Amino acid dipepetide frequency for Streptococcus phage Javan182

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.097AlaAla: 6.097 ± 1.179
0.197AlaCys: 0.197 ± 0.137
4.72AlaAsp: 4.72 ± 0.796
5.507AlaGlu: 5.507 ± 0.922
2.753AlaPhe: 2.753 ± 0.496
5.015AlaGly: 5.015 ± 1.261
0.885AlaHis: 0.885 ± 0.305
7.179AlaIle: 7.179 ± 1.112
7.179AlaLys: 7.179 ± 0.829
6.097AlaLeu: 6.097 ± 0.645
1.475AlaMet: 1.475 ± 0.475
4.524AlaAsn: 4.524 ± 0.704
1.278AlaPro: 1.278 ± 0.297
2.753AlaGln: 2.753 ± 0.612
2.262AlaArg: 2.262 ± 0.514
4.327AlaSer: 4.327 ± 0.85
3.245AlaThr: 3.245 ± 0.73
4.032AlaVal: 4.032 ± 0.646
0.688AlaTrp: 0.688 ± 0.306
2.95AlaTyr: 2.95 ± 0.378
0.0AlaXaa: 0.0 ± 0.0
Cys
0.492CysAla: 0.492 ± 0.186
0.197CysCys: 0.197 ± 0.12
0.492CysAsp: 0.492 ± 0.258
0.393CysGlu: 0.393 ± 0.195
0.393CysPhe: 0.393 ± 0.21
0.787CysGly: 0.787 ± 0.341
0.393CysHis: 0.393 ± 0.194
0.59CysIle: 0.59 ± 0.247
0.492CysLys: 0.492 ± 0.248
0.688CysLeu: 0.688 ± 0.221
0.098CysMet: 0.098 ± 0.121
0.393CysAsn: 0.393 ± 0.215
0.197CysPro: 0.197 ± 0.161
0.197CysGln: 0.197 ± 0.143
0.295CysArg: 0.295 ± 0.213
0.197CysSer: 0.197 ± 0.154
0.0CysThr: 0.0 ± 0.0
0.492CysVal: 0.492 ± 0.253
0.0CysTrp: 0.0 ± 0.0
0.393CysTyr: 0.393 ± 0.2
0.0CysXaa: 0.0 ± 0.0
Asp
3.835AspAla: 3.835 ± 0.83
0.492AspCys: 0.492 ± 0.209
4.524AspAsp: 4.524 ± 0.48
4.72AspGlu: 4.72 ± 0.75
3.048AspPhe: 3.048 ± 0.528
5.015AspGly: 5.015 ± 0.627
0.787AspHis: 0.787 ± 0.233
4.819AspIle: 4.819 ± 0.724
5.212AspLys: 5.212 ± 0.682
5.704AspLeu: 5.704 ± 0.707
1.082AspMet: 1.082 ± 0.328
3.639AspAsn: 3.639 ± 0.565
1.082AspPro: 1.082 ± 0.258
1.18AspGln: 1.18 ± 0.283
1.967AspArg: 1.967 ± 0.395
3.934AspSer: 3.934 ± 0.628
3.343AspThr: 3.343 ± 0.573
5.507AspVal: 5.507 ± 0.58
0.885AspTrp: 0.885 ± 0.348
3.639AspTyr: 3.639 ± 0.653
0.0AspXaa: 0.0 ± 0.0
Glu
4.917GluAla: 4.917 ± 0.831
0.197GluCys: 0.197 ± 0.141
2.458GluAsp: 2.458 ± 0.725
5.114GluGlu: 5.114 ± 1.052
2.753GluPhe: 2.753 ± 0.48
2.262GluGly: 2.262 ± 0.444
0.59GluHis: 0.59 ± 0.25
6.687GluIle: 6.687 ± 0.915
5.704GluLys: 5.704 ± 0.776
7.277GluLeu: 7.277 ± 1.109
1.377GluMet: 1.377 ± 0.378
3.54GluAsn: 3.54 ± 0.664
2.065GluPro: 2.065 ± 0.523
3.048GluGln: 3.048 ± 0.627
2.852GluArg: 2.852 ± 0.63
4.032GluSer: 4.032 ± 0.668
4.229GluThr: 4.229 ± 0.716
5.015GluVal: 5.015 ± 0.853
1.082GluTrp: 1.082 ± 0.405
3.343GluTyr: 3.343 ± 0.658
0.0GluXaa: 0.0 ± 0.0
Phe
3.835PheAla: 3.835 ± 0.697
0.295PheCys: 0.295 ± 0.168
3.54PheAsp: 3.54 ± 0.622
3.048PheGlu: 3.048 ± 0.543
1.573PhePhe: 1.573 ± 0.33
3.048PheGly: 3.048 ± 0.604
0.295PheHis: 0.295 ± 0.183
1.868PheIle: 1.868 ± 0.514
2.852PheLys: 2.852 ± 0.523
2.458PheLeu: 2.458 ± 0.549
0.492PheMet: 0.492 ± 0.204
2.557PheAsn: 2.557 ± 0.712
0.492PhePro: 0.492 ± 0.213
0.787PheGln: 0.787 ± 0.288
1.868PheArg: 1.868 ± 0.337
2.458PheSer: 2.458 ± 0.583
1.967PheThr: 1.967 ± 0.43
2.458PheVal: 2.458 ± 0.431
0.492PheTrp: 0.492 ± 0.223
1.18PheTyr: 1.18 ± 0.376
0.0PheXaa: 0.0 ± 0.0
Gly
3.835GlyAla: 3.835 ± 1.025
0.59GlyCys: 0.59 ± 0.299
4.13GlyAsp: 4.13 ± 0.604
4.032GlyGlu: 4.032 ± 0.722
2.753GlyPhe: 2.753 ± 0.736
5.015GlyGly: 5.015 ± 0.709
1.082GlyHis: 1.082 ± 0.331
5.409GlyIle: 5.409 ± 0.808
6.49GlyLys: 6.49 ± 0.827
6.884GlyLeu: 6.884 ± 1.132
2.065GlyMet: 2.065 ± 0.388
3.54GlyAsn: 3.54 ± 0.417
2.557GlyPro: 2.557 ± 1.591
2.95GlyGln: 2.95 ± 0.591
1.868GlyArg: 1.868 ± 0.401
3.639GlySer: 3.639 ± 0.704
3.639GlyThr: 3.639 ± 0.709
4.229GlyVal: 4.229 ± 0.696
0.885GlyTrp: 0.885 ± 0.381
3.934GlyTyr: 3.934 ± 0.544
0.0GlyXaa: 0.0 ± 0.0
His
0.983HisAla: 0.983 ± 0.337
0.197HisCys: 0.197 ± 0.138
0.393HisAsp: 0.393 ± 0.201
1.082HisGlu: 1.082 ± 0.316
0.59HisPhe: 0.59 ± 0.255
0.885HisGly: 0.885 ± 0.277
0.295HisHis: 0.295 ± 0.19
0.983HisIle: 0.983 ± 0.341
0.688HisLys: 0.688 ± 0.248
1.475HisLeu: 1.475 ± 0.396
0.197HisMet: 0.197 ± 0.136
0.688HisAsn: 0.688 ± 0.336
0.59HisPro: 0.59 ± 0.279
0.59HisGln: 0.59 ± 0.229
0.885HisArg: 0.885 ± 0.249
1.475HisSer: 1.475 ± 0.404
0.885HisThr: 0.885 ± 0.276
0.983HisVal: 0.983 ± 0.349
0.393HisTrp: 0.393 ± 0.214
0.688HisTyr: 0.688 ± 0.22
0.0HisXaa: 0.0 ± 0.0
Ile
5.31IleAla: 5.31 ± 0.943
0.492IleCys: 0.492 ± 0.218
5.507IleAsp: 5.507 ± 0.905
5.507IleGlu: 5.507 ± 0.815
2.262IlePhe: 2.262 ± 0.43
4.819IleGly: 4.819 ± 0.756
0.885IleHis: 0.885 ± 0.254
5.015IleIle: 5.015 ± 0.823
8.555IleLys: 8.555 ± 1.157
6.195IleLeu: 6.195 ± 0.836
1.475IleMet: 1.475 ± 0.638
4.229IleAsn: 4.229 ± 0.709
2.36IlePro: 2.36 ± 0.52
1.278IleGln: 1.278 ± 0.371
3.048IleArg: 3.048 ± 0.467
6.49IleSer: 6.49 ± 1.1
4.819IleThr: 4.819 ± 0.783
3.54IleVal: 3.54 ± 0.597
0.295IleTrp: 0.295 ± 0.171
1.77IleTyr: 1.77 ± 0.549
0.0IleXaa: 0.0 ± 0.0
Lys
5.114LysAla: 5.114 ± 0.849
0.59LysCys: 0.59 ± 0.256
5.31LysAsp: 5.31 ± 0.865
5.605LysGlu: 5.605 ± 0.906
1.868LysPhe: 1.868 ± 0.46
6.097LysGly: 6.097 ± 0.777
1.672LysHis: 1.672 ± 0.373
6.982LysIle: 6.982 ± 0.875
6.49LysLys: 6.49 ± 1.113
6.392LysLeu: 6.392 ± 0.688
2.557LysMet: 2.557 ± 0.531
5.114LysAsn: 5.114 ± 0.739
1.77LysPro: 1.77 ± 0.485
4.622LysGln: 4.622 ± 0.746
4.13LysArg: 4.13 ± 0.651
6.49LysSer: 6.49 ± 0.599
5.409LysThr: 5.409 ± 0.725
5.9LysVal: 5.9 ± 0.644
0.885LysTrp: 0.885 ± 0.251
3.048LysTyr: 3.048 ± 0.611
0.0LysXaa: 0.0 ± 0.0
Leu
6.785LeuAla: 6.785 ± 0.771
0.197LeuCys: 0.197 ± 0.125
5.507LeuAsp: 5.507 ± 0.659
5.704LeuGlu: 5.704 ± 0.725
3.737LeuPhe: 3.737 ± 0.595
5.507LeuGly: 5.507 ± 0.929
0.885LeuHis: 0.885 ± 0.385
5.015LeuIle: 5.015 ± 0.625
9.342LeuLys: 9.342 ± 1.17
6.785LeuLeu: 6.785 ± 1.089
1.377LeuMet: 1.377 ± 0.384
3.835LeuAsn: 3.835 ± 0.493
3.442LeuPro: 3.442 ± 0.605
3.442LeuGln: 3.442 ± 0.54
3.343LeuArg: 3.343 ± 0.71
6.589LeuSer: 6.589 ± 0.967
5.507LeuThr: 5.507 ± 0.797
5.409LeuVal: 5.409 ± 0.724
0.983LeuTrp: 0.983 ± 0.4
2.655LeuTyr: 2.655 ± 0.536
0.0LeuXaa: 0.0 ± 0.0
Met
2.36MetAla: 2.36 ± 0.514
0.197MetCys: 0.197 ± 0.143
1.967MetAsp: 1.967 ± 0.481
1.278MetGlu: 1.278 ± 0.404
0.492MetPhe: 0.492 ± 0.239
1.573MetGly: 1.573 ± 0.573
0.197MetHis: 0.197 ± 0.121
2.163MetIle: 2.163 ± 0.37
1.18MetLys: 1.18 ± 0.426
1.573MetLeu: 1.573 ± 0.468
0.393MetMet: 0.393 ± 0.25
0.59MetAsn: 0.59 ± 0.234
0.688MetPro: 0.688 ± 0.266
0.688MetGln: 0.688 ± 0.303
0.885MetArg: 0.885 ± 0.366
1.377MetSer: 1.377 ± 0.34
2.065MetThr: 2.065 ± 0.444
1.082MetVal: 1.082 ± 0.321
0.098MetTrp: 0.098 ± 0.091
0.492MetTyr: 0.492 ± 0.19
0.0MetXaa: 0.0 ± 0.0
Asn
4.327AsnAla: 4.327 ± 0.749
0.59AsnCys: 0.59 ± 0.282
2.557AsnAsp: 2.557 ± 0.425
2.753AsnGlu: 2.753 ± 0.599
2.36AsnPhe: 2.36 ± 0.456
5.212AsnGly: 5.212 ± 0.573
1.082AsnHis: 1.082 ± 0.364
3.442AsnIle: 3.442 ± 0.61
2.753AsnLys: 2.753 ± 0.527
5.114AsnLeu: 5.114 ± 0.691
1.672AsnMet: 1.672 ± 0.343
1.77AsnAsn: 1.77 ± 0.439
2.95AsnPro: 2.95 ± 0.549
2.262AsnGln: 2.262 ± 0.492
1.967AsnArg: 1.967 ± 0.514
3.048AsnSer: 3.048 ± 0.613
2.852AsnThr: 2.852 ± 0.52
3.934AsnVal: 3.934 ± 0.716
0.787AsnTrp: 0.787 ± 0.326
1.573AsnTyr: 1.573 ± 0.312
0.0AsnXaa: 0.0 ± 0.0
Pro
2.655ProAla: 2.655 ± 0.532
0.197ProCys: 0.197 ± 0.159
2.065ProAsp: 2.065 ± 0.495
1.573ProGlu: 1.573 ± 0.439
0.983ProPhe: 0.983 ± 0.334
1.377ProGly: 1.377 ± 0.549
0.492ProHis: 0.492 ± 0.298
1.278ProIle: 1.278 ± 0.376
3.147ProLys: 3.147 ± 0.591
1.868ProLeu: 1.868 ± 0.446
0.59ProMet: 0.59 ± 0.213
1.278ProAsn: 1.278 ± 0.452
0.983ProPro: 0.983 ± 0.435
1.868ProGln: 1.868 ± 0.669
1.18ProArg: 1.18 ± 0.382
1.868ProSer: 1.868 ± 0.388
2.262ProThr: 2.262 ± 0.492
2.36ProVal: 2.36 ± 0.613
0.197ProTrp: 0.197 ± 0.127
0.688ProTyr: 0.688 ± 0.277
0.0ProXaa: 0.0 ± 0.0
Gln
2.557GlnAla: 2.557 ± 0.483
0.59GlnCys: 0.59 ± 0.307
1.967GlnAsp: 1.967 ± 0.462
3.147GlnGlu: 3.147 ± 0.696
1.573GlnPhe: 1.573 ± 0.414
3.147GlnGly: 3.147 ± 0.988
0.492GlnHis: 0.492 ± 0.197
3.245GlnIle: 3.245 ± 0.62
4.13GlnLys: 4.13 ± 0.618
3.442GlnLeu: 3.442 ± 0.489
0.787GlnMet: 0.787 ± 0.262
2.458GlnAsn: 2.458 ± 0.466
1.082GlnPro: 1.082 ± 0.35
1.475GlnGln: 1.475 ± 0.332
1.082GlnArg: 1.082 ± 0.274
2.458GlnSer: 2.458 ± 0.564
2.262GlnThr: 2.262 ± 0.7
1.868GlnVal: 1.868 ± 0.511
0.393GlnTrp: 0.393 ± 0.187
1.377GlnTyr: 1.377 ± 0.342
0.0GlnXaa: 0.0 ± 0.0
Arg
2.163ArgAla: 2.163 ± 0.429
0.295ArgCys: 0.295 ± 0.199
2.458ArgAsp: 2.458 ± 0.608
2.36ArgGlu: 2.36 ± 0.47
1.377ArgPhe: 1.377 ± 0.374
2.262ArgGly: 2.262 ± 0.604
0.688ArgHis: 0.688 ± 0.282
2.655ArgIle: 2.655 ± 0.576
3.639ArgLys: 3.639 ± 0.715
4.425ArgLeu: 4.425 ± 0.702
0.885ArgMet: 0.885 ± 0.265
2.262ArgAsn: 2.262 ± 0.635
0.688ArgPro: 0.688 ± 0.258
1.18ArgGln: 1.18 ± 0.359
1.77ArgArg: 1.77 ± 0.34
2.753ArgSer: 2.753 ± 0.582
2.262ArgThr: 2.262 ± 0.536
2.163ArgVal: 2.163 ± 0.474
0.393ArgTrp: 0.393 ± 0.18
1.77ArgTyr: 1.77 ± 0.417
0.0ArgXaa: 0.0 ± 0.0
Ser
5.704SerAla: 5.704 ± 1.316
0.59SerCys: 0.59 ± 0.221
5.114SerAsp: 5.114 ± 0.756
4.524SerGlu: 4.524 ± 0.762
3.048SerPhe: 3.048 ± 0.679
5.015SerGly: 5.015 ± 0.845
1.278SerHis: 1.278 ± 0.424
3.934SerIle: 3.934 ± 0.678
4.917SerLys: 4.917 ± 0.757
5.999SerLeu: 5.999 ± 0.927
1.868SerMet: 1.868 ± 0.352
3.54SerAsn: 3.54 ± 0.652
1.77SerPro: 1.77 ± 0.466
2.852SerGln: 2.852 ± 0.557
2.163SerArg: 2.163 ± 0.456
3.934SerSer: 3.934 ± 0.734
3.048SerThr: 3.048 ± 0.545
3.343SerVal: 3.343 ± 0.558
0.885SerTrp: 0.885 ± 0.273
2.557SerTyr: 2.557 ± 0.505
0.0SerXaa: 0.0 ± 0.0
Thr
4.032ThrAla: 4.032 ± 0.735
0.393ThrCys: 0.393 ± 0.193
2.557ThrAsp: 2.557 ± 0.535
4.032ThrGlu: 4.032 ± 0.445
2.065ThrPhe: 2.065 ± 0.416
5.507ThrGly: 5.507 ± 0.952
1.18ThrHis: 1.18 ± 0.376
5.605ThrIle: 5.605 ± 0.906
4.622ThrLys: 4.622 ± 0.624
4.819ThrLeu: 4.819 ± 0.775
0.688ThrMet: 0.688 ± 0.278
3.343ThrAsn: 3.343 ± 0.49
1.573ThrPro: 1.573 ± 0.393
2.852ThrGln: 2.852 ± 0.552
1.672ThrArg: 1.672 ± 0.389
3.147ThrSer: 3.147 ± 0.423
3.442ThrThr: 3.442 ± 0.589
4.032ThrVal: 4.032 ± 0.755
0.295ThrTrp: 0.295 ± 0.156
1.672ThrTyr: 1.672 ± 0.513
0.0ThrXaa: 0.0 ± 0.0
Val
4.819ValAla: 4.819 ± 0.789
0.295ValCys: 0.295 ± 0.198
5.605ValAsp: 5.605 ± 0.839
4.72ValGlu: 4.72 ± 0.854
2.163ValPhe: 2.163 ± 0.467
3.54ValGly: 3.54 ± 0.593
0.59ValHis: 0.59 ± 0.259
4.032ValIle: 4.032 ± 0.701
4.524ValLys: 4.524 ± 0.676
5.409ValLeu: 5.409 ± 0.846
1.278ValMet: 1.278 ± 0.341
3.048ValAsn: 3.048 ± 0.429
1.672ValPro: 1.672 ± 0.483
2.852ValGln: 2.852 ± 0.488
2.655ValArg: 2.655 ± 0.478
4.425ValSer: 4.425 ± 0.562
4.032ValThr: 4.032 ± 0.801
5.212ValVal: 5.212 ± 0.881
0.295ValTrp: 0.295 ± 0.185
3.343ValTyr: 3.343 ± 0.661
0.0ValXaa: 0.0 ± 0.0
Trp
0.59TrpAla: 0.59 ± 0.266
0.393TrpCys: 0.393 ± 0.165
0.295TrpAsp: 0.295 ± 0.208
0.885TrpGlu: 0.885 ± 0.296
0.492TrpPhe: 0.492 ± 0.331
1.082TrpGly: 1.082 ± 0.396
0.295TrpHis: 0.295 ± 0.206
0.492TrpIle: 0.492 ± 0.233
0.59TrpLys: 0.59 ± 0.287
0.688TrpLeu: 0.688 ± 0.264
0.197TrpMet: 0.197 ± 0.147
0.787TrpAsn: 0.787 ± 0.252
0.393TrpPro: 0.393 ± 0.171
0.393TrpGln: 0.393 ± 0.212
0.885TrpArg: 0.885 ± 0.35
0.885TrpSer: 0.885 ± 0.295
0.098TrpThr: 0.098 ± 0.091
0.393TrpVal: 0.393 ± 0.201
0.098TrpTrp: 0.098 ± 0.102
0.59TrpTyr: 0.59 ± 0.211
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.753TyrAla: 2.753 ± 0.631
0.197TyrCys: 0.197 ± 0.157
3.245TyrAsp: 3.245 ± 0.622
2.557TyrGlu: 2.557 ± 0.445
1.278TyrPhe: 1.278 ± 0.399
2.36TyrGly: 2.36 ± 0.369
0.885TyrHis: 0.885 ± 0.312
2.458TyrIle: 2.458 ± 0.391
3.54TyrLys: 3.54 ± 0.656
2.753TyrLeu: 2.753 ± 0.569
0.688TyrMet: 0.688 ± 0.3
1.868TyrAsn: 1.868 ± 0.408
1.278TyrPro: 1.278 ± 0.326
2.262TyrGln: 2.262 ± 0.435
1.672TyrArg: 1.672 ± 0.437
2.557TyrSer: 2.557 ± 0.511
2.163TyrThr: 2.163 ± 0.476
2.557TyrVal: 2.557 ± 0.481
0.59TyrTrp: 0.59 ± 0.222
1.18TyrTyr: 1.18 ± 0.334
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 49 proteins (10170 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski