Amino acid dipepetide frequency for Staphylococcus phage vB_SauS_IMEP5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.607AlaAla: 2.607 ± 0.584
0.298AlaCys: 0.298 ± 0.142
3.277AlaAsp: 3.277 ± 0.518
4.32AlaGlu: 4.32 ± 0.648
2.235AlaPhe: 2.235 ± 0.364
3.575AlaGly: 3.575 ± 0.932
1.043AlaHis: 1.043 ± 0.266
4.171AlaIle: 4.171 ± 0.522
6.182AlaLys: 6.182 ± 0.834
5.14AlaLeu: 5.14 ± 0.635
1.192AlaMet: 1.192 ± 0.492
2.756AlaAsn: 2.756 ± 0.465
1.937AlaPro: 1.937 ± 0.43
1.937AlaGln: 1.937 ± 0.438
1.49AlaArg: 1.49 ± 0.387
3.426AlaSer: 3.426 ± 0.437
3.65AlaThr: 3.65 ± 0.655
4.171AlaVal: 4.171 ± 0.56
0.67AlaTrp: 0.67 ± 0.191
2.309AlaTyr: 2.309 ± 0.462
0.0AlaXaa: 0.0 ± 0.0
Cys
0.223CysAla: 0.223 ± 0.139
0.0CysCys: 0.0 ± 0.0
0.298CysAsp: 0.298 ± 0.141
0.298CysGlu: 0.298 ± 0.174
0.372CysPhe: 0.372 ± 0.173
0.521CysGly: 0.521 ± 0.204
0.223CysHis: 0.223 ± 0.131
0.521CysIle: 0.521 ± 0.243
0.298CysLys: 0.298 ± 0.145
0.447CysLeu: 0.447 ± 0.177
0.074CysMet: 0.074 ± 0.102
0.074CysAsn: 0.074 ± 0.068
0.074CysPro: 0.074 ± 0.073
0.074CysGln: 0.074 ± 0.064
0.223CysArg: 0.223 ± 0.14
0.521CysSer: 0.521 ± 0.231
0.372CysThr: 0.372 ± 0.166
0.521CysVal: 0.521 ± 0.206
0.0CysTrp: 0.0 ± 0.0
0.223CysTyr: 0.223 ± 0.113
0.0CysXaa: 0.0 ± 0.0
Asp
3.054AspAla: 3.054 ± 0.556
0.223AspCys: 0.223 ± 0.116
4.32AspAsp: 4.32 ± 0.65
4.916AspGlu: 4.916 ± 0.94
2.533AspPhe: 2.533 ± 0.472
4.916AspGly: 4.916 ± 0.736
0.67AspHis: 0.67 ± 0.213
5.214AspIle: 5.214 ± 0.527
4.991AspLys: 4.991 ± 0.524
4.469AspLeu: 4.469 ± 0.734
1.788AspMet: 1.788 ± 0.406
5.289AspAsn: 5.289 ± 0.754
2.011AspPro: 2.011 ± 0.296
1.49AspGln: 1.49 ± 0.34
2.16AspArg: 2.16 ± 0.369
3.203AspSer: 3.203 ± 0.473
4.097AspThr: 4.097 ± 0.443
4.842AspVal: 4.842 ± 0.498
0.447AspTrp: 0.447 ± 0.174
3.575AspTyr: 3.575 ± 0.55
0.0AspXaa: 0.0 ± 0.0
Glu
3.575GluAla: 3.575 ± 0.668
0.67GluCys: 0.67 ± 0.229
4.693GluAsp: 4.693 ± 0.75
7.151GluGlu: 7.151 ± 1.235
2.831GluPhe: 2.831 ± 0.442
3.873GluGly: 3.873 ± 0.486
1.192GluHis: 1.192 ± 0.271
4.618GluIle: 4.618 ± 0.632
6.331GluLys: 6.331 ± 0.83
7.523GluLeu: 7.523 ± 1.169
2.682GluMet: 2.682 ± 0.516
4.544GluAsn: 4.544 ± 0.686
2.235GluPro: 2.235 ± 0.573
3.575GluGln: 3.575 ± 0.631
3.501GluArg: 3.501 ± 0.742
3.501GluSer: 3.501 ± 0.473
4.395GluThr: 4.395 ± 0.586
5.363GluVal: 5.363 ± 1.041
0.745GluTrp: 0.745 ± 0.262
3.128GluTyr: 3.128 ± 0.625
0.0GluXaa: 0.0 ± 0.0
Phe
2.011PheAla: 2.011 ± 0.47
0.149PheCys: 0.149 ± 0.099
2.384PheAsp: 2.384 ± 0.442
1.937PheGlu: 1.937 ± 0.312
1.788PhePhe: 1.788 ± 0.381
2.458PheGly: 2.458 ± 0.402
0.372PheHis: 0.372 ± 0.155
2.384PheIle: 2.384 ± 0.496
4.395PheLys: 4.395 ± 0.62
2.905PheLeu: 2.905 ± 0.392
1.266PheMet: 1.266 ± 0.341
3.352PheAsn: 3.352 ± 0.463
0.819PhePro: 0.819 ± 0.255
1.341PheGln: 1.341 ± 0.261
1.341PheArg: 1.341 ± 0.37
2.533PheSer: 2.533 ± 0.368
2.831PheThr: 2.831 ± 0.5
2.235PheVal: 2.235 ± 0.399
0.223PheTrp: 0.223 ± 0.121
2.533PheTyr: 2.533 ± 0.546
0.0PheXaa: 0.0 ± 0.0
Gly
3.501GlyAla: 3.501 ± 0.945
0.074GlyCys: 0.074 ± 0.077
3.054GlyAsp: 3.054 ± 0.564
4.097GlyGlu: 4.097 ± 0.593
3.575GlyPhe: 3.575 ± 0.551
4.246GlyGly: 4.246 ± 1.348
1.341GlyHis: 1.341 ± 0.341
4.32GlyIle: 4.32 ± 0.741
6.034GlyLys: 6.034 ± 0.727
5.512GlyLeu: 5.512 ± 0.721
2.086GlyMet: 2.086 ± 0.679
4.246GlyAsn: 4.246 ± 0.471
1.713GlyPro: 1.713 ± 0.451
3.277GlyGln: 3.277 ± 0.457
2.533GlyArg: 2.533 ± 0.433
4.097GlySer: 4.097 ± 0.717
3.799GlyThr: 3.799 ± 0.613
4.246GlyVal: 4.246 ± 1.165
1.192GlyTrp: 1.192 ± 0.327
3.054GlyTyr: 3.054 ± 0.438
0.0GlyXaa: 0.0 ± 0.0
His
0.745HisAla: 0.745 ± 0.229
0.149HisCys: 0.149 ± 0.109
0.745HisAsp: 0.745 ± 0.242
0.596HisGlu: 0.596 ± 0.223
1.117HisPhe: 1.117 ± 0.338
1.117HisGly: 1.117 ± 0.298
0.223HisHis: 0.223 ± 0.153
0.894HisIle: 0.894 ± 0.262
1.564HisLys: 1.564 ± 0.346
1.639HisLeu: 1.639 ± 0.34
0.521HisMet: 0.521 ± 0.19
0.67HisAsn: 0.67 ± 0.204
0.67HisPro: 0.67 ± 0.17
0.521HisGln: 0.521 ± 0.183
0.596HisArg: 0.596 ± 0.27
0.67HisSer: 0.67 ± 0.199
1.266HisThr: 1.266 ± 0.352
1.117HisVal: 1.117 ± 0.317
0.149HisTrp: 0.149 ± 0.104
0.894HisTyr: 0.894 ± 0.255
0.0HisXaa: 0.0 ± 0.0
Ile
4.097IleAla: 4.097 ± 0.463
0.223IleCys: 0.223 ± 0.127
5.438IleAsp: 5.438 ± 0.808
7.3IleGlu: 7.3 ± 1.053
2.384IlePhe: 2.384 ± 0.639
3.799IleGly: 3.799 ± 0.564
0.968IleHis: 0.968 ± 0.303
3.948IleIle: 3.948 ± 0.515
8.194IleLys: 8.194 ± 0.82
2.607IleLeu: 2.607 ± 0.438
1.713IleMet: 1.713 ± 0.391
4.171IleAsn: 4.171 ± 0.487
2.384IlePro: 2.384 ± 0.421
2.831IleGln: 2.831 ± 0.479
2.607IleArg: 2.607 ± 0.394
4.618IleSer: 4.618 ± 0.529
4.469IleThr: 4.469 ± 0.692
3.203IleVal: 3.203 ± 0.426
1.341IleTrp: 1.341 ± 0.627
2.756IleTyr: 2.756 ± 0.638
0.0IleXaa: 0.0 ± 0.0
Lys
6.108LysAla: 6.108 ± 0.682
0.745LysCys: 0.745 ± 0.302
6.331LysAsp: 6.331 ± 0.792
8.268LysGlu: 8.268 ± 1.031
2.533LysPhe: 2.533 ± 0.461
7.449LysGly: 7.449 ± 1.149
1.788LysHis: 1.788 ± 0.459
5.512LysIle: 5.512 ± 0.648
8.641LysLys: 8.641 ± 1.21
6.182LysLeu: 6.182 ± 0.85
1.713LysMet: 1.713 ± 0.432
7.747LysAsn: 7.747 ± 0.874
2.831LysPro: 2.831 ± 0.493
3.724LysGln: 3.724 ± 0.61
4.171LysArg: 4.171 ± 0.65
4.618LysSer: 4.618 ± 0.748
6.108LysThr: 6.108 ± 0.827
5.363LysVal: 5.363 ± 0.719
1.043LysTrp: 1.043 ± 0.373
3.799LysTyr: 3.799 ± 0.666
0.0LysXaa: 0.0 ± 0.0
Leu
4.32LeuAla: 4.32 ± 0.742
0.298LeuCys: 0.298 ± 0.143
4.991LeuAsp: 4.991 ± 0.705
5.065LeuGlu: 5.065 ± 0.852
2.756LeuPhe: 2.756 ± 0.618
3.799LeuGly: 3.799 ± 0.643
1.415LeuHis: 1.415 ± 0.371
6.48LeuIle: 6.48 ± 0.653
6.778LeuLys: 6.778 ± 0.712
5.289LeuLeu: 5.289 ± 0.79
2.235LeuMet: 2.235 ± 0.39
5.736LeuAsn: 5.736 ± 0.765
2.309LeuPro: 2.309 ± 0.397
2.533LeuGln: 2.533 ± 0.446
3.352LeuArg: 3.352 ± 0.59
5.214LeuSer: 5.214 ± 0.684
4.693LeuThr: 4.693 ± 0.526
4.097LeuVal: 4.097 ± 0.553
0.521LeuTrp: 0.521 ± 0.221
3.277LeuTyr: 3.277 ± 0.577
0.0LeuXaa: 0.0 ± 0.0
Met
2.607MetAla: 2.607 ± 0.598
0.0MetCys: 0.0 ± 0.0
1.788MetAsp: 1.788 ± 0.354
1.192MetGlu: 1.192 ± 0.328
0.894MetPhe: 0.894 ± 0.239
1.341MetGly: 1.341 ± 0.548
0.298MetHis: 0.298 ± 0.138
1.564MetIle: 1.564 ± 0.345
2.831MetLys: 2.831 ± 0.45
1.415MetLeu: 1.415 ± 0.293
0.298MetMet: 0.298 ± 0.134
2.533MetAsn: 2.533 ± 0.387
0.894MetPro: 0.894 ± 0.248
0.968MetGln: 0.968 ± 0.235
0.894MetArg: 0.894 ± 0.235
1.937MetSer: 1.937 ± 0.373
2.086MetThr: 2.086 ± 0.31
1.266MetVal: 1.266 ± 0.387
0.298MetTrp: 0.298 ± 0.131
1.415MetTyr: 1.415 ± 0.354
0.0MetXaa: 0.0 ± 0.0
Asn
4.916AsnAla: 4.916 ± 0.585
0.149AsnCys: 0.149 ± 0.109
4.171AsnAsp: 4.171 ± 0.702
6.182AsnGlu: 6.182 ± 0.811
3.128AsnPhe: 3.128 ± 0.499
6.034AsnGly: 6.034 ± 0.817
0.894AsnHis: 0.894 ± 0.269
4.842AsnIle: 4.842 ± 0.761
6.331AsnLys: 6.331 ± 0.847
5.065AsnLeu: 5.065 ± 0.47
1.415AsnMet: 1.415 ± 0.369
4.767AsnAsn: 4.767 ± 0.627
2.011AsnPro: 2.011 ± 0.372
1.788AsnGln: 1.788 ± 0.409
2.533AsnArg: 2.533 ± 0.421
2.607AsnSer: 2.607 ± 0.444
4.022AsnThr: 4.022 ± 0.622
4.469AsnVal: 4.469 ± 0.674
0.819AsnTrp: 0.819 ± 0.251
2.384AsnTyr: 2.384 ± 0.577
0.0AsnXaa: 0.0 ± 0.0
Pro
1.266ProAla: 1.266 ± 0.317
0.074ProCys: 0.074 ± 0.077
2.011ProAsp: 2.011 ± 0.432
2.831ProGlu: 2.831 ± 0.667
1.043ProPhe: 1.043 ± 0.346
1.341ProGly: 1.341 ± 0.367
0.67ProHis: 0.67 ± 0.214
2.011ProIle: 2.011 ± 0.382
3.054ProLys: 3.054 ± 0.422
2.011ProLeu: 2.011 ± 0.563
1.043ProMet: 1.043 ± 0.309
2.16ProAsn: 2.16 ± 0.473
1.117ProPro: 1.117 ± 0.294
0.968ProGln: 0.968 ± 0.293
1.266ProArg: 1.266 ± 0.382
1.639ProSer: 1.639 ± 0.365
2.011ProThr: 2.011 ± 0.403
1.937ProVal: 1.937 ± 0.519
0.0ProTrp: 0.0 ± 0.0
1.117ProTyr: 1.117 ± 0.284
0.0ProXaa: 0.0 ± 0.0
Gln
2.384GlnAla: 2.384 ± 0.379
0.372GlnCys: 0.372 ± 0.152
1.937GlnAsp: 1.937 ± 0.4
2.682GlnGlu: 2.682 ± 0.63
1.937GlnPhe: 1.937 ± 0.432
2.98GlnGly: 2.98 ± 0.7
0.596GlnHis: 0.596 ± 0.244
2.905GlnIle: 2.905 ± 0.365
2.756GlnLys: 2.756 ± 0.423
3.724GlnLeu: 3.724 ± 0.444
1.117GlnMet: 1.117 ± 0.372
2.309GlnAsn: 2.309 ± 0.412
0.819GlnPro: 0.819 ± 0.262
1.415GlnGln: 1.415 ± 0.435
1.266GlnArg: 1.266 ± 0.267
2.086GlnSer: 2.086 ± 0.488
1.788GlnThr: 1.788 ± 0.52
1.788GlnVal: 1.788 ± 0.39
0.447GlnTrp: 0.447 ± 0.149
1.937GlnTyr: 1.937 ± 0.412
0.0GlnXaa: 0.0 ± 0.0
Arg
1.937ArgAla: 1.937 ± 0.391
0.223ArgCys: 0.223 ± 0.152
2.533ArgAsp: 2.533 ± 0.478
2.458ArgGlu: 2.458 ± 0.649
1.49ArgPhe: 1.49 ± 0.348
2.831ArgGly: 2.831 ± 0.565
0.596ArgHis: 0.596 ± 0.221
2.235ArgIle: 2.235 ± 0.448
3.799ArgLys: 3.799 ± 0.702
3.575ArgLeu: 3.575 ± 0.441
0.968ArgMet: 0.968 ± 0.298
2.98ArgAsn: 2.98 ± 0.428
1.266ArgPro: 1.266 ± 0.341
1.937ArgGln: 1.937 ± 0.406
1.788ArgArg: 1.788 ± 0.31
1.937ArgSer: 1.937 ± 0.364
2.235ArgThr: 2.235 ± 0.443
2.384ArgVal: 2.384 ± 0.332
0.223ArgTrp: 0.223 ± 0.119
1.49ArgTyr: 1.49 ± 0.418
0.0ArgXaa: 0.0 ± 0.0
Ser
2.011SerAla: 2.011 ± 0.437
0.596SerCys: 0.596 ± 0.25
4.693SerAsp: 4.693 ± 0.689
3.575SerGlu: 3.575 ± 0.431
2.607SerPhe: 2.607 ± 0.426
3.948SerGly: 3.948 ± 0.865
1.117SerHis: 1.117 ± 0.324
3.873SerIle: 3.873 ± 0.668
5.14SerLys: 5.14 ± 0.766
4.022SerLeu: 4.022 ± 0.672
1.415SerMet: 1.415 ± 0.338
3.203SerAsn: 3.203 ± 0.589
1.713SerPro: 1.713 ± 0.356
2.16SerGln: 2.16 ± 0.546
2.235SerArg: 2.235 ± 0.395
3.426SerSer: 3.426 ± 0.552
4.022SerThr: 4.022 ± 0.668
4.32SerVal: 4.32 ± 0.489
1.043SerTrp: 1.043 ± 0.274
2.533SerTyr: 2.533 ± 0.555
0.0SerXaa: 0.0 ± 0.0
Thr
3.575ThrAla: 3.575 ± 0.722
0.298ThrCys: 0.298 ± 0.16
4.32ThrAsp: 4.32 ± 0.751
3.799ThrGlu: 3.799 ± 0.63
2.756ThrPhe: 2.756 ± 0.448
5.065ThrGly: 5.065 ± 0.947
0.67ThrHis: 0.67 ± 0.256
4.916ThrIle: 4.916 ± 0.7
5.959ThrLys: 5.959 ± 0.781
4.916ThrLeu: 4.916 ± 0.651
1.266ThrMet: 1.266 ± 0.327
3.724ThrAsn: 3.724 ± 0.57
2.309ThrPro: 2.309 ± 0.372
2.011ThrGln: 2.011 ± 0.37
2.16ThrArg: 2.16 ± 0.443
3.948ThrSer: 3.948 ± 0.524
3.724ThrThr: 3.724 ± 0.538
5.065ThrVal: 5.065 ± 0.929
0.596ThrTrp: 0.596 ± 0.177
2.384ThrTyr: 2.384 ± 0.527
0.0ThrXaa: 0.0 ± 0.0
Val
4.246ValAla: 4.246 ± 0.718
0.298ValCys: 0.298 ± 0.179
4.246ValAsp: 4.246 ± 0.674
5.214ValGlu: 5.214 ± 0.624
1.862ValPhe: 1.862 ± 0.394
3.128ValGly: 3.128 ± 0.77
0.745ValHis: 0.745 ± 0.261
4.469ValIle: 4.469 ± 0.699
5.885ValLys: 5.885 ± 0.65
4.097ValLeu: 4.097 ± 0.79
2.086ValMet: 2.086 ± 0.511
4.395ValAsn: 4.395 ± 0.625
1.192ValPro: 1.192 ± 0.319
2.16ValGln: 2.16 ± 0.346
2.533ValArg: 2.533 ± 0.397
4.842ValSer: 4.842 ± 0.504
5.587ValThr: 5.587 ± 1.025
3.277ValVal: 3.277 ± 0.617
0.67ValTrp: 0.67 ± 0.182
1.639ValTyr: 1.639 ± 0.444
0.0ValXaa: 0.0 ± 0.0
Trp
0.819TrpAla: 0.819 ± 0.311
0.0TrpCys: 0.0 ± 0.0
0.67TrpAsp: 0.67 ± 0.203
0.596TrpGlu: 0.596 ± 0.218
0.447TrpPhe: 0.447 ± 0.186
0.745TrpGly: 0.745 ± 0.304
0.223TrpHis: 0.223 ± 0.131
0.819TrpIle: 0.819 ± 0.249
0.968TrpLys: 0.968 ± 0.338
1.043TrpLeu: 1.043 ± 0.345
0.149TrpMet: 0.149 ± 0.094
0.819TrpAsn: 0.819 ± 0.414
0.223TrpPro: 0.223 ± 0.106
0.745TrpGln: 0.745 ± 0.216
0.521TrpArg: 0.521 ± 0.192
0.67TrpSer: 0.67 ± 0.234
0.521TrpThr: 0.521 ± 0.294
0.745TrpVal: 0.745 ± 0.311
0.298TrpTrp: 0.298 ± 0.175
0.298TrpTyr: 0.298 ± 0.133
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.384TyrAla: 2.384 ± 0.36
0.521TyrCys: 0.521 ± 0.183
2.384TyrAsp: 2.384 ± 0.549
3.65TyrGlu: 3.65 ± 0.59
0.968TyrPhe: 0.968 ± 0.279
2.831TyrGly: 2.831 ± 0.438
0.819TyrHis: 0.819 ± 0.244
3.352TyrIle: 3.352 ± 0.623
4.544TyrLys: 4.544 ± 0.826
3.575TyrLeu: 3.575 ± 0.753
1.415TyrMet: 1.415 ± 0.382
3.054TyrAsn: 3.054 ± 0.585
1.043TyrPro: 1.043 ± 0.262
1.788TyrGln: 1.788 ± 0.334
1.713TyrArg: 1.713 ± 0.416
2.16TyrSer: 2.16 ± 0.366
1.788TyrThr: 1.788 ± 0.331
2.16TyrVal: 2.16 ± 0.482
0.596TyrTrp: 0.596 ± 0.327
1.415TyrTyr: 1.415 ± 0.346
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 67 proteins (13426 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski