Amino acid dipepetide frequency for Sulfitobacter sp. SK012

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.449AlaAla: 14.449 ± 0.124
1.083AlaCys: 1.083 ± 0.03
6.762AlaAsp: 6.762 ± 0.077
6.969AlaGlu: 6.969 ± 0.07
4.34AlaPhe: 4.34 ± 0.054
9.613AlaGly: 9.613 ± 0.092
2.308AlaHis: 2.308 ± 0.043
5.985AlaIle: 5.985 ± 0.064
4.249AlaLys: 4.249 ± 0.063
12.62AlaLeu: 12.62 ± 0.126
3.628AlaMet: 3.628 ± 0.053
3.069AlaAsn: 3.069 ± 0.057
5.092AlaPro: 5.092 ± 0.061
4.717AlaGln: 4.717 ± 0.062
7.136AlaArg: 7.136 ± 0.082
5.789AlaSer: 5.789 ± 0.062
6.03AlaThr: 6.03 ± 0.062
7.819AlaVal: 7.819 ± 0.075
1.348AlaTrp: 1.348 ± 0.033
2.55AlaTyr: 2.55 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
1.071CysAla: 1.071 ± 0.027
0.114CysCys: 0.114 ± 0.009
0.625CysAsp: 0.625 ± 0.023
0.466CysGlu: 0.466 ± 0.018
0.36CysPhe: 0.36 ± 0.016
0.944CysGly: 0.944 ± 0.028
0.283CysHis: 0.283 ± 0.014
0.489CysIle: 0.489 ± 0.017
0.262CysLys: 0.262 ± 0.016
0.884CysLeu: 0.884 ± 0.025
0.196CysMet: 0.196 ± 0.01
0.259CysAsn: 0.259 ± 0.013
0.473CysPro: 0.473 ± 0.019
0.257CysGln: 0.257 ± 0.015
0.472CysArg: 0.472 ± 0.019
0.524CysSer: 0.524 ± 0.02
0.469CysThr: 0.469 ± 0.018
0.652CysVal: 0.652 ± 0.02
0.126CysTrp: 0.126 ± 0.009
0.228CysTyr: 0.228 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
7.519AspAla: 7.519 ± 0.097
0.529AspCys: 0.529 ± 0.021
3.578AspAsp: 3.578 ± 0.067
3.3AspGlu: 3.3 ± 0.052
2.426AspPhe: 2.426 ± 0.049
5.616AspGly: 5.616 ± 0.078
1.432AspHis: 1.432 ± 0.035
3.473AspIle: 3.473 ± 0.055
1.836AspLys: 1.836 ± 0.041
6.268AspLeu: 6.268 ± 0.073
1.733AspMet: 1.733 ± 0.032
1.508AspAsn: 1.508 ± 0.037
3.463AspPro: 3.463 ± 0.058
2.131AspGln: 2.131 ± 0.041
3.691AspArg: 3.691 ± 0.052
2.212AspSer: 2.212 ± 0.04
3.198AspThr: 3.198 ± 0.058
4.829AspVal: 4.829 ± 0.064
1.12AspTrp: 1.12 ± 0.028
1.488AspTyr: 1.488 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
6.958GluAla: 6.958 ± 0.071
0.358GluCys: 0.358 ± 0.016
3.178GluAsp: 3.178 ± 0.054
2.991GluGlu: 2.991 ± 0.056
1.953GluPhe: 1.953 ± 0.04
4.378GluGly: 4.378 ± 0.061
1.169GluHis: 1.169 ± 0.029
3.568GluIle: 3.568 ± 0.044
2.252GluLys: 2.252 ± 0.046
5.147GluLeu: 5.147 ± 0.064
1.868GluMet: 1.868 ± 0.035
2.021GluAsn: 2.021 ± 0.039
2.298GluPro: 2.298 ± 0.044
2.023GluGln: 2.023 ± 0.042
3.625GluArg: 3.625 ± 0.056
2.094GluSer: 2.094 ± 0.038
3.827GluThr: 3.827 ± 0.056
4.158GluVal: 4.158 ± 0.057
0.74GluTrp: 0.74 ± 0.024
1.115GluTyr: 1.115 ± 0.028
0.0GluXaa: 0.0 ± 0.0
Phe
4.562PheAla: 4.562 ± 0.056
0.457PheCys: 0.457 ± 0.019
3.09PheAsp: 3.09 ± 0.049
2.489PheGlu: 2.489 ± 0.043
1.574PhePhe: 1.574 ± 0.033
3.902PheGly: 3.902 ± 0.055
0.764PheHis: 0.764 ± 0.026
1.859PheIle: 1.859 ± 0.04
1.148PheLys: 1.148 ± 0.029
3.507PheLeu: 3.507 ± 0.061
0.978PheMet: 0.978 ± 0.032
1.155PheAsn: 1.155 ± 0.028
1.584PhePro: 1.584 ± 0.033
1.129PheGln: 1.129 ± 0.028
1.97PheArg: 1.97 ± 0.04
2.464PheSer: 2.464 ± 0.045
2.15PheThr: 2.15 ± 0.035
2.916PheVal: 2.916 ± 0.045
0.629PheTrp: 0.629 ± 0.024
1.012PheTyr: 1.012 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
8.997GlyAla: 8.997 ± 0.1
0.867GlyCys: 0.867 ± 0.025
4.8GlyAsp: 4.8 ± 0.079
4.178GlyGlu: 4.178 ± 0.059
3.826GlyPhe: 3.826 ± 0.049
7.232GlyGly: 7.232 ± 0.108
1.926GlyHis: 1.926 ± 0.036
4.766GlyIle: 4.766 ± 0.065
3.343GlyLys: 3.343 ± 0.049
8.716GlyLeu: 8.716 ± 0.093
2.588GlyMet: 2.588 ± 0.041
2.552GlyAsn: 2.552 ± 0.055
3.573GlyPro: 3.573 ± 0.052
3.126GlyGln: 3.126 ± 0.05
5.002GlyArg: 5.002 ± 0.063
4.618GlySer: 4.618 ± 0.063
4.871GlyThr: 4.871 ± 0.064
6.305GlyVal: 6.305 ± 0.069
1.49GlyTrp: 1.49 ± 0.034
2.4GlyTyr: 2.4 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
2.278HisAla: 2.278 ± 0.048
0.24HisCys: 0.24 ± 0.013
1.283HisAsp: 1.283 ± 0.036
1.052HisGlu: 1.052 ± 0.03
0.884HisPhe: 0.884 ± 0.024
1.825HisGly: 1.825 ± 0.037
0.55HisHis: 0.55 ± 0.019
1.148HisIle: 1.148 ± 0.025
0.637HisLys: 0.637 ± 0.021
2.129HisLeu: 2.129 ± 0.039
0.594HisMet: 0.594 ± 0.023
0.577HisAsn: 0.577 ± 0.021
1.312HisPro: 1.312 ± 0.029
0.655HisGln: 0.655 ± 0.02
1.203HisArg: 1.203 ± 0.029
1.09HisSer: 1.09 ± 0.03
0.93HisThr: 0.93 ± 0.028
1.566HisVal: 1.566 ± 0.034
0.341HisTrp: 0.341 ± 0.015
0.564HisTyr: 0.564 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
7.249IleAla: 7.249 ± 0.073
0.675IleCys: 0.675 ± 0.024
3.73IleAsp: 3.73 ± 0.058
3.64IleGlu: 3.64 ± 0.052
1.988IlePhe: 1.988 ± 0.04
5.147IleGly: 5.147 ± 0.067
0.94IleHis: 0.94 ± 0.028
2.737IleIle: 2.737 ± 0.047
1.868IleLys: 1.868 ± 0.034
4.917IleLeu: 4.917 ± 0.066
1.291IleMet: 1.291 ± 0.032
1.644IleAsn: 1.644 ± 0.037
2.497IlePro: 2.497 ± 0.043
1.384IleGln: 1.384 ± 0.028
2.941IleArg: 2.941 ± 0.048
3.564IleSer: 3.564 ± 0.051
3.214IleThr: 3.214 ± 0.047
3.966IleVal: 3.966 ± 0.054
0.828IleTrp: 0.828 ± 0.026
1.334IleTyr: 1.334 ± 0.032
0.0IleXaa: 0.0 ± 0.0
Lys
3.836LysAla: 3.836 ± 0.054
0.222LysCys: 0.222 ± 0.013
2.05LysAsp: 2.05 ± 0.036
1.728LysGlu: 1.728 ± 0.037
1.15LysPhe: 1.15 ± 0.032
2.966LysGly: 2.966 ± 0.052
0.734LysHis: 0.734 ± 0.023
2.023LysIle: 2.023 ± 0.037
1.401LysLys: 1.401 ± 0.044
3.418LysLeu: 3.418 ± 0.055
1.094LysMet: 1.094 ± 0.03
1.051LysAsn: 1.051 ± 0.025
1.972LysPro: 1.972 ± 0.038
1.09LysGln: 1.09 ± 0.032
2.37LysArg: 2.37 ± 0.045
2.208LysSer: 2.208 ± 0.041
2.328LysThr: 2.328 ± 0.039
2.401LysVal: 2.401 ± 0.043
0.463LysTrp: 0.463 ± 0.02
0.708LysTyr: 0.708 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
11.71LeuAla: 11.71 ± 0.101
0.949LeuCys: 0.949 ± 0.027
5.833LeuAsp: 5.833 ± 0.061
5.442LeuGlu: 5.442 ± 0.057
3.622LeuPhe: 3.622 ± 0.054
8.318LeuGly: 8.318 ± 0.088
1.866LeuHis: 1.866 ± 0.035
5.599LeuIle: 5.599 ± 0.085
3.505LeuLys: 3.505 ± 0.05
8.81LeuLeu: 8.81 ± 0.111
2.778LeuMet: 2.778 ± 0.05
3.122LeuAsn: 3.122 ± 0.05
5.181LeuPro: 5.181 ± 0.071
2.846LeuGln: 2.846 ± 0.042
6.548LeuArg: 6.548 ± 0.075
6.973LeuSer: 6.973 ± 0.084
5.778LeuThr: 5.778 ± 0.079
6.6LeuVal: 6.6 ± 0.073
1.268LeuTrp: 1.268 ± 0.032
1.913LeuTyr: 1.913 ± 0.037
0.0LeuXaa: 0.0 ± 0.0
Met
3.445MetAla: 3.445 ± 0.05
0.222MetCys: 0.222 ± 0.012
1.483MetAsp: 1.483 ± 0.033
1.31MetGlu: 1.31 ± 0.03
0.971MetPhe: 0.971 ± 0.025
2.33MetGly: 2.33 ± 0.035
0.525MetHis: 0.525 ± 0.018
1.783MetIle: 1.783 ± 0.036
1.186MetLys: 1.186 ± 0.031
2.793MetLeu: 2.793 ± 0.047
0.862MetMet: 0.862 ± 0.025
0.985MetAsn: 0.985 ± 0.027
1.543MetPro: 1.543 ± 0.037
1.058MetGln: 1.058 ± 0.026
1.897MetArg: 1.897 ± 0.037
1.949MetSer: 1.949 ± 0.035
2.095MetThr: 2.095 ± 0.041
1.912MetVal: 1.912 ± 0.037
0.274MetTrp: 0.274 ± 0.014
0.421MetTyr: 0.421 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.459AsnAla: 3.459 ± 0.048
0.297AsnCys: 0.297 ± 0.016
1.859AsnAsp: 1.859 ± 0.048
1.427AsnGlu: 1.427 ± 0.034
1.201AsnPhe: 1.201 ± 0.032
2.723AsnGly: 2.723 ± 0.048
0.578AsnHis: 0.578 ± 0.021
1.653AsnIle: 1.653 ± 0.033
0.846AsnLys: 0.846 ± 0.023
2.901AsnLeu: 2.901 ± 0.045
0.805AsnMet: 0.805 ± 0.023
0.934AsnAsn: 0.934 ± 0.033
1.972AsnPro: 1.972 ± 0.037
0.875AsnGln: 0.875 ± 0.025
1.716AsnArg: 1.716 ± 0.036
1.514AsnSer: 1.514 ± 0.034
1.616AsnThr: 1.616 ± 0.038
2.172AsnVal: 2.172 ± 0.043
0.547AsnTrp: 0.547 ± 0.02
0.785AsnTyr: 0.785 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
4.999ProAla: 4.999 ± 0.061
0.333ProCys: 0.333 ± 0.016
3.694ProAsp: 3.694 ± 0.055
3.602ProGlu: 3.602 ± 0.06
2.049ProPhe: 2.049 ± 0.042
3.798ProGly: 3.798 ± 0.059
1.056ProHis: 1.056 ± 0.028
2.472ProIle: 2.472 ± 0.035
1.974ProLys: 1.974 ± 0.039
4.509ProLeu: 4.509 ± 0.06
1.379ProMet: 1.379 ± 0.036
1.619ProAsn: 1.619 ± 0.032
1.995ProPro: 1.995 ± 0.041
1.763ProGln: 1.763 ± 0.04
2.417ProArg: 2.417 ± 0.047
2.748ProSer: 2.748 ± 0.046
2.548ProThr: 2.548 ± 0.042
3.807ProVal: 3.807 ± 0.05
0.668ProTrp: 0.668 ± 0.021
1.144ProTyr: 1.144 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
3.878GlnAla: 3.878 ± 0.053
0.236GlnCys: 0.236 ± 0.012
1.916GlnAsp: 1.916 ± 0.036
1.715GlnGlu: 1.715 ± 0.036
1.233GlnPhe: 1.233 ± 0.032
2.622GlnGly: 2.622 ± 0.047
0.688GlnHis: 0.688 ± 0.023
2.342GlnIle: 2.342 ± 0.037
1.185GlnLys: 1.185 ± 0.031
2.994GlnLeu: 2.994 ± 0.047
1.215GlnMet: 1.215 ± 0.028
1.141GlnAsn: 1.141 ± 0.028
1.579GlnPro: 1.579 ± 0.035
1.206GlnGln: 1.206 ± 0.031
2.107GlnArg: 2.107 ± 0.037
2.129GlnSer: 2.129 ± 0.04
2.196GlnThr: 2.196 ± 0.041
2.399GlnVal: 2.399 ± 0.038
0.409GlnTrp: 0.409 ± 0.017
0.651GlnTyr: 0.651 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
6.86ArgAla: 6.86 ± 0.067
0.476ArgCys: 0.476 ± 0.017
3.853ArgAsp: 3.853 ± 0.054
3.204ArgGlu: 3.204 ± 0.053
2.485ArgPhe: 2.485 ± 0.044
4.126ArgGly: 4.126 ± 0.054
1.394ArgHis: 1.394 ± 0.029
3.462ArgIle: 3.462 ± 0.052
2.369ArgLys: 2.369 ± 0.043
6.193ArgLeu: 6.193 ± 0.067
1.869ArgMet: 1.869 ± 0.038
1.84ArgAsn: 1.84 ± 0.036
2.735ArgPro: 2.735 ± 0.051
2.077ArgGln: 2.077 ± 0.044
4.05ArgArg: 4.05 ± 0.062
3.378ArgSer: 3.378 ± 0.049
2.948ArgThr: 2.948 ± 0.048
4.269ArgVal: 4.269 ± 0.064
0.873ArgTrp: 0.873 ± 0.028
1.459ArgTyr: 1.459 ± 0.027
0.0ArgXaa: 0.0 ± 0.0
Ser
5.954SerAla: 5.954 ± 0.063
0.495SerCys: 0.495 ± 0.019
3.668SerAsp: 3.668 ± 0.058
3.187SerGlu: 3.187 ± 0.049
2.58SerPhe: 2.58 ± 0.045
5.629SerGly: 5.629 ± 0.051
1.173SerHis: 1.173 ± 0.035
3.033SerIle: 3.033 ± 0.045
1.966SerLys: 1.966 ± 0.038
5.336SerLeu: 5.336 ± 0.07
1.629SerMet: 1.629 ± 0.031
1.707SerAsn: 1.707 ± 0.037
2.59SerPro: 2.59 ± 0.042
1.878SerGln: 1.878 ± 0.041
3.099SerArg: 3.099 ± 0.046
3.072SerSer: 3.072 ± 0.044
2.838SerThr: 2.838 ± 0.049
4.124SerVal: 4.124 ± 0.046
0.724SerTrp: 0.724 ± 0.026
1.447SerTyr: 1.447 ± 0.029
0.0SerXaa: 0.0 ± 0.0
Thr
6.194ThrAla: 6.194 ± 0.067
0.533ThrCys: 0.533 ± 0.02
3.345ThrAsp: 3.345 ± 0.056
2.807ThrGlu: 2.807 ± 0.042
2.081ThrPhe: 2.081 ± 0.04
5.26ThrGly: 5.26 ± 0.058
1.221ThrHis: 1.221 ± 0.032
2.97ThrIle: 2.97 ± 0.049
1.828ThrLys: 1.828 ± 0.034
6.225ThrLeu: 6.225 ± 0.078
1.424ThrMet: 1.424 ± 0.032
1.521ThrAsn: 1.521 ± 0.036
3.446ThrPro: 3.446 ± 0.047
1.98ThrGln: 1.98 ± 0.04
3.251ThrArg: 3.251 ± 0.043
3.176ThrSer: 3.176 ± 0.045
3.065ThrThr: 3.065 ± 0.055
4.202ThrVal: 4.202 ± 0.052
0.716ThrTrp: 0.716 ± 0.023
1.396ThrTyr: 1.396 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
8.255ValAla: 8.255 ± 0.079
0.674ValCys: 0.674 ± 0.023
4.125ValAsp: 4.125 ± 0.062
4.209ValGlu: 4.209 ± 0.057
3.01ValPhe: 3.01 ± 0.051
5.571ValGly: 5.571 ± 0.076
1.381ValHis: 1.381 ± 0.029
4.415ValIle: 4.415 ± 0.055
2.195ValLys: 2.195 ± 0.045
7.398ValLeu: 7.398 ± 0.079
2.168ValMet: 2.168 ± 0.042
2.028ValAsn: 2.028 ± 0.035
3.458ValPro: 3.458 ± 0.047
2.266ValGln: 2.266 ± 0.039
3.965ValArg: 3.965 ± 0.056
4.48ValSer: 4.48 ± 0.068
4.576ValThr: 4.576 ± 0.063
5.526ValVal: 5.526 ± 0.078
0.977ValTrp: 0.977 ± 0.027
1.506ValTyr: 1.506 ± 0.032
0.0ValXaa: 0.0 ± 0.0
Trp
1.36TrpAla: 1.36 ± 0.034
0.151TrpCys: 0.151 ± 0.01
0.829TrpAsp: 0.829 ± 0.024
0.693TrpGlu: 0.693 ± 0.02
0.608TrpPhe: 0.608 ± 0.021
1.011TrpGly: 1.011 ± 0.031
0.365TrpHis: 0.365 ± 0.014
0.76TrpIle: 0.76 ± 0.024
0.496TrpLys: 0.496 ± 0.023
1.557TrpLeu: 1.557 ± 0.034
0.424TrpMet: 0.424 ± 0.02
0.491TrpAsn: 0.491 ± 0.018
0.697TrpPro: 0.697 ± 0.024
0.639TrpGln: 0.639 ± 0.021
0.964TrpArg: 0.964 ± 0.026
0.85TrpSer: 0.85 ± 0.024
0.767TrpThr: 0.767 ± 0.024
0.95TrpVal: 0.95 ± 0.027
0.239TrpTrp: 0.239 ± 0.012
0.306TrpTyr: 0.306 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.525TyrAla: 2.525 ± 0.035
0.244TyrCys: 0.244 ± 0.012
1.649TyrAsp: 1.649 ± 0.033
1.312TyrGlu: 1.312 ± 0.03
0.997TyrPhe: 0.997 ± 0.024
2.168TyrGly: 2.168 ± 0.044
0.507TyrHis: 0.507 ± 0.019
1.016TyrIle: 1.016 ± 0.026
0.665TyrLys: 0.665 ± 0.022
2.338TyrLeu: 2.338 ± 0.04
0.52TyrMet: 0.52 ± 0.02
0.658TyrAsn: 0.658 ± 0.022
1.114TyrPro: 1.114 ± 0.026
0.74TyrGln: 0.74 ± 0.022
1.495TyrArg: 1.495 ± 0.036
1.296TyrSer: 1.296 ± 0.031
1.196TyrThr: 1.196 ± 0.033
1.612TyrVal: 1.612 ± 0.033
0.377TyrTrp: 0.377 ± 0.015
0.617TyrTyr: 0.617 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4800 proteins (1475871 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski