Amino acid dipepetide frequency for Mycobacterium phage Xavia

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.866AlaAla: 15.866 ± 1.617
0.999AlaCys: 0.999 ± 0.26
7.621AlaAsp: 7.621 ± 0.804
9.245AlaGlu: 9.245 ± 0.961
3.061AlaPhe: 3.061 ± 0.457
8.495AlaGly: 8.495 ± 1.033
2.061AlaHis: 2.061 ± 0.355
5.934AlaIle: 5.934 ± 0.644
3.873AlaLys: 3.873 ± 0.611
10.806AlaLeu: 10.806 ± 0.852
2.374AlaMet: 2.374 ± 0.359
3.436AlaAsn: 3.436 ± 0.503
6.496AlaPro: 6.496 ± 0.856
3.998AlaGln: 3.998 ± 0.669
7.496AlaArg: 7.496 ± 0.79
6.059AlaSer: 6.059 ± 0.66
5.934AlaThr: 5.934 ± 0.772
7.121AlaVal: 7.121 ± 0.786
1.874AlaTrp: 1.874 ± 0.363
3.248AlaTyr: 3.248 ± 0.376
0.0AlaXaa: 0.0 ± 0.0
Cys
0.937CysAla: 0.937 ± 0.261
0.062CysCys: 0.062 ± 0.061
0.812CysAsp: 0.812 ± 0.27
0.937CysGlu: 0.937 ± 0.256
0.062CysPhe: 0.062 ± 0.063
1.437CysGly: 1.437 ± 0.3
0.5CysHis: 0.5 ± 0.18
0.125CysIle: 0.125 ± 0.08
0.187CysLys: 0.187 ± 0.121
0.437CysLeu: 0.437 ± 0.16
0.125CysMet: 0.125 ± 0.092
0.312CysAsn: 0.312 ± 0.126
0.999CysPro: 0.999 ± 0.373
0.312CysGln: 0.312 ± 0.171
0.937CysArg: 0.937 ± 0.203
0.5CysSer: 0.5 ± 0.216
1.062CysThr: 1.062 ± 0.255
0.312CysVal: 0.312 ± 0.155
0.062CysTrp: 0.062 ± 0.052
0.187CysTyr: 0.187 ± 0.094
0.0CysXaa: 0.0 ± 0.0
Asp
7.933AspAla: 7.933 ± 0.833
0.687AspCys: 0.687 ± 0.242
5.06AspAsp: 5.06 ± 0.586
5.559AspGlu: 5.559 ± 0.769
1.687AspPhe: 1.687 ± 0.308
6.371AspGly: 6.371 ± 0.85
1.312AspHis: 1.312 ± 0.226
2.249AspIle: 2.249 ± 0.3
1.749AspLys: 1.749 ± 0.275
5.809AspLeu: 5.809 ± 0.64
1.374AspMet: 1.374 ± 0.237
1.437AspAsn: 1.437 ± 0.256
4.872AspPro: 4.872 ± 0.497
1.687AspGln: 1.687 ± 0.356
4.373AspArg: 4.373 ± 0.455
2.686AspSer: 2.686 ± 0.585
3.186AspThr: 3.186 ± 0.472
5.06AspVal: 5.06 ± 0.591
1.749AspTrp: 1.749 ± 0.271
1.749AspTyr: 1.749 ± 0.297
0.0AspXaa: 0.0 ± 0.0
Glu
7.558GluAla: 7.558 ± 0.777
1.062GluCys: 1.062 ± 0.322
3.623GluAsp: 3.623 ± 0.513
3.061GluGlu: 3.061 ± 0.515
1.687GluPhe: 1.687 ± 0.312
3.81GluGly: 3.81 ± 0.46
1.312GluHis: 1.312 ± 0.316
3.873GluIle: 3.873 ± 0.566
1.936GluLys: 1.936 ± 0.351
7.246GluLeu: 7.246 ± 0.893
1.062GluMet: 1.062 ± 0.236
1.749GluAsn: 1.749 ± 0.295
2.811GluPro: 2.811 ± 0.495
2.936GluGln: 2.936 ± 0.439
4.81GluArg: 4.81 ± 0.626
3.123GluSer: 3.123 ± 0.528
3.123GluThr: 3.123 ± 0.394
4.497GluVal: 4.497 ± 0.648
1.811GluTrp: 1.811 ± 0.373
1.374GluTyr: 1.374 ± 0.302
0.0GluXaa: 0.0 ± 0.0
Phe
2.748PheAla: 2.748 ± 0.428
0.187PheCys: 0.187 ± 0.106
2.374PheAsp: 2.374 ± 0.405
1.999PheGlu: 1.999 ± 0.368
0.562PhePhe: 0.562 ± 0.195
3.998PheGly: 3.998 ± 0.575
0.562PheHis: 0.562 ± 0.167
1.749PheIle: 1.749 ± 0.342
0.937PheLys: 0.937 ± 0.214
1.874PheLeu: 1.874 ± 0.371
0.687PheMet: 0.687 ± 0.211
0.75PheAsn: 0.75 ± 0.192
1.936PhePro: 1.936 ± 0.386
1.249PheGln: 1.249 ± 0.274
1.562PheArg: 1.562 ± 0.282
1.437PheSer: 1.437 ± 0.325
1.562PheThr: 1.562 ± 0.373
2.561PheVal: 2.561 ± 0.408
0.5PheTrp: 0.5 ± 0.158
0.562PheTyr: 0.562 ± 0.167
0.0PheXaa: 0.0 ± 0.0
Gly
8.558GlyAla: 8.558 ± 1.084
0.687GlyCys: 0.687 ± 0.223
5.06GlyAsp: 5.06 ± 0.512
4.872GlyGlu: 4.872 ± 0.742
2.873GlyPhe: 2.873 ± 0.543
8.87GlyGly: 8.87 ± 1.408
1.562GlyHis: 1.562 ± 0.299
3.248GlyIle: 3.248 ± 0.443
3.373GlyLys: 3.373 ± 0.452
7.308GlyLeu: 7.308 ± 0.741
1.312GlyMet: 1.312 ± 0.307
2.936GlyAsn: 2.936 ± 0.763
4.685GlyPro: 4.685 ± 0.701
3.56GlyGln: 3.56 ± 0.634
5.559GlyArg: 5.559 ± 0.54
5.622GlySer: 5.622 ± 0.75
5.809GlyThr: 5.809 ± 0.759
6.934GlyVal: 6.934 ± 0.792
1.999GlyTrp: 1.999 ± 0.4
2.624GlyTyr: 2.624 ± 0.357
0.0GlyXaa: 0.0 ± 0.0
His
1.562HisAla: 1.562 ± 0.28
0.125HisCys: 0.125 ± 0.087
1.874HisAsp: 1.874 ± 0.267
1.312HisGlu: 1.312 ± 0.372
0.312HisPhe: 0.312 ± 0.127
1.811HisGly: 1.811 ± 0.362
0.999HisHis: 0.999 ± 0.324
1.124HisIle: 1.124 ± 0.285
0.625HisLys: 0.625 ± 0.198
1.437HisLeu: 1.437 ± 0.301
0.312HisMet: 0.312 ± 0.119
1.062HisAsn: 1.062 ± 0.277
1.062HisPro: 1.062 ± 0.283
0.875HisGln: 0.875 ± 0.278
1.499HisArg: 1.499 ± 0.301
0.875HisSer: 0.875 ± 0.272
1.374HisThr: 1.374 ± 0.294
1.749HisVal: 1.749 ± 0.391
0.562HisTrp: 0.562 ± 0.201
0.75HisTyr: 0.75 ± 0.219
0.0HisXaa: 0.0 ± 0.0
Ile
5.934IleAla: 5.934 ± 0.514
0.375IleCys: 0.375 ± 0.151
3.498IleAsp: 3.498 ± 0.428
3.623IleGlu: 3.623 ± 0.49
0.625IlePhe: 0.625 ± 0.176
3.685IleGly: 3.685 ± 0.614
0.625IleHis: 0.625 ± 0.185
1.062IleIle: 1.062 ± 0.256
1.187IleLys: 1.187 ± 0.188
1.936IleLeu: 1.936 ± 0.324
0.562IleMet: 0.562 ± 0.218
1.062IleAsn: 1.062 ± 0.264
2.249IlePro: 2.249 ± 0.331
1.624IleGln: 1.624 ± 0.35
3.998IleArg: 3.998 ± 0.532
2.624IleSer: 2.624 ± 0.348
3.436IleThr: 3.436 ± 0.459
2.748IleVal: 2.748 ± 0.494
0.562IleTrp: 0.562 ± 0.201
0.999IleTyr: 0.999 ± 0.318
0.0IleXaa: 0.0 ± 0.0
Lys
3.623LysAla: 3.623 ± 0.541
0.25LysCys: 0.25 ± 0.125
1.124LysAsp: 1.124 ± 0.209
1.062LysGlu: 1.062 ± 0.246
1.187LysPhe: 1.187 ± 0.238
2.061LysGly: 2.061 ± 0.362
0.5LysHis: 0.5 ± 0.184
1.437LysIle: 1.437 ± 0.327
0.937LysLys: 0.937 ± 0.23
3.186LysLeu: 3.186 ± 0.486
0.562LysMet: 0.562 ± 0.209
0.875LysAsn: 0.875 ± 0.255
3.061LysPro: 3.061 ± 0.45
0.812LysGln: 0.812 ± 0.21
2.811LysArg: 2.811 ± 0.522
1.624LysSer: 1.624 ± 0.356
2.624LysThr: 2.624 ± 0.404
2.436LysVal: 2.436 ± 0.379
0.25LysTrp: 0.25 ± 0.148
0.875LysTyr: 0.875 ± 0.209
0.0LysXaa: 0.0 ± 0.0
Leu
10.057LeuAla: 10.057 ± 0.823
0.999LeuCys: 0.999 ± 0.266
5.559LeuAsp: 5.559 ± 0.549
4.373LeuGlu: 4.373 ± 0.531
1.936LeuPhe: 1.936 ± 0.33
7.496LeuGly: 7.496 ± 0.538
1.437LeuHis: 1.437 ± 0.357
4.435LeuIle: 4.435 ± 0.552
2.061LeuLys: 2.061 ± 0.394
7.059LeuLeu: 7.059 ± 0.613
1.811LeuMet: 1.811 ± 0.351
2.499LeuAsn: 2.499 ± 0.327
5.06LeuPro: 5.06 ± 0.537
2.311LeuGln: 2.311 ± 0.464
5.997LeuArg: 5.997 ± 0.604
4.622LeuSer: 4.622 ± 0.47
4.935LeuThr: 4.935 ± 0.503
5.809LeuVal: 5.809 ± 0.641
1.124LeuTrp: 1.124 ± 0.322
1.312LeuTyr: 1.312 ± 0.352
0.0LeuXaa: 0.0 ± 0.0
Met
3.498MetAla: 3.498 ± 0.431
0.125MetCys: 0.125 ± 0.09
0.937MetAsp: 0.937 ± 0.268
0.437MetGlu: 0.437 ± 0.189
0.5MetPhe: 0.5 ± 0.143
1.124MetGly: 1.124 ± 0.241
0.312MetHis: 0.312 ± 0.134
0.437MetIle: 0.437 ± 0.153
0.687MetLys: 0.687 ± 0.213
2.061MetLeu: 2.061 ± 0.407
0.187MetMet: 0.187 ± 0.133
0.687MetAsn: 0.687 ± 0.188
1.312MetPro: 1.312 ± 0.258
0.625MetGln: 0.625 ± 0.186
1.749MetArg: 1.749 ± 0.361
1.562MetSer: 1.562 ± 0.292
1.811MetThr: 1.811 ± 0.295
0.75MetVal: 0.75 ± 0.174
0.25MetTrp: 0.25 ± 0.124
0.312MetTyr: 0.312 ± 0.139
0.0MetXaa: 0.0 ± 0.0
Asn
2.998AsnAla: 2.998 ± 0.557
0.312AsnCys: 0.312 ± 0.16
1.499AsnAsp: 1.499 ± 0.308
1.624AsnGlu: 1.624 ± 0.298
0.937AsnPhe: 0.937 ± 0.246
2.936AsnGly: 2.936 ± 0.486
0.875AsnHis: 0.875 ± 0.255
1.187AsnIle: 1.187 ± 0.293
0.562AsnLys: 0.562 ± 0.204
1.999AsnLeu: 1.999 ± 0.366
0.375AsnMet: 0.375 ± 0.159
0.812AsnAsn: 0.812 ± 0.204
2.311AsnPro: 2.311 ± 0.365
0.875AsnGln: 0.875 ± 0.247
2.436AsnArg: 2.436 ± 0.448
2.249AsnSer: 2.249 ± 0.371
2.061AsnThr: 2.061 ± 0.371
1.874AsnVal: 1.874 ± 0.323
1.124AsnTrp: 1.124 ± 0.232
0.625AsnTyr: 0.625 ± 0.226
0.0AsnXaa: 0.0 ± 0.0
Pro
6.746ProAla: 6.746 ± 0.826
0.375ProCys: 0.375 ± 0.18
4.622ProAsp: 4.622 ± 0.583
3.998ProGlu: 3.998 ± 0.601
2.186ProPhe: 2.186 ± 0.351
6.746ProGly: 6.746 ± 0.733
1.187ProHis: 1.187 ± 0.321
1.562ProIle: 1.562 ± 0.229
1.999ProLys: 1.999 ± 0.316
4.185ProLeu: 4.185 ± 0.574
0.75ProMet: 0.75 ± 0.219
1.999ProAsn: 1.999 ± 0.445
3.56ProPro: 3.56 ± 0.541
2.374ProGln: 2.374 ± 0.317
4.872ProArg: 4.872 ± 0.607
3.061ProSer: 3.061 ± 0.438
3.685ProThr: 3.685 ± 0.6
4.248ProVal: 4.248 ± 0.518
1.437ProTrp: 1.437 ± 0.277
0.875ProTyr: 0.875 ± 0.185
0.0ProXaa: 0.0 ± 0.0
Gln
3.998GlnAla: 3.998 ± 0.631
0.312GlnCys: 0.312 ± 0.142
1.687GlnAsp: 1.687 ± 0.336
1.874GlnGlu: 1.874 ± 0.378
1.562GlnPhe: 1.562 ± 0.443
2.936GlnGly: 2.936 ± 0.636
0.812GlnHis: 0.812 ± 0.211
1.874GlnIle: 1.874 ± 0.331
1.499GlnLys: 1.499 ± 0.222
2.561GlnLeu: 2.561 ± 0.473
0.999GlnMet: 0.999 ± 0.226
0.875GlnAsn: 0.875 ± 0.286
2.436GlnPro: 2.436 ± 0.332
2.436GlnGln: 2.436 ± 0.425
2.811GlnArg: 2.811 ± 0.428
1.499GlnSer: 1.499 ± 0.3
2.624GlnThr: 2.624 ± 0.384
2.624GlnVal: 2.624 ± 0.439
0.625GlnTrp: 0.625 ± 0.17
0.375GlnTyr: 0.375 ± 0.128
0.0GlnXaa: 0.0 ± 0.0
Arg
8.308ArgAla: 8.308 ± 0.696
1.062ArgCys: 1.062 ± 0.278
5.247ArgAsp: 5.247 ± 0.573
4.06ArgGlu: 4.06 ± 0.621
3.186ArgPhe: 3.186 ± 0.35
4.81ArgGly: 4.81 ± 0.63
1.749ArgHis: 1.749 ± 0.288
3.123ArgIle: 3.123 ± 0.535
2.936ArgLys: 2.936 ± 0.566
5.247ArgLeu: 5.247 ± 0.534
1.936ArgMet: 1.936 ± 0.375
2.061ArgAsn: 2.061 ± 0.355
3.81ArgPro: 3.81 ± 0.625
3.061ArgGln: 3.061 ± 0.426
6.434ArgArg: 6.434 ± 0.962
3.748ArgSer: 3.748 ± 0.643
3.935ArgThr: 3.935 ± 0.433
4.622ArgVal: 4.622 ± 0.673
0.999ArgTrp: 0.999 ± 0.276
2.186ArgTyr: 2.186 ± 0.386
0.0ArgXaa: 0.0 ± 0.0
Ser
6.809SerAla: 6.809 ± 0.655
0.25SerCys: 0.25 ± 0.124
3.123SerAsp: 3.123 ± 0.478
2.561SerGlu: 2.561 ± 0.533
1.811SerPhe: 1.811 ± 0.31
6.496SerGly: 6.496 ± 1.196
0.75SerHis: 0.75 ± 0.2
1.811SerIle: 1.811 ± 0.377
1.811SerLys: 1.811 ± 0.401
3.998SerLeu: 3.998 ± 0.505
1.687SerMet: 1.687 ± 0.307
1.936SerAsn: 1.936 ± 0.411
3.311SerPro: 3.311 ± 0.447
2.124SerGln: 2.124 ± 0.385
3.186SerArg: 3.186 ± 0.462
2.686SerSer: 2.686 ± 0.368
3.623SerThr: 3.623 ± 0.527
4.185SerVal: 4.185 ± 0.524
1.187SerTrp: 1.187 ± 0.268
0.875SerTyr: 0.875 ± 0.19
0.0SerXaa: 0.0 ± 0.0
Thr
6.684ThrAla: 6.684 ± 0.532
0.562ThrCys: 0.562 ± 0.218
4.248ThrAsp: 4.248 ± 0.407
3.748ThrGlu: 3.748 ± 0.606
1.437ThrPhe: 1.437 ± 0.374
5.247ThrGly: 5.247 ± 0.63
1.374ThrHis: 1.374 ± 0.36
2.998ThrIle: 2.998 ± 0.462
1.811ThrLys: 1.811 ± 0.282
5.622ThrLeu: 5.622 ± 0.671
1.187ThrMet: 1.187 ± 0.297
1.312ThrAsn: 1.312 ± 0.248
4.685ThrPro: 4.685 ± 0.583
1.874ThrGln: 1.874 ± 0.257
3.81ThrArg: 3.81 ± 0.563
3.186ThrSer: 3.186 ± 0.522
4.685ThrThr: 4.685 ± 0.721
5.372ThrVal: 5.372 ± 0.653
1.312ThrTrp: 1.312 ± 0.297
1.936ThrTyr: 1.936 ± 0.369
0.0ThrXaa: 0.0 ± 0.0
Val
7.621ValAla: 7.621 ± 0.822
1.062ValCys: 1.062 ± 0.279
5.934ValAsp: 5.934 ± 0.645
5.684ValGlu: 5.684 ± 0.602
2.624ValPhe: 2.624 ± 0.356
5.622ValGly: 5.622 ± 0.751
2.186ValHis: 2.186 ± 0.424
2.374ValIle: 2.374 ± 0.353
1.811ValLys: 1.811 ± 0.351
4.81ValLeu: 4.81 ± 0.436
1.249ValMet: 1.249 ± 0.267
2.436ValAsn: 2.436 ± 0.44
3.81ValPro: 3.81 ± 0.558
1.874ValGln: 1.874 ± 0.339
4.185ValArg: 4.185 ± 0.588
4.497ValSer: 4.497 ± 0.731
4.872ValThr: 4.872 ± 0.602
5.809ValVal: 5.809 ± 0.91
1.437ValTrp: 1.437 ± 0.277
1.562ValTyr: 1.562 ± 0.331
0.0ValXaa: 0.0 ± 0.0
Trp
1.936TrpAla: 1.936 ± 0.295
0.437TrpCys: 0.437 ± 0.167
1.249TrpAsp: 1.249 ± 0.279
1.187TrpGlu: 1.187 ± 0.25
0.875TrpPhe: 0.875 ± 0.24
1.249TrpGly: 1.249 ± 0.272
0.562TrpHis: 0.562 ± 0.169
0.875TrpIle: 0.875 ± 0.207
0.625TrpLys: 0.625 ± 0.175
1.562TrpLeu: 1.562 ± 0.367
0.437TrpMet: 0.437 ± 0.155
0.812TrpAsn: 0.812 ± 0.187
0.812TrpPro: 0.812 ± 0.262
1.062TrpGln: 1.062 ± 0.256
1.874TrpArg: 1.874 ± 0.415
1.062TrpSer: 1.062 ± 0.255
1.062TrpThr: 1.062 ± 0.355
1.062TrpVal: 1.062 ± 0.289
0.687TrpTrp: 0.687 ± 0.205
0.812TrpTyr: 0.812 ± 0.232
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.624TyrAla: 2.624 ± 0.364
0.375TyrCys: 0.375 ± 0.146
1.437TyrAsp: 1.437 ± 0.365
1.249TyrGlu: 1.249 ± 0.226
0.687TyrPhe: 0.687 ± 0.216
2.249TyrGly: 2.249 ± 0.335
0.625TyrHis: 0.625 ± 0.193
0.937TyrIle: 0.937 ± 0.286
0.687TyrLys: 0.687 ± 0.186
1.749TyrLeu: 1.749 ± 0.317
0.312TyrMet: 0.312 ± 0.123
0.625TyrAsn: 0.625 ± 0.153
1.187TyrPro: 1.187 ± 0.304
0.75TyrGln: 0.75 ± 0.228
2.186TyrArg: 2.186 ± 0.371
1.499TyrSer: 1.499 ± 0.341
1.687TyrThr: 1.687 ± 0.318
1.687TyrVal: 1.687 ± 0.304
0.687TyrTrp: 0.687 ± 0.191
0.812TyrTyr: 0.812 ± 0.211
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 71 proteins (16010 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski