Amino acid dipepetide frequency for Mycobacterium phage Cooper

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.441AlaAla: 18.441 ± 1.793
0.973AlaCys: 0.973 ± 0.193
9.95AlaAsp: 9.95 ± 0.809
7.916AlaGlu: 7.916 ± 0.697
2.078AlaPhe: 2.078 ± 0.327
11.763AlaGly: 11.763 ± 0.873
2.344AlaHis: 2.344 ± 0.434
4.201AlaIle: 4.201 ± 0.482
4.245AlaLys: 4.245 ± 0.511
11.365AlaLeu: 11.365 ± 1.018
2.432AlaMet: 2.432 ± 0.334
3.67AlaAsn: 3.67 ± 0.519
7.385AlaPro: 7.385 ± 0.71
4.776AlaGln: 4.776 ± 0.42
7.474AlaArg: 7.474 ± 0.57
5.97AlaSer: 5.97 ± 0.468
7.65AlaThr: 7.65 ± 0.61
10.127AlaVal: 10.127 ± 0.74
2.521AlaTrp: 2.521 ± 0.379
2.476AlaTyr: 2.476 ± 0.282
0.0AlaXaa: 0.0 ± 0.0
Cys
1.194CysAla: 1.194 ± 0.265
0.044CysCys: 0.044 ± 0.039
0.752CysAsp: 0.752 ± 0.199
0.442CysGlu: 0.442 ± 0.126
0.486CysPhe: 0.486 ± 0.144
1.415CysGly: 1.415 ± 0.291
0.442CysHis: 0.442 ± 0.151
0.133CysIle: 0.133 ± 0.082
0.177CysLys: 0.177 ± 0.092
0.486CysLeu: 0.486 ± 0.183
0.354CysMet: 0.354 ± 0.134
0.221CysAsn: 0.221 ± 0.098
0.973CysPro: 0.973 ± 0.258
0.354CysGln: 0.354 ± 0.114
1.017CysArg: 1.017 ± 0.236
0.531CysSer: 0.531 ± 0.122
0.619CysThr: 0.619 ± 0.154
0.486CysVal: 0.486 ± 0.151
0.177CysTrp: 0.177 ± 0.096
0.31CysTyr: 0.31 ± 0.124
0.0CysXaa: 0.0 ± 0.0
Asp
7.827AspAla: 7.827 ± 0.593
0.708AspCys: 0.708 ± 0.174
4.953AspAsp: 4.953 ± 0.669
5.262AspGlu: 5.262 ± 0.598
1.415AspPhe: 1.415 ± 0.31
5.97AspGly: 5.97 ± 0.564
1.282AspHis: 1.282 ± 0.246
3.096AspIle: 3.096 ± 0.355
2.344AspLys: 2.344 ± 0.325
5.086AspLeu: 5.086 ± 0.432
1.548AspMet: 1.548 ± 0.322
1.592AspAsn: 1.592 ± 0.219
4.997AspPro: 4.997 ± 0.447
2.698AspGln: 2.698 ± 0.328
3.626AspArg: 3.626 ± 0.495
2.653AspSer: 2.653 ± 0.322
3.936AspThr: 3.936 ± 0.414
4.466AspVal: 4.466 ± 0.411
1.371AspTrp: 1.371 ± 0.244
1.459AspTyr: 1.459 ± 0.285
0.0AspXaa: 0.0 ± 0.0
Glu
6.854GluAla: 6.854 ± 0.567
0.619GluCys: 0.619 ± 0.151
3.14GluAsp: 3.14 ± 0.352
2.211GluGlu: 2.211 ± 0.328
1.946GluPhe: 1.946 ± 0.269
3.936GluGly: 3.936 ± 0.348
1.415GluHis: 1.415 ± 0.291
1.592GluIle: 1.592 ± 0.317
1.238GluLys: 1.238 ± 0.269
5.837GluLeu: 5.837 ± 0.612
0.84GluMet: 0.84 ± 0.196
1.415GluAsn: 1.415 ± 0.268
3.847GluPro: 3.847 ± 0.496
3.007GluGln: 3.007 ± 0.304
3.582GluArg: 3.582 ± 0.376
1.592GluSer: 1.592 ± 0.25
3.67GluThr: 3.67 ± 0.441
5.262GluVal: 5.262 ± 0.525
0.708GluTrp: 0.708 ± 0.178
1.15GluTyr: 1.15 ± 0.21
0.0GluXaa: 0.0 ± 0.0
Phe
2.874PheAla: 2.874 ± 0.305
0.044PheCys: 0.044 ± 0.044
2.034PheAsp: 2.034 ± 0.296
0.973PheGlu: 0.973 ± 0.241
0.752PhePhe: 0.752 ± 0.185
3.361PheGly: 3.361 ± 0.481
0.663PheHis: 0.663 ± 0.174
0.84PheIle: 0.84 ± 0.183
0.796PheLys: 0.796 ± 0.179
1.592PheLeu: 1.592 ± 0.314
0.398PheMet: 0.398 ± 0.133
0.708PheAsn: 0.708 ± 0.165
1.238PhePro: 1.238 ± 0.214
0.752PheGln: 0.752 ± 0.203
1.592PheArg: 1.592 ± 0.284
1.282PheSer: 1.282 ± 0.23
1.813PheThr: 1.813 ± 0.308
1.813PheVal: 1.813 ± 0.29
0.398PheTrp: 0.398 ± 0.12
0.619PheTyr: 0.619 ± 0.165
0.0PheXaa: 0.0 ± 0.0
Gly
9.994GlyAla: 9.994 ± 1.155
1.106GlyCys: 1.106 ± 0.264
4.511GlyAsp: 4.511 ± 0.477
4.334GlyGlu: 4.334 ± 0.388
2.034GlyPhe: 2.034 ± 0.365
13.488GlyGly: 13.488 ± 2.905
1.504GlyHis: 1.504 ± 0.273
4.82GlyIle: 4.82 ± 0.601
3.538GlyLys: 3.538 ± 0.418
7.341GlyLeu: 7.341 ± 0.533
2.123GlyMet: 2.123 ± 0.4
3.272GlyAsn: 3.272 ± 0.462
3.803GlyPro: 3.803 ± 0.379
4.113GlyGln: 4.113 ± 0.657
5.13GlyArg: 5.13 ± 0.456
6.899GlySer: 6.899 ± 0.623
6.987GlyThr: 6.987 ± 0.83
6.678GlyVal: 6.678 ± 0.702
2.565GlyTrp: 2.565 ± 0.445
3.096GlyTyr: 3.096 ± 0.348
0.0GlyXaa: 0.0 ± 0.0
His
2.255HisAla: 2.255 ± 0.31
0.265HisCys: 0.265 ± 0.122
1.194HisAsp: 1.194 ± 0.235
0.619HisGlu: 0.619 ± 0.151
0.663HisPhe: 0.663 ± 0.171
1.592HisGly: 1.592 ± 0.231
0.796HisHis: 0.796 ± 0.24
0.663HisIle: 0.663 ± 0.183
0.398HisLys: 0.398 ± 0.134
1.636HisLeu: 1.636 ± 0.302
0.354HisMet: 0.354 ± 0.134
0.442HisAsn: 0.442 ± 0.134
1.548HisPro: 1.548 ± 0.262
0.796HisGln: 0.796 ± 0.172
1.813HisArg: 1.813 ± 0.257
0.796HisSer: 0.796 ± 0.202
1.459HisThr: 1.459 ± 0.282
1.415HisVal: 1.415 ± 0.276
0.486HisTrp: 0.486 ± 0.155
0.354HisTyr: 0.354 ± 0.125
0.0HisXaa: 0.0 ± 0.0
Ile
4.732IleAla: 4.732 ± 0.402
0.575IleCys: 0.575 ± 0.151
3.405IleAsp: 3.405 ± 0.314
2.388IleGlu: 2.388 ± 0.345
1.017IlePhe: 1.017 ± 0.189
4.157IleGly: 4.157 ± 0.633
0.929IleHis: 0.929 ± 0.198
1.68IleIle: 1.68 ± 0.299
1.282IleLys: 1.282 ± 0.312
1.946IleLeu: 1.946 ± 0.326
0.398IleMet: 0.398 ± 0.123
1.504IleAsn: 1.504 ± 0.251
2.255IlePro: 2.255 ± 0.276
1.415IleGln: 1.415 ± 0.314
2.034IleArg: 2.034 ± 0.334
2.211IleSer: 2.211 ± 0.282
3.449IleThr: 3.449 ± 0.343
2.653IleVal: 2.653 ± 0.284
0.619IleTrp: 0.619 ± 0.154
0.575IleTyr: 0.575 ± 0.157
0.0IleXaa: 0.0 ± 0.0
Lys
4.378LysAla: 4.378 ± 0.583
0.265LysCys: 0.265 ± 0.117
1.857LysAsp: 1.857 ± 0.347
1.194LysGlu: 1.194 ± 0.266
0.708LysPhe: 0.708 ± 0.183
2.874LysGly: 2.874 ± 0.523
0.486LysHis: 0.486 ± 0.171
1.415LysIle: 1.415 ± 0.262
0.884LysLys: 0.884 ± 0.226
2.963LysLeu: 2.963 ± 0.407
0.398LysMet: 0.398 ± 0.123
1.061LysAsn: 1.061 ± 0.182
1.238LysPro: 1.238 ± 0.25
1.327LysGln: 1.327 ± 0.248
1.946LysArg: 1.946 ± 0.312
1.282LysSer: 1.282 ± 0.292
1.504LysThr: 1.504 ± 0.317
2.255LysVal: 2.255 ± 0.351
0.398LysTrp: 0.398 ± 0.12
0.884LysTyr: 0.884 ± 0.169
0.0LysXaa: 0.0 ± 0.0
Leu
12.559LeuAla: 12.559 ± 0.767
0.531LeuCys: 0.531 ± 0.171
5.572LeuAsp: 5.572 ± 0.534
4.599LeuGlu: 4.599 ± 0.393
1.946LeuPhe: 1.946 ± 0.334
7.341LeuGly: 7.341 ± 0.71
1.415LeuHis: 1.415 ± 0.273
3.582LeuIle: 3.582 ± 0.371
1.592LeuLys: 1.592 ± 0.26
6.987LeuLeu: 6.987 ± 0.46
1.725LeuMet: 1.725 ± 0.228
2.432LeuAsn: 2.432 ± 0.569
6.545LeuPro: 6.545 ± 0.544
2.388LeuGln: 2.388 ± 0.402
4.732LeuArg: 4.732 ± 0.431
3.361LeuSer: 3.361 ± 0.457
5.97LeuThr: 5.97 ± 0.523
5.793LeuVal: 5.793 ± 0.49
0.929LeuTrp: 0.929 ± 0.235
1.902LeuTyr: 1.902 ± 0.312
0.0LeuXaa: 0.0 ± 0.0
Met
2.786MetAla: 2.786 ± 0.403
0.354MetCys: 0.354 ± 0.107
1.371MetAsp: 1.371 ± 0.199
1.061MetGlu: 1.061 ± 0.238
0.708MetPhe: 0.708 ± 0.154
1.68MetGly: 1.68 ± 0.304
0.354MetHis: 0.354 ± 0.131
0.84MetIle: 0.84 ± 0.176
0.663MetLys: 0.663 ± 0.177
1.459MetLeu: 1.459 ± 0.233
0.265MetMet: 0.265 ± 0.111
0.708MetAsn: 0.708 ± 0.198
2.078MetPro: 2.078 ± 0.277
0.531MetGln: 0.531 ± 0.151
0.929MetArg: 0.929 ± 0.155
1.548MetSer: 1.548 ± 0.212
2.167MetThr: 2.167 ± 0.34
1.504MetVal: 1.504 ± 0.256
0.31MetTrp: 0.31 ± 0.118
0.398MetTyr: 0.398 ± 0.135
0.0MetXaa: 0.0 ± 0.0
Asn
4.245AsnAla: 4.245 ± 0.562
0.31AsnCys: 0.31 ± 0.106
1.902AsnAsp: 1.902 ± 0.303
1.548AsnGlu: 1.548 ± 0.258
0.575AsnPhe: 0.575 ± 0.135
3.228AsnGly: 3.228 ± 0.655
0.531AsnHis: 0.531 ± 0.153
0.884AsnIle: 0.884 ± 0.22
0.884AsnLys: 0.884 ± 0.306
2.432AsnLeu: 2.432 ± 0.392
0.663AsnMet: 0.663 ± 0.187
0.663AsnAsn: 0.663 ± 0.173
1.946AsnPro: 1.946 ± 0.27
0.84AsnGln: 0.84 ± 0.171
1.592AsnArg: 1.592 ± 0.264
1.061AsnSer: 1.061 ± 0.211
2.3AsnThr: 2.3 ± 0.485
2.344AsnVal: 2.344 ± 0.326
0.442AsnTrp: 0.442 ± 0.137
0.663AsnTyr: 0.663 ± 0.149
0.0AsnXaa: 0.0 ± 0.0
Pro
7.739ProAla: 7.739 ± 0.642
0.619ProCys: 0.619 ± 0.188
5.086ProAsp: 5.086 ± 0.593
4.555ProGlu: 4.555 ± 0.556
1.769ProPhe: 1.769 ± 0.298
6.854ProGly: 6.854 ± 0.615
0.973ProHis: 0.973 ± 0.216
2.255ProIle: 2.255 ± 0.338
1.415ProLys: 1.415 ± 0.261
3.892ProLeu: 3.892 ± 0.415
1.459ProMet: 1.459 ± 0.253
1.636ProAsn: 1.636 ± 0.283
4.466ProPro: 4.466 ± 0.602
1.725ProGln: 1.725 ± 0.351
3.405ProArg: 3.405 ± 0.394
2.742ProSer: 2.742 ± 0.45
3.715ProThr: 3.715 ± 0.405
6.191ProVal: 6.191 ± 0.665
1.194ProTrp: 1.194 ± 0.314
1.194ProTyr: 1.194 ± 0.257
0.0ProXaa: 0.0 ± 0.0
Gln
5.262GlnAla: 5.262 ± 0.672
0.531GlnCys: 0.531 ± 0.163
1.238GlnAsp: 1.238 ± 0.255
1.194GlnGlu: 1.194 ± 0.176
1.061GlnPhe: 1.061 ± 0.19
2.83GlnGly: 2.83 ± 0.338
0.442GlnHis: 0.442 ± 0.142
1.548GlnIle: 1.548 ± 0.34
1.061GlnLys: 1.061 ± 0.228
3.759GlnLeu: 3.759 ± 0.412
1.017GlnMet: 1.017 ± 0.223
1.238GlnAsn: 1.238 ± 0.265
2.123GlnPro: 2.123 ± 0.357
1.15GlnGln: 1.15 ± 0.246
3.051GlnArg: 3.051 ± 0.329
1.15GlnSer: 1.15 ± 0.218
2.388GlnThr: 2.388 ± 0.305
3.272GlnVal: 3.272 ± 0.325
1.017GlnTrp: 1.017 ± 0.214
0.929GlnTyr: 0.929 ± 0.173
0.0GlnXaa: 0.0 ± 0.0
Arg
7.65ArgAla: 7.65 ± 0.636
0.663ArgCys: 0.663 ± 0.167
3.715ArgAsp: 3.715 ± 0.448
3.626ArgGlu: 3.626 ± 0.347
1.548ArgPhe: 1.548 ± 0.22
4.024ArgGly: 4.024 ± 0.477
1.548ArgHis: 1.548 ± 0.266
2.3ArgIle: 2.3 ± 0.339
2.344ArgLys: 2.344 ± 0.322
5.66ArgLeu: 5.66 ± 0.55
1.813ArgMet: 1.813 ± 0.407
1.857ArgAsn: 1.857 ± 0.257
3.228ArgPro: 3.228 ± 0.437
2.521ArgGln: 2.521 ± 0.282
5.218ArgArg: 5.218 ± 0.609
2.963ArgSer: 2.963 ± 0.335
3.936ArgThr: 3.936 ± 0.408
4.201ArgVal: 4.201 ± 0.519
1.68ArgTrp: 1.68 ± 0.294
2.167ArgTyr: 2.167 ± 0.399
0.0ArgXaa: 0.0 ± 0.0
Ser
5.484SerAla: 5.484 ± 0.498
0.619SerCys: 0.619 ± 0.194
3.272SerAsp: 3.272 ± 0.295
2.167SerGlu: 2.167 ± 0.331
1.282SerPhe: 1.282 ± 0.218
5.174SerGly: 5.174 ± 0.605
0.752SerHis: 0.752 ± 0.124
1.946SerIle: 1.946 ± 0.224
1.813SerLys: 1.813 ± 0.299
3.67SerLeu: 3.67 ± 0.452
1.459SerMet: 1.459 ± 0.276
1.194SerAsn: 1.194 ± 0.288
3.184SerPro: 3.184 ± 0.344
1.725SerGln: 1.725 ± 0.237
2.919SerArg: 2.919 ± 0.368
2.432SerSer: 2.432 ± 0.342
3.67SerThr: 3.67 ± 0.366
3.361SerVal: 3.361 ± 0.327
1.282SerTrp: 1.282 ± 0.227
0.973SerTyr: 0.973 ± 0.237
0.0SerXaa: 0.0 ± 0.0
Thr
9.331ThrAla: 9.331 ± 0.629
0.708ThrCys: 0.708 ± 0.186
4.024ThrAsp: 4.024 ± 0.458
3.405ThrGlu: 3.405 ± 0.38
1.459ThrPhe: 1.459 ± 0.249
7.164ThrGly: 7.164 ± 0.605
1.327ThrHis: 1.327 ± 0.22
3.051ThrIle: 3.051 ± 0.338
1.99ThrLys: 1.99 ± 0.247
5.086ThrLeu: 5.086 ± 0.543
1.946ThrMet: 1.946 ± 0.24
1.946ThrAsn: 1.946 ± 0.381
4.378ThrPro: 4.378 ± 0.641
1.99ThrGln: 1.99 ± 0.292
3.847ThrArg: 3.847 ± 0.502
3.803ThrSer: 3.803 ± 0.379
4.953ThrThr: 4.953 ± 0.47
5.97ThrVal: 5.97 ± 0.644
1.238ThrTrp: 1.238 ± 0.294
1.327ThrTyr: 1.327 ± 0.227
0.0ThrXaa: 0.0 ± 0.0
Val
9.021ValAla: 9.021 ± 0.583
0.796ValCys: 0.796 ± 0.188
4.909ValAsp: 4.909 ± 0.539
4.378ValGlu: 4.378 ± 0.406
1.902ValPhe: 1.902 ± 0.277
6.81ValGly: 6.81 ± 0.547
1.327ValHis: 1.327 ± 0.225
2.83ValIle: 2.83 ± 0.388
2.034ValLys: 2.034 ± 0.301
6.766ValLeu: 6.766 ± 0.391
1.68ValMet: 1.68 ± 0.315
2.609ValAsn: 2.609 ± 0.26
5.174ValPro: 5.174 ± 0.503
2.521ValGln: 2.521 ± 0.319
5.086ValArg: 5.086 ± 0.543
3.759ValSer: 3.759 ± 0.38
5.749ValThr: 5.749 ± 0.807
6.501ValVal: 6.501 ± 0.594
1.459ValTrp: 1.459 ± 0.248
1.636ValTyr: 1.636 ± 0.267
0.0ValXaa: 0.0 ± 0.0
Trp
2.123TrpAla: 2.123 ± 0.325
0.619TrpCys: 0.619 ± 0.193
1.504TrpAsp: 1.504 ± 0.269
0.84TrpGlu: 0.84 ± 0.194
0.752TrpPhe: 0.752 ± 0.253
1.017TrpGly: 1.017 ± 0.207
0.663TrpHis: 0.663 ± 0.168
0.796TrpIle: 0.796 ± 0.178
0.221TrpLys: 0.221 ± 0.098
1.857TrpLeu: 1.857 ± 0.282
0.486TrpMet: 0.486 ± 0.13
0.531TrpAsn: 0.531 ± 0.156
1.15TrpPro: 1.15 ± 0.244
0.796TrpGln: 0.796 ± 0.213
1.504TrpArg: 1.504 ± 0.257
1.327TrpSer: 1.327 ± 0.244
1.504TrpThr: 1.504 ± 0.326
1.017TrpVal: 1.017 ± 0.25
0.575TrpTrp: 0.575 ± 0.177
0.486TrpTyr: 0.486 ± 0.152
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.007TyrAla: 3.007 ± 0.36
0.265TyrCys: 0.265 ± 0.101
1.946TyrAsp: 1.946 ± 0.228
1.15TyrGlu: 1.15 ± 0.205
0.442TyrPhe: 0.442 ± 0.156
2.653TyrGly: 2.653 ± 0.399
0.354TyrHis: 0.354 ± 0.111
0.752TyrIle: 0.752 ± 0.208
0.398TyrLys: 0.398 ± 0.154
2.078TyrLeu: 2.078 ± 0.35
0.31TyrMet: 0.31 ± 0.12
0.354TyrAsn: 0.354 ± 0.122
1.327TyrPro: 1.327 ± 0.253
0.84TyrGln: 0.84 ± 0.192
2.167TyrArg: 2.167 ± 0.379
1.017TyrSer: 1.017 ± 0.202
1.504TyrThr: 1.504 ± 0.348
1.636TyrVal: 1.636 ± 0.242
0.398TyrTrp: 0.398 ± 0.139
0.398TyrTyr: 0.398 ± 0.151
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 99 proteins (22614 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski