Amino acid dipepetide frequency for Ahrensia sp. R2A130

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.486AlaAla: 14.486 ± 0.166
1.024AlaCys: 1.024 ± 0.034
7.427AlaAsp: 7.427 ± 0.115
6.833AlaGlu: 6.833 ± 0.092
4.404AlaPhe: 4.404 ± 0.072
9.667AlaGly: 9.667 ± 0.094
2.027AlaHis: 2.027 ± 0.051
6.335AlaIle: 6.335 ± 0.086
4.923AlaLys: 4.923 ± 0.089
11.79AlaLeu: 11.79 ± 0.137
3.774AlaMet: 3.774 ± 0.067
3.534AlaAsn: 3.534 ± 0.063
4.901AlaPro: 4.901 ± 0.079
3.76AlaGln: 3.76 ± 0.061
6.606AlaArg: 6.606 ± 0.096
6.572AlaSer: 6.572 ± 0.082
6.456AlaThr: 6.456 ± 0.085
8.325AlaVal: 8.325 ± 0.108
1.292AlaTrp: 1.292 ± 0.04
2.262AlaTyr: 2.262 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
0.962CysAla: 0.962 ± 0.032
0.136CysCys: 0.136 ± 0.012
0.581CysAsp: 0.581 ± 0.023
0.48CysGlu: 0.48 ± 0.022
0.345CysPhe: 0.345 ± 0.018
0.91CysGly: 0.91 ± 0.028
0.221CysHis: 0.221 ± 0.015
0.463CysIle: 0.463 ± 0.021
0.257CysLys: 0.257 ± 0.014
0.752CysLeu: 0.752 ± 0.026
0.192CysMet: 0.192 ± 0.015
0.25CysAsn: 0.25 ± 0.017
0.413CysPro: 0.413 ± 0.022
0.226CysGln: 0.226 ± 0.013
0.529CysArg: 0.529 ± 0.025
0.484CysSer: 0.484 ± 0.021
0.446CysThr: 0.446 ± 0.021
0.625CysVal: 0.625 ± 0.028
0.133CysTrp: 0.133 ± 0.011
0.189CysTyr: 0.189 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
7.37AspAla: 7.37 ± 0.094
0.542AspCys: 0.542 ± 0.023
4.365AspAsp: 4.365 ± 0.1
4.2AspGlu: 4.2 ± 0.063
2.394AspPhe: 2.394 ± 0.045
6.385AspGly: 6.385 ± 0.176
1.425AspHis: 1.425 ± 0.041
3.557AspIle: 3.557 ± 0.067
2.1AspLys: 2.1 ± 0.047
5.76AspLeu: 5.76 ± 0.079
1.796AspMet: 1.796 ± 0.043
1.846AspAsn: 1.846 ± 0.053
3.113AspPro: 3.113 ± 0.054
1.77AspGln: 1.77 ± 0.037
3.898AspArg: 3.898 ± 0.066
2.473AspSer: 2.473 ± 0.06
3.698AspThr: 3.698 ± 0.109
4.769AspVal: 4.769 ± 0.093
0.973AspTrp: 0.973 ± 0.032
1.549AspTyr: 1.549 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
7.34GluAla: 7.34 ± 0.096
0.394GluCys: 0.394 ± 0.022
3.265GluAsp: 3.265 ± 0.059
3.364GluGlu: 3.364 ± 0.076
1.926GluPhe: 1.926 ± 0.043
4.489GluGly: 4.489 ± 0.064
1.207GluHis: 1.207 ± 0.038
3.37GluIle: 3.37 ± 0.053
2.603GluLys: 2.603 ± 0.068
5.315GluLeu: 5.315 ± 0.075
1.647GluMet: 1.647 ± 0.041
2.066GluAsn: 2.066 ± 0.048
2.706GluPro: 2.706 ± 0.062
2.218GluGln: 2.218 ± 0.042
4.409GluArg: 4.409 ± 0.078
2.405GluSer: 2.405 ± 0.051
3.762GluThr: 3.762 ± 0.065
3.819GluVal: 3.819 ± 0.063
0.764GluTrp: 0.764 ± 0.025
1.006GluTyr: 1.006 ± 0.032
0.0GluXaa: 0.0 ± 0.0
Phe
4.724PheAla: 4.724 ± 0.065
0.416PheCys: 0.416 ± 0.019
3.105PheAsp: 3.105 ± 0.069
2.297PheGlu: 2.297 ± 0.05
1.542PhePhe: 1.542 ± 0.043
3.82PheGly: 3.82 ± 0.074
0.755PheHis: 0.755 ± 0.031
2.016PheIle: 2.016 ± 0.044
1.154PheLys: 1.154 ± 0.036
3.229PheLeu: 3.229 ± 0.064
0.929PheMet: 0.929 ± 0.031
1.223PheAsn: 1.223 ± 0.038
1.552PhePro: 1.552 ± 0.041
1.156PheGln: 1.156 ± 0.036
1.925PheArg: 1.925 ± 0.042
2.45PheSer: 2.45 ± 0.053
2.352PheThr: 2.352 ± 0.059
2.77PheVal: 2.77 ± 0.052
0.527PheTrp: 0.527 ± 0.021
0.921PheTyr: 0.921 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
8.487GlyAla: 8.487 ± 0.105
0.829GlyCys: 0.829 ± 0.029
5.15GlyAsp: 5.15 ± 0.137
5.135GlyGlu: 5.135 ± 0.07
3.739GlyPhe: 3.739 ± 0.064
7.591GlyGly: 7.591 ± 0.161
1.782GlyHis: 1.782 ± 0.045
4.695GlyIle: 4.695 ± 0.068
3.636GlyLys: 3.636 ± 0.07
8.038GlyLeu: 8.038 ± 0.085
2.466GlyMet: 2.466 ± 0.047
2.815GlyAsn: 2.815 ± 0.087
3.122GlyPro: 3.122 ± 0.054
2.793GlyGln: 2.793 ± 0.047
5.051GlyArg: 5.051 ± 0.079
5.188GlySer: 5.188 ± 0.117
5.23GlyThr: 5.23 ± 0.139
5.882GlyVal: 5.882 ± 0.067
1.238GlyTrp: 1.238 ± 0.039
2.281GlyTyr: 2.281 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
2.132HisAla: 2.132 ± 0.05
0.261HisCys: 0.261 ± 0.015
1.362HisAsp: 1.362 ± 0.041
1.065HisGlu: 1.065 ± 0.034
0.839HisPhe: 0.839 ± 0.03
1.814HisGly: 1.814 ± 0.05
0.609HisHis: 0.609 ± 0.028
1.077HisIle: 1.077 ± 0.031
0.583HisLys: 0.583 ± 0.023
1.866HisLeu: 1.866 ± 0.047
0.538HisMet: 0.538 ± 0.022
0.547HisAsn: 0.547 ± 0.021
1.132HisPro: 1.132 ± 0.035
0.538HisGln: 0.538 ± 0.022
1.236HisArg: 1.236 ± 0.04
1.011HisSer: 1.011 ± 0.033
0.952HisThr: 0.952 ± 0.031
1.433HisVal: 1.433 ± 0.037
0.301HisTrp: 0.301 ± 0.016
0.513HisTyr: 0.513 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
7.487IleAla: 7.487 ± 0.095
0.572IleCys: 0.572 ± 0.024
3.998IleAsp: 3.998 ± 0.079
3.684IleGlu: 3.684 ± 0.066
1.991IlePhe: 1.991 ± 0.046
4.924IleGly: 4.924 ± 0.071
0.961IleHis: 0.961 ± 0.027
3.097IleIle: 3.097 ± 0.064
1.581IleLys: 1.581 ± 0.046
4.238IleLeu: 4.238 ± 0.067
1.24IleMet: 1.24 ± 0.031
1.617IleAsn: 1.617 ± 0.038
2.244IlePro: 2.244 ± 0.045
1.21IleGln: 1.21 ± 0.033
2.905IleArg: 2.905 ± 0.054
3.288IleSer: 3.288 ± 0.06
3.385IleThr: 3.385 ± 0.072
4.284IleVal: 4.284 ± 0.068
0.671IleTrp: 0.671 ± 0.025
1.234IleTyr: 1.234 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
4.62LysAla: 4.62 ± 0.089
0.221LysCys: 0.221 ± 0.015
1.954LysAsp: 1.954 ± 0.05
1.814LysGlu: 1.814 ± 0.049
1.156LysPhe: 1.156 ± 0.037
2.93LysGly: 2.93 ± 0.078
0.732LysHis: 0.732 ± 0.029
1.985LysIle: 1.985 ± 0.044
1.742LysLys: 1.742 ± 0.061
3.787LysLeu: 3.787 ± 0.071
1.061LysMet: 1.061 ± 0.031
1.134LysAsn: 1.134 ± 0.038
2.412LysPro: 2.412 ± 0.058
1.275LysGln: 1.275 ± 0.034
2.808LysArg: 2.808 ± 0.066
2.235LysSer: 2.235 ± 0.056
2.368LysThr: 2.368 ± 0.057
2.584LysVal: 2.584 ± 0.059
0.454LysTrp: 0.454 ± 0.02
0.699LysTyr: 0.699 ± 0.03
0.0LysXaa: 0.0 ± 0.0
Leu
11.629LeuAla: 11.629 ± 0.129
0.814LeuCys: 0.814 ± 0.032
6.037LeuAsp: 6.037 ± 0.082
5.183LeuGlu: 5.183 ± 0.087
3.529LeuPhe: 3.529 ± 0.07
7.454LeuGly: 7.454 ± 0.089
1.73LeuHis: 1.73 ± 0.047
4.769LeuIle: 4.769 ± 0.078
3.647LeuLys: 3.647 ± 0.065
8.39LeuLeu: 8.39 ± 0.115
2.393LeuMet: 2.393 ± 0.051
2.944LeuAsn: 2.944 ± 0.052
4.906LeuPro: 4.906 ± 0.077
2.782LeuGln: 2.782 ± 0.05
5.685LeuArg: 5.685 ± 0.082
6.216LeuSer: 6.216 ± 0.074
5.641LeuThr: 5.641 ± 0.08
6.86LeuVal: 6.86 ± 0.085
1.062LeuTrp: 1.062 ± 0.039
1.957LeuTyr: 1.957 ± 0.043
0.0LeuXaa: 0.0 ± 0.0
Met
3.4MetAla: 3.4 ± 0.065
0.213MetCys: 0.213 ± 0.015
1.521MetAsp: 1.521 ± 0.037
1.479MetGlu: 1.479 ± 0.038
0.888MetPhe: 0.888 ± 0.031
2.101MetGly: 2.101 ± 0.046
0.436MetHis: 0.436 ± 0.019
1.479MetIle: 1.479 ± 0.045
1.284MetLys: 1.284 ± 0.04
2.529MetLeu: 2.529 ± 0.066
0.818MetMet: 0.818 ± 0.031
0.978MetAsn: 0.978 ± 0.034
1.47MetPro: 1.47 ± 0.04
0.925MetGln: 0.925 ± 0.031
1.798MetArg: 1.798 ± 0.047
1.874MetSer: 1.874 ± 0.042
1.926MetThr: 1.926 ± 0.045
2.018MetVal: 2.018 ± 0.042
0.247MetTrp: 0.247 ± 0.017
0.317MetTyr: 0.317 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.587AsnAla: 3.587 ± 0.06
0.284AsnCys: 0.284 ± 0.017
2.221AsnAsp: 2.221 ± 0.095
1.638AsnGlu: 1.638 ± 0.033
1.239AsnPhe: 1.239 ± 0.034
3.019AsnGly: 3.019 ± 0.091
0.592AsnHis: 0.592 ± 0.025
1.716AsnIle: 1.716 ± 0.044
0.924AsnLys: 0.924 ± 0.031
2.774AsnLeu: 2.774 ± 0.049
0.812AsnMet: 0.812 ± 0.03
0.932AsnAsn: 0.932 ± 0.038
1.915AsnPro: 1.915 ± 0.039
0.871AsnGln: 0.871 ± 0.03
2.016AsnArg: 2.016 ± 0.046
1.726AsnSer: 1.726 ± 0.043
1.659AsnThr: 1.659 ± 0.048
2.353AsnVal: 2.353 ± 0.044
0.498AsnTrp: 0.498 ± 0.021
0.747AsnTyr: 0.747 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
5.129ProAla: 5.129 ± 0.082
0.3ProCys: 0.3 ± 0.019
3.449ProAsp: 3.449 ± 0.056
3.206ProGlu: 3.206 ± 0.064
1.948ProPhe: 1.948 ± 0.039
3.552ProGly: 3.552 ± 0.061
1.006ProHis: 1.006 ± 0.033
2.369ProIle: 2.369 ± 0.045
1.984ProLys: 1.984 ± 0.053
4.238ProLeu: 4.238 ± 0.07
1.193ProMet: 1.193 ± 0.033
1.564ProAsn: 1.564 ± 0.038
1.934ProPro: 1.934 ± 0.052
1.594ProGln: 1.594 ± 0.039
2.352ProArg: 2.352 ± 0.05
2.765ProSer: 2.765 ± 0.05
2.669ProThr: 2.669 ± 0.051
4.111ProVal: 4.111 ± 0.067
0.61ProTrp: 0.61 ± 0.03
1.082ProTyr: 1.082 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
3.733GlnAla: 3.733 ± 0.066
0.212GlnCys: 0.212 ± 0.015
1.485GlnAsp: 1.485 ± 0.042
1.418GlnGlu: 1.418 ± 0.039
1.16GlnPhe: 1.16 ± 0.032
2.282GlnGly: 2.282 ± 0.046
0.632GlnHis: 0.632 ± 0.025
1.873GlnIle: 1.873 ± 0.044
1.192GlnLys: 1.192 ± 0.039
3.069GlnLeu: 3.069 ± 0.058
0.963GlnMet: 0.963 ± 0.031
1.099GlnAsn: 1.099 ± 0.032
1.607GlnPro: 1.607 ± 0.039
1.352GlnGln: 1.352 ± 0.051
2.239GlnArg: 2.239 ± 0.053
1.877GlnSer: 1.877 ± 0.049
1.952GlnThr: 1.952 ± 0.047
2.204GlnVal: 2.204 ± 0.049
0.429GlnTrp: 0.429 ± 0.019
0.565GlnTyr: 0.565 ± 0.021
0.0GlnXaa: 0.0 ± 0.0
Arg
6.226ArgAla: 6.226 ± 0.097
0.467ArgCys: 0.467 ± 0.021
3.976ArgAsp: 3.976 ± 0.069
3.866ArgGlu: 3.866 ± 0.057
2.639ArgPhe: 2.639 ± 0.052
4.136ArgGly: 4.136 ± 0.072
1.41ArgHis: 1.41 ± 0.039
3.424ArgIle: 3.424 ± 0.062
2.535ArgLys: 2.535 ± 0.06
6.111ArgLeu: 6.111 ± 0.088
1.785ArgMet: 1.785 ± 0.044
1.933ArgAsn: 1.933 ± 0.044
2.61ArgPro: 2.61 ± 0.05
2.08ArgGln: 2.08 ± 0.05
3.951ArgArg: 3.951 ± 0.074
3.598ArgSer: 3.598 ± 0.058
3.175ArgThr: 3.175 ± 0.056
4.106ArgVal: 4.106 ± 0.063
0.827ArgTrp: 0.827 ± 0.03
1.48ArgTyr: 1.48 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
6.273SerAla: 6.273 ± 0.088
0.425SerCys: 0.425 ± 0.018
3.802SerAsp: 3.802 ± 0.079
3.026SerGlu: 3.026 ± 0.061
2.452SerPhe: 2.452 ± 0.056
6.008SerGly: 6.008 ± 0.091
1.121SerHis: 1.121 ± 0.038
3.262SerIle: 3.262 ± 0.054
2.121SerLys: 2.121 ± 0.053
5.244SerLeu: 5.244 ± 0.081
1.519SerMet: 1.519 ± 0.04
1.888SerAsn: 1.888 ± 0.05
2.616SerPro: 2.616 ± 0.049
1.824SerGln: 1.824 ± 0.043
3.366SerArg: 3.366 ± 0.068
3.367SerSer: 3.367 ± 0.069
3.107SerThr: 3.107 ± 0.053
4.187SerVal: 4.187 ± 0.065
0.778SerTrp: 0.778 ± 0.028
1.36SerTyr: 1.36 ± 0.037
0.0SerXaa: 0.0 ± 0.0
Thr
6.744ThrAla: 6.744 ± 0.085
0.467ThrCys: 0.467 ± 0.022
3.481ThrAsp: 3.481 ± 0.079
2.78ThrGlu: 2.78 ± 0.057
2.474ThrPhe: 2.474 ± 0.058
5.734ThrGly: 5.734 ± 0.112
1.057ThrHis: 1.057 ± 0.032
3.612ThrIle: 3.612 ± 0.081
1.971ThrLys: 1.971 ± 0.048
5.756ThrLeu: 5.756 ± 0.082
1.591ThrMet: 1.591 ± 0.039
1.824ThrAsn: 1.824 ± 0.044
3.247ThrPro: 3.247 ± 0.06
1.631ThrGln: 1.631 ± 0.042
3.037ThrArg: 3.037 ± 0.053
3.427ThrSer: 3.427 ± 0.067
3.436ThrThr: 3.436 ± 0.071
4.925ThrVal: 4.925 ± 0.116
0.657ThrTrp: 0.657 ± 0.021
1.348ThrTyr: 1.348 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
8.56ValAla: 8.56 ± 0.099
0.641ValCys: 0.641 ± 0.024
4.598ValAsp: 4.598 ± 0.085
4.732ValGlu: 4.732 ± 0.073
2.761ValPhe: 2.761 ± 0.048
5.412ValGly: 5.412 ± 0.075
1.338ValHis: 1.338 ± 0.039
3.896ValIle: 3.896 ± 0.066
2.579ValLys: 2.579 ± 0.058
7.089ValLeu: 7.089 ± 0.092
2.09ValMet: 2.09 ± 0.049
2.168ValAsn: 2.168 ± 0.057
3.583ValPro: 3.583 ± 0.058
2.156ValGln: 2.156 ± 0.048
4.121ValArg: 4.121 ± 0.065
4.698ValSer: 4.698 ± 0.079
4.899ValThr: 4.899 ± 0.112
5.786ValVal: 5.786 ± 0.084
0.956ValTrp: 0.956 ± 0.032
1.328ValTyr: 1.328 ± 0.032
0.0ValXaa: 0.0 ± 0.0
Trp
1.184TrpAla: 1.184 ± 0.038
0.159TrpCys: 0.159 ± 0.01
0.645TrpAsp: 0.645 ± 0.027
0.587TrpGlu: 0.587 ± 0.027
0.582TrpPhe: 0.582 ± 0.029
0.864TrpGly: 0.864 ± 0.034
0.296TrpHis: 0.296 ± 0.019
0.624TrpIle: 0.624 ± 0.029
0.513TrpLys: 0.513 ± 0.021
1.541TrpLeu: 1.541 ± 0.046
0.426TrpMet: 0.426 ± 0.019
0.504TrpAsn: 0.504 ± 0.021
0.639TrpPro: 0.639 ± 0.024
0.549TrpGln: 0.549 ± 0.02
0.894TrpArg: 0.894 ± 0.03
0.847TrpSer: 0.847 ± 0.03
0.804TrpThr: 0.804 ± 0.025
0.816TrpVal: 0.816 ± 0.03
0.231TrpTrp: 0.231 ± 0.015
0.275TrpTyr: 0.275 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.323TyrAla: 2.323 ± 0.042
0.22TyrCys: 0.22 ± 0.013
1.565TyrAsp: 1.565 ± 0.043
1.285TyrGlu: 1.285 ± 0.038
0.853TyrPhe: 0.853 ± 0.027
2.056TyrGly: 2.056 ± 0.047
0.47TyrHis: 0.47 ± 0.02
0.991TyrIle: 0.991 ± 0.031
0.642TyrLys: 0.642 ± 0.026
2.112TyrLeu: 2.112 ± 0.049
0.468TyrMet: 0.468 ± 0.02
0.66TyrAsn: 0.66 ± 0.026
0.935TyrPro: 0.935 ± 0.029
0.63TyrGln: 0.63 ± 0.024
1.512TyrArg: 1.512 ± 0.039
1.245TyrSer: 1.245 ± 0.041
1.282TyrThr: 1.282 ± 0.038
1.536TyrVal: 1.536 ± 0.039
0.33TyrTrp: 0.33 ± 0.018
0.527TyrTyr: 0.527 ± 0.02
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3622 proteins (1133679 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski