Amino acid dipepetide frequency for Pseudomonas saudiphocaensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.54AlaAla: 12.54 ± 0.138	1.238AlaCys: 1.238 ± 0.035	5.606AlaAsp: 5.606 ± 0.077	7.887AlaGlu: 7.887 ± 0.078	3.719AlaPhe: 3.719 ± 0.06	8.964AlaGly: 8.964 ± 0.109	2.135AlaHis: 2.135 ± 0.048	5.173AlaIle: 5.173 ± 0.087	3.452AlaLys: 3.452 ± 0.064	13.705AlaLeu: 13.705 ± 0.138	2.917AlaMet: 2.917 ± 0.058	2.787AlaAsn: 2.787 ± 0.052	4.426AlaPro: 4.426 ± 0.082	4.869AlaGln: 4.869 ± 0.064	7.278AlaArg: 7.278 ± 0.092	6.015AlaSer: 6.015 ± 0.083	4.77AlaThr: 4.77 ± 0.077	7.348AlaVal: 7.348 ± 0.084	1.567AlaTrp: 1.567 ± 0.045	2.419AlaTyr: 2.419 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.097CysAla: 1.097 ± 0.038	0.134CysCys: 0.134 ± 0.012	0.524CysAsp: 0.524 ± 0.025	0.573CysGlu: 0.573 ± 0.024	0.369CysPhe: 0.369 ± 0.017	0.961CysGly: 0.961 ± 0.033	0.3CysHis: 0.3 ± 0.019	0.514CysIle: 0.514 ± 0.023	0.272CysLys: 0.272 ± 0.019	1.144CysLeu: 1.144 ± 0.035	0.212CysMet: 0.212 ± 0.013	0.265CysAsn: 0.265 ± 0.015	0.507CysPro: 0.507 ± 0.021	0.401CysGln: 0.401 ± 0.02	0.679CysArg: 0.679 ± 0.025	0.599CysSer: 0.599 ± 0.024	0.443CysThr: 0.443 ± 0.02	0.616CysVal: 0.616 ± 0.024	0.155CysTrp: 0.155 ± 0.012	0.255CysTyr: 0.255 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.505AspAla: 5.505 ± 0.081	0.548AspCys: 0.548 ± 0.023	2.808AspAsp: 2.808 ± 0.052	3.933AspGlu: 3.933 ± 0.064	2.064AspPhe: 2.064 ± 0.045	4.398AspGly: 4.398 ± 0.064	1.095AspHis: 1.095 ± 0.032	2.82AspIle: 2.82 ± 0.059	1.833AspLys: 1.833 ± 0.037	5.824AspLeu: 5.824 ± 0.079	1.309AspMet: 1.309 ± 0.039	1.554AspAsn: 1.554 ± 0.042	2.725AspPro: 2.725 ± 0.051	2.006AspGln: 2.006 ± 0.046	3.189AspArg: 3.189 ± 0.054	2.982AspSer: 2.982 ± 0.054	2.273AspThr: 2.273 ± 0.043	3.384AspVal: 3.384 ± 0.063	0.935AspTrp: 0.935 ± 0.032	1.675AspTyr: 1.675 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	7.315GluAla: 7.315 ± 0.083	0.476GluCys: 0.476 ± 0.021	2.873GluAsp: 2.873 ± 0.051	3.759GluGlu: 3.759 ± 0.075	1.93GluPhe: 1.93 ± 0.047	4.301GluGly: 4.301 ± 0.072	1.721GluHis: 1.721 ± 0.039	3.065GluIle: 3.065 ± 0.062	2.275GluLys: 2.275 ± 0.051	7.84GluLeu: 7.84 ± 0.102	1.536GluMet: 1.536 ± 0.037	1.727GluAsn: 1.727 ± 0.047	2.829GluPro: 2.829 ± 0.056	4.228GluGln: 4.228 ± 0.062	5.555GluArg: 5.555 ± 0.085	2.898GluSer: 2.898 ± 0.051	2.876GluThr: 2.876 ± 0.055	4.521GluVal: 4.521 ± 0.068	0.748GluTrp: 0.748 ± 0.03	1.294GluTyr: 1.294 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.972PheAla: 3.972 ± 0.068	0.444PheCys: 0.444 ± 0.019	2.389PheAsp: 2.389 ± 0.048	2.241PheGlu: 2.241 ± 0.049	1.449PhePhe: 1.449 ± 0.05	3.26PheGly: 3.26 ± 0.063	0.752PheHis: 0.752 ± 0.026	1.918PheIle: 1.918 ± 0.044	1.156PheLys: 1.156 ± 0.033	3.291PheLeu: 3.291 ± 0.058	0.815PheMet: 0.815 ± 0.029	1.294PheAsn: 1.294 ± 0.039	1.418PhePro: 1.418 ± 0.039	1.207PheGln: 1.207 ± 0.034	1.942PheArg: 1.942 ± 0.04	2.467PheSer: 2.467 ± 0.054	1.839PheThr: 1.839 ± 0.043	2.493PheVal: 2.493 ± 0.045	0.562PheTrp: 0.562 ± 0.024	1.023PheTyr: 1.023 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	7.22GlyAla: 7.22 ± 0.097	0.978GlyCys: 0.978 ± 0.034	3.995GlyAsp: 3.995 ± 0.066	5.205GlyGlu: 5.205 ± 0.071	3.329GlyPhe: 3.329 ± 0.059	5.995GlyGly: 5.995 ± 0.106	1.818GlyHis: 1.818 ± 0.037	4.325GlyIle: 4.325 ± 0.063	3.266GlyLys: 3.266 ± 0.065	9.323GlyLeu: 9.323 ± 0.107	2.349GlyMet: 2.349 ± 0.053	2.357GlyAsn: 2.357 ± 0.05	2.509GlyPro: 2.509 ± 0.053	3.508GlyGln: 3.508 ± 0.065	5.108GlyArg: 5.108 ± 0.078	4.587GlySer: 4.587 ± 0.062	3.697GlyThr: 3.697 ± 0.063	5.793GlyVal: 5.793 ± 0.078	1.306GlyTrp: 1.306 ± 0.04	2.354GlyTyr: 2.354 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.295HisAla: 2.295 ± 0.049	0.344HisCys: 0.344 ± 0.018	1.165HisAsp: 1.165 ± 0.032	1.34HisGlu: 1.34 ± 0.034	0.955HisPhe: 0.955 ± 0.031	1.961HisGly: 1.961 ± 0.05	0.59HisHis: 0.59 ± 0.026	1.011HisIle: 1.011 ± 0.03	0.647HisLys: 0.647 ± 0.027	2.527HisLeu: 2.527 ± 0.05	0.519HisMet: 0.519 ± 0.021	0.654HisAsn: 0.654 ± 0.023	1.425HisPro: 1.425 ± 0.04	0.984HisGln: 0.984 ± 0.03	1.382HisArg: 1.382 ± 0.04	1.197HisSer: 1.197 ± 0.031	0.947HisThr: 0.947 ± 0.025	1.279HisVal: 1.279 ± 0.036	0.414HisTrp: 0.414 ± 0.019	0.728HisTyr: 0.728 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.846IleAla: 5.846 ± 0.082	0.515IleCys: 0.515 ± 0.023	3.236IleAsp: 3.236 ± 0.063	3.736IleGlu: 3.736 ± 0.072	1.528IlePhe: 1.528 ± 0.044	4.606IleGly: 4.606 ± 0.083	0.991IleHis: 0.991 ± 0.031	2.178IleIle: 2.178 ± 0.047	1.666IleLys: 1.666 ± 0.043	4.469IleLeu: 4.469 ± 0.079	0.926IleMet: 0.926 ± 0.034	1.696IleAsn: 1.696 ± 0.043	2.279IlePro: 2.279 ± 0.043	1.654IleGln: 1.654 ± 0.036	3.263IleArg: 3.263 ± 0.055	3.012IleSer: 3.012 ± 0.051	2.517IleThr: 2.517 ± 0.05	3.193IleVal: 3.193 ± 0.058	0.524IleTrp: 0.524 ± 0.022	1.178IleTyr: 1.178 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.831LysAla: 3.831 ± 0.07	0.202LysCys: 0.202 ± 0.017	1.569LysAsp: 1.569 ± 0.043	1.674LysGlu: 1.674 ± 0.052	0.862LysPhe: 0.862 ± 0.029	2.461LysGly: 2.461 ± 0.059	0.73LysHis: 0.73 ± 0.028	1.538LysIle: 1.538 ± 0.042	1.266LysLys: 1.266 ± 0.041	3.718LysLeu: 3.718 ± 0.062	0.71LysMet: 0.71 ± 0.024	0.993LysAsn: 0.993 ± 0.035	1.981LysPro: 1.981 ± 0.05	1.594LysGln: 1.594 ± 0.042	2.434LysArg: 2.434 ± 0.048	1.741LysSer: 1.741 ± 0.045	1.709LysThr: 1.709 ± 0.041	2.577LysVal: 2.577 ± 0.051	0.329LysTrp: 0.329 ± 0.017	0.659LysTyr: 0.659 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	14.487LeuAla: 14.487 ± 0.156	1.236LeuCys: 1.236 ± 0.036	6.893LeuAsp: 6.893 ± 0.092	7.252LeuGlu: 7.252 ± 0.099	4.277LeuPhe: 4.277 ± 0.07	9.231LeuGly: 9.231 ± 0.109	2.478LeuHis: 2.478 ± 0.049	5.736LeuIle: 5.736 ± 0.083	4.194LeuLys: 4.194 ± 0.075	14.235LeuLeu: 14.235 ± 0.211	2.626LeuMet: 2.626 ± 0.054	3.511LeuAsn: 3.511 ± 0.061	6.362LeuPro: 6.362 ± 0.085	5.051LeuGln: 5.051 ± 0.083	7.776LeuArg: 7.776 ± 0.113	7.04LeuSer: 7.04 ± 0.092	5.562LeuThr: 5.562 ± 0.074	8.043LeuVal: 8.043 ± 0.102	1.439LeuTrp: 1.439 ± 0.039	2.636LeuTyr: 2.636 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.658MetAla: 2.658 ± 0.053	0.168MetCys: 0.168 ± 0.011	1.1MetAsp: 1.1 ± 0.037	1.057MetGlu: 1.057 ± 0.027	0.678MetPhe: 0.678 ± 0.026	1.723MetGly: 1.723 ± 0.043	0.526MetHis: 0.526 ± 0.022	1.209MetIle: 1.209 ± 0.035	0.91MetLys: 0.91 ± 0.027	3.001MetLeu: 3.001 ± 0.057	0.56MetMet: 0.56 ± 0.024	0.83MetAsn: 0.83 ± 0.022	1.419MetPro: 1.419 ± 0.032	1.149MetGln: 1.149 ± 0.031	1.662MetArg: 1.662 ± 0.039	1.729MetSer: 1.729 ± 0.035	1.446MetThr: 1.446 ± 0.039	1.629MetVal: 1.629 ± 0.044	0.177MetTrp: 0.177 ± 0.013	0.384MetTyr: 0.384 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.078AsnAla: 3.078 ± 0.056	0.29AsnCys: 0.29 ± 0.015	1.467AsnAsp: 1.467 ± 0.037	1.647AsnGlu: 1.647 ± 0.041	1.092AsnPhe: 1.092 ± 0.031	2.411AsnGly: 2.411 ± 0.049	0.647AsnHis: 0.647 ± 0.023	1.487AsnIle: 1.487 ± 0.039	0.91AsnLys: 0.91 ± 0.031	3.536AsnLeu: 3.536 ± 0.06	0.633AsnMet: 0.633 ± 0.025	0.893AsnAsn: 0.893 ± 0.032	1.943AsnPro: 1.943 ± 0.037	1.257AsnGln: 1.257 ± 0.037	2.02AsnArg: 2.02 ± 0.046	1.44AsnSer: 1.44 ± 0.043	1.377AsnThr: 1.377 ± 0.036	1.859AsnVal: 1.859 ± 0.039	0.434AsnTrp: 0.434 ± 0.021	0.76AsnTyr: 0.76 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	5.404ProAla: 5.404 ± 0.093	0.37ProCys: 0.37 ± 0.022	2.797ProAsp: 2.797 ± 0.045	3.795ProGlu: 3.795 ± 0.061	1.788ProPhe: 1.788 ± 0.04	3.873ProGly: 3.873 ± 0.066	1.028ProHis: 1.028 ± 0.031	2.055ProIle: 2.055 ± 0.05	1.421ProLys: 1.421 ± 0.039	5.693ProLeu: 5.693 ± 0.083	1.137ProMet: 1.137 ± 0.026	1.353ProAsn: 1.353 ± 0.038	1.899ProPro: 1.899 ± 0.05	2.218ProGln: 2.218 ± 0.051	2.723ProArg: 2.723 ± 0.047	2.597ProSer: 2.597 ± 0.05	2.12ProThr: 2.12 ± 0.047	3.724ProVal: 3.724 ± 0.063	0.707ProTrp: 0.707 ± 0.025	1.168ProTyr: 1.168 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	5.848GlnAla: 5.848 ± 0.084	0.296GlnCys: 0.296 ± 0.017	1.769GlnAsp: 1.769 ± 0.038	2.171GlnGlu: 2.171 ± 0.053	1.268GlnPhe: 1.268 ± 0.033	3.303GlnGly: 3.303 ± 0.056	1.104GlnHis: 1.104 ± 0.032	2.079GlnIle: 2.079 ± 0.042	1.162GlnLys: 1.162 ± 0.036	5.88GlnLeu: 5.88 ± 0.099	1.097GlnMet: 1.097 ± 0.034	1.12GlnAsn: 1.12 ± 0.039	2.552GlnPro: 2.552 ± 0.047	2.876GlnGln: 2.876 ± 0.069	3.896GlnArg: 3.896 ± 0.063	2.231GlnSer: 2.231 ± 0.05	1.935GlnThr: 1.935 ± 0.045	3.495GlnVal: 3.495 ± 0.053	0.636GlnTrp: 0.636 ± 0.023	0.99GlnTyr: 0.99 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	6.262ArgAla: 6.262 ± 0.076	0.647ArgCys: 0.647 ± 0.028	3.675ArgAsp: 3.675 ± 0.069	4.771ArgGlu: 4.771 ± 0.072	2.831ArgPhe: 2.831 ± 0.053	4.273ArgGly: 4.273 ± 0.069	1.713ArgHis: 1.713 ± 0.046	3.682ArgIle: 3.682 ± 0.063	2.153ArgLys: 2.153 ± 0.048	8.978ArgLeu: 8.978 ± 0.12	1.784ArgMet: 1.784 ± 0.04	2.104ArgAsn: 2.104 ± 0.047	2.866ArgPro: 2.866 ± 0.049	3.705ArgGln: 3.705 ± 0.062	4.639ArgArg: 4.639 ± 0.088	3.624ArgSer: 3.624 ± 0.061	2.799ArgThr: 2.799 ± 0.056	4.617ArgVal: 4.617 ± 0.068	1.077ArgTrp: 1.077 ± 0.038	2.09ArgTyr: 2.09 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.741SerAla: 5.741 ± 0.077	0.53SerCys: 0.53 ± 0.021	2.726SerAsp: 2.726 ± 0.055	3.496SerGlu: 3.496 ± 0.058	2.177SerPhe: 2.177 ± 0.046	5.105SerGly: 5.105 ± 0.072	1.259SerHis: 1.259 ± 0.032	2.793SerIle: 2.793 ± 0.048	1.614SerLys: 1.614 ± 0.041	7.052SerLeu: 7.052 ± 0.1	1.458SerMet: 1.458 ± 0.033	1.669SerAsn: 1.669 ± 0.038	2.564SerPro: 2.564 ± 0.05	2.348SerGln: 2.348 ± 0.054	3.867SerArg: 3.867 ± 0.059	3.383SerSer: 3.383 ± 0.065	2.613SerThr: 2.613 ± 0.055	3.773SerVal: 3.773 ± 0.064	0.822SerTrp: 0.822 ± 0.027	1.358SerTyr: 1.358 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	4.796ThrAla: 4.796 ± 0.075	0.461ThrCys: 0.461 ± 0.022	2.403ThrAsp: 2.403 ± 0.05	2.572ThrGlu: 2.572 ± 0.051	1.637ThrPhe: 1.637 ± 0.044	4.181ThrGly: 4.181 ± 0.07	1.052ThrHis: 1.052 ± 0.027	2.023ThrIle: 2.023 ± 0.042	1.064ThrLys: 1.064 ± 0.03	6.471ThrLeu: 6.471 ± 0.082	0.865ThrMet: 0.865 ± 0.031	1.221ThrAsn: 1.221 ± 0.034	2.936ThrPro: 2.936 ± 0.06	1.873ThrGln: 1.873 ± 0.039	3.183ThrArg: 3.183 ± 0.051	2.549ThrSer: 2.549 ± 0.055	2.258ThrThr: 2.258 ± 0.048	3.136ThrVal: 3.136 ± 0.052	0.586ThrTrp: 0.586 ± 0.023	1.093ThrTyr: 1.093 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	7.378ValAla: 7.378 ± 0.097	0.666ValCys: 0.666 ± 0.026	3.919ValAsp: 3.919 ± 0.061	4.76ValGlu: 4.76 ± 0.07	2.487ValPhe: 2.487 ± 0.056	5.053ValGly: 5.053 ± 0.071	1.434ValHis: 1.434 ± 0.037	3.797ValIle: 3.797 ± 0.069	2.16ValLys: 2.16 ± 0.051	8.093ValLeu: 8.093 ± 0.093	1.772ValMet: 1.772 ± 0.038	2.027ValAsn: 2.027 ± 0.044	3.285ValPro: 3.285 ± 0.056	2.645ValGln: 2.645 ± 0.051	4.577ValArg: 4.577 ± 0.068	4.007ValSer: 4.007 ± 0.052	3.504ValThr: 3.504 ± 0.059	5.481ValVal: 5.481 ± 0.072	0.821ValTrp: 0.821 ± 0.028	1.48ValTyr: 1.48 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.109TrpAla: 1.109 ± 0.03	0.164TrpCys: 0.164 ± 0.013	0.626TrpAsp: 0.626 ± 0.024	0.585TrpGlu: 0.585 ± 0.024	0.52TrpPhe: 0.52 ± 0.023	0.866TrpGly: 0.866 ± 0.025	0.426TrpHis: 0.426 ± 0.019	0.633TrpIle: 0.633 ± 0.025	0.42TrpLys: 0.42 ± 0.021	2.307TrpLeu: 2.307 ± 0.058	0.362TrpMet: 0.362 ± 0.019	0.431TrpAsn: 0.431 ± 0.021	0.68TrpPro: 0.68 ± 0.029	0.89TrpGln: 0.89 ± 0.032	1.092TrpArg: 1.092 ± 0.035	0.753TrpSer: 0.753 ± 0.031	0.571TrpThr: 0.571 ± 0.025	0.863TrpVal: 0.863 ± 0.029	0.232TrpTrp: 0.232 ± 0.017	0.334TrpTyr: 0.334 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.435TyrAla: 2.435 ± 0.047	0.311TyrCys: 0.311 ± 0.018	1.321TyrAsp: 1.321 ± 0.033	1.314TyrGlu: 1.314 ± 0.038	0.974TyrPhe: 0.974 ± 0.029	2.093TyrGly: 2.093 ± 0.047	0.563TyrHis: 0.563 ± 0.024	0.979TyrIle: 0.979 ± 0.031	0.739TyrLys: 0.739 ± 0.027	2.979TyrLeu: 2.979 ± 0.055	0.426TyrMet: 0.426 ± 0.021	0.695TyrAsn: 0.695 ± 0.026	1.263TyrPro: 1.263 ± 0.032	1.246TyrGln: 1.246 ± 0.031	2.028TyrArg: 2.028 ± 0.046	1.496TyrSer: 1.496 ± 0.04	1.1TyrThr: 1.1 ± 0.03	1.519TyrVal: 1.519 ± 0.039	0.395TyrTrp: 0.395 ± 0.02	0.705TyrTyr: 0.705 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3411 proteins (1093476 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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