Amino acid dipepetide frequency for Lasiodiplodia theobromae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.412AlaAla: 12.412 ± 0.085	1.131AlaCys: 1.131 ± 0.016	5.102AlaAsp: 5.102 ± 0.037	5.877AlaGlu: 5.877 ± 0.042	3.389AlaPhe: 3.389 ± 0.022	6.807AlaGly: 6.807 ± 0.048	1.993AlaHis: 1.993 ± 0.02	4.146AlaIle: 4.146 ± 0.027	4.259AlaLys: 4.259 ± 0.033	8.468AlaLeu: 8.468 ± 0.048	2.04AlaMet: 2.04 ± 0.019	3.173AlaAsn: 3.173 ± 0.024	5.586AlaPro: 5.586 ± 0.046	3.707AlaGln: 3.707 ± 0.031	5.453AlaArg: 5.453 ± 0.038	7.812AlaSer: 7.812 ± 0.051	5.842AlaThr: 5.842 ± 0.043	6.178AlaVal: 6.178 ± 0.043	1.333AlaTrp: 1.333 ± 0.015	2.404AlaTyr: 2.404 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	1.025CysAla: 1.025 ± 0.012	0.24CysCys: 0.24 ± 0.008	0.632CysAsp: 0.632 ± 0.011	0.595CysGlu: 0.595 ± 0.011	0.5CysPhe: 0.5 ± 0.009	0.966CysGly: 0.966 ± 0.016	0.282CysHis: 0.282 ± 0.007	0.615CysIle: 0.615 ± 0.01	0.473CysLys: 0.473 ± 0.009	1.099CysLeu: 1.099 ± 0.015	0.266CysMet: 0.266 ± 0.007	0.41CysAsn: 0.41 ± 0.009	0.617CysPro: 0.617 ± 0.013	0.383CysGln: 0.383 ± 0.008	0.713CysArg: 0.713 ± 0.012	0.836CysSer: 0.836 ± 0.013	0.689CysThr: 0.689 ± 0.011	0.805CysVal: 0.805 ± 0.012	0.205CysTrp: 0.205 ± 0.006	0.347CysTyr: 0.347 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	5.674AspAla: 5.674 ± 0.036	0.619AspCys: 0.619 ± 0.012	4.895AspAsp: 4.895 ± 0.048	4.782AspGlu: 4.782 ± 0.037	2.247AspPhe: 2.247 ± 0.021	4.526AspGly: 4.526 ± 0.027	1.179AspHis: 1.179 ± 0.017	2.74AspIle: 2.74 ± 0.022	2.291AspLys: 2.291 ± 0.024	4.801AspLeu: 4.801 ± 0.033	1.214AspMet: 1.214 ± 0.014	1.795AspAsn: 1.795 ± 0.021	3.454AspPro: 3.454 ± 0.027	1.811AspGln: 1.811 ± 0.019	2.996AspArg: 2.996 ± 0.028	3.945AspSer: 3.945 ± 0.032	2.826AspThr: 2.826 ± 0.024	4.02AspVal: 4.02 ± 0.029	0.942AspTrp: 0.942 ± 0.013	1.65AspTyr: 1.65 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	5.855GluAla: 5.855 ± 0.042	0.605GluCys: 0.605 ± 0.012	4.324GluAsp: 4.324 ± 0.034	6.051GluGlu: 6.051 ± 0.054	1.863GluPhe: 1.863 ± 0.018	4.172GluGly: 4.172 ± 0.036	1.416GluHis: 1.416 ± 0.014	2.72GluIle: 2.72 ± 0.028	3.836GluLys: 3.836 ± 0.036	5.239GluLeu: 5.239 ± 0.04	1.518GluMet: 1.518 ± 0.016	2.157GluAsn: 2.157 ± 0.019	2.817GluPro: 2.817 ± 0.034	2.641GluGln: 2.641 ± 0.028	4.279GluArg: 4.279 ± 0.034	3.869GluSer: 3.869 ± 0.032	3.253GluThr: 3.253 ± 0.025	3.667GluVal: 3.667 ± 0.023	0.963GluTrp: 0.963 ± 0.012	1.622GluTyr: 1.622 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.363PheAla: 3.363 ± 0.024	0.53PheCys: 0.53 ± 0.01	2.343PheAsp: 2.343 ± 0.021	2.128PheGlu: 2.128 ± 0.02	1.65PhePhe: 1.65 ± 0.021	2.909PheGly: 2.909 ± 0.026	0.849PheHis: 0.849 ± 0.013	1.612PheIle: 1.612 ± 0.018	1.445PheLys: 1.445 ± 0.018	3.265PheLeu: 3.265 ± 0.026	0.74PheMet: 0.74 ± 0.012	1.378PheAsn: 1.378 ± 0.015	1.918PhePro: 1.918 ± 0.02	1.26PheGln: 1.26 ± 0.014	1.889PheArg: 1.889 ± 0.02	2.823PheSer: 2.823 ± 0.023	2.134PheThr: 2.134 ± 0.031	2.506PheVal: 2.506 ± 0.025	0.661PheTrp: 0.661 ± 0.012	1.084PheTyr: 1.084 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	6.374GlyAla: 6.374 ± 0.037	0.897GlyCys: 0.897 ± 0.014	3.873GlyAsp: 3.873 ± 0.032	4.101GlyGlu: 4.101 ± 0.028	2.871GlyPhe: 2.871 ± 0.023	7.161GlyGly: 7.161 ± 0.068	1.638GlyHis: 1.638 ± 0.019	3.302GlyIle: 3.302 ± 0.028	3.412GlyLys: 3.412 ± 0.028	6.075GlyLeu: 6.075 ± 0.058	1.66GlyMet: 1.66 ± 0.024	2.514GlyAsn: 2.514 ± 0.02	3.466GlyPro: 3.466 ± 0.031	2.474GlyGln: 2.474 ± 0.023	4.263GlyArg: 4.263 ± 0.033	5.95GlySer: 5.95 ± 0.051	4.096GlyThr: 4.096 ± 0.046	4.761GlyVal: 4.761 ± 0.036	1.272GlyTrp: 1.272 ± 0.016	2.144GlyTyr: 2.144 ± 0.021	0.0GlyXaa: 0.0 ± 0.0
His	2.116HisAla: 2.116 ± 0.021	0.312HisCys: 0.312 ± 0.008	1.31HisAsp: 1.31 ± 0.017	1.313HisGlu: 1.313 ± 0.013	0.926HisPhe: 0.926 ± 0.013	1.715HisGly: 1.715 ± 0.016	1.003HisHis: 1.003 ± 0.02	1.045HisIle: 1.045 ± 0.013	0.846HisLys: 0.846 ± 0.013	2.117HisLeu: 2.117 ± 0.02	0.456HisMet: 0.456 ± 0.009	0.789HisAsn: 0.789 ± 0.012	1.653HisPro: 1.653 ± 0.019	0.969HisGln: 0.969 ± 0.014	1.517HisArg: 1.517 ± 0.02	1.669HisSer: 1.669 ± 0.019	1.223HisThr: 1.223 ± 0.016	1.45HisVal: 1.45 ± 0.016	0.348HisTrp: 0.348 ± 0.009	0.692HisTyr: 0.692 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.124IleAla: 4.124 ± 0.029	0.643IleCys: 0.643 ± 0.011	2.654IleAsp: 2.654 ± 0.023	2.597IleGlu: 2.597 ± 0.022	1.782IlePhe: 1.782 ± 0.019	3.002IleGly: 3.002 ± 0.023	1.056IleHis: 1.056 ± 0.013	2.176IleIle: 2.176 ± 0.023	1.965IleLys: 1.965 ± 0.019	3.944IleLeu: 3.944 ± 0.028	0.911IleMet: 0.911 ± 0.012	1.625IleAsn: 1.625 ± 0.018	2.76IlePro: 2.76 ± 0.026	1.6IleGln: 1.6 ± 0.017	2.492IleArg: 2.492 ± 0.019	3.296IleSer: 3.296 ± 0.025	2.688IleThr: 2.688 ± 0.041	3.007IleVal: 3.007 ± 0.028	0.672IleTrp: 0.672 ± 0.01	1.246IleTyr: 1.246 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	4.347LysAla: 4.347 ± 0.038	0.455LysCys: 0.455 ± 0.009	2.739LysAsp: 2.739 ± 0.028	3.396LysGlu: 3.396 ± 0.032	1.372LysPhe: 1.372 ± 0.016	2.944LysGly: 2.944 ± 0.028	1.097LysHis: 1.097 ± 0.015	1.99LysIle: 1.99 ± 0.023	3.491LysLys: 3.491 ± 0.046	3.843LysLeu: 3.843 ± 0.033	0.989LysMet: 0.989 ± 0.013	1.634LysAsn: 1.634 ± 0.019	2.625LysPro: 2.625 ± 0.03	1.802LysGln: 1.802 ± 0.019	3.357LysArg: 3.357 ± 0.026	3.056LysSer: 3.056 ± 0.027	2.628LysThr: 2.628 ± 0.023	2.7LysVal: 2.7 ± 0.022	0.656LysTrp: 0.656 ± 0.01	1.269LysTyr: 1.269 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	8.277LeuAla: 8.277 ± 0.047	1.144LeuCys: 1.144 ± 0.016	5.06LeuAsp: 5.06 ± 0.028	5.318LeuGlu: 5.318 ± 0.042	3.221LeuPhe: 3.221 ± 0.027	5.799LeuGly: 5.799 ± 0.034	2.217LeuHis: 2.217 ± 0.022	3.489LeuIle: 3.489 ± 0.03	3.897LeuLys: 3.897 ± 0.033	8.082LeuLeu: 8.082 ± 0.046	1.707LeuMet: 1.707 ± 0.018	2.944LeuAsn: 2.944 ± 0.022	5.527LeuPro: 5.527 ± 0.065	3.566LeuGln: 3.566 ± 0.03	5.771LeuArg: 5.771 ± 0.034	6.727LeuSer: 6.727 ± 0.036	4.641LeuThr: 4.641 ± 0.036	5.361LeuVal: 5.361 ± 0.034	1.205LeuTrp: 1.205 ± 0.015	2.242LeuTyr: 2.242 ± 0.019	0.0LeuXaa: 0.0 ± 0.0
Met	2.279MetAla: 2.279 ± 0.021	0.224MetCys: 0.224 ± 0.006	1.248MetAsp: 1.248 ± 0.016	1.255MetGlu: 1.255 ± 0.016	0.711MetPhe: 0.711 ± 0.012	1.461MetGly: 1.461 ± 0.019	0.503MetHis: 0.503 ± 0.01	0.876MetIle: 0.876 ± 0.013	0.959MetLys: 0.959 ± 0.01	1.811MetLeu: 1.811 ± 0.018	0.55MetMet: 0.55 ± 0.011	0.74MetAsn: 0.74 ± 0.011	1.293MetPro: 1.293 ± 0.018	0.855MetGln: 0.855 ± 0.013	1.315MetArg: 1.315 ± 0.015	1.697MetSer: 1.697 ± 0.018	1.213MetThr: 1.213 ± 0.012	1.275MetVal: 1.275 ± 0.014	0.286MetTrp: 0.286 ± 0.008	0.505MetTyr: 0.505 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.369AsnAla: 3.369 ± 0.023	0.413AsnCys: 0.413 ± 0.009	1.972AsnAsp: 1.972 ± 0.02	1.92AsnGlu: 1.92 ± 0.018	1.347AsnPhe: 1.347 ± 0.016	3.06AsnGly: 3.06 ± 0.028	0.782AsnHis: 0.782 ± 0.012	1.804AsnIle: 1.804 ± 0.02	1.467AsnLys: 1.467 ± 0.018	2.944AsnLeu: 2.944 ± 0.026	0.775AsnMet: 0.775 ± 0.012	1.556AsnAsn: 1.556 ± 0.024	2.298AsnPro: 2.298 ± 0.021	1.189AsnGln: 1.189 ± 0.015	1.775AsnArg: 1.775 ± 0.019	2.54AsnSer: 2.54 ± 0.022	2.096AsnThr: 2.096 ± 0.023	2.269AsnVal: 2.269 ± 0.02	0.54AsnTrp: 0.54 ± 0.011	1.019AsnTyr: 1.019 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	6.221ProAla: 6.221 ± 0.051	0.476ProCys: 0.476 ± 0.01	3.408ProAsp: 3.408 ± 0.026	3.796ProGlu: 3.796 ± 0.036	2.075ProPhe: 2.075 ± 0.024	4.095ProGly: 4.095 ± 0.042	1.412ProHis: 1.412 ± 0.018	2.281ProIle: 2.281 ± 0.021	2.523ProLys: 2.523 ± 0.024	4.731ProLeu: 4.731 ± 0.028	1.038ProMet: 1.038 ± 0.013	2.069ProAsn: 2.069 ± 0.02	5.836ProPro: 5.836 ± 0.073	2.509ProGln: 2.509 ± 0.029	3.382ProArg: 3.382 ± 0.033	5.899ProSer: 5.899 ± 0.067	4.102ProThr: 4.102 ± 0.076	3.603ProVal: 3.603 ± 0.033	0.759ProTrp: 0.759 ± 0.011	1.542ProTyr: 1.542 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.551GlnAla: 3.551 ± 0.03	0.395GlnCys: 0.395 ± 0.009	1.972GlnAsp: 1.972 ± 0.02	2.36GlnGlu: 2.36 ± 0.022	1.165GlnPhe: 1.165 ± 0.015	2.261GlnGly: 2.261 ± 0.024	1.148GlnHis: 1.148 ± 0.018	1.61GlnIle: 1.61 ± 0.015	1.871GlnLys: 1.871 ± 0.022	3.347GlnLeu: 3.347 ± 0.025	0.881GlnMet: 0.881 ± 0.015	1.404GlnAsn: 1.404 ± 0.018	2.672GlnPro: 2.672 ± 0.032	2.88GlnGln: 2.88 ± 0.05	2.676GlnArg: 2.676 ± 0.024	2.755GlnSer: 2.755 ± 0.026	2.162GlnThr: 2.162 ± 0.018	2.025GlnVal: 2.025 ± 0.019	0.577GlnTrp: 0.577 ± 0.01	1.084GlnTyr: 1.084 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	5.235ArgAla: 5.235 ± 0.031	0.703ArgCys: 0.703 ± 0.012	3.375ArgAsp: 3.375 ± 0.027	3.956ArgGlu: 3.956 ± 0.033	2.134ArgPhe: 2.134 ± 0.019	3.88ArgGly: 3.88 ± 0.036	1.5ArgHis: 1.5 ± 0.017	2.712ArgIle: 2.712 ± 0.021	3.398ArgLys: 3.398 ± 0.028	5.409ArgLeu: 5.409 ± 0.034	1.331ArgMet: 1.331 ± 0.016	2.175ArgAsn: 2.175 ± 0.022	3.488ArgPro: 3.488 ± 0.032	2.47ArgGln: 2.47 ± 0.023	5.248ArgArg: 5.248 ± 0.049	4.479ArgSer: 4.479 ± 0.039	3.283ArgThr: 3.283 ± 0.025	3.473ArgVal: 3.473 ± 0.028	1.013ArgTrp: 1.013 ± 0.014	1.607ArgTyr: 1.607 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	7.419SerAla: 7.419 ± 0.059	0.778SerCys: 0.778 ± 0.012	4.096SerAsp: 4.096 ± 0.032	3.885SerGlu: 3.885 ± 0.033	2.841SerPhe: 2.841 ± 0.023	5.769SerGly: 5.769 ± 0.083	1.686SerHis: 1.686 ± 0.018	3.544SerIle: 3.544 ± 0.029	3.233SerLys: 3.233 ± 0.028	6.456SerLeu: 6.456 ± 0.041	1.54SerMet: 1.54 ± 0.016	2.859SerAsn: 2.859 ± 0.028	5.404SerPro: 5.404 ± 0.054	2.802SerGln: 2.802 ± 0.024	4.473SerArg: 4.473 ± 0.039	9.102SerSer: 9.102 ± 0.076	5.523SerThr: 5.523 ± 0.05	4.424SerVal: 4.424 ± 0.027	1.089SerTrp: 1.089 ± 0.015	1.993SerTyr: 1.993 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.94ThrAla: 5.94 ± 0.05	0.696ThrCys: 0.696 ± 0.012	2.894ThrAsp: 2.894 ± 0.022	2.928ThrGlu: 2.928 ± 0.025	2.224ThrPhe: 2.224 ± 0.02	4.208ThrGly: 4.208 ± 0.054	1.251ThrHis: 1.251 ± 0.015	2.873ThrIle: 2.873 ± 0.033	2.384ThrLys: 2.384 ± 0.021	5.089ThrLeu: 5.089 ± 0.038	1.118ThrMet: 1.118 ± 0.013	2.095ThrAsn: 2.095 ± 0.019	4.491ThrPro: 4.491 ± 0.05	1.959ThrGln: 1.959 ± 0.019	2.973ThrArg: 2.973 ± 0.023	5.073ThrSer: 5.073 ± 0.053	4.791ThrThr: 4.791 ± 0.071	3.795ThrVal: 3.795 ± 0.037	0.865ThrTrp: 0.865 ± 0.012	1.621ThrTyr: 1.621 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	5.889ValAla: 5.889 ± 0.037	0.828ValCys: 0.828 ± 0.012	3.876ValAsp: 3.876 ± 0.026	4.18ValGlu: 4.18 ± 0.033	2.462ValPhe: 2.462 ± 0.021	4.396ValGly: 4.396 ± 0.029	1.364ValHis: 1.364 ± 0.015	2.714ValIle: 2.714 ± 0.027	2.82ValLys: 2.82 ± 0.026	5.624ValLeu: 5.624 ± 0.034	1.336ValMet: 1.336 ± 0.015	2.148ValAsn: 2.148 ± 0.019	3.73ValPro: 3.73 ± 0.043	2.34ValGln: 2.34 ± 0.019	3.705ValArg: 3.705 ± 0.029	4.415ValSer: 4.415 ± 0.032	3.455ValThr: 3.455 ± 0.04	4.798ValVal: 4.798 ± 0.039	0.942ValTrp: 0.942 ± 0.013	1.721ValTyr: 1.721 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.265TrpAla: 1.265 ± 0.015	0.21TrpCys: 0.21 ± 0.006	0.94TrpAsp: 0.94 ± 0.012	0.898TrpGlu: 0.898 ± 0.014	0.555TrpPhe: 0.555 ± 0.01	0.995TrpGly: 0.995 ± 0.015	0.376TrpHis: 0.376 ± 0.008	0.724TrpIle: 0.724 ± 0.012	0.799TrpLys: 0.799 ± 0.011	1.375TrpLeu: 1.375 ± 0.016	0.386TrpMet: 0.386 ± 0.009	0.61TrpAsn: 0.61 ± 0.01	0.646TrpPro: 0.646 ± 0.011	0.574TrpGln: 0.574 ± 0.009	1.04TrpArg: 1.04 ± 0.013	1.042TrpSer: 1.042 ± 0.015	0.974TrpThr: 0.974 ± 0.013	0.946TrpVal: 0.946 ± 0.014	0.305TrpTrp: 0.305 ± 0.008	0.445TrpTyr: 0.445 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.378TyrAla: 2.378 ± 0.018	0.4TyrCys: 0.4 ± 0.008	1.692TyrAsp: 1.692 ± 0.02	1.532TyrGlu: 1.532 ± 0.019	1.156TyrPhe: 1.156 ± 0.013	2.181TyrGly: 2.181 ± 0.023	0.718TyrHis: 0.718 ± 0.011	1.267TyrIle: 1.267 ± 0.016	1.018TyrLys: 1.018 ± 0.012	2.472TyrLeu: 2.472 ± 0.02	0.596TyrMet: 0.596 ± 0.01	1.059TyrAsn: 1.059 ± 0.015	1.478TyrPro: 1.478 ± 0.018	1.007TyrGln: 1.007 ± 0.012	1.553TyrArg: 1.553 ± 0.017	1.929TyrSer: 1.929 ± 0.019	1.649TyrThr: 1.649 ± 0.023	1.681TyrVal: 1.681 ± 0.017	0.469TyrTrp: 0.469 ± 0.009	0.952TyrTyr: 0.952 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.008XaaXaa: 0.008 ± 0.004

Statistics based on 12895 proteins (6232502 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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