Amino acid dipepetide frequency for Butyricicoccus porcorum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.849AlaAla: 10.849 ± 0.177	1.739AlaCys: 1.739 ± 0.049	5.779AlaAsp: 5.779 ± 0.099	6.638AlaGlu: 6.638 ± 0.093	3.405AlaPhe: 3.405 ± 0.065	7.263AlaGly: 7.263 ± 0.122	1.665AlaHis: 1.665 ± 0.048	5.363AlaIle: 5.363 ± 0.095	4.53AlaLys: 4.53 ± 0.09	8.736AlaLeu: 8.736 ± 0.12	2.807AlaMet: 2.807 ± 0.064	2.578AlaAsn: 2.578 ± 0.061	2.873AlaPro: 2.873 ± 0.075	3.895AlaGln: 3.895 ± 0.078	4.469AlaArg: 4.469 ± 0.093	4.517AlaSer: 4.517 ± 0.081	3.744AlaThr: 3.744 ± 0.084	7.946AlaVal: 7.946 ± 0.116	0.782AlaTrp: 0.782 ± 0.033	2.933AlaTyr: 2.933 ± 0.072	0.004AlaXaa: 0.004 ± 0.002
Cys	1.842CysAla: 1.842 ± 0.052	0.396CysCys: 0.396 ± 0.023	1.088CysAsp: 1.088 ± 0.038	1.072CysGlu: 1.072 ± 0.042	0.696CysPhe: 0.696 ± 0.029	2.128CysGly: 2.128 ± 0.05	0.369CysHis: 0.369 ± 0.023	1.207CysIle: 1.207 ± 0.037	0.726CysLys: 0.726 ± 0.031	1.406CysLeu: 1.406 ± 0.043	0.521CysMet: 0.521 ± 0.026	0.587CysAsn: 0.587 ± 0.027	0.846CysPro: 0.846 ± 0.037	0.421CysGln: 0.421 ± 0.027	1.086CysArg: 1.086 ± 0.044	1.001CysSer: 1.001 ± 0.039	1.15CysThr: 1.15 ± 0.039	1.343CysVal: 1.343 ± 0.041	0.166CysTrp: 0.166 ± 0.016	0.59CysTyr: 0.59 ± 0.028	0.001CysXaa: 0.001 ± 0.001
Asp	5.744AspAla: 5.744 ± 0.1	1.132AspCys: 1.132 ± 0.044	3.435AspAsp: 3.435 ± 0.087	4.2AspGlu: 4.2 ± 0.083	2.465AspPhe: 2.465 ± 0.052	5.255AspGly: 5.255 ± 0.109	0.993AspHis: 0.993 ± 0.039	4.383AspIle: 4.383 ± 0.078	2.649AspLys: 2.649 ± 0.063	4.545AspLeu: 4.545 ± 0.069	1.914AspMet: 1.914 ± 0.056	1.991AspAsn: 1.991 ± 0.057	2.168AspPro: 2.168 ± 0.058	1.355AspGln: 1.355 ± 0.043	3.059AspArg: 3.059 ± 0.07	3.324AspSer: 3.324 ± 0.073	3.6AspThr: 3.6 ± 0.069	3.979AspVal: 3.979 ± 0.084	0.672AspTrp: 0.672 ± 0.033	2.268AspTyr: 2.268 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	5.75GluAla: 5.75 ± 0.102	0.839GluCys: 0.839 ± 0.031	3.79GluAsp: 3.79 ± 0.09	5.206GluGlu: 5.206 ± 0.12	2.051GluPhe: 2.051 ± 0.048	4.01GluGly: 4.01 ± 0.081	1.509GluHis: 1.509 ± 0.053	4.486GluIle: 4.486 ± 0.08	4.275GluLys: 4.275 ± 0.079	6.4GluLeu: 6.4 ± 0.098	2.177GluMet: 2.177 ± 0.052	3.066GluAsn: 3.066 ± 0.069	2.278GluPro: 2.278 ± 0.099	3.69GluGln: 3.69 ± 0.094	3.651GluArg: 3.651 ± 0.083	2.947GluSer: 2.947 ± 0.067	3.822GluThr: 3.822 ± 0.075	3.825GluVal: 3.825 ± 0.074	0.533GluTrp: 0.533 ± 0.025	2.46GluTyr: 2.46 ± 0.062	0.003GluXaa: 0.003 ± 0.002
Phe	3.54PheAla: 3.54 ± 0.074	0.877PheCys: 0.877 ± 0.033	2.698PheAsp: 2.698 ± 0.057	2.165PheGlu: 2.165 ± 0.058	1.557PhePhe: 1.557 ± 0.057	3.269PheGly: 3.269 ± 0.078	0.822PheHis: 0.822 ± 0.034	2.056PheIle: 2.056 ± 0.067	1.256PheLys: 1.256 ± 0.041	3.651PheLeu: 3.651 ± 0.082	0.885PheMet: 0.885 ± 0.041	1.223PheAsn: 1.223 ± 0.047	1.361PhePro: 1.361 ± 0.045	1.065PheGln: 1.065 ± 0.034	2.078PheArg: 2.078 ± 0.053	2.635PheSer: 2.635 ± 0.061	2.274PheThr: 2.274 ± 0.067	2.727PheVal: 2.727 ± 0.069	0.377PheTrp: 0.377 ± 0.028	1.423PheTyr: 1.423 ± 0.044	0.003PheXaa: 0.003 ± 0.002
Gly	6.414GlyAla: 6.414 ± 0.107	1.635GlyCys: 1.635 ± 0.052	3.836GlyAsp: 3.836 ± 0.072	4.573GlyGlu: 4.573 ± 0.089	3.023GlyPhe: 3.023 ± 0.063	5.438GlyGly: 5.438 ± 0.099	1.458GlyHis: 1.458 ± 0.039	5.671GlyIle: 5.671 ± 0.107	4.634GlyLys: 4.634 ± 0.087	6.291GlyLeu: 6.291 ± 0.097	2.73GlyMet: 2.73 ± 0.061	2.55GlyAsn: 2.55 ± 0.062	1.351GlyPro: 1.351 ± 0.044	2.437GlyGln: 2.437 ± 0.06	3.692GlyArg: 3.692 ± 0.075	4.432GlySer: 4.432 ± 0.088	4.931GlyThr: 4.931 ± 0.103	5.596GlyVal: 5.596 ± 0.095	0.772GlyTrp: 0.772 ± 0.034	3.063GlyTyr: 3.063 ± 0.068	0.004GlyXaa: 0.004 ± 0.002
His	1.802HisAla: 1.802 ± 0.055	0.425HisCys: 0.425 ± 0.022	1.113HisAsp: 1.113 ± 0.048	1.176HisGlu: 1.176 ± 0.051	0.854HisPhe: 0.854 ± 0.032	1.5HisGly: 1.5 ± 0.045	0.482HisHis: 0.482 ± 0.039	1.499HisIle: 1.499 ± 0.047	0.83HisLys: 0.83 ± 0.037	1.765HisLeu: 1.765 ± 0.049	0.61HisMet: 0.61 ± 0.031	0.762HisAsn: 0.762 ± 0.03	1.108HisPro: 1.108 ± 0.037	0.616HisGln: 0.616 ± 0.027	1.14HisArg: 1.14 ± 0.043	1.149HisSer: 1.149 ± 0.039	1.236HisThr: 1.236 ± 0.041	1.308HisVal: 1.308 ± 0.043	0.208HisTrp: 0.208 ± 0.016	0.745HisTyr: 0.745 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	6.178IleAla: 6.178 ± 0.102	1.351IleCys: 1.351 ± 0.041	4.084IleAsp: 4.084 ± 0.068	3.808IleGlu: 3.808 ± 0.073	2.272IlePhe: 2.272 ± 0.066	4.89IleGly: 4.89 ± 0.095	1.303IleHis: 1.303 ± 0.037	3.673IleIle: 3.673 ± 0.094	2.471IleLys: 2.471 ± 0.052	5.623IleLeu: 5.623 ± 0.1	1.548IleMet: 1.548 ± 0.045	2.139IleAsn: 2.139 ± 0.06	3.037IlePro: 3.037 ± 0.064	2.054IleGln: 2.054 ± 0.049	3.787IleArg: 3.787 ± 0.071	4.175IleSer: 4.175 ± 0.082	3.722IleThr: 3.722 ± 0.07	4.827IleVal: 4.827 ± 0.083	0.543IleTrp: 0.543 ± 0.028	2.039IleTyr: 2.039 ± 0.06	0.003IleXaa: 0.003 ± 0.002
Lys	4.217LysAla: 4.217 ± 0.082	0.647LysCys: 0.647 ± 0.03	2.555LysAsp: 2.555 ± 0.064	3.482LysGlu: 3.482 ± 0.082	1.485LysPhe: 1.485 ± 0.043	3.071LysGly: 3.071 ± 0.071	0.919LysHis: 0.919 ± 0.036	3.305LysIle: 3.305 ± 0.08	4.056LysLys: 4.056 ± 0.076	4.4LysLeu: 4.4 ± 0.083	1.626LysMet: 1.626 ± 0.046	2.389LysAsn: 2.389 ± 0.051	1.981LysPro: 1.981 ± 0.049	2.231LysGln: 2.231 ± 0.058	2.754LysArg: 2.754 ± 0.066	2.691LysSer: 2.691 ± 0.07	3.292LysThr: 3.292 ± 0.074	2.929LysVal: 2.929 ± 0.065	0.524LysTrp: 0.524 ± 0.027	1.948LysTyr: 1.948 ± 0.058	0.005LysXaa: 0.005 ± 0.002
Leu	8.206LeuAla: 8.206 ± 0.125	2.136LeuCys: 2.136 ± 0.056	5.456LeuAsp: 5.456 ± 0.096	5.798LeuGlu: 5.798 ± 0.101	3.832LeuPhe: 3.832 ± 0.092	6.203LeuGly: 6.203 ± 0.095	2.036LeuHis: 2.036 ± 0.052	5.116LeuIle: 5.116 ± 0.1	4.258LeuLys: 4.258 ± 0.081	8.884LeuLeu: 8.884 ± 0.145	2.615LeuMet: 2.615 ± 0.056	3.073LeuAsn: 3.073 ± 0.069	4.148LeuPro: 4.148 ± 0.075	2.599LeuGln: 2.599 ± 0.064	5.349LeuArg: 5.349 ± 0.097	6.253LeuSer: 6.253 ± 0.107	5.758LeuThr: 5.758 ± 0.108	5.532LeuVal: 5.532 ± 0.097	0.795LeuTrp: 0.795 ± 0.035	3.09LeuTyr: 3.09 ± 0.077	0.001LeuXaa: 0.001 ± 0.001
Met	2.578MetAla: 2.578 ± 0.059	0.398MetCys: 0.398 ± 0.021	1.829MetAsp: 1.829 ± 0.05	2.154MetGlu: 2.154 ± 0.048	0.925MetPhe: 0.925 ± 0.039	2.066MetGly: 2.066 ± 0.052	0.605MetHis: 0.605 ± 0.031	1.733MetIle: 1.733 ± 0.05	1.998MetLys: 1.998 ± 0.054	2.994MetLeu: 2.994 ± 0.061	0.875MetMet: 0.875 ± 0.036	1.235MetAsn: 1.235 ± 0.039	1.297MetPro: 1.297 ± 0.039	1.414MetGln: 1.414 ± 0.045	1.629MetArg: 1.629 ± 0.049	1.769MetSer: 1.769 ± 0.05	1.882MetThr: 1.882 ± 0.053	1.824MetVal: 1.824 ± 0.048	0.199MetTrp: 0.199 ± 0.016	0.826MetTyr: 0.826 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	3.188AsnAla: 3.188 ± 0.071	0.603AsnCys: 0.603 ± 0.026	1.849AsnAsp: 1.849 ± 0.052	2.063AsnGlu: 2.063 ± 0.052	1.186AsnPhe: 1.186 ± 0.037	3.054AsnGly: 3.054 ± 0.069	0.717AsnHis: 0.717 ± 0.035	2.466AsnIle: 2.466 ± 0.056	1.657AsnLys: 1.657 ± 0.046	3.126AsnLeu: 3.126 ± 0.069	1.042AsnMet: 1.042 ± 0.033	1.285AsnAsn: 1.285 ± 0.045	1.891AsnPro: 1.891 ± 0.052	1.096AsnGln: 1.096 ± 0.036	2.06AsnArg: 2.06 ± 0.05	1.949AsnSer: 1.949 ± 0.065	2.12AsnThr: 2.12 ± 0.065	2.196AsnVal: 2.196 ± 0.057	0.358AsnTrp: 0.358 ± 0.024	1.349AsnTyr: 1.349 ± 0.053	0.001AsnXaa: 0.001 ± 0.001
Pro	3.445ProAla: 3.445 ± 0.071	0.556ProCys: 0.556 ± 0.03	2.868ProAsp: 2.868 ± 0.069	3.672ProGlu: 3.672 ± 0.094	1.522ProPhe: 1.522 ± 0.048	2.5ProGly: 2.5 ± 0.059	0.852ProHis: 0.852 ± 0.036	2.062ProIle: 2.062 ± 0.048	1.759ProLys: 1.759 ± 0.046	3.183ProLeu: 3.183 ± 0.067	1.068ProMet: 1.068 ± 0.04	1.308ProAsn: 1.308 ± 0.035	1.105ProPro: 1.105 ± 0.039	1.472ProGln: 1.472 ± 0.044	1.526ProArg: 1.526 ± 0.048	2.044ProSer: 2.044 ± 0.055	1.892ProThr: 1.892 ± 0.051	3.479ProVal: 3.479 ± 0.07	0.337ProTrp: 0.337 ± 0.021	1.37ProTyr: 1.37 ± 0.041	0.001ProXaa: 0.001 ± 0.001
Gln	3.623GlnAla: 3.623 ± 0.085	0.509GlnCys: 0.509 ± 0.027	1.68GlnAsp: 1.68 ± 0.048	2.464GlnGlu: 2.464 ± 0.069	1.266GlnPhe: 1.266 ± 0.035	1.872GlnGly: 1.872 ± 0.048	0.723GlnHis: 0.723 ± 0.039	2.193GlnIle: 2.193 ± 0.054	2.178GlnLys: 2.178 ± 0.065	3.741GlnLeu: 3.741 ± 0.083	1.263GlnMet: 1.263 ± 0.041	1.463GlnAsn: 1.463 ± 0.047	1.446GlnPro: 1.446 ± 0.054	1.737GlnGln: 1.737 ± 0.055	2.002GlnArg: 2.002 ± 0.065	1.909GlnSer: 1.909 ± 0.046	2.157GlnThr: 2.157 ± 0.055	2.065GlnVal: 2.065 ± 0.051	0.351GlnTrp: 0.351 ± 0.026	1.461GlnTyr: 1.461 ± 0.052	0.003GlnXaa: 0.003 ± 0.002
Arg	4.779ArgAla: 4.779 ± 0.103	0.907ArgCys: 0.907 ± 0.037	2.969ArgAsp: 2.969 ± 0.069	4.007ArgGlu: 4.007 ± 0.078	2.069ArgPhe: 2.069 ± 0.054	3.491ArgGly: 3.491 ± 0.073	1.13ArgHis: 1.13 ± 0.042	3.647ArgIle: 3.647 ± 0.069	3.081ArgLys: 3.081 ± 0.083	4.871ArgLeu: 4.871 ± 0.096	1.901ArgMet: 1.901 ± 0.056	1.877ArgAsn: 1.877 ± 0.053	1.939ArgPro: 1.939 ± 0.058	2.322ArgGln: 2.322 ± 0.06	3.925ArgArg: 3.925 ± 0.084	2.703ArgSer: 2.703 ± 0.055	3.063ArgThr: 3.063 ± 0.068	3.43ArgVal: 3.43 ± 0.073	0.489ArgTrp: 0.489 ± 0.024	2.078ArgTyr: 2.078 ± 0.054	0.005ArgXaa: 0.005 ± 0.003
Ser	5.422SerAla: 5.422 ± 0.097	1.011SerCys: 1.011 ± 0.037	3.488SerAsp: 3.488 ± 0.077	3.458SerGlu: 3.458 ± 0.068	2.444SerPhe: 2.444 ± 0.055	5.388SerGly: 5.388 ± 0.094	1.115SerHis: 1.115 ± 0.04	3.708SerIle: 3.708 ± 0.073	2.578SerLys: 2.578 ± 0.066	4.838SerLeu: 4.838 ± 0.076	1.846SerMet: 1.846 ± 0.049	1.837SerAsn: 1.837 ± 0.06	2.058SerPro: 2.058 ± 0.055	1.77SerGln: 1.77 ± 0.049	3.108SerArg: 3.108 ± 0.069	3.535SerSer: 3.535 ± 0.101	2.974SerThr: 2.974 ± 0.078	4.244SerVal: 4.244 ± 0.076	0.563SerTrp: 0.563 ± 0.03	2.102SerTyr: 2.102 ± 0.057	0.003SerXaa: 0.003 ± 0.002
Thr	5.915ThrAla: 5.915 ± 0.105	0.92ThrCys: 0.92 ± 0.035	3.606ThrAsp: 3.606 ± 0.072	3.845ThrGlu: 3.845 ± 0.079	2.048ThrPhe: 2.048 ± 0.056	5.172ThrGly: 5.172 ± 0.087	1.078ThrHis: 1.078 ± 0.04	3.762ThrIle: 3.762 ± 0.078	2.415ThrLys: 2.415 ± 0.06	5.154ThrLeu: 5.154 ± 0.087	1.62ThrMet: 1.62 ± 0.051	1.721ThrAsn: 1.721 ± 0.047	2.587ThrPro: 2.587 ± 0.059	1.825ThrGln: 1.825 ± 0.051	2.676ThrArg: 2.676 ± 0.062	2.946ThrSer: 2.946 ± 0.077	3.153ThrThr: 3.153 ± 0.087	5.042ThrVal: 5.042 ± 0.103	0.526ThrTrp: 0.526 ± 0.026	1.93ThrTyr: 1.93 ± 0.059	0.001ThrXaa: 0.001 ± 0.001
Val	5.339ValAla: 5.339 ± 0.096	1.717ValCys: 1.717 ± 0.049	3.926ValAsp: 3.926 ± 0.07	4.148ValGlu: 4.148 ± 0.079	2.874ValPhe: 2.874 ± 0.065	4.626ValGly: 4.626 ± 0.088	1.472ValHis: 1.472 ± 0.045	4.512ValIle: 4.512 ± 0.083	3.151ValLys: 3.151 ± 0.067	7.172ValLeu: 7.172 ± 0.111	2.012ValMet: 2.012 ± 0.054	2.367ValAsn: 2.367 ± 0.068	2.985ValPro: 2.985 ± 0.068	2.341ValGln: 2.341 ± 0.059	4.005ValArg: 4.005 ± 0.079	4.932ValSer: 4.932 ± 0.089	4.413ValThr: 4.413 ± 0.099	4.778ValVal: 4.778 ± 0.083	0.645ValTrp: 0.645 ± 0.03	2.469ValTyr: 2.469 ± 0.057	0.001ValXaa: 0.001 ± 0.001
Trp	0.663TrpAla: 0.663 ± 0.032	0.199TrpCys: 0.199 ± 0.018	0.614TrpAsp: 0.614 ± 0.028	0.625TrpGlu: 0.625 ± 0.029	0.422TrpPhe: 0.422 ± 0.025	0.558TrpGly: 0.558 ± 0.026	0.26TrpHis: 0.26 ± 0.018	0.556TrpIle: 0.556 ± 0.025	0.576TrpLys: 0.576 ± 0.026	0.933TrpLeu: 0.933 ± 0.036	0.304TrpMet: 0.304 ± 0.02	0.493TrpAsn: 0.493 ± 0.027	0.201TrpPro: 0.201 ± 0.017	0.423TrpGln: 0.423 ± 0.032	0.486TrpArg: 0.486 ± 0.027	0.491TrpSer: 0.491 ± 0.026	0.475TrpThr: 0.475 ± 0.027	0.502TrpVal: 0.502 ± 0.025	0.089TrpTrp: 0.089 ± 0.013	0.37TrpTyr: 0.37 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.015TyrAla: 3.015 ± 0.058	0.643TyrCys: 0.643 ± 0.031	2.469TyrAsp: 2.469 ± 0.064	2.21TyrGlu: 2.21 ± 0.05	1.546TyrPhe: 1.546 ± 0.05	2.774TyrGly: 2.774 ± 0.068	0.821TyrHis: 0.821 ± 0.034	2.129TyrIle: 2.129 ± 0.058	1.428TyrLys: 1.428 ± 0.054	3.425TyrLeu: 3.425 ± 0.071	0.862TyrMet: 0.862 ± 0.034	1.31TyrAsn: 1.31 ± 0.044	1.358TyrPro: 1.358 ± 0.043	1.343TyrGln: 1.343 ± 0.054	2.199TyrArg: 2.199 ± 0.055	2.087TyrSer: 2.087 ± 0.062	2.278TyrThr: 2.278 ± 0.059	2.307TyrVal: 2.307 ± 0.052	0.311TyrTrp: 0.311 ± 0.02	1.569TyrTyr: 1.569 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.005XaaAla: 0.005 ± 0.002	0.001XaaCys: 0.001 ± 0.001	0.001XaaAsp: 0.001 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.003XaaGly: 0.003 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.003XaaLys: 0.003 ± 0.002	0.004XaaLeu: 0.004 ± 0.002	0.001XaaMet: 0.001 ± 0.001	0.003XaaAsn: 0.003 ± 0.002	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.003XaaArg: 0.003 ± 0.002	0.003XaaSer: 0.003 ± 0.003	0.004XaaThr: 0.004 ± 0.002	0.005XaaVal: 0.005 ± 0.003	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.008XaaXaa: 0.008 ± 0.004

Statistics based on 2566 proteins (777331 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---