ValHis: 1.46 ± 0.038	3.292ValIle: 3.292 ± 0.067	2.557ValLys: 2.557 ± 0.064	7.869ValLeu: 7.869 ± 0.124	1.791ValMet: 1.791 ± 0.046	2.128ValAsn: 2.128 ± 0.05	3.825ValPro: 3.825 ± 0.067	2.299ValGln: 2.299 ± 0.044	5.193ValArg: 5.193 ± 0.087	3.972ValSer: 3.972 ± 0.068	3.747ValThr: 3.747 ± 0.064	5.781ValVal: 5.781 ± 0.086	1.039ValTrp: 1.039 ± 0.033	1.744ValTyr: 1.744 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	1.404TrpAla: 1.404 ± 0.047	0.149TrpCys: 0.149 ± 0.011	0.663TrpAsp: 0.663 ± 0.029	0.546TrpGlu: 0.546 ± 0.026	0.52TrpPhe: 0.52 ± 0.025	0.864TrpGly: 0.864 ± 0.035	0.411TrpHis: 0.411 ± 0.022	0.73TrpIle: 0.73 ± 0.027	0.476TrpLys: 0.476 ± 0.024	2.279TrpLeu: 2.279 ± 0.063	0.448TrpMet: 0.448 ± 0.022	0.429TrpAsn: 0.429 ± 0.023	0.735TrpPro: 0.735 ± 0.027	0.786TrpGln: 0.786 ± 0.029	1.263TrpArg: 1.263 ± 0.039	0.661TrpSer: 0.661 ± 0.029	0.688TrpThr: 0.688 ± 0.031	1.048TrpVal: 1.048 ± 0.034	0.241TrpTrp: 0.241 ± 0.019	0.304TrpTyr: 0.304 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.068TyrAla: 3.068 ± 0.054	0.26TyrCys: 0.26 ± 0.017	1.425TyrAsp: 1.425 ± 0.052	1.158TyrGlu: 1.158 ± 0.036	1.061TyrPhe: 1.061 ± 0.031	2.163TyrGly: 2.163 ± 0.058	0.488TyrHis: 0.488 ± 0.023	0.827TyrIle: 0.827 ± 0.029	0.659TyrLys: 0.659 ± 0.028	2.739TyrLeu: 2.739 ± 0.047	0.469TyrMet: 0.469 ± 0.024	0.623TyrAsn: 0.623 ± 0.027	1.269TyrPro: 1.269 ± 0.038	0.917TyrGln: 0.917 ± 0.029	2.092TyrArg: 2.092 ± 0.048	1.161TyrSer: 1.161 ± 0.037	1.306TyrThr: 1.306 ± 0.043	1.813TyrVal: 1.813 ± 0.04	0.366TyrTrp: 0.366 ± 0.02	0.727TyrTyr: 0.727 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3025 proteins (953606 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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