Amino acid dipepetide frequency for Photobacterium lipolyticum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.427AlaAla: 8.427 ± 0.111
1.072AlaCys: 1.072 ± 0.032
4.972AlaAsp: 4.972 ± 0.072
6.085AlaGlu: 6.085 ± 0.074
3.318AlaPhe: 3.318 ± 0.059
6.312AlaGly: 6.312 ± 0.081
1.628AlaHis: 1.628 ± 0.038
6.103AlaIle: 6.103 ± 0.072
4.677AlaLys: 4.677 ± 0.057
9.661AlaLeu: 9.661 ± 0.094
2.863AlaMet: 2.863 ± 0.051
3.534AlaAsn: 3.534 ± 0.055
2.875AlaPro: 2.875 ± 0.053
3.724AlaGln: 3.724 ± 0.055
3.893AlaArg: 3.893 ± 0.066
5.383AlaSer: 5.383 ± 0.083
4.592AlaThr: 4.592 ± 0.059
6.243AlaVal: 6.243 ± 0.072
0.922AlaTrp: 0.922 ± 0.027
2.335AlaTyr: 2.335 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.845CysAla: 0.845 ± 0.026
0.194CysCys: 0.194 ± 0.012
0.661CysAsp: 0.661 ± 0.022
0.68CysGlu: 0.68 ± 0.027
0.532CysPhe: 0.532 ± 0.02
1.002CysGly: 1.002 ± 0.028
0.414CysHis: 0.414 ± 0.019
0.623CysIle: 0.623 ± 0.022
0.467CysLys: 0.467 ± 0.02
1.037CysLeu: 1.037 ± 0.031
0.26CysMet: 0.26 ± 0.013
0.422CysAsn: 0.422 ± 0.017
0.476CysPro: 0.476 ± 0.023
0.537CysGln: 0.537 ± 0.021
0.573CysArg: 0.573 ± 0.021
0.766CysSer: 0.766 ± 0.024
0.516CysThr: 0.516 ± 0.025
0.664CysVal: 0.664 ± 0.023
0.154CysTrp: 0.154 ± 0.01
0.408CysTyr: 0.408 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
4.513AspAla: 4.513 ± 0.062
0.616AspCys: 0.616 ± 0.021
3.204AspAsp: 3.204 ± 0.061
3.901AspGlu: 3.901 ± 0.065
2.476AspPhe: 2.476 ± 0.046
3.837AspGly: 3.837 ± 0.074
1.211AspHis: 1.211 ± 0.029
4.081AspIle: 4.081 ± 0.055
3.193AspLys: 3.193 ± 0.048
5.305AspLeu: 5.305 ± 0.07
1.453AspMet: 1.453 ± 0.031
2.51AspAsn: 2.51 ± 0.044
2.187AspPro: 2.187 ± 0.037
2.167AspGln: 2.167 ± 0.039
2.416AspArg: 2.416 ± 0.046
3.299AspSer: 3.299 ± 0.066
2.71AspThr: 2.71 ± 0.054
3.976AspVal: 3.976 ± 0.065
0.867AspTrp: 0.867 ± 0.028
1.994AspTyr: 1.994 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
5.445GluAla: 5.445 ± 0.071
0.601GluCys: 0.601 ± 0.023
2.826GluAsp: 2.826 ± 0.051
3.647GluGlu: 3.647 ± 0.066
2.35GluPhe: 2.35 ± 0.04
3.696GluGly: 3.696 ± 0.053
1.551GluHis: 1.551 ± 0.034
3.92GluIle: 3.92 ± 0.051
3.751GluLys: 3.751 ± 0.062
7.332GluLeu: 7.332 ± 0.08
1.864GluMet: 1.864 ± 0.037
2.529GluAsn: 2.529 ± 0.038
2.174GluPro: 2.174 ± 0.043
4.139GluGln: 4.139 ± 0.062
3.445GluArg: 3.445 ± 0.047
3.444GluSer: 3.444 ± 0.052
3.138GluThr: 3.138 ± 0.048
4.2GluVal: 4.2 ± 0.06
0.773GluTrp: 0.773 ± 0.025
1.691GluTyr: 1.691 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
3.536PheAla: 3.536 ± 0.061
0.502PheCys: 0.502 ± 0.019
2.675PheAsp: 2.675 ± 0.046
2.403PheGlu: 2.403 ± 0.042
1.637PhePhe: 1.637 ± 0.039
3.116PheGly: 3.116 ± 0.055
0.837PheHis: 0.837 ± 0.025
2.673PheIle: 2.673 ± 0.049
1.846PheLys: 1.846 ± 0.036
3.356PheLeu: 3.356 ± 0.058
0.98PheMet: 0.98 ± 0.034
1.972PheAsn: 1.972 ± 0.04
1.372PhePro: 1.372 ± 0.03
1.198PheGln: 1.198 ± 0.029
1.618PheArg: 1.618 ± 0.037
3.267PheSer: 3.267 ± 0.056
2.415PheThr: 2.415 ± 0.048
2.621PheVal: 2.621 ± 0.046
0.521PheTrp: 0.521 ± 0.021
1.256PheTyr: 1.256 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
5.155GlyAla: 5.155 ± 0.068
0.992GlyCys: 0.992 ± 0.026
3.777GlyAsp: 3.777 ± 0.06
4.418GlyGlu: 4.418 ± 0.054
3.201GlyPhe: 3.201 ± 0.046
4.841GlyGly: 4.841 ± 0.072
1.615GlyHis: 1.615 ± 0.034
4.979GlyIle: 4.979 ± 0.066
3.987GlyLys: 3.987 ± 0.059
7.192GlyLeu: 7.192 ± 0.083
2.203GlyMet: 2.203 ± 0.038
2.684GlyAsn: 2.684 ± 0.056
1.723GlyPro: 1.723 ± 0.041
2.912GlyGln: 2.912 ± 0.048
3.264GlyArg: 3.264 ± 0.047
4.089GlySer: 4.089 ± 0.057
3.496GlyThr: 3.496 ± 0.058
4.977GlyVal: 4.977 ± 0.06
1.015GlyTrp: 1.015 ± 0.026
2.594GlyTyr: 2.594 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
1.693HisAla: 1.693 ± 0.041
0.368HisCys: 0.368 ± 0.017
1.217HisAsp: 1.217 ± 0.034
1.159HisGlu: 1.159 ± 0.029
1.079HisPhe: 1.079 ± 0.029
1.593HisGly: 1.593 ± 0.039
0.734HisHis: 0.734 ± 0.026
1.407HisIle: 1.407 ± 0.03
1.003HisLys: 1.003 ± 0.025
2.262HisLeu: 2.262 ± 0.051
0.484HisMet: 0.484 ± 0.02
0.952HisAsn: 0.952 ± 0.023
1.17HisPro: 1.17 ± 0.027
1.253HisGln: 1.253 ± 0.033
1.173HisArg: 1.173 ± 0.034
1.392HisSer: 1.392 ± 0.032
1.104HisThr: 1.104 ± 0.03
1.251HisVal: 1.251 ± 0.026
0.361HisTrp: 0.361 ± 0.015
0.865HisTyr: 0.865 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
6.364IleAla: 6.364 ± 0.077
0.781IleCys: 0.781 ± 0.025
4.227IleAsp: 4.227 ± 0.058
4.576IleGlu: 4.576 ± 0.061
2.273IlePhe: 2.273 ± 0.047
4.696IleGly: 4.696 ± 0.067
1.277IleHis: 1.277 ± 0.034
3.782IleIle: 3.782 ± 0.06
3.297IleLys: 3.297 ± 0.056
5.274IleLeu: 5.274 ± 0.068
1.394IleMet: 1.394 ± 0.035
3.089IleAsn: 3.089 ± 0.049
2.786IlePro: 2.786 ± 0.045
2.283IleGln: 2.283 ± 0.043
2.981IleArg: 2.981 ± 0.052
4.535IleSer: 4.535 ± 0.064
3.968IleThr: 3.968 ± 0.058
4.134IleVal: 4.134 ± 0.06
0.608IleTrp: 0.608 ± 0.022
1.743IleTyr: 1.743 ± 0.036
0.0IleXaa: 0.0 ± 0.0
Lys
4.858LysAla: 4.858 ± 0.062
0.378LysCys: 0.378 ± 0.016
2.609LysAsp: 2.609 ± 0.048
3.323LysGlu: 3.323 ± 0.052
1.529LysPhe: 1.529 ± 0.034
3.312LysGly: 3.312 ± 0.049
1.233LysHis: 1.233 ± 0.032
3.117LysIle: 3.117 ± 0.052
2.969LysLys: 2.969 ± 0.058
5.228LysLeu: 5.228 ± 0.07
1.439LysMet: 1.439 ± 0.032
2.184LysAsn: 2.184 ± 0.045
2.397LysPro: 2.397 ± 0.045
2.77LysGln: 2.77 ± 0.052
2.706LysArg: 2.706 ± 0.045
2.909LysSer: 2.909 ± 0.049
2.831LysThr: 2.831 ± 0.05
3.653LysVal: 3.653 ± 0.057
0.539LysTrp: 0.539 ± 0.019
1.386LysTyr: 1.386 ± 0.032
0.0LysXaa: 0.0 ± 0.0
Leu
10.366LeuAla: 10.366 ± 0.106
1.141LeuCys: 1.141 ± 0.033
5.89LeuAsp: 5.89 ± 0.069
6.063LeuGlu: 6.063 ± 0.072
4.176LeuPhe: 4.176 ± 0.068
6.864LeuGly: 6.864 ± 0.083
2.085LeuHis: 2.085 ± 0.035
6.306LeuIle: 6.306 ± 0.089
5.371LeuLys: 5.371 ± 0.07
10.938LeuLeu: 10.938 ± 0.128
2.736LeuMet: 2.736 ± 0.047
4.538LeuAsn: 4.538 ± 0.061
4.972LeuPro: 4.972 ± 0.069
3.837LeuGln: 3.837 ± 0.061
4.69LeuArg: 4.69 ± 0.069
7.597LeuSer: 7.597 ± 0.09
6.235LeuThr: 6.235 ± 0.065
7.018LeuVal: 7.018 ± 0.084
1.079LeuTrp: 1.079 ± 0.033
2.515LeuTyr: 2.515 ± 0.048
0.0LeuXaa: 0.0 ± 0.0
Met
2.799MetAla: 2.799 ± 0.046
0.236MetCys: 0.236 ± 0.014
1.276MetAsp: 1.276 ± 0.032
1.33MetGlu: 1.33 ± 0.035
0.957MetPhe: 0.957 ± 0.03
1.891MetGly: 1.891 ± 0.039
0.476MetHis: 0.476 ± 0.022
1.658MetIle: 1.658 ± 0.04
1.528MetLys: 1.528 ± 0.033
2.948MetLeu: 2.948 ± 0.047
0.903MetMet: 0.903 ± 0.032
1.148MetAsn: 1.148 ± 0.024
1.294MetPro: 1.294 ± 0.031
1.1MetGln: 1.1 ± 0.031
1.213MetArg: 1.213 ± 0.03
1.877MetSer: 1.877 ± 0.04
1.73MetThr: 1.73 ± 0.033
1.975MetVal: 1.975 ± 0.044
0.213MetTrp: 0.213 ± 0.013
0.56MetTyr: 0.56 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.418AsnAla: 3.418 ± 0.053
0.436AsnCys: 0.436 ± 0.018
2.292AsnAsp: 2.292 ± 0.049
2.408AsnGlu: 2.408 ± 0.042
1.475AsnPhe: 1.475 ± 0.036
3.05AsnGly: 3.05 ± 0.048
0.965AsnHis: 0.965 ± 0.025
2.849AsnIle: 2.849 ± 0.049
2.202AsnLys: 2.202 ± 0.044
3.855AsnLeu: 3.855 ± 0.048
1.043AsnMet: 1.043 ± 0.03
1.983AsnAsn: 1.983 ± 0.048
2.107AsnPro: 2.107 ± 0.038
2.045AsnGln: 2.045 ± 0.042
2.075AsnArg: 2.075 ± 0.04
2.399AsnSer: 2.399 ± 0.044
2.284AsnThr: 2.284 ± 0.046
2.646AsnVal: 2.646 ± 0.043
0.605AsnTrp: 0.605 ± 0.023
1.35AsnTyr: 1.35 ± 0.03
0.0AsnXaa: 0.0 ± 0.0
Pro
3.547ProAla: 3.547 ± 0.052
0.354ProCys: 0.354 ± 0.017
2.608ProAsp: 2.608 ± 0.045
3.344ProGlu: 3.344 ± 0.05
1.722ProPhe: 1.722 ± 0.034
2.455ProGly: 2.455 ± 0.047
0.853ProHis: 0.853 ± 0.029
2.347ProIle: 2.347 ± 0.045
1.831ProLys: 1.831 ± 0.033
4.306ProLeu: 4.306 ± 0.061
1.027ProMet: 1.027 ± 0.027
1.485ProAsn: 1.485 ± 0.031
1.225ProPro: 1.225 ± 0.032
1.739ProGln: 1.739 ± 0.035
1.457ProArg: 1.457 ± 0.033
2.376ProSer: 2.376 ± 0.044
2.093ProThr: 2.093 ± 0.038
3.406ProVal: 3.406 ± 0.058
0.525ProTrp: 0.525 ± 0.021
1.255ProTyr: 1.255 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
4.526GlnAla: 4.526 ± 0.064
0.458GlnCys: 0.458 ± 0.02
2.05GlnAsp: 2.05 ± 0.041
2.491GlnGlu: 2.491 ± 0.046
1.624GlnPhe: 1.624 ± 0.034
3.023GlnGly: 3.023 ± 0.039
1.168GlnHis: 1.168 ± 0.029
2.608GlnIle: 2.608 ± 0.052
1.999GlnLys: 1.999 ± 0.037
5.565GlnLeu: 5.565 ± 0.068
1.151GlnMet: 1.151 ± 0.028
1.542GlnAsn: 1.542 ± 0.035
1.952GlnPro: 1.952 ± 0.039
3.339GlnGln: 3.339 ± 0.071
2.421GlnArg: 2.421 ± 0.052
2.63GlnSer: 2.63 ± 0.051
2.131GlnThr: 2.131 ± 0.043
3.113GlnVal: 3.113 ± 0.047
0.655GlnTrp: 0.655 ± 0.023
1.406GlnTyr: 1.406 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
3.506ArgAla: 3.506 ± 0.056
0.548ArgCys: 0.548 ± 0.022
2.635ArgAsp: 2.635 ± 0.048
3.108ArgGlu: 3.108 ± 0.048
2.212ArgPhe: 2.212 ± 0.043
2.784ArgGly: 2.784 ± 0.05
1.317ArgHis: 1.317 ± 0.032
3.119ArgIle: 3.119 ± 0.051
2.401ArgLys: 2.401 ± 0.049
5.218ArgLeu: 5.218 ± 0.071
1.279ArgMet: 1.279 ± 0.03
1.976ArgAsn: 1.976 ± 0.041
1.72ArgPro: 1.72 ± 0.035
2.522ArgGln: 2.522 ± 0.047
2.619ArgArg: 2.619 ± 0.053
2.662ArgSer: 2.662 ± 0.042
2.194ArgThr: 2.194 ± 0.039
3.172ArgVal: 3.172 ± 0.055
0.627ArgTrp: 0.627 ± 0.021
1.798ArgTyr: 1.798 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
5.27SerAla: 5.27 ± 0.066
0.656SerCys: 0.656 ± 0.024
3.661SerAsp: 3.661 ± 0.068
3.857SerGlu: 3.857 ± 0.045
2.669SerPhe: 2.669 ± 0.046
4.965SerGly: 4.965 ± 0.067
1.546SerHis: 1.546 ± 0.034
3.869SerIle: 3.869 ± 0.06
3.012SerLys: 3.012 ± 0.048
6.811SerLeu: 6.811 ± 0.094
1.699SerMet: 1.699 ± 0.037
2.386SerAsn: 2.386 ± 0.045
2.4SerPro: 2.4 ± 0.046
3.001SerGln: 3.001 ± 0.049
3.025SerArg: 3.025 ± 0.048
4.154SerSer: 4.154 ± 0.059
3.219SerThr: 3.219 ± 0.049
4.457SerVal: 4.457 ± 0.068
0.857SerTrp: 0.857 ± 0.029
1.979SerTyr: 1.979 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
4.872ThrAla: 4.872 ± 0.068
0.533ThrCys: 0.533 ± 0.022
3.057ThrAsp: 3.057 ± 0.052
3.321ThrGlu: 3.321 ± 0.046
2.043ThrPhe: 2.043 ± 0.045
4.208ThrGly: 4.208 ± 0.064
1.163ThrHis: 1.163 ± 0.029
3.388ThrIle: 3.388 ± 0.053
2.367ThrLys: 2.367 ± 0.048
6.122ThrLeu: 6.122 ± 0.073
1.263ThrMet: 1.263 ± 0.031
2.0ThrAsn: 2.0 ± 0.037
2.588ThrPro: 2.588 ± 0.039
2.257ThrGln: 2.257 ± 0.044
2.312ThrArg: 2.312 ± 0.042
3.23ThrSer: 3.23 ± 0.054
2.952ThrThr: 2.952 ± 0.054
4.122ThrVal: 4.122 ± 0.069
0.54ThrTrp: 0.54 ± 0.022
1.412ThrTyr: 1.412 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
6.461ValAla: 6.461 ± 0.074
0.806ValCys: 0.806 ± 0.025
3.999ValAsp: 3.999 ± 0.062
4.408ValGlu: 4.408 ± 0.059
2.654ValPhe: 2.654 ± 0.046
4.621ValGly: 4.621 ± 0.063
1.272ValHis: 1.272 ± 0.034
4.88ValIle: 4.88 ± 0.063
3.631ValLys: 3.631 ± 0.058
6.875ValLeu: 6.875 ± 0.075
2.105ValMet: 2.105 ± 0.041
2.958ValAsn: 2.958 ± 0.054
2.671ValPro: 2.671 ± 0.044
2.236ValGln: 2.236 ± 0.04
3.028ValArg: 3.028 ± 0.046
4.779ValSer: 4.779 ± 0.063
4.184ValThr: 4.184 ± 0.067
5.354ValVal: 5.354 ± 0.072
0.717ValTrp: 0.717 ± 0.028
1.772ValTyr: 1.772 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
0.816TrpAla: 0.816 ± 0.026
0.149TrpCys: 0.149 ± 0.011
0.619TrpAsp: 0.619 ± 0.024
0.513TrpGlu: 0.513 ± 0.018
0.576TrpPhe: 0.576 ± 0.018
0.761TrpGly: 0.761 ± 0.023
0.365TrpHis: 0.365 ± 0.019
0.681TrpIle: 0.681 ± 0.022
0.531TrpLys: 0.531 ± 0.022
1.823TrpLeu: 1.823 ± 0.04
0.332TrpMet: 0.332 ± 0.017
0.466TrpAsn: 0.466 ± 0.017
0.492TrpPro: 0.492 ± 0.019
0.953TrpGln: 0.953 ± 0.029
0.681TrpArg: 0.681 ± 0.026
0.659TrpSer: 0.659 ± 0.022
0.478TrpThr: 0.478 ± 0.02
0.767TrpVal: 0.767 ± 0.025
0.199TrpTrp: 0.199 ± 0.014
0.405TrpTyr: 0.405 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.201TyrAla: 2.201 ± 0.046
0.41TyrCys: 0.41 ± 0.018
1.66TyrAsp: 1.66 ± 0.037
1.48TyrGlu: 1.48 ± 0.034
1.297TyrPhe: 1.297 ± 0.03
2.084TyrGly: 2.084 ± 0.041
0.811TyrHis: 0.811 ± 0.026
1.679TyrIle: 1.679 ± 0.038
1.308TyrLys: 1.308 ± 0.028
3.31TyrLeu: 3.31 ± 0.06
0.635TyrMet: 0.635 ± 0.02
1.129TyrAsn: 1.129 ± 0.03
1.376TyrPro: 1.376 ± 0.029
1.839TyrGln: 1.839 ± 0.04
1.827TyrArg: 1.827 ± 0.04
2.045TyrSer: 2.045 ± 0.038
1.482TyrThr: 1.482 ± 0.037
1.662TyrVal: 1.662 ± 0.03
0.489TyrTrp: 0.489 ± 0.018
0.973TyrTyr: 0.973 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4228 proteins (1369385 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski